Germline BRCA testing in Denmark following invasive breast cancer: Progress since 2000 by Aleksandar M. Kostov, Maj-Britt Jensen, Bent Ejlertsen, Mads Thomassen, Caroline Maria Rossing, Inge S. Pedersen, Annabeth H. Petersen, Lise Lotte Christensen, Karin A.W. Wadt, Anne-Vibeke Lænkholm

“…BRCA test rates were higher for oestrogen receptor-negative/human epidermal growth factor receptor 2-negative BC (25% in 2000–2005 vs. 38% in 2012–2017), and these findings were confirmed in multivariate regression models. Interpretation: Our results indicate a critical need for an intensified focus on BRCA testing among BC patients older than 40, where a mainstreamed testing approach might overcome delayed or missed testing. …”
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Les textiles dans les tombes gauloises à dépôt de crémation en vase métallique : usages pratiques, mises en scène et perspectives anthropologiques (seconde moitié du vie s.-ve s. a... by Elsa Desplanques

“…Considerations of the anthropological interpretation of textile use are based on Greek written sources prior to or contemporary with the 5th c. …”
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Feedback of aggregate patient-reported outcomes (PROs) data to clinicians and hospital end users: findings from an Australian codesign workshop process by Monique F Kilkenny, Dominique A Cadilhac, Shaun L Hancock, Violet Marion, Paulette Kelly, Sibilah Breen, Benjamin Clissold, Lauren Sanders, Olivia Francis Ryan, Penina Gunzburg, Shae Cooke, Lauren Guy

“…At the final workshop, recommendations to enhance communication of PROs data for comparing health service performance were made including tailoring feedback to professional roles and use of case-mix adjustment to ensure fair comparisons.Conclusions Our research provides guidance on PROs reporting for optimising data interpretation and comparing hospital performance.…”
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Typological and cumulative approaches to risk and adversity in Child and Adolescent Mental Health Services (CAMHS): Retrospective cohort analysis in South London by Barry Coughlan, Nicole Marshall, Matt Woolgar, Julia Mannes, Paige Erkiert, Ayla Humphrey, Jack Smith, Taliah Drayak, Francesca Crozier-Roche, Tessa Morgan, Dustin Hutchinson, David Graham, Rick Hood, Robbie Duschinsky

“…Associations between individual risk typologies and psychiatric diagnosis and service activity are discussed. Interpretation: Our findings suggest that typological and cumulative approaches to risk and adversity can produce unique insights about diagnostic practices and service activity. …”
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The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 by Ceyda Dincer Yazan, Can Ilgin, Onur Elbasan, Tugce Apaydin, Saida Dashdamirova, Tayfun Yigit, Uluhan Sili, Aysegul Karahasan Yagci, Onder Sirikci, Goncagul Haklar, Hulya Gozu

“…Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. …”
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Cancer type-specific adverse events of immune checkpoint inhibitors: A systematic review and meta-analysis by Xuhui Tong, Rong Tang, Jin Xu, Wei Wang, Qiong Du, Si Shi, Xianjun Yu

“…In anti-CTLA-4 monotherapy, the incidences of both all-grade and severe diarrhea occurred most frequently in prostate cancer patients (41.9 %, 95 % CI 37.9%–47.9; 14.8 %, 95 % CI 11.5%–18.7 %, respectively). Interpretation: This is the first comprehensive study addressing the distribution of various TRAEs across cancer types. …”
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Antibodies against neuronal surface antigens in acute stroke: a systematic review and meta-analysis by Matteo Paolucci, Andrea Zini, Luana Morelli, Luana Morelli, Rocco Liguori, Rocco Liguori, Maria Pia Giannoccaro, Maria Pia Giannoccaro

“…Due to several methodological issues, these findings should be interpreted cautiously. Additional, methodologically robust studies are needed to clarify the prevalence and significance of NMDAR-Abs in patients with stroke.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
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Quality of care delivery in patients with acute heart failure: insights from the international REPORT-HF registryResearch in context by Wan Ting Tay, Tiew-Hwa Katherine Teng, Wouter Ouwerkerk, Christiane E. Angermann, Kenneth Dickstein, John G.F. Cleland, Ulf Dahlstrom, Georg Ertl, Mahmoud Hassanein, Sergio V. Perrone, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Sean P. Collins, Gerasimos Filippatos, Carolyn S.P. Lam, Jasper Tromp

