The financial toxicity of cancer: unveiling global burden and risk factors – a systematic review and meta-analysis by Addisu Getie, Alemu Birara Zemariam, Befkad Derese Tilahun, Ribka Nigatu Haile, Tegene Atamenta Kitaw, Molla Azmeraw Bizuayehu

“…This systematic review and meta-analysis aims to provide a comprehensive overview of cancer-related financial toxicity and identify key risk factors contributing to this burden.Methods We conducted a systematic review and meta-analysis, searching databases like Medline, Web of Science, PubMed, Scopus, International Scientific Indexing and Google Scholar for peer-reviewed observational studies. …”
Get full text

Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…Despite previous investigations in other tumor types, immune-related adverse events (irAEs) have not been well evaluated in patients with MSI-H cancers treated with ICIs.Methods We conducted an international cohort study at tertiary cancer centers collecting clinic-pathological features from 331 patients with MSI-H mCRC treated with ICIs. …”
Get full text

Molecular Phylogenetics and Estimation of Evolutionary Divergence and Biogeography of the Family Cordycipitaceae (Ascomycota, Hypocreales) by Huili Pu, Jiao Yang, Nemat O. Keyhani, Lixia Yang, Minhai Zheng, Chenghao Qiu, Yuchen Mao, Junya Shang, Yongsheng Lin, Chengjie Xiong, Longbing Lin, Pengyu Lai, Yanbin Huang, Xin Yuan, Huiling Liang, Longfei Fan, Xiaoli Ma, Chunjin Qiu, Junzhi Qiu

“…Based on Bayesian evolutionary analysis of five genomic loci(the small subunit of ribosomal RNA (SSU) gene, the large subunit of ribosomal RNA (LSU) gene, the translation elongation factor 1-α (<i>tef1-α</i>) gene, the largest subunit of RNA polymerase II (<i>rpb1</i>), and the second largest subunit of RNA polymerase II (<i>rpb2</i>), we inferred the divergence times for members of the Cordycipitaceae, improving the internal phylogeny of this fungal family. Molecular clock analyses indicate that the ancestor of <i>Akanthomyces sensu lato</i> occurred in the Paleogene period (34.57 Mya, 95% HPD: 31.41–37.67 Mya), and that most species appeared in the Neogene period. …”
Get full text

Characteristics and association mechanisms of the transition between dominant morphology and recessive morphology of rural settlements by ZHANG Bailin, ZHANG Xinyu, ZHAO Yining, LIU Hongwu

“…[Methods] This paper draws on the “conflict-coordination” theoretical model of regional land use, and introduces the coupling coordination model, Pearson correlation coefficient and grey correlation degree model to analyze the internal correlation mechanism of the transition of rural settlements in Tianjin from 1980 to 2020. …”
Get full text

INFLUENCE OF EXO- AND ENDOGENOUS FACTORS ON THE MORPHOLOGICAL AND FUNCTIONAL STATE OF THE SPLEEN AS AN IMPORTANT MEDICAL AND SOCIAL PROBLEM OF THE HEALTH CARE SYSTEM by O.V. Mamai, S.M. Bilash, R.M. Grinko

“…Diseases of the spleen play an important role in the system of pathologies of the human internal organs. The spleen is often considered a “forgotten organ” among clinicians and radiologists. …”
Get full text

Machine learning Nomogram for Predicting endometrial lesions after tamoxifen therapy in breast Cancer patients by Cao Shaoshan, Chen Niannian, Ma Ying

“…The best-performing model was selected to construct a nomogram of endometrial lesions. Internal validation was conducted using the bootstrap method, and the model’s accuracy and fit were assessed using the concordance index (C-index) and calibration curves. …”
Get full text

Psychiatric Referrals in a Tertiary Care Hospital in North India: A Retrospective Study by Akansha Bhardwaj, Dimple Gupta, Rashmi Prakash, Nimmi A. Jose

“…All referred patients were evaluated by a Psychiatrist (MD Psychiatry) and the diagnosis was made as per the International Statistical Classification of Diseases 10 criteria. …”
Get full text

Diagnostic Model of In-Hospital Mortality in Patients with Acute ST-Segment Elevation Myocardial Infarction Used Artificial Intelligence Methods by Yong Li

“…We registered this study with the registration number ChiCTR1900027129 (the WHO International Clinical Trials Registry Platform (ICTRP) on 1 November 2019).…”
Get full text

