Relationship between Serum Ferritin Levels and Sarcopenia in Transfusion-Dependent Thalassemia Patient by Rendra Prasetya Saefudin, Siprianus Ugroseno Yudho Bintoro, Sony Wibisono Mudjanarko, Merlyna Savitri, Lukita Pradhevi, Agustinus Vincent, Michael Austin Pradipta Lusida, Kartika Afrida Fauzia

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Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher-Risk MDS Patients by Regulating the ROS-Related Wnt/β-Catenin Pathway by Lei Huang, Zhaoyun Liu, Hui Liu, Kai Ding, Fu Mi, Chenhuan Xiang, Guanrou Wang, Yixuan Guo, Rong Fu

“…The higher incidence of ASXL1 and TET2 gene mutations in our iron overload (IO) MDS patients suggests that IO may be involved in the pathogenesis of MDS. …”
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Advanced Imaging Techniques for Assessing Fat, Iron, and Fibrosis in Chronic Liver Disease by Sabarish Narayanasamy, Manuela Franca, Ilkay S. Idilman, Meng Yin, Sudhakar K. Venkatesh

Subjects: “…chronic liver disease; steatosis; iron overload; liver fibrosis; steatohepatitis…”
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The effect of blood transfusion on serum hepcidin levels in chronically transfused patients of β-thalassemia major: An observational study in a tertiary care centre in Western Maha... by Sujay Bhowmik, Amit Kumar Biswas, Ajay Kumar Baranwal, Amit Ajay Pawar, Ujjwal Dimri

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Primary Terminal Haemochromatosis in a 50 Year-Old Patient by M. I. Gonik, M. S. Zharkova, O. Yu. Kiseleva, E. V. Berezina, Sh. A. Ondos, Yu. V. Lerner, E. A. Kogan, V. T. Ivashkin

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Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: Results from the EPIC Clinical Trial by John Porter, Donald K. Bowden, Marina Economou, Jacques Troncy, Arnold Ganser, Dany Habr, Nicolas Martin, Adam Gater, Diana Rofail, Linda Abetz-Webb, Helen Lau, Maria Domenica Cappellini

“…Treatment of iron overload using deferoxamine (DFO) is associated with significant deficits in patients' health-related quality of life (HRQOL) and low treatment satisfaction. …”
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Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice by Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo

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Exploring Liraglutide’s mechanism in reducing renal fibrosis: the Fsp1-CoQ10-NAD(P)H pathway by Qi Chen, Ji-Xian Song, Zhi Zhang, Ji-Ren An, Yu-Jing Gou, Miao Tan, Yashuo Zhao

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Clinical Manifestations of Hemochromatosis in HFE C282Y Homozygotes Identified by Screening by Gordon D McLaren, Christine E McLaren, Paul C Adams, James C Barton, David M Reboussin, Victor R Gordeuk, Ronald T Acton, Emily L Harris, Mark R Speechley, Phyliss Sholinsky, Fitzroy W Dawkins, Beverly M Snively, Thomas M Vogt, John H Eckfeldt, for the Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators

“…BACKGROUND: Patients with hemochromatosis may suffer organ damage from iron overload, often with serious clinical consequences.…”
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Secondary Hemochromatosis due to Chronic Oral Iron Supplementation by Ronald Lands, Emmanuel Isang

“…We present a patient who developed iron overload due to chronic ingestion of oral ferrous sulfate. …”
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Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the ALAS2 gene leading to X-linked sideroblastic anemia—a family study by Salam Al kindi, Salam Al kindi, Altaf Al-Mamari, Shoaib Al-Zadjali, Mohamed Al-Rawahi, Ali Al Madhani, Anil V. Pathare

“…They did not have anemia or iron overload.…”
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Investigating Oxidative Stress and Antioxidant Dynamics in Beta-thalassemia Major: A Comparative Study from Al-Diwaniyah, Iraq by Hadeer Hayder Inteek, Shaymaa Rabeea Madhkhoor

“…This status induces iron overload from transfusions that can lead to the onset of oxidative stress and hence worsen cellular impairment. …”
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Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI by Siqi Zhang, Wen Zhao, Longwei Sun, Guohua Liang, Xiaodong Wang, Hongwu Zeng

“…This study investigated whether genotype correlates with distinct myocardial iron overload patterns, assessed by cardiovascular magnetic resonance (CMR) T2* values. …”
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Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders by Clara Camaschella, Laura Silvestri

“…Iron is essential for human life, but toxic if present in excess. To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. …”
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Iron Chelation Therapy in Myelodysplastic Syndromes by Emanuela Messa, Daniela Cilloni, Giuseppe Saglio

“…This review aims to summarize what is currently known about the incidence and clinical consequences of iron overload in MDS patients and the state-of the-art of iron chelation therapy in this setting. …”
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The Hereditary Hyperferritinemia-Cataract Syndrome in 2 Italian Families by Katia Perruccio, Francesco Arcioni, Carla Cerri, Roberta La Starza, Donatella Romanelli, Ilaria Capolsini, Maurizio Caniglia

“…Magnetic resonance imaging in the mother was positive for iron overload in the spleen. Cataract was diagnosed in mother and child. …”
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Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage by Mira Hanna, Ahmed M. A. Akabawy, Mohamed Mansour Khalifa, Mohamed Mansour Khalifa, Marawan Abd Elbaset, Reda Abdelnasser Imam, Hanan Seddiek

“…We tackled the relationship between intracellular iron overload and macrophage polarization within 6, 24, and 72 h of sepsis induction. …”
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Hereditary Hyperferritinemia-Cataract Syndrome in 3 Generations of a Family in East Tennessee by Heidi A. Worth, Zachary Marlette, David Aljadir, Ronald Lands

“…Hereditary hyperferritinemia and cataracts syndrome (HHCS) without iron overload is a syndrome first identified less than 3 decades ago. …”
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Extracellular vesicles in thalassemia: Mechanisms, implications, and therapeutic potential by Shahzad Ali Jiskani

“…Key contributors to thalassemia complications, particularly, in patients with β-thalassemia major, are ineffective erythropoiesis and iron overload. These complications can lead to a variety of severe health issues, including chronic inflammation, organ dysfunction, thrombosis, vascular abnormalities, and systemic iron overload. …”
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Juvenile Hemochromatosis due to a Homozygous Variant in the HJV Gene by María-Belén Moreno-Risco, Manuel Méndez, María-Isabel Moreno-Carralero, Ana-María López-Moreno, José-Manuel Vagace-Valero, María-José Morán-Jiménez

“…We report a child with hepatic iron overload and family history of hemochromatosis. …”
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