“…. <50%) achievement of cumulative QIs was associated with lower 30-day (hazard ratio [HR] 0.58, 95% Confidence Interval [CI] 0.40–0.83; p < 0.001), and 1-year mortality (HR 0.58, 95% CI 0.50–0.68; p < 0.001). Interpretation: QoC is lower in lower-than higher-income countries and lower QoC is associated with worse outcomes. …”
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The accumulation of harmful genes within the ROH hotspot regions of the Tibetan sheep genome does not lead to genetic load by Lixia Sun, Chao Yuan, Tingting Guo, Yaqin Bai, Zengkui Lu, Jianbin Liu

“…Conclusions This study provides a comprehensive and precise genomic analysis and interpretation of Tibetan sheep, offering theoretical basis for genetic breeding and evolution in Tibetan sheep.…”
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Advancing presurgical non-invasive spread through air spaces prediction in clinical stage IA lung adenocarcinoma using artificial intelligence and CT signatures by Guanchao Ye, Guangyao Wu, Yiying Li, Chi Zhang, Lili Qin, Lili Qin, Jianlin Wu, Jun Fan, Yu Qi, Fan Yang, Yongde Liao

“…BackgroundTo accurately identify spread through air spaces (STAS) in clinical stage IA lung adenocarcinoma, our study developed a non-invasive and interpretable biomarker combining clinical and radiomics features using preoperative CT.MethodsThe study included a cohort of 1,325 lung adenocarcinoma patients from three centers, which was divided into four groups: a training cohort (n = 930), a testing cohort (n = 238), an external validation 1 cohort (n = 93), and 2 cohort (n = 64). …”
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Revealing viral hepatitis epidemiology in the Democratic Republic of Congo: insights from yellow fever surveillance reanalysis by Patrick Mukadi-Kakoni, Yannick Munyeku-Bazitama, Gracia Kashitu-Mujinga, Marguerite Manwana-Pemba, Niclette Zenga-Bibi, Patient Okitale-Talunda, Christelle Mbelu-Kabongo, Fleurette Domai-Mbuyakala, Elisabeth Pukuta-Simbu, Pierre Mutantu-Nsele, Yoshinao Kubo, Sheila Makiala-Mandanda, Steve Ahuka-Mundeke, Koya Ariyoshi, Jean-Jacques Muyembe-Tamfum

“…National yellow fever surveillance is a valuable resource for understanding hepatitis epidemiology, though careful interpretation is necessary. Tailored interventions are required for mitigating the burden of viral hepatitis in each province.…”
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Effectiveness of the addition of visual aids to conversational preoperative education in glaucoma filtering surgery: A randomized controlled trial by Peimin Lin, Laiwen Lv, Ruqing Tang, Dehua Li, Xiaoxuan Chen, Jie Fang, Zhenggen Wu, Chukai Huang, Kusheng Wu

“…Furthermore, the ocular positioning compliance and cooperation during the surgery were significantly lower in the oral education group compared to the visual aids group (p < 0.001). Interpretation: The inclusion of visual aids in preoperative education significantly improves patient outcomes in glaucoma filtering surgery by reducing anxiety and pain and stabilizing physiological parameters. …”
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Green Synthesis of Nanostructure CeO2 Using Tea Extract: Characterization and Adsorption of Dye from Aqueous Phase by Chengshun Liu, Xiyao Liu, Yilin Wu, Zhuotong Chen, Zhuanrong Wu, Shumao Wang, Hua Han, Zhenbang Xie, Yixuan Wang, Tzu-Hsing Ko

“…The kinetic analysis showed that the second-order model was the appropriate model to interpret the adsorption behavior of synthesized CeO2. …”
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Comparison of Performance on the Clock Drawing Test Using Three Different Scales in Dialysis Patients by Taim Abdullah Muayqil, Ahmad Raed Tarakji, Abdullah Mohammad Khattab, Nasser Talal Balbaid, Ahmad Mohedeen Al-Dawalibi, Sami Ahmed Alqarni, Reema Ali Hazazi, Mohammed H. Alanazy

