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8721
Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021
Published 2025-03-01“…However, the study’s reliance on modeling and available data suggests cautious interpretation, and further research is needed to validate these findings in clinical and real-world settings.…”
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8722
A novel ddPCR™ assay for eDNA detection and quantification of Greater Amberjack Seriola dumerilli and three congeners in US waters: challenges and application to fisheries independ...
Published 2025-01-01“…Key to progressing the field is Droplet Digital™ PCR (ddPCR™), a highly sensitive technique with advanced multiplexing and direct quantification capabilities that can provide fisheries scientists with improved interpretation of eDNA data. Methods We developed and validated a novel tetraplex ddPCR™ assay able to detect and distinguish between S. dumerili, S. fasciata, S. rivoliana, and S. zonata from seawater eDNA samples. …”
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8723
Evolving trends in lung cancer risk factors in the ten most populous countries: an analysis of data from the 2019 Global Burden of Disease StudyResearch in context
Published 2025-01-01“…Despite a decline in asbestos-associated TBL cancer ASMR from 8.91/100,000 to 6.0/100,000, the rate in the United States remained twice higher than the global average for the entire study period. Interpretation: Tobacco-associated TBL cancer mortality is declining but still predominant. …”
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8724
Association of clinical signs of possible serious bacterial infections identified by community health workers with mortality of young infants in South Asia: a prospective, observat...
Published 2025-02-01“…Hypothermia had particularly high risk for mortality during days 7–<60 (HR 45.1, 95% CI 27.6–73.4). Interpretation: WHO reconsideration of hypothermia as a sign of critical illness is warranted. …”
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8725
Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context
Published 2025-02-01“…Fluoxetine was well tolerated, there were no serious adverse events and only one grade 3 adverse event in the intervention arm. Interpretation: Overall, the evidence from this study is compatible with fluoxetine having a weak in vivo antiviral activity against SARS-CoV-2, although the primary endpoint is also compatible with no effect. …”
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8726
Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context
Published 2025-03-01“…There was no significant difference in risk for FQ versus CPH (ARD, 0.11 per 1000 person-year; calibrated HR, 1.01 [95% CI 0.82–1.25]). Interpretation: This large-scale study used a rigorous design with objective diagnostics to address bias and confounding. …”
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8727
SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort studyResearch in context
Published 2025-02-01“…After adjusting for relevant demographic, lifestyle, and clinical variables, we found a significant association between the risk of experiencing PASC and multiple SARS-COV-2 infections (RR = 1.41 [1.14–1.74]), severe COVID-19 (RR = 3.17 [2.41–4.16]), and being unvaccinated at first infection (RR = 3.29 [2.46–4.41]). Interpretation: Although the pathogenetic mechanism for PASC remains unclear, identifying risk factors such as lack of vaccination or re-infection can assist in better understanding and managing the condition. …”
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8728
Coal mining-induced composite damage to geological bodies and geological guarantee against damage reduction
Published 2025-01-01“…., a precise exploration system, an intelligent perception system, a rapid interpretation system, a risk assessment system, an engineering loss reduction system, and a comprehensive analysis platform for mining-induced composite damage. …”
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8729
Prevalence and determinants of post-neonatal mortality in East Africa: a multilevel analysis of the recent demographic and health survey
Published 2025-01-01“…In the multilevel logistic regression model, significant factors were deemed to be associated with post-neonatal mortality at p-values <0.05. The data were interpreted using the adjusted odds ratio (AOR) and confidence interval (CI). …”
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8730
Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context
Published 2025-02-01“…PRS for BD type-I was associated with increased odds of psychotic MDD, while BD type-II PRS showed no significant association with psychotic MDD. Interpretation: This study provides evidence for the genetic basis of psychotic MDD, underscoring its unique position bridging the spectrum of mood and psychotic disorders. …”
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8731
Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context
Published 2025-01-01“…For all endometrial carcinomas together, including index carriers, cumulative incidence was 22.7% at age 70. Interpretation: In a nation-wide cohort of Lynch syndrome carriers, nearly one-third of eligible carriers did not undergo gynaecological surveillance. …”
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8732