Exploring alternative preschool education methods in Georgia: Enhancing accessibility by N. Kitoshvili

“…Drawing upon the experiences of post-Soviet nations, alongside international insights and local perspectives, the study aims to provide comprehensive insights into the feasibility and effectiveness of alternative models in Georgia. …”
Get full text

Cost-Effectiveness and Budget Impact of Emerging Minimally Invasive Surgical Treatments for Benign Prostatic Hyperplasia by Bilal Chughtai, Sirikan Rojanasarot, Kurt Neeser, Dmitry Gultyaev, Stacey L. Amorosi, Neal D. Shore

“…The models were populated with males with a mean age of 63 and an average International Prostate Symptom Score (IPSS) of 22. Clinical inputs were extracted from the LIFT and Rezum II randomized controlled trials at 4 years. …”
Get full text

Externally validated nomogram for predicting short-term pregnancy outcome of singleton pregnancies with fetal growth restriction (FGR) by Yang Li, Xiaohong Zhang, Junshu Xie, Fufen Yin, Mingrui Jin, Yujing Li, Xiuju Yin

“…In the training cohort of the internal validation set, the nomogram estimated pregnancy prognosis of FGR singleton pregnancies based on these five variables, with a concordance index (C-index) of 0.859 (95% CI: 0.81 to 0.90) for predicting termination of pregnancy (TOP), which included intrauterine fetal death and therapeutic lethal induction, with a C-index of 0.92 (95% CI: 0.86 to 0.98) for predicting stillbirth, and a C-index of 0.87 (95% CI: 0.83 to 0.92) for predicting therapeutic lethal induction with indications. …”
Get full text

National Dialogue: Bahrain Case by E. I. Vulakh

“…The all-inclusive interparty negotiations on a national basis aimed at ending an internal conflict, overcoming its consequences and securing conditions for a peaceful development of the society are not by themselves a new phenomenon. …”
Get full text

МЕТОДИКИ СТАНДАРТУ ISA-106 ДЛЯ АВТОМАТИЗАЦІЇ ПРОЦЕДУР ОПЕРАЦІЙ НЕПЕРЕРВНИХ ПРОЦЕСІВ by О. М. Пупена

“…Авторитетна організація по стандартизації International Society of Automation у 2023-му році випустила стандарт ISA-106, мета якого передати кращі практики для автоматизації процедур. …”
Get full text

Optimized Identification of Sentence-Level Multiclass Events on Urdu-Language-Text Using Machine Learning Techniques by Somia Ali, Uzma Jamil, Muhammad Younas, Bushra Zafar, Muhammad Kashif Hanif

“…We used sentence-level classification to categorize sentences including terrorist attacks, national news, sports, entertainment, politics, safety, earthquakes, fraud and corruption, sexual assault, weather, accidents, forces, inflation, murder and death, education, and international news. Deep learning, transformer-based and machine learning classifiers are used for event classification. …”
Get full text

A harmonized dataset relating alternative farmer management practices to crop yield, soil organic carbon stock, nitrous oxide emissions, and nitrate leaching generated using IPCC m... by Roberta Calone, Angela Fiore, Guido Pellis, Maria Luz Cayuela, Gabriele Mongiano, Alessandra Lagomarsino, Simone Bregaglio

“…The four trade-off components have been estimated by combining available information from i) the 2019 Refinement to the 2006 IPCC Guidelines for National Greenhouse Gas Inventories, ii) the guidelines for Green Water Footprint Accounting, iii) the Italian National Institute of Statistics, iv) and other international meta-analytic studies. The dataset presents four ∑i series, corresponding to alternative perceptions of sustainability from three potential stakeholder categories (young farmers’ cooperative, agrochemical company, public agricultural policy agency) plus one equally weighted option. …”
Get full text

Effectiveness of ‘Tackle Your Tics’, a brief, intensive group-based exposure therapy programme for children with tic disorders: study protocol of a randomised controlled trial by Danielle Cath, Annet Heijerman-Holtgrefe, Chaim Huyser, Cara Verdellen, Jolande van de Griendt, Laura Beljaars, Kees-Jan Kan, Ramón Lindauer, Pieter Hoekstra, Lisbeth Utens

“…Findings will be presented on national and international conferences, peer-reviewed scientific journals, patient organisation meetings and public media. …”
Get full text