“…The MCS is likely to yield useful information but should be interpreted as part of the MoCA.…”
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Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity by Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)

“…Plasma samples from 903 COVID-19 patients collected during their admission during acute phase of COVID-19 and 295 hospitalized controls were assessed leading to 1198 interpretable proteomic profiles. Levels of anti-SARS-CoV-2 IgG were measured by ELISA and a cell-binding assay.ResultsThe median age of the participants was 59 years, 46% were female, 65% had comorbidities. …”
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Transcatheter edge-to-edge mitral valve repair <i>versus</i> medical therapy for secondary mitral regurgitation: a meta-analysis of randomized controlled trials by Emídio Mata, Bárbara Lage Garcia, Mariana Tinoco, Margarida Castro, Luísa Pinheiro, João Português, Francisco Ferreira, Silvia Ribeiro, Bruno Melica, António Lourenço

“…High trial heterogeneity requires careful interpretation of pooled estimates. Differences in medical therapy and patient characteristics likely affected outcomes across trials. …”
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Prognostic value of multi-PLD ASL radiomics in acute ischemic stroke by Zhenyu Wang, Yuan Shen, Xianxian Zhang, Qingqing Li, Congsong Dong, Shu Wang, Haihua Sun, Mingzhu Chen, Xiaolu Xu, Pinglei Pan, Pinglei Pan, Zhenyu Dai, Fei Chen, Fei Chen

“…Shapley Additive exPlanations was applied to interpret feature contributions.ResultsThe combined model of extreme gradient boosting demonstrated superior predictive performance, achieving an area under the curve (AUC) of 0.876. …”
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Genomic interrogation of invasive group A Streptococcus (iGAS) epidemiology and COVID-19 impacts in Victoria, Australia: a 6-year retrospective studyResearch in context by Jacqueline M. Morris, Jake A. Lacey, Kerrie Stevens, Lamali Sadeesh Kumar, Mathilda Wilmot, Janet Strachan, Marion Easton, Daneeta Hennessy, Tony M. Korman, Andrew J. Daley, Katherine B. Gibney, Adam W.J. Jenney, Steven Y.C. Tong, Benjamin P. Howden, Norelle L. Sherry

“…In Victoria, M1Aus was the dominant emm1 variant in 2017 and 2018, more recently replaced by the M1UK lineage as the dominant variant, further demonstrating the worldwide impact of M1UK. Interpretation: This comprehensive genomic study of iGAS in Victoria, Australia provides valuable insights into the population dynamics, genetic diversity, and impact of pandemic public health measures on iGAS epidemiology. …”
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Unleashing the potential of geostationary satellite observations in air quality forecasting through artificial intelligence techniques by C. Zhang, X. Niu, H. Wu, Z. Ding, K. L. Chan, J. Kim, T. Wagner, C. Liu, C. Liu, C. Liu

“…Evaluation against ground-based measurements demonstrates that GeoNet accurately predicts diurnal variations and spatial distribution details of next-day NO<span class="inline-formula">₂</span> pollution, yielding a coefficient of determination of 0.68 and a root mean square of error of 12.31 <span class="inline-formula">µg</span> m<span class="inline-formula">⁻³</span>, significantly surpassing traditional air quality model forecasts. The model's interpretability reveals that geostationary satellite observations notably improve NO<span class="inline-formula">₂</span> forecast capability more than other input features, especially over polluted regions. …”
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Ebbs and Flows of Marine Biodiversity: Navigating Spatiotemporal Patterns of Environmental DNA in a Coastal Tidal Ecosystem by Michelle Scriver, Ulla vonAmmon, Xavier Pochon, Martin Zirngibl, Francois Audrezet, Kaeden Leonard, Kylie Pedersen, Nick Bamford, Ngairo Tahere, Jo‐Ann L. Stanton, Neil J. Gemmell, Anastasija Zaiko

“…Understanding eDNA dynamics in tidal areas is critical for guiding sampling strategy design and interpreting molecular detection results. In a field study conducted at Ōpua, Bay of Islands, Aotearoa, New Zealand, an international marina with a dynamic coastal environment, we investigated eDNA detection patterns across a local spatial and temporal gradient. …”
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