A Multicentre Randomized Controlled Trial of Recombinant Interferon-Alpha-2a in the Treatment of Patients with Chronic Hepatitis C by Masafumi Komatsu, Tsuyoshi Ono, Ko Nakajima, Itaru Toyoshima, Mitsuro Chiba, Osamu Masamune, Shunji Ohkubo, Tsukasa Yoshida, Hitoshi Yagisawa, Kanji Komatsu, Hideki Wakamatsu, Nobuo Yamada, Hiroyuki Watanabe, Tsuyoshi Mukojima, Mitsuo Goto

“…Sixty-one chronic hepatitis C patients were randomly assigned to receive either 6x106 or 9x106 U of recombinant interferon-alpha-2a (IFNα-2a) six days a week for the first two weeks of treatment, followed in both cases by 6x106 U three days a week for the next 22 weeks. …”
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Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy by Dorota Zarębska-Michaluk, Iwona Buczyńska, Krzysztof Simon, Magdalena Tudrujek-Zdunek, Ewa Janczewska, Dorota Dybowska, Marek Sitko, Beata Dobracka, Jerzy Jaroszewicz, Paweł Pabjan, Jakub Klapaczyński, Łukasz Laurans, Włodzimierz Mazur, Łukasz Socha, Olga Tronina, Miłosz Parczewski, Robert Flisiak

“…The development of interferon- (IFN-) free regimens substantially improved efficacy of treatment for HCV, but despite excellent effectiveness the failures still occur. …”
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Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes by Murali Ganesan, Anup S. Pathania, Grace Bybee, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna

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Transcriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering by Ryohei Yamamura, Makoto Kinoshita, Yoshiaki Yasumizu, Yoshiaki Yasumizu, Yoshiaki Yasumizu, Tomohiro Yata, Keigo Kihara, Daisuke Motooka, Daisuke Motooka, Naoyuki Shiraishi, Yasuko Sugiyama, Shohei Beppu, Hisashi Murata, Naoshi Koizumi, Itsuki Sano, Toru Koda, Tatsusada Okuno, Hideki Mochizuki

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Cellular aspects of immunity involved in the development of atherosclerosis by Khalil Khalaf, Khalil Khalaf, Khalil Khalaf, Marc Chamieh, Natalia Welc, Chandpreet Singh, Joanne Lynn Kaouk, Aiden Kaouk, Andrzej Mackiewicz, Andrzej Mackiewicz, Mariusz Kaczmarek, Mariusz Kaczmarek, Bartlomiej Perek

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Heberferón®’s economic feasibility in patients with high-grade brain tumors without therapeutic options by María Margarita Ríos Cabrera, Iraldo Bello Rivero, Javier Cruz Rodríguez

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Interferon-Gamma Release Assays for Screening of Health Care Workers in Low Tuberculosis Incidence Settings: Dynamic Patterns and Interpretational Challenges by Madhukar Pai, Kevin Elwood

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RNA-Seq Based Transcriptome Analysis of the Type I Interferon Host Response upon Vaccinia Virus Infection of Mouse Cells by Bruno Hernáez, Graciela Alonso, Juan Manuel Alonso-Lobo, Alberto Rastrojo, Cornelius Fischer, Sascha Sauer, Begoña Aguado, Antonio Alcamí

“…Vaccinia virus (VACV) encodes the soluble type I interferon (IFN) binding protein B18 that is secreted from infected cells and also attaches to the cell surface, as an immunomodulatory strategy to inhibit the host IFN response. …”
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Interferon-gamma rescues dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching by Amit Adlakha, Thomas J. Williams, Xinxin Shou, Anna K. Reed, Boris Lenhard, Darius Armstrong-James

“…We previously identified a role for the calcineurin pathway in innate immune responses to A. fumigatus and have used exogenous interferon-gamma successfully to treat aspergillosis in this setting. …”
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Early Changes in Hepatitis C Virus (HCV) RNA Levels Predict Response to Interferon Treatment in Non-Cirrhotic HCV Patients by Glen Fallows, Kelly Kaita, Gerald Minuk, Faye Penner, Gerry Smart, Magdy Dawood, Barry Rosser

