Elderly Patients Are at Greater Risk of Cytopenia During Antiviral Therapy for Hepatitis C by CG Nudo, P Wong, N Hilzenrat, M Deschênes

“…The results of antiviral therapy for hepatitis C virus (HCV) have improved recently with the use of pegylated interferon (PEG-IFN)/ribavirin (RBV) combination therapy. …”
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Characterization of the First Marine Pestivirus, Phocoena Pestivirus (PhoPeV) by Lars Söder, Denise Meyer, Olaf Isken, Norbert Tautz, Matthias König, Alexander Postel, Paul Becher

“…Pestiviruses generally counteract the cellular innate immune response by degradation of interferon regulatory factor 3 (IRF3) mediated by the viral N-terminal protease (N^pro). …”
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Cytokines and Water Distribution in Anorexia Nervosa by Hubertus Himmerich, Bethan Dalton, Olivia Patsalos, Ulrike Schmidt, Iain C. Campbell

“…Following blood collection, 27 cytokines and chemokines were quantified using multiplex ELISA-based technology: Eotaxin, Eotaxin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon- (IFN-) γ, interleukin- (IL-) 1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, interferon γ-induced protein- (IP-) 10, macrophage inflammatory protein- (MIP-) 1α, MIP-1β, monocyte chemoattractant protein- (MCP-) 1, MCP-4, thymus and activation-regulated chemokine (TARC), TNF-α, and TNF-β. …”
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Predictors of Antiviral Therapy in a Post-Transfusion Cohort of Hepatitis C Patients by Maciej Witkos, Qi-Long Yi, Jenny Heathcote, Moira K Kapral, Murray D Krahn

“…The efficacy of therapy has recently improved with the addition of ribavirin and pegylated interferon. The aim of the present study was to identify the clinical, socioeconomic and health-system predictors of antiviral treatment for HCV.…”
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Hyperferritinemia at the patient with chronic hepatitis C by Ye. N. German, A. O. Buyeverov, M. V. Mayevskaya, Ch. S. Pavlov, V. T. Ivashkin, A. A. Levina

“…., 38 years, despite of rapid virologic response at combined antiviral therapy by pegilated interferon α-2а and ribavirin, had persistently high activity of transaminases and initially high level of serum ferritin increase twice.Conclusion. …”
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A Rare Form of Chronic Granulomatous Disease (Type Iva) Presenting as Inflammatory Bowel Disease by Francisco A Sylvester

“…His gastrointestinal symptoms markedly improved during therapy with gamma-interferon. Chronic granulomatous disease can present initially with a clinical picture suggestive of chronic intestinal inflammation. …”
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CANDLE syndrome – a narrative review by Aleksandra Snopkowska, Joanna Gołda, Julia Mężyk, Piotr Gacka, Marcin Dołęga

“…The syndrome is associated with gene mutations encoding proteasome or immunoproteasome subunits, particularly PSMB8, contributing to disrupted proteostasis and aberrant type 1 interferon production. The diagnostic criteria remain undefined, necessitating a multidisciplinary approach for accurate diagnosis and management. …”
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Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of <i>Mycobacterium bovis</i>-Infected Domestic Dogs (<i>Canis lupus familiaris</i>) by Conor O’Halloran, Paul Burr, Danielle A. Gunn-Moore, Jayne C. Hope

“…Circulating serum cytokine concentrations of interferon gamma and TNF-α were not statistically different between the high- and low-risk groups of dogs. …”
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DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge by Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

“…DDO268 safely induces local type I interferon production and stimulates dendritic cell activation providing enhanced protection against IAV challenge. …”
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Viral Response to Specifically Targeted Antiviral Therapy for Hepatitis C and the Implications for Treatment Success by Curtis L Cooper

