A Simple Machine Learning-Based Quantitative Structure–Activity Relationship Model for Predicting pIC₅₀ Inhibition Values of FLT3 Tyrosine Kinase by Jackson J. Alcázar, Ignacio Sánchez, Cristian Merino, Bruno Monasterio, Gaspar Sajuria, Diego Miranda, Felipe Díaz, Paola R. Campodónico

“…<b>Results:</b> Key molecular descriptors influencing the inhibitor potency were identified, thereby improving the interpretability of structural requirements. Additionally, a user-friendly computational tool was developed to enable rapid prediction of pIC₅₀ values and facilitate ligand-based virtual screening, leading to the identification of promising FLT3 inhibitors. …”
Get full text

Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection by Wei Zhang, Chao Wu, Hanchen Huang, Paulina Bleu, Wini Zambare, Janet Alvarez, Lily Wang, Philip B. Paty, Paul B. Romesser, J. Joshua Smith, X. Steven Chen

“…The matched tumor-organoid data approach proved effective in capturing relevant biomarkers, enhancing prediction reliability. Interpretation: This study provides a robust framework for improving CRC chemotherapy response predictions by leveraging matched tumor and organoid gene expression data. …”
Get full text

Personalized screening strategies for TP53 R337H carriers: a retrospective cohort study of tumor spectrum in Li-Fraumeni syndrome adult carriersResearch in context by Pedro A.F. Galante, Gabriela D.A. Guardia, Janina Pisani, Renata L. Sandoval, Mateus C. Barros-Filho, Ana Carolina Leite Vieira Costa Gifoni, Diogo F.C. Patrão, Patricia Ashton-Prolla, Vitor Fiorin de Vasconcellos, Claire Freycon, Arnold Levine, Pierre Hainaut, Maria Isabel Achatz

“…Common second malignancies were breast cancer in females and lung cancer in males. Interpretation: This study shows that R337H is associated with a lifetime risk of multiple LFS-spectrum cancers but with incomplete penetrance, particularly in males. …”
Get full text

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

“…Abstract Background Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the interpretation of pathogenicity and pathophysiology. To address this challenge, we propose a high-throughput screening of cellular functionality through an imaging flow cytometry (IFC)-based platform. …”
Get full text

Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review by Laura García-Bravo, Ángela Villegas, Bárbara López Uceda, Anaís Mariscal, Cristina Vadillo, M Asunción Nieto Barbero, Juan Luis Rodríguez-Hermosa, Beatriz Mediero Valeros, José Carlos Plaza-Hernández, Miguel Fernández-Arquero, María Guzmán-Fulgencio, Gloria Candelas-Rodríguez, Silvia Sánchez-Ramón, Juliana Ochoa-Grullón

“…Anti-ARS autoantibodies were identified using three complementary methods: immunoblotting, western blotting (WB) and the method considered the gold standard, immunoprecipitation (IP), which ensures accurate interpretation of results. The study highlights the clinical and pathogenic overlap between ASS-ILD and SARS-CoV-2-related lung involvement.Both conditions share similar high-resolution computed tomography (HRCT) patterns, including inflammation and pulmonary fibrosis (PF), driven by IFN-γ signaling, which complicates accurate diagnosis. …”
Get full text

Residency training programs to support residents working in First Nations, Inuit, and Métis communities by Marghalara Rashid, Julie Nguyen, Wayne Clark, Jessica L. Foulds, Ida John, Ming-Ka Chan, Molly Whalen-Browne, Pamela Roach, Melanie Morris, Sarah Forgie

“…Methods A qualitative approach was used, guided by a relational lens for collecting data and a constructivist grounded theory for data interpretation. Theoretical sampling was used to recruit 35 participants from three main study sites across two western Canadian provinces. …”
Get full text

Dispersion and Intersection of Hydrothermal Plumes in the Manus Back-Arc Basin, Western Pacific by Zhigang Zeng, Xiaoyuan Wang, Bramley J. Murton, Haiyan Qi, Berit Lehrmann, Xiaohui Li, Zuxing Chen, Yunchao Shu

