The Middle to Late Triassic of Central Saudi Arabia with emphasis on the Jilh Formation. Part I: lithostratigraphy, facies and paleoenvironments, palaeontology and biostratigraphic... by Le Nindre, Yves-Michel, Vaslet, Denis, Vrielynck, Bruno, Krystyn, Leopold, Manivit, Jacques, Memesh, Abdullah, Davies, Roger Brett

“…Instead, new identifications of Middle and Late Triassic conodonts in the formation and at the base of the overlying Minjur Sandstone/Formation, allied to re-interpretation of previously described ammonoids, provide new paleogeographic and chronostratigraphic data, which improve our understanding of transgressive–regressive (T–R) sequences at the outcrop and platform scales and demonstrate that the lithostratigraphic units of the Jilh Formation were inconsistently recognized at outcrop north of 25°30$^{\prime }$N due to erosion by a fourth unit of early Alaunian (Middle Norian) age; this raises the issue of the Jilh–Minjur boundary addressed in Part II. …”
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Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT by Mateusz Koziński, Doruk Oner, Jakub Gwizdała, Catherine Beigelman-Aubry, Pascal Fua, Angela Koutsokera, Alessio Casutt, Argyro Vraka, Michele De Palma, John-David Aubert, Horst Bischof, Christophe von Garnier, Sahand Jamal Rahi, Martin Urschler, Nahal Mansouri

“…It also demonstrates the ability to predict BOS in at-risk patients (FEV1 between 80% and 90% of best FEV1) with a ROC-AUC of 0.87 (95% CI: 0.735–0.974). Using visual interpretation techniques for DNNs, we reveal sensitivity to hyperlucent/hypoattenuated areas indicative of air-trapping or bronchiectasis. …”
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Phylogeographic breaks and how to find them: An empirical attempt at separating vicariance from isolation by distance in a lizard with restricted dispersal by Rancilhac, Loïs, Miralles, Aurélien, Geniez, Philippe, Mendez-Aranda, Daniel, Beddek, Menad, Brito, José Carlos, Leblois, Raphaël, Crochet, Pierre-André

“…Aim: Discontinuity in the distribution of genetic diversity (often based on mtDNA) is usually interpreted as evidence for phylogeographic breaks, underlying vicariant units. …”
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Longitudinal immunogenicity cohort study of SARS-CoV-2 mRNA vaccines across individuals with different immunocompromising conditions: heterogeneity in the immune response and cruci... by Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Jacopo Polvere, Simone Lucchesi, Chiara Coppola, Simone Costagli, Gabiria Pastore, Anna Sicuranza, Monica Tozzi, Arianna Lippi, Francesca Panza, Monica Bocchia, Alessandro Bucalossi, Guido Garosi, David Bennett, Sonia Bernazzali, Massimiliano Fabbiani, Francesca Montagnani, Donata Medaglini

“…Despite repeated vaccinations, a subset of persistent low-responders, especially among SOT, was identified. Interpretation: Our study highlights the heterogeneous immune response across individuals with different pathologies, the pivotal role of the first booster dose, the primary activation of Omicron-specific B cells elicited by updated variant-adapted vaccines and the persistence of low-responders despite multiple vaccine administrations. …”
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Longitudinal impact of past-year reproductive coercion on contraceptive use dynamics in Sub-Saharan Africa: evidence from eight population-based cohortsResearch in context by Shannon N. Wood, Haley L. Thomas, Georges Guiella, Rosine Mosso, Peter Gichangi, Simon P.S. Kibira, Fredrick Makumbi, Pierre Z. Akilimali, Funmilola M. OlaOlorun, Elizabeth Omoluabi, Michele R. Decker

“…In Uganda, past-year RC was marginally associated with reduced odds of contraceptive adoption, compared to continued non-use (p<0.1). Interpretation: In this first longitudinal study of RC, trajectories varied across settings, as did RC’s impact on contraception, affirming the importance of context. …”
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Investigating a caregiver-assisted social skills group programme for primary and early high school-aged children with acquired brain injury or cerebral palsy: protocol for a pilot... by Koa Whittingham, Roslyn N Boyd, Rose Gilmore, Leanne Sakzewski, Nicola Hilton, Afroz Keramat, Bianca Thompson, Jacqui Barfoot, Christine T Moody

“…Following completion of the PEERS Plus programme, semistructured focus group interviews will be conducted separately with caregivers and children to explore the lived experience of PEERS. Interpretive description will be used to identify patterns and themes related to participants’ experiences. …”
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Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

“…No significant interaction was observed between treatment effect and subphenotypes. Interpretation: Subphenotypes with the highest concentration of biomarkers of endothelial dysfunction and inflammation (inflammatory) or myocardial injury/fibrosis (cardiopathic) were associated with mortality independently from the SCAI shock stages. …”
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Nature, prevalence and determinants of mental health problems experienced by adolescents in south Asia: a systematic reviewResearch in context by Chethana Mudunna, Medhavi Weerasinghe, Thach Tran, Josefine Antoniades, Lorena Romero, Miyuru Chandradasa, Jane Fisher