“…The role of hepatitis C virus (HCV) RNA quantification in determining ideal interferon (IFN) treatment of noncirrhotic HCV liver disease is uncertain. …”
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Interferon-γ production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles by Takeharu Watanabe, Masayuki Hayashi, Masaaki Arai, Sho Matsushita, Hiroshi Handa, Masaaki Kawano

“…In this study, administration of chicken ovalbumin (OVA) incorporated within SV40 VLPs induced interferon (IFN)-γ production in response to the OVA CTL epitope. …”
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Defective production of interferon-γ and tumour necrosis factor-α by AIDS mononuclear cells after in vitro exposure to Rhodococcus equi by S. Delia, C. M. Mastroianni, M. Lichtner, F. Mengoni, S. Moretti, V. Vullo

“…The production of interferon-γ and tumour necrosis factor-α was evaluated in the peripheral blood mononuclear cells (PBMCs) from healthy donors and AIDS patients after Rhodococcus equi infection in vitro. …”
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Efficacy and Safety of a Novel Pegylated Interferon Alpha-2a in Egyptian Patients with Genotype 4 Chronic Hepatitis C by Alaa Awad Taha, Ahmad El-Ray, Maged El-Ghannam, Bahaa Mounir

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NRF2 Antioxidant Response and Interferon‐Stimulated Genes Are Differentially Expressed in SARS‐CoV‐2‐Positive Young Subjects by Walter Toscanelli, Matteo Fracella, Marta De Angelis, Carolina Scagnolari, Leonardo Sorrentino, Elena Piselli, Maria Elena Marcocci, Fabio Midulla, Enrica Mancino, Raffaella Nenna, Laura Petrarca, Anna Teresa Palamara, Guido Antonelli, Alessandra Pierangeli, Lucia Nencioni

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Efficacy and Safety of Immunotherapy with Interferon-Gamma in the Management of Chronic Sulfur Mustard-Induced Cutaneous Complications: Comparison with Topical Betamethasone 1% by Yunes Panahi, Amirhossein Sahebkar, Seyyed Masoud Davoudi, Mojtaba Amiri, Fatemeh Beiraghdar

“…The present trial investigated the efficacy of immunotherapy with interferon-gamma (IFN-γ) in the treatment of sulfur mustard (SM)-induced chronic skin complications. …”
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Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling by Chalystha Yie Qin Lee, Yee Teng Chan, Yi Ying Cheok, Grace Min Yi Tan, Ting Fang Tang, Heng Choon Cheong, Jamuna Vadivelu, Suhailah Abdullah, Chung Yeng Looi, Won Fen Wong

“…Additionally, TLR7/8 antagonist treatment reduced H. pylori infection-mediated phosphorylation of interferon regulatory factor 7 (IRF7). Our study suggests a novel role of TLR8 signaling in host immunity against H. pylori through sensing live bacteria to elicit the production of type I interferon.…”
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Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C by Y. Kishida, N. Imaizumi, H. Tanimura, Y. Haruna, S. Kashiwamura, T. Kashiwagi

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Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis by Ying Wang, Yongsheng Zhang, Wenting Lu, Liying Wang

“…The objective of this study was to explore potential changes in levels of serum tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) associated with pediatric MPP. …”
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Induction of translation-suppressive G3BP1+ stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA by Vladimir Majerciak, Zhi-Ming Zheng

“…The elevated levels of phosphorylated eukaryotic translation initiation factor 2 subunit alpha (eIF2α), interferon regulatory factor 3 (IRF3), and signal transducer and activator of transcription 1 (STAT1) were induced in plasmid DNA-transfected cells. …”
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Rare Form of Erdheim-Chester Disease Presenting with Isolated Central Skeletal Lesions Treated with a Combination of Alfa-Interferon and Zoledronic Acid by E. N. Bulycheva, V. V. Baykov, M. I. Zaraĭskiĭ, G. N. Salogub

“…Here, we present a case report of a young male patient with isolated lesions of the spine, ribs, and pelvis, who was successfully treated with a combination therapy of alfa-interferon and zoledronic acid.…”
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