Publishing Trends of Informal Lithuanian Youth Publications –Fanzines – at the End of the 20th Century and the Beginning of the 21st Century by Aušra Kairaitytė-Užupė

“…The language used in fanzines and its style helped to form a close relationship with readers, revealed the identity traits of subcultural groups, and helped metal music fanzine authors to integrate into the international fanzine culture context. Seeking independence and individuality, fanzine creators disregarded professional publishing standards. …”
Get full text

Effects of cardiovascular health, musculoskeletal health and physical fitness on occupational performance of firefighters: protocol for a systematic review and meta-analysis by Andre Pascal Kengne, Denise Smith, Jaron Ras, Elpidoforos Soterakis Soteriades, Lloyd Leach

“…We will disseminate the findings of in peer-reviewed journals and at national and international conferences. The protocol will form part of a chapter for a doctoral thesis.PROSPERO registration number CRD42021258898.…”
Get full text

Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collab... by Giulia Turri, MD, Luigi Martinelli, MD, Daniela Rega, MD, Nicolò Tamini, MD, Lucia Paiano, MD, Simona Deidda, MD, QuocRiccardo Bao, MD, Laura Lorenzon, MD, PhD, Raffaele De Luca, MD, Caterina Foppa, MD, PhD, Valentina Mari, MD, Giovanni Taffurelli, MD, Arcangelo Picciariello, MD, PhD, Patrizia Marsanic, MD, Leandro Siragusa, MD, Francesco Bagolini, MD, Riccardo Nascimbeni, MD, Gianluca Rizzo, MD, PhD, Sara Vertaldi, MD, Michele Zuolo, MD, Giorgio Bianchi, MD, Lisa Marie Rorato, MD, Rossella Reddavid, MD, PhD, Gaetano Gallo, MD, PhD, Lorenzo Crepaz, MD, Alberto Di Leo, MD, Mario Trompetto, MD, Enrico Potenza, MD, Mauro Santarelli, MD, Nicola de’Angelis, MD, PhD, Francesco Ciarleglio, MD, Marco Milone, MD, PhD, Claudio Coco, MD, Guido Alberto Tiberio, MD, Gabriele Anania, MD, Giuseppe S. Sica, MD, PhD, Andrea Muratore, MD, Donato Francesco Altomare, MD, Isacco Montroni, MD, PhD, Maurizio De Luca, MD, Antonino Spinelli, MD, PhD, Michele Simone, MD, Roberto Persiani, MD, Gaya Spolverato, MD, Angelo Restivo, MD, Nicolò de Manzini, MD, Marco Braga, MD, Paolo Delrio, MD, Giuseppe Verlato, MD, PhD, Corrado Pedrazzani, MD, Adriana Gioia, Cristina Vacca, Dario Parini, Giovanni Tomasicchio, Marcello Calabrò, Bruno Sensi, Filomena Misuriello, Carlo Alberto Schena, Silvia Picotto

“…Given the low risk of recurrence of stage I CC, some international guidelines do not recommend intensive follow-up after surgery. …”
Get full text

Analysis of medical services provided to patients with ankle sprains in Korea between 2015 and 2017: a cross-sectional study of the health insurance review and assessment service n... by In-Hyuk Ha, Boyoung Jung, Jiyoon Yeo, Dongwoo Nam, Ho-sun Ryu, Jae-Hong Kim

“…Objectives To provide useful information for policy-makers and clinicians by analysing the medical service use—divided into Western medicine (WM) and Korean medicine (KM)—of patients with ankle sprains in South Korea between 2015 and 2017.Design Cross-sectional, retrospective, observational study.Setting Tertiary hospitals, WM hospitals, WM clinics, KM hospitals, KM clinics and others in South Korea.Participants We analysed claim data and patient information from the 2015 to 2017 Health Insurance Review and Assessment National Patient Sample (HIRA-NPS) dataset, including 151 415 patients diagnosed with a ‘dislocation, sprain and strain of joints and ligaments at ankle and foot level’ (10th revision of the International Statistical Classification of Diseases code S93) who used medical services at least once in 3 years between January 2015 and December 2017 in South Korea.Primary and secondary outcome measures Cost of medical care, number of consultations, type of institution visited, types of treatment.Results There were 160 200 consultations and 53 044 patients in 2015, 149 956 consultations and 50 830 patients in 2016 and 140 651 consultations and 47 541 patients in 2017. …”
Get full text