“…Increased physical activity, adequate nutrition, safe/positive homes/family environment, being unmarried females, higher maternal education, peer support/friendship, higher education level and engaging in extra-curricular activities were protective of mental well-being. Interpretation: Prevalence of MHPs among south Asian adolescents appears high. …”
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Worldwide patterns and trends in ovarian cancer incidence by histological subtype: a population-based analysis from 1988 to 2017Research in context by Yi-Fan Wei, Li Ning, Yi-Lin Xu, Jing Ma, Dong-Run Li, Zan-Fei Feng, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Peng Li, Yong-Pei Yu, Dong-Hui Huang, Xiao-Ying Li, Song Gao, Chun-Qing Lin, Ting-Ting Gong, Qi-Jun Wu, Jing-He Lang

“…Although trends in subtypes also remained stable, ASRs increased over time for serous carcinomas and germ cell tumor in most countries, while mucinous carcinomas and adenocarcinoma NOS showed a decline. Interpretation: Variations in global patterns and trends in OC incidence and its subtypes might be influenced by genetic and reproductive factors. …”
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Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context by Anne M. Gehrels, Pauline A.J. Vissers, Mirjam A.G. Sprangers, Nienke M. Fijnheer, Esther N. Pijnappel, Lydia G. van der Geest, Geert A. Cirkel, Judith de Vos-Geelen, Marjolein Y.V. Homs, Geert- Jan Creemers, Martijn W.J. Stommel, Lois A. Daamen, Marc G. Besselink, Johanna W. Wilmink, Hanneke W.M. van Laarhoven

“…In BSC, hepatic symptoms decreased and flatulence increased. Interpretation: This nationwide study identified specific improvements and deteriorations in various HRQoL domains during 6 months follow-up. …”
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Post-vaccination campaign evaluation of systemic and mucosal immunity of trivalent oral poliovirus vaccine in Karachi, Pakistan (2020–2021): a cross-sectional studyResearch in cont... by Ali Faisal Saleem, Visalakshi Jeyaseelan, Zaubina Kazi, Mahjabeen Zehra, Muhammad Masroor Alam, Grace Macklin, Rocio Lopez Cavestany, Sajid Muhammad, Najeeb Rehman, Ondrej Mach

“…Seven days after the first and second tOPV campaigns, 32.7% and 18.6% excreted Sabin (vaccine) poliovirus type 2, respectively. Interpretation: The study demonstrated enhanced mucosal immunity as well as a high type 2 seroconversion rate and antibody seroprevalence after two tOPV campaigns. …”
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Interplay between physical activity volume and intensity with modeled life expectancy in women and men: A prospective cohort analysis by Francesco Zaccardi, Alex V. Rowlands, Paddy C. Dempsey, Cameron Razieh, Joe Henson, Jonathan Goldney, Benjamin D. Maylor, Atanu Bhattacharjee, Yogini Chudasama, Charlotte Edwardson, Jari A. Laukkanen, Ulf Ekelund, Melanie J. Davies, Kamlesh Khunti, Thomas Yates

“…The purpose of the study was to investigate the interplay between objectively measured PA volume and intensity profiles with modeled life expectancy in women and men within the UK Biobank cohort study and interpret findings in relation to brisk walking. Methods: Individuals from UK Biobank with wrist-worn accelerometer data were included. …”
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Prevalence of potential drug‒drug interactions and associated factors among elderly patients in Ethiopia: a systematic review and meta-analysis by Tekletsadik Tekleslassie Alemayehu, Yilkal Abebaw Wassie, Abaynesh Fentahun Bekalu, Addisu Afrassa Tegegne, Wondim Ayenew, Gebresilassie Tadesse, Demis Getachew, Abebaw Setegn Yazie, Bisrat Birke Teketelew, Mekonnen Derese Mekete, Setegn Fentahun, Tesfaye Birhanu Abebe, Tefera Minwagaw, Gebremariam Wulie Geremew

“…As a result, a single DDIs identification database needs to be authorized; otherwise, clinical knowledge should be taken into account when interpreting the information obtained.…”
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Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation studyResearch in context by Shruti Agrawal, Claudia Smith, Stefan Y. Bogli, Michal M. Placek, Manuel Cabeleira, Deborah White, Esther Daubney, Adam Young, Erta Beqiri, Riaz Kayani, Diarmuid O'Donnell, Nazima Pathan, Suzanna Watson, Anna Maw, Matthew Ganrett, Hari Krishan Kanthimathianathan, Harish Bangalore, Santosh Sundararajan, Gayathri Subramanian, Dusan Raffaj, Avishay Sarfatti, Simona Lampareillo, Anton Mayer, Oliver Ross, Marek Czosnyka, Peter J. Hutchinson, Peter Smielewski, Carly Tooke, Caroline Payne, Holly Belfield, Amisha Mistry, Collette Spencer, Claire Jennings, Lara Bunni, Laura Anderson, Emily Morgan, Melanie James, Rebecca Beckley, Tahnima Khatun, Hafiza Khatun, Olivia Nugent, Richard Aldridge, Ruth Morgan, Julie Morcombe, Martin Quinton, Catherine Postlethwaite, Jenny Pond, Jessica Cutler, Caitlin Oxford

