Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching by Yuyang Sun, Jiqing Tang, Cui Li, Jun Liu, Haijie Liu

“…The expression levels of M1 associated maker genes induced by DSS or lipopolysaccharide (LPS) plus interferon gamma-γ (IFN-γ) were suppressed by sulforaphane while M2 marker gene expression levels were improved. …”
Get full text

A new vaccination approach for Salmonellosis employing a multi-epitope vaccine based on live microbial cell factory from Lactococcus lactis by Reyhaneh Sadat Moosavi-Kohnehsari, Mahnaz Jafari-Sohi, Tohid Piri-Gharaghie, Shakiba Tolou-Shikhzadeh-Yazdi, Mona Aghassizadeh-Sherbaf, Romina Hosseinzadeh

“…Birds that received the L. lactis/pNZ8121-Multi epitope vaccination showed increased levels of interferon (IFN-γ) and NFkB1α, increased transcription rates of cytokines, and a significant presence of IgY antibodies specific to the multi epitope gene in their serum. …”
Get full text

Intra-Articular Injection of Human Synovial Membrane-Derived Mesenchymal Stem Cells in Murine Collagen-Induced Arthritis: Assessment of Immunomodulatory Capacity In Vivo by Minglu Yan, Xin Liu, Qiujie Dang, He Huang, Fan Yang, Yang Li

“…Decrease in tumor necrosis factor-α, interferon-γ, and interleukin- (IL-) 17A and increase in IL-10 production were observed after SM-MSC treatment. …”
Get full text

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi. by Sajith Raghunandanan, Kai Zhang, Yan Zhang, Raj Priya, Ching Wooen Sze, Yongliang Lou, Michael J Lynch, Brian R Crane, Mark H Kaplan, Chunhao Li, X Frank Yang

“…Co-culture assays with NK cells and macrophages revealed that the mcp5 mutant enhanced interferon-gamma production by NK cells. In the tick vector, the mcp5 mutants survived feeding but failed to transmit to mice. …”
Get full text

Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma by Heike Loeser, Max Kraemer, Florian Gebauer, Christiane Bruns, Wolfgang Schröder, Thomas Zander, Hakan Alakus, Arnulf Hoelscher, Reinhard Buettner, Philipp Lohneis, Alexander Quaas

“…Indoleamine 2,3-dioxygenase (IDO) is an interferon-inducible immune checkpoint expressed on tumor-infiltrating lymphocytes (TILs). …”
Get full text

Systemic Inflammation and Oxidative Stress in Childhood Obesity: Sex Differences in Adiposity Indices and Cardiovascular Risk by Tjaša Hertiš Petek, Evgenija Homšak, Mateja Svetej, Nataša Marčun Varda

“…We also aimed to assess the potential of the interferon-inducible T-cell alpha chemoattractant (I-TAC/CXCL11) as a novel biomarker. …”
Get full text

The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages by Hwa-Jin Chung, Wonil Koh, Won Kyung Kim, Joon-Shik Shin, Jinho Lee, Sang Kook Lee, In-Hyuk Ha

“…Three mechanisms explaining the effects of Shinbaro3 in RAW 264.7 cells were identified as follows: (1) inhibition of the extracellular signal-regulated kinase 1 and 2 (ERK1/2), stress-activated protein kinase (SAPK)/c-Jun N-terminal protein kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) pathways; (2) suppression of IκB kinase-α/β (IKK-α/β) phosphorylation and nuclear factor-kappa B (NF-κB) subunits in the NF-κB pathway, which are involved in MyD88-dependent signalling; and (3) downregulation of IFN-β mRNA expression via inhibition of interferon regulatory factor 3 (IRF3) and Janus-activated kinase 1 (JAK1)/signal transducer and activator of transcription 1 (STAT1) phosphorylation, which is involved in TRIF-dependent signalling. …”
Get full text

OMP38 of Carbapenem‐Resistant Acinetobacter Baumannii‐Mediated mtDNA Release Activates the cGAS‐STING Signaling to Induce Inflammatory Response by Yang Yang, Yuanyuan Zeng, Jianjie Zhu, Jianjun Li, Lei Gu, Lin Wei, Zeyi Liu, Jian‐an Huang

“…The cytosolic DNA sensor cyclic GMP‐AMP synthase (cGAS) and the adaptor protein stimulator of interferon genes (STING) are required for CRAB‐induced IFN‐β expression in macrophages. …”
Get full text

Fish Tank Granuloma Presenting as a Nasal Cavity Mass by Motoki Sekine, Fumiyuki Goto, Kosuke Saito, Shoji Kaneda, Hikaru Yamamoto, Tomoaki Murakami, Takahide Hamano, Kenji Okami

“…The granuloma recurred 3 months after resection. The interferon-gamma release assay (IGRA) test was positive, and therefore, a mycobacterial tissue culture test was performed because of suspected nasal tuberculosis, which identified M. marinum. …”
Get full text

The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and related signaling pathw... by Ning Chai, Tanja Stachon, Sabrina Häcker, Tim Berger, Zhen Li, Maryam Amini, Shweta Suiwal, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry

“…The expression levels of interleukin-1β (IL-1β), IL-6, IL-8, interferon alpha 2 (IFNA2), IFNB1, intercellular adhesion molecule 1 (ICAM-1), chemokine (C-C motif) ligand 4 (CCL-4), collagen I, collagen V, lysyl oxidase (LOX), transforming growth factor β 1(TGF-β1) were measured using qPCR, ELISA, or western blot. …”
Get full text

Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis C by P. O. Bogomolov, A. O. Bueverov, V. E. Bakirova, E. O. Lyusina, E. A. Fedosyina, S. V. Koblov, O. V. Sumtsova

“…A retrospective analysis included the data from patients with subcompensated liver cirrhosis (LC) of HCV etiology (genotype 1b) (7–9 points of the Child-Pugh score) having received interferon-free antiviral therapy (AVT) with ombitasvir/paritaprevir/ritonavir and dasabuvir during 12 weeks from September to December 2015. …”
Get full text

Chemokines and Growth Factors Produced by Lymphocytes in the Incompetent Great Saphenous Vein by Ewa Grudzińska, Sławomir Grzegorczyn, Zenon P. Czuba

“…Eotaxin, interleukin 8 (IL-8), macrophage inflammatory protein 1 A and 1B (MIP-1A and MIP-1B), interferon gamma-induced protein (IP-10), monocyte chemoattractant protein-1 (MCP-1), interleukin 5 (IL-5), fibroblast growth factor (FGF), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), platelet-derived growth factor-BB (PDGF-BB), and vascular endothelial growth factor (VEGF) were assessed in culture supernatants by a Bio-Plex assay. …”
Get full text

Periductal Mastitis: An Inflammatory Disease Related to Bacterial Infection and Consequent Immune Responses? by Lu Liu, Fei Zhou, Pin Wang, Lixiang Yu, Zhongbing Ma, Yuyang Li, Dezong Gao, Qiang Zhang, Liang Li, Zhigang Yu

“…We also measured the levels of interferon-γ, interleukin-12A, and interleukin-17A by semiquantitative immunohistochemistry method. …”
Get full text

Nicotinamide Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice through Its Anti-Inflammatory Properties and Modulates the Gut Microbiota by Kai Kang, Yue Sun, Dan Pan, Bing Chang, Li-Xuan Sang

“…Moreover, enzyme-linked immunosorbent assay (ELISA) analysis of LPL cells revealed that the level of interleukin- (IL-) 6, IL-12p70, IL-1β, tumor necrosis factor- (TNF-) α, interferon- (IFN-) γ, IL-21, and IL-17A was increased, while IL-10 was reduced, in the chronic colitis group compared to the control group, but the levels of all these factors were restored after NAM treatment. …”
Get full text

Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis by Hongbin Luo, Qunya Zheng, Youzheng Zhou, Weipeng Lai, Nanwen Zhang, Peng Chen

“…Furthermore, three upregulated genes (spectrin repeat containing nuclear envelope protein 2 [SYNE2], S100 calcium binding protein A9 [S100A9], and interferon induced protein with tetratricopeptide repeats 3 [IFIT3]) and four downregulated genes (ribonuclease 1 [RNASE1], granulin [GRN], FN1, and sorbin and SH3 domain containing 2 [SORBS2]) were co-expressed in RA-associated RBPs and ASEs. …”
Get full text

The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator? by Daniel S. Smyk, Athanasios Mavropoulos, Giorgina Mieli-Vergani, Diego Vergani, Marco Lenzi, Dimitrios P. Bogdanos

“…CD1d-restricted iNKT cells are regulators of immune responses and produce cytokines that may be proinflammatory (such as interferon-gamma (IFN-γ)) or anti-inflammatory (such as IL-4). iNKT cells also appear to play a role in B cell regulation and antibody production. …”
Get full text

Complex Monitoring of Biochemical and Radionuclide Parameters in Patients with Metastatic Renal Cell Carcinoma during Immunotherapy by M. S. Sayapina, S. G. Averinova, T. V. Zacharova, A. V. Kashkadaeva, S. V. Shiryaev, M. V. Poluectova, O. A. Vorob’eva

“…Materials and Methods. 41 mRCC patients after nephrectomy received nivolumab (n = 23) and interferon-α (n = 18) from 2015 to 2017. At baseline and 2 months after, all patients underwent blood chemistry, urinalysis, Rehberg test, and ELISA to determine serum levels of IL-17A, TGF-β, and erythropoietin. …”
Get full text

Improvement of Liver Transplantation Outcome by Heme Oxygenase-1-Transduced Bone Marrow Mesenchymal Stem Cells in Rats by Bin Wu, Hong-Li Song, Yang Yang, Ming-Li Yin, Bo-Ya Zhang, Yi Cao, Chong Dong, Zhong-Yang Shen

“…Interleukin- (IL-) 10 and transforming growth factor-β levels were significantly increased, while IL-2, IL-6, IL-17, IL-23, tumor necrosis factor-α, and interferon-γ levels were significantly decreased in the HO-1/MSCs group when compared to the other groups. …”
Get full text

Pre-injection of exosomes can significantly suppress ovarian cancer growth by activating the immune system in mice by Yuanyuan Wang, Changyi Zhang, Huimin Zeng, Liangliang Wang, Zanhong Wang, Zhiqiang Han

“…Additionally, there was a notable elevation in the concentration of interferon-gamma (IFN-γ) in peripheral blood. In vitro results indicated that exosomes could be internalized by dendritic cells (DCs), promote DC differentiation, and subsequently induce the production of granzyme B and IFN-γ in T cells. …”
Get full text

Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients by Rahul Saxena, Baskar Chakrapani, M. P. Sarath Krishnan, Amit Gupta, Sweety Gupta, Jayanta Das, Subash C. Gupta, Anissa A. Mirza, Shalinee Rao, Bela Goyal

“…Kirsten rat sarcoma virus (KRAS), AR, and interferon gamma (IFN-γ) pathways were identified among the key pathways potentially amenable to targeted therapy. …”
Get full text