“…Strategies including induction dosing with interferon and ribavirin, use of combination high-potency STAT-C molecules and an intensive emphasis on adherence to HCV antiviral therapy will be critical to the success of this promising advance in HCV therapy.…”
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Simultaneous measurement of multiple Th1 and Th2 serum cytokines in psoriasis and correlation with disease severity by Sharon E. Jacob, Mehdi Nassiri, Francisco A. Kerdel, Vladimir Vincek

“…Serum levels of interleukin (IL)-6, IL-7, IL-8, and interferon (IFN)-γ have been reported elevated in psoriatic patients.…”
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Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis by Adrianos Nezos, Clio P. Mavragani

“…Moreover, genetic variations outside the MHC locus involving genes in type I interferon pathway, NF-κB signaling, B- and T-cell function and methylation processes have been shown to be associated with both SS and SS-related lymphoma development. …”
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Treatment of HIV-1 Infection with Combination Therapy: Antiretroviral Agents and Biological Response Modifiers by Steven M Schnittman

“…Preliminary evaluations of the combination of zidovudine wilh interferon alpha (IFN-α) have demonstrated enhanced antiviral. antitumour and immunomodulatory activity. …”
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Vancomycin Hypersensitivity Diagnosed by Lymphocyte Blast Transformation by Nguyen P. Tran, Jeremy Katcher, Erin Rohman, Mary Francis Hall, Christie F. Michael, Isao Miyairi, D. Betty Lew

“…Lymphocyte blast transformation (LBT), a method of detecting cellular immune response by measuring levels of interferon-γ (IFN-γ), was used to diagnose vancomycin hypersensitivity and guide antibiotic selection.…”
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Recurrent Respiratory Papillomatosis Causing Chronic Stridor and Delayed Speech in an 18-Month-Old Boy by Adel Alharbi, Derek Drummond, Alfredo Pinto, Valerie Kirk

“…CO2 laser evaporation of papillomas and adjuvant drug therapy using lymphoblastoid interferon-alpha are the most common treatments. However, several other treatments have been tried, with varying success. …”
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Biology of Inflammation in Crohn's Disease: Mechanisms of Action of Anti-TNF-αAlpha Therapy by Stephan R Targan

“…Corresponding in vitro investigation has shown that T helper 1 (Th1) -mediated cytokine production of interferon-gamma is downregulated in the involved mucosa to a level consistent with that seen in uninflamed mucosa. …”
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Two ways to one goal: new strategy of antiviral therapy for chronic hepatitis C by S. N. Batskikh

“…New algorithms of antiviral therapy for patients infected by the 1-st virus genotype not treated earlier, and after treatment failure, implicate presence or absence of so-called «induction phase», the kernel of which is application of pegilated interferon-α and ribavirin combination at the beginning of treatment with subsequent addition of the third agent (the direct action antiviral agent). …”
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Antiviral therapy for chronic hepatitis C: is there a time to change existing standards? by D. T. Abdurakhmanov

“…At CHC patients with the rapid virologic response (absence of viremia at the 4-th week) it is possible to limit duration of treatment by pegilated interferon and ribavirin in the case of the 1-st HCV genotype to 24 wks, in the case of the 2 and 3-rd genotypes to 12–16 wk. …”
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Role of Carbamazepine in the Symptomatic Treatment of Subacute Sclerosing Panencephalitis: A Case Report and Review of the Literature by Sandhya Ravikumar, John Ross Crawford

“…Combination immunomodulatory therapy with isoprinosine, ribavirin, and intra-Ommaya interferon alpha did not result in clinical improvement. …”
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Induction Versus Noninduction Antiviral Therapy for Chronic Hepatitis C Virus in Patients with Congenital Coagulation Disorders: A Canadian Multicentre Trial by A Chatterjee, MG Swain, SS Lee, VG Bain, K Peltekian, K Croitoru, PC Adams, K Kaita, J Teitel, EJ Heathcote

“…The present study compared induction therapy with interferon-alpha (IFN-α)-2b with standard IFN-α2b therapy. …”
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