Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia by Nikolaos Papadopoulos, Melanie Deutsch, Athanasios Georgalas, Helias Poulakidas, Lazaros Karnesis

“…She was considered as illegible for pegylated-interferon-free treatment with direct acting antivirals and a course with simeprevir and sofosbuvir (SOF) combination for twelve weeks was planned. …”
Get full text

Blocking Interleukin-33 Alleviates the Joint Inflammation and Inhibits the Development of Collagen-Induced Arthritis in Mice by Yan Li, Yeqin Fu, Huan Chen, Xiaojin Liu, Mingcai Li

“…Anti-IL-33 treatment also significantly decreased the serum levels of interferon-γ(IFN-γ),IL-6, IL-12, IL-33, and tumor necrosis factor-α (TNF-α). …”
Get full text

Within-host bayesian joint modeling of longitudinal and time-to-event data of Leishmania infection. by Felix M Pabon-Rodriguez, Grant D Brown, Breanna M Scorza, Christine A Petersen

“…In addition to measuring antibody levels produced by the immune system, we adapt data from CD4+ and CD8+ T cell proliferation, and expression of interleukin 10, interferon-gamma, and programmed cell death 1 as inflammatory or regulatory factors mediating the disease process. …”
Get full text

BRM Immunotherapy of Orthotopically Implanted Murine Bladder Tumours: Treatment Response by Monitoring MRI by Salam A Kadhim, Joseph L Chin, Bertha M Garcia, Peeyush K Lala, Chris J Norley, Barbara A McLean, Stephen J Karlik

“…The authors evaluated magnetic resonance imaging (MRI) for monitoring orthotopic bladder tumour growth and treatment response to intravesical immunotherapy with the biological response modifiers (BRMs): recombinant tumour necrosis factor alpha (TNF-α), combination of TNF-α plus interferon gamma (IFN-γ) and interleukin-2 (IL-2). MRI demonstrated detection of early superficial murine bladder tumour (MBT-2) and accurate sequential assessment of the topography and depth of intravesical tumour involvement. …”
Get full text

Myasthenia Gravis Development and Crisis Subsequent to Multiple Sclerosis by Kurosh Gharagozli, Maziar Shojaei, Ali Amini Harandi, Nayyereh Akbari, Manouchehr Ilkhani

“…Here, we present a case of an MS patient who developed an MG crisis. She had received interferon for relapsing remitting MS. Interestingly, she developed an MG crisis 4 years after the diagnosis of MS. …”
Get full text

Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…Innate immunity changes revealed in last years, related to mutations of genes of bacterial structures receptors (NOD2, toll-like receptors, autophagy), cause disorder of endocellular signal processes and pathological activation of cells of adaptive immunodefense of intestinal mucosa and conforming profile of cytokines with development of chronic inflammation which will be mediated: at Crohn's disease – by Th1-and Th17-cells, cytokines IL-12, interferon-γ etc., at ulcerative colitis – by Th2-and NKT-cells, cytokines IL-4 and IL-3 in combination to incompetence of suppressor function of regulatory Т-cells and their cytokines TGF-β (transforming growth factor) and IL-10.Conclusion. …”
Get full text

Porphyromonas gulae and canine periodontal disease: Current understanding and future directions by Kyu Hwan Kwack, Eun-Young Jang, Cheul Kim, Young-Suk Choi, Jae-Hyung Lee, Ji-Hoi Moon

“…Control strategies discussed include polyphosphate to disrupt haeme/iron utilization, clindamycin with interferon alpha to reduce bacterial load and enhance the immune response, and a protease inhibitor. …”
Get full text

The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling. by Yongkui Li, Moran Li, Heng Xiao, Feng Liao, Miaomiao Shen, Weiwei Ge, Junxian Ou, Yuqing Liu, Lumiao Chen, Yue Zhao, Pin Wan, Jinbiao Liu, Jun Chen, Xianwu Lan, Shaorong Wu, Qiang Ding, Geng Li, Qiwei Zhang, Pan Pan

“…The R203M/D377Y mutations thus enhanced the suppressive activity of the N protein on RIG-I-mediated interferon induction both in vitro and in vivo, which in turn promoted viral replication. …”
Get full text

State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization by Cecilia Trucchi, Andrea Orsi, Cristiano Alicino, Laura Sticchi, Giancarlo Icardi, Filippo Ansaldi

“…New generation of direct-acting antiviral agents (DAAs) has been recently introduced in clinical practice promising to cure HCV and to overcome the issues related to the interferon-based therapies. However, the emergence of drug resistance and the suboptimal activity of DAAs therapies against diverse HCV genotypes have been observed, determining treatment failure and hampering an effective control of HCV spread worldwide. …”
Get full text

Low agreement and frequent invalid controls in two SARS-CoV-2 T-cell assays in people with compromised immune function. by Annette Audigé, Alain Amstutz, Macé M Schuurmans, Patrizia Amico, Dominique L Braun, Marcel P Stoeckle, Barbara Hasse, René Hage, Dominik Damm, Michael Tamm, Nicolas J Mueller, Huldrych F Günthard, Michael T Koller, Christof M Schönenberger, Alexandra Griessbach, Niklaus D Labhardt, Roger D Kouyos, Alexandra Trkola, Michael Huber, Katharina Kusejko, Heiner C Bucher, Irene A Abela, Matthias Briel, Frédérique Chammartin, Benjamin Speich, Swiss HIV Cohort Study, and the Swiss Transplant Cohort Study