“…This implied that the plumes proximal to their vent fluid sources, which were interpreted to have relatively young ages, dispersed chemically over time, and their concentrations became more similar to those of the plumes that were more distal from their vent fluid sources.…”
Get full text

Cost savings of reducing opioid prescribing for the treatment of people with low back pain in general practice: a modelling studyResearch in context by Anagha Killedar, Romi Haas, Alexandra Gorelik, Sean Docking, Rachelle Buchbinder, Chris G. Maher, Chung-Wei Christine Lin, Alison Hayes

“…A relative reduction in opioid prescribing of 1.2% and 10.3% would be needed to recoup the costs of a strategy costing $500,000 and $4 million, respectively, over one year. Interpretation: The study highlights the short-term health and economic benefits of reducing opioid prescribing for LBP and suggests that a low to medium intensity strategy could be cost-neutral or cost-saving. …”
Get full text

Preferred labels and language to improve communication about lesions at low risk of progressing to cancer: qualitative interviews with patients and physicians by Antonio Finelli, Anna R Gagliardi, Frances C Wright, Rachel Kupets, Mavis S Lyons, Clara Baker, Genevieve Chaput, Nicole J Look Hong

“…Objectives We explored how to improve communication about low-risk lesions including labels, language and other strategies.Design Qualitative description and thematic analysis to examine the transcripts of telephone interviews with patients who had low-risk lesions and physicians; and mapping to Communication Accommodation Theory to interpret themes.Setting CanadaParticipants 15 patients: 6 (40%) bladder, 5 (33%) prostate and 4 (27%) cervix lesions; and 13 physicians: 7 (54%) cervix, 3 (23%) bladder and 3 (23%) prostate lesions.Main outcome measures Patient and physician views of labels, language and other strategies to improve communication about low-risk lesions.Results Patients and clinicians held discordant views about low-risk lesion label impact, preferences and rationale. …”
Get full text

Changes in sediment connectivity and its impact on sediment transport in a typical watershed of Southern Jiangxi Province, China by Fei Sheng, Tingxin Yi, Yanyan Wang, Haijin Zheng, Shiyu Liu, Xiaofei Nie, Longsong Hu, Haifeng Li

“…These changes were closely related to the location and quantity of sediment sources caused by the large-scale development of orchards in the watershed. The interpretation of ICmax to the changes in S3a and S5a was 51.5%, indicating a highly significant effect. …”
Get full text

PneumoniaCheck, a novel aerosol collection device, permits capture of airborne Mycobacterium tuberculosis and characterisation of the cough aeromicrobiome in people with tuberculos... by Tinaye L. Chiyaka, Georgina R. Nyawo, Charissa C. Naidoo, Suventha Moodley, Jose C. Clemente, Stephanus T. Malherbe, Robin M. Warren, David N. Ku, Leopoldo N. Segal, Grant Theron

“…Compared to BALF, none of the aerosol-enriched taxa were enriched in oral washes or sputum. Interpretation PMC captures aerosols with Ultra-detectable MTBC and MTBC is more detectable in aerosols than sputum by sequencing. …”
Get full text

Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank by Monika Kasper-Sonnenberg, Claudia Pälmke, Sonja Wrobel, Thomas Brüning, Aline Murawski, Petra Apel, Till Weber, Marike Kolossa-Gehring, Holger M. Koch

“…In the current measurement campaign only three individuals (0.7 %) exceeded the HI of 1 (with exceedances still driven by DEHP and DnBP).In 2022, 20 % of the individuals still had an HI > 0.2, which we propose as a benchmark for interpreting phthalate mixture risk, considering concurrent exposures to other anti-androgens. …”
Get full text

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Additionally, we identified unique immune signatures associated with smoking, obesity, and diseases such as osteoporosis, heart failure, and gout. Interpretation: This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. …”
Get full text