Impact of antiparasitic therapy on cardiovascular outcomes in chronic Chagas disease. A systematic review and meta-analysisResearch in context
Published 2025-01-01“…Compared to no treatment or placebo, antiparasitic treatment led to a reduction in i) ECG changes (17 studies, 4994 participants: risk ratio (RR): 0.48, 95% CI 0.36–0.66, p < 0.001; I2 = 76.4%) with a number needed to treat (NNT) of 5; ii) disease progression (12 studies, 5722 participants: RR: 0.35, 95% CI 0.23–0.51, p < 0.001; I2 = 72.4%) NNT of 6; iii) cardiovascular death (7 studies, 5662 participants: RR: 0.44, 95% CI 0.21–0.95, p = 0.04; I2 = 50.5%) NNT of 22; and iv) overall mortality (10 studies, 7694 participants: RR: 0.54, 95% CI 0.34–0.87, p < 0.001; I2 = 60%) NNT of 23. Interpretation: We found compelling evidence that antiparasitic treatment significantly reduces the risk of ECG changes, disease progression, cardiovascular death, and overall mortality in chronic Chagas disease. …”
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8733
Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context
Published 2025-02-01“…In the treatment of stroke with neuroprotective agents, although the drug dosage of ICO injection was lower than intravenous injection, drug accumulation in the brain increased after ICO injection, which helped repair nerve damage, reduce neuronal apoptosis, and decrease the expression of inflammatory factors. Interpretation: ICO injection is a central nervous system drug delivery method that utilizes natural microchannels between the skull and dura mater for efficient drug delivery. …”
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8734
Prediction model for type 2 diabetes mellitus and its association with mortality using machine learning in three independent cohorts from South Korea, Japan, and the UK: a model de...
Published 2025-02-01“…Similar patterns and trends were observed in the validation cohorts (T1: 1.74 [1.49–2.03], T2: 1.97 [1.69–2.30], and T3: 3.31 [2.82–3.38] in validation cohort A; T1: 1.33 [1.03–1.71], T2: 1.54 [1.21–1.96], and T3: 1.73 [1.36–2.20] in validation cohort B). Interpretation: This study derived and validated an ML-based model to predict the incidence of T2DM within 5 years across three countries (South Korea, Japan, and the UK), showing that the model probability is associated with an increased risk of mortality. …”
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8735
Prevalence and determinants of faecal carriage of carbapenem- and third-generation cephalosporin-resistant Enterobacterales: a cross-sectional household survey in northern VietnamR...
Published 2025-01-01“…For participants 5-years and older, chicken consumption was associated with increased likelihood of C3GRE carriage (aOR 3.45 [1.45–8.22]), while a protective association was observed for regular tofu (aOR 0.32 [0.14–0.74]) and fermented food consumption (aOR 0.55 [0.31–0.96]). Interpretation: In this high-prevalence setting, colonisation with C3GRE was not associated with individual antibiotic use, while environmental exposures, including food and sanitary conditions, were associated with C3GRE colonisation. …”
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8736
Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from...
Published 2025-02-01“…In contrast, older (OR 1.57, 95% CI 1.40–1.77 for those aged 12–17 years), non-Hispanic White individuals and those with chronic pre-existing neurologic conditions (OR 2.04, 95% CI 1.78–2.35) were more likely to have a neurologic PASC diagnosis. Interpretation: Racial and ethnic differences in healthcare utilization for neurologic and respiratory PASC may reflect social drivers of health and inequities in access to care. …”
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8737
Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology
Published 2025-02-01“…The existence of substantial variability among analysis outcomes raises important questions about how ecologists and evolutionary biologists should interpret published results, and how they should conduct analyses in the future.…”
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8738
Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch...
Published 2025-03-01“…The genetically determined concentration of nine proteins influenced fat mass, and one influenced lean body mass. Interpretation: These data reveal biological links between cardiovascular diseases and fragility fractures. …”
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8739
Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor...
Published 2025-02-01“…Among patients <1 year, Black patients in the South (OR 2.35, 95% CI 1.52–3.63, p < 0.001) and West (OR 2.47, 95% CI 1.35–4.49, p = 0.003) and Hispanic/Latino patients in the Northeast (OR 2.36, 95% CI 1.46–3.66, p = 0.031) had the highest mortality, relative to White patients <1 year in the Northeast. Interpretation: We found evidence of racial and ethnic disparities in mortality for children diagnosed with community-acquired pneumonia. …”
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8740
Analyzing the discourse of tourism development with a justice-oriented and moderate approach
Published 2024-09-01“…The sample size of the research was a total of 60 texts that were interpreted and analyzed. Finally, with the results of the investigations, it was concluded that all 60 are basic texts. …”
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