“…The critical PRx threshold identified were 0.5 for mortality and 0.0 for favourable outcome. Interpretation: With STARSHIP, we validate the outcome association of CA derangements as assessed by PRx in pTBI in the first prospective observational multicentre study. …”
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Faecal microbiota transplantation for patients with diabetes type 1 and severe gastrointestinal neuropathy (FADIGAS): a randomised, double-blinded, placebo-controlled trialResearch... by Katrine Lundby Høyer, Simon Mark Dahl Baunwall, Ditte Smed Kornum, Mette Winther Klinge, Asbjørn Mohr Drewes, Knud Bonnet Yderstræde, Louise Bruun Thingholm, Martin Steen Mortensen, Susan Mikkelsen, Christian Erikstrup, Christian Lodberg Hvas, Klaus Krogh

“…The Patient Assessment of Gastrointestinal Symptom Severity Index declined from a median of 42 (28–47) to 25 (14–31) after FMT and 47 (31–69) to 41 (36–64) after placebo (p = 0.03). Interpretation: FMT was safe and improved clinical outcomes for patients with type 1 diabetes suffering from bowel symptoms. …”
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Exploring expressed concerns and uncanny feeling in patients with shortness of breath calling out-of-hours primary care by Michelle Spek, Dorien L. Zwart, Esther de Groot, Michelle R. Timmerman, Maarten van Smeden, Daphne C. A. Erkelens, Anna S. M. Dobbe, Mathé Delissen, Frans H. Rutten, Roderick P. Venekamp

“…Critical reflective interpretation is needed as uncanny feelings are difficult to judge. …”
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Investigation on the status of professional identity of nursing staff in a Grade 3A Chinese medicine hospital (某三级甲等中医院护理人员职业认同感现状调查及相关性分析)... by HONG Yanyan (洪艳燕), GUO Xiujun (郭秀君), LI Jian (李健), LIU Hui (刘翚), LIU Yuanyuan (刘园园)

“…Results The results indicated that the model's performance was appropriate with a cumulative interpretation rate of 85. 71% (＞80%). According to the investigation results, the average score of professional recognition of 705 nurses was (112. 238±22. 409), lower score were found associated with nurses' sense of self-determination and organizational influence, which were at the moderate level (≥4), and the rest were at the high level(＞5). …”
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Characteristics and outcomes of patients with LAM receiving sirolimus in France based on real-life data by Vincent Cottin, Vincent Cottin, Antoine Cases, Virginie Bourdin, Martine Reynaud-Gaubert, Sandrine Hirschi, Mallorie Kerjouan, Rémi Diesler, Rémi Diesler, Brieux Chardès, Stéphane Fiévez, Nada Assi, Aurélie Schmidt, Hélène Denis, Lidwine Wémeau-Stervinou, Yurdagul Uzunhan

“…Even though some of the results should be interpreted cautiously in the light of limitations related to the use of claims database, evolution of the disease and missing safety data, the information retrieved in this study is very valuable, as few studies provide real-world information on LAM populations.…”
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Prediction accuracy of discrete choice experiments in health-related research: a systematic review and meta-analysisResearch in context by Ying Zhang, Thi Quynh Anh Ho, Fern Terris-Prestholt, Matthew Quaife, Esther de Bekker-Grob, Peter Vickerman, Jason J. Ong

“…DCEs conducted under clinical settings and analysed using the heteroskedastic multinomial logit model, incorporating systematic preference heterogeneity and random opt-out utility, had higher specificity than non-clinical settings and alternative models. Interpretation: DCEs are valuable for capturing health-related preferences and possess reasonable external validity to predict health-related behaviours, particularly for opt-in choices. …”
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Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experien... by Alex Durand Nka, Yagai Bouba, Wilfried Rooker Tsapi Lontsi, Davy-Hyacinte Gouissi Anguechia, Georges Teto, Aude christelle Ka’e, Ezechiel Ngoufack Jagni Semengue, Collins Ambe Chenwi, Désiré Takou, Lum Forgwei, Tatiana Anim-Keng Tekoh, Aurelie Minelle Kengni Ngueko, Bernadette Bomgning Fokou, Jeremiah Efakika Gabisa, Michel Carlos Tommo Tchouaket, Willy Leroi TognaPabo, Derrick Tambe Ayuk Ngwese, Jacky Njiki Bikoi, Daniele Armenia, Vittorio Colizzi, Marcel Yotebieng, Nicaise Ndembi, Maria-Mercedes Santoro, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Alexis Ndjolo, Joseph Fokam

“…Drug resistance mutations (DRMs) were interpreted using Stanford HIVdb.v9, and covariation patterns between M184V and major NRTI/NNRTI DRMs were assessed. …”
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