Mineralogy as a potential driver of irregular radiocarbon patterns among Icelandic fluvial carbon pools by Nora Gallarotti, Lisa Bröder, Julie Lattaud, Stephan Wartenweiler, Negar Haghipour, Timothy I Eglinton

“…However, the myriad of carbon sources, including ancient ‘petrogenic’ OC from sedimentary rocks or freshly assimilated OC derived from aquatic in-situ production, makes it challenging to interpret ^14 C signatures in the context of terrestrial biospheric OC turnover and residence times. …”
Get full text

Automatic GPR detection of grouting defects behind the tunnel shield segments based on wavelet coherence analysis combined with modified Res-RCNN by Dengyi Wang, Ming Peng, Liu Liu, Xiongyao Xie, Zhenming Shi, Yaoying Liang, Jian Shen, Qiyu Wu

“…Ground penetrating radar (GPR), a widely used non-destructive testing technique for detecting grouting defects behind tunnel shield segments, faces challenges like steel rebar interference, low working efficiency, and expert interpretation reliance. To address these, this paper introduces an automated approach using wavelet coherence and a modified Res-RCNN. …”
Get full text

Perspectives of the COVID-19 pandemic and vaccination among racially and ethnically diverse gay, bisexual, and other men who have sex with men with and without HIV in the US South:... by Jake S. Waldman, Jorge Alonzo, Lilli Mann-Jackson, Sandy K. Aguilar-Palma, Manuel Garcia, Benjamin D. Smart, Scott D. Rhodes

“…Methods We collected, analyzed, and interpreted qualitative in-depth interview data from a diverse sample of GBMSM (N = 30) in North Carolina, USA. …”
Get full text

Clinical characteristics of EGFR-ctDNA shedders in EGFR-mutant NSCLC patients by Martina Ruglioni, Iacopo Petrini, Stefania Crucitta, Andrea Sbrana, Giovanna Irene Luculli, Leila Sadeghi Gol, Carola Forte, Antonio Chella, Christian Rolfo, Romano Danesi, Marzia Del Re

“…This study aims to understand the determinants for ctDNA shedding based on clinical characteristics of lung cancer patients, for a better interpretation of false negative results to be considered when ordering ctDNA analysis for clinical practice. …”
Get full text

The prevalence and burden of musculoskeletal disorders amongst Indigenous people in Pimicikamak, northern Manitoba, Canada: A community health survey by André Bussières, Melissa Atkinson-Graham, Jennifer Ward, Muriel Scott, Jean Moss, Patricia Tavares, Deborah Kopansky-Giles, Jacqueline Ladwig, Cheryl Glazebrook, David A. Monias, Helga Hamilton, Donald Z. Mckay, Randall Smolinski, Scott Haldeman, Sheilah Hogg-Johnson, Steven Passmore

“…We used descriptive and cross-tabulations and consulted the community for data interpretation. Results: The survey was completed by 130 adults (65 % females, mean age, 48.4 years). …”
Get full text

Deep-Learning-Based Land Cover Mapping in Franciacorta Wine Growing Area by Girma Tariku, Isabella Ghiglieno, Andres Sanchez Morchio, Luca Facciano, Celine Birolleau, Anna Simonetto, Ivan Serina, Gianni Gilioli

“…Additionally, addressing challenges such as data availability, computational resources, and model interpretability is essential for advancing the field of remote sensing, in support of biodiversity conservation and the provision of ecosystem services and sustainable agriculture.…”
Get full text

INTERFAITH MARRIAGE CONTROVERSIES IN SEMARANG: AN ANALYSIS OF QUR'ANIC LEGAL EXEGESIS by Abdul Basid, Lilik Nur Kholidah, Muhammad Fahmi Hidayatullah, Eka Kurnia Firmansyah, Ahmad Iwan Zunaih, Reza Ahmad Zahid

“…This dispute includes discussions of Qur’anic interpretation and Islamic law as they assert different viewpoints regarding the legitimacy of marriage of Muslims with Ahl al-Kitab. …”
Get full text