“…We assessed 173 blood samples from 81 participants (62 samples from 35 PWH; 111 samples from 46 SOT recipients [lung and kidney]) with two commercial SARS-CoV-2 Interferon-γ (IFN-γ) release assays (IGRA; SARS-CoV-2 IGRA by Euroimmun, and IGRA SARS-CoV-2 by Roche). …”
Get full text

Morphine in Combination with Ketamine Improves Cervical Cancer Pain and Suppresses Immune Function via the JAK3/STAT5 Pathway by Yurong Jiang, Tong Li, Yi Qian, Xiaoming Zuo, Jinmei Liu

“…The percentages of CD4+ and CD8+ were analyzed by flow cytometry. The levels of interferon (IFN)-γ, interleukin (IL)-2, and IL-17 and the corresponding mRNA expression in vitro were determined using ELISA and qRT-PCR, respectively. …”
Get full text

A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists by Yu‐an Li, Yi Feng, Wenjing Li, Yuqin Zhang, Yanni Sun, Shifeng Wang, Roy Curtiss III, Huoying Shi

“…This system integrates three modules: (1) self‐assembling nanoparticles, (2) self‐catalyzed synthesis of small‐molecule stimulator of interferon gene (STING) agonists, and (3) delivery vectors that target the cytosolic surveillance system. …”
Get full text

Future destinations: how people cured of hepatitis C using direct acting antiviral drugs progress in a new HCV-free world. A thematic analysis by Sarah R. Donaldson, Andrew Radley, John F. Dillon

“…Abstract Background The introduction of Direct-Acting Antivirals (DAAs) transformed Hepatitis C (HCV) treatment, despite this uptake of DAAs remains lower than required to meet the WHO Sustainable Development Goal (3.3). Treatment with interferon was suggested to be able to deliver important outcomes for people who use drugs in addition to a viral cure, such as social redemption, and shift from a stigmatised identity. …”
Get full text

Cost-effectiveness of Triple Therapy with Telaprevir for Chronic Hepatitis C Virus Patients in Germany by Jona T. Stahmeyer, Svenja Schauer, Siegbert Rossol, Hans Heinrich Wedemeyer, Daniel Wirth, Florence Bianic, Christian Krauth

“…**Methods:** We used a Markov model on disease progression and natural history to assess the cost-effectiveness of triple therapy with telaprevir compared to standard treatment with pegylated interferon and ribavirin. Model structure and inputs were discussed with clinical experts. …”
Get full text

Role of cytokines and nitric oxide in the induction of tuberculostatic macrophage functions by Vera L. Petricevich, Rosely C. B. Alves

“…Tumour necrosis factor (TNF) activity was assayed by measuring its cytotoxic activity on L-929 cells, interleukin-6 (IL-6) and interferon γ (IFN-γ) were assayed by enzyme-linked immunosorbent assay (ELISA), whereas NO levels were detected by Griess colorimetric reactions in the culture supernatant of macrophages incubated with IFN-γ , TNF or NO and subsequently exposed to either BCG-I or BCG-S. …”
Get full text

Oral Tolerance: A New Tool for the Treatment of Gastrointestinal Inflammatory Disorders and Liver-Directed Gene Therapy by Yaron Ilan

“…In both models, tolerized animals developed an increase in transforming growth factor-beta, interleukin-4 and interleukin-10, and a decrease in the mRNA of interferon-gamma lymphocytes and serum levels. Adoptive transfer of tolerized lymphocytes enabled the transfer of tolerance toward adenoviruses and colon-extracted proteins. …”
Get full text

Potentiating intratumoral therapy with immune checkpoint inhibitors: shifting the paradigm of multimodality therapeutics by B.E. Nelson, A. Naing, S. Fu, R.A. Sheth, R. Murthy, S. Piha-Paul

“…Notable IT approaches include oncolytic viruses, toll-like receptor agonists, and stimulator of interferon gene agonists with ICIs. Overall, combining ITs with ICIs offers a rational strategy to potentiate antitumor immune response and overcome resistance. …”
Get full text

Direct-Acting Antivirals for the Treatment of Chronic Hepatitis C: Open Issues and Future Perspectives by Hee Bok Chae, Seon Mee Park, Sei Jin Youn

“…Oral drug combinations can be favored because interferon (IFN) not only has to be given as intradermal injection, but also can cause several serious side effects. …”
Get full text

The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response by Liqian Zhu, Clinton Jones, Gaiping Zhang

“…Recent studies have shown that some PLC isoforms are involved in multiple stages in TLR4-, CD14-, and FcγRs-mediated activation of nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and interferon regulatory factors (IRFs), all of which are associated with the regulation of the inflammatory response. …”
Get full text

Emerging Roles of TRIM56 in Antiviral Innate Immunity by Dang Wang, Kui Li

“…Apart from exerting direct, restrictive effects on viral propagation, TRIM56 is implicated in regulating innate immune signaling pathways that orchestrate type I interferon response or autophagy, through which it indirectly impacts viral fitness. …”
Get full text