Down syndrome and outcomes in critically ill pediatric patients by José Tantaleán Da Fieno, Rosa León Paredes, Patricia Palomo Luck, Carlos Del Águila Villar, Emiliana Rizo Patrón

“…IntroductionInformation regarding children with Down syndrome (DS) in the Pediatric Intensive Care Unit (PICU) is limited and conflicting. …”
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Outcome in patients undergoing postponed elective surgery during the COVID-19 pandemic (TRACE II): study protocol for a multicentre prospective observational study by Markus W Hollmann, Gert Jan Scheffer, Wolfgang Buhre, Sander van Kuijk, Seppe Koopman, Dianne de Korte-de Boer, Peter G Noordzij, Alice C Werger, Jennifer Breel, Carolien S E Bulte, Bas A in ‘t Veld, Carin G C L Wensing

“…Secondary outcome measures include the 30-day incidence of minor postoperative complications, 1 year mortality, length of stay (in hospital, medium care and intensive care), quality of recovery 30 days after surgery and postoperative quality of life up to 1 year following surgery. …”
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Evaluation of the Relationship between Nutritional Status of COVID-19 Patients Admitted to the ICU and Patients’ Prognosis: A Cohort Study by Parsa Mohammadi, Hesam Aldin Varpaei, Alireza Khafaee pour khamseh, Mostafa Mohammadi, Mojgan Rahimi, Amirhossein Orandi

“…In this single-center prospective cohort study, 110 patients admitted to the Intensive Care Unit of Imam Khomeini Hospital Complex (Tehran, Iran) between April and September 2021 were enrolled. …”
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A Simple Nomogram for Predicting the Development of ARDS in Postoperative Patients with Gastrointestinal Perforation: A Single-Center Retrospective Study by Zhang Z, Zhao H, Zhang Z, Jia L, Long L, Fu Y, Du Q

“…Ze Zhang,1 Haotian Zhao,2 Zhiyang Zhang,1 Lijing Jia,1 Ling Long,1 You Fu,1 Quansheng Du1 1Department of Intensive Care Unit, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Ultrasound, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of ChinaCorrespondence: Quansheng Du, Department of Intensive Care Unit, Hebei General Hospital, Shijiazhuang, 050000, Hebei, People’s Republic of China, Email duquansheng@hebmu.edu.cnBackground: Acute respiratory distress syndrome (ARDS) is a severe form of organ dysfunction and a common postoperative complication. …”
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Association between stress hyperglycemia ratio and all-cause mortality in critically ill patients with sepsis: results from the MIMIC-IV database by Shijie Zhang, Hechen Shen, Yuchao Wang, Meng Ning, Jianghui Zhou, Xiaoyu Liang, Yun Chang, Wenqing Gao, Tong Li

“…Methods This retrospective observational cohort study was conducted using the Medical Information Mart for Intensive Care-IV (MIMIC-IV v2.2) database. Patients were categorized into 4 SHR quartiles. …”
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Second Trimester Umbilical Cord Coiling Index and Perinatal Outcomes by Yusuf Aytaç Tohma, Mehmet Metin Altay, Derya Turgut, Selcan Coşkun, Eylem Ünlübilgin, Sertaç Esin, Orhan Gelişen, Okyar Erol

“…Newborns with hypercoiling or hypocoiling were needed more neonatal intensive care unit. CONCLUSIONS: There was measured correlation between umbilical cord diameter and aUCI between 18-24 weeks and perinatal outcome but new prospective studies about umbilical artery morphology and perinatal outcomes are also needed. …”
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Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury by Susan Bengs, Alexia Rossi, Martina Haberecker, Nidaa Mikail, Alexander Meisel, Achi Haider, Muriel Grämer, Angela Portmann, Atanas Todorov, Christof Schönenberger, Caroline E. Gebhard, Gabriela M. Kuster, Vera Regitz-Zagrosek, Catherine Gebhard

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RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis by Qin Y, Liao S, Sun J, Ye H, Li J, Pan J, He J, Xia Z, Shao Y

“…Yuting Qin,1,* Shuanglin Liao,1,* Jianbo Sun,2 Huiyun Ye,1 Jiafu Li,1 Jiahui Pan,1 Junbing He,3 Zhengyuan Xia,4,5 Yiming Shao1,6 1Dongguan Key Laboratory of Sepsis Translational Medicine, The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 2Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 3The Key Laboratory of Organ Dysfunction and Protection Translational Medicine, Jieyang Medical Research Center, Jieyang People’s Hospital, Jieyang, Guangdong, People’s Republic of China; 4Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China; 5State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 6The Key Laboratory of Sepsis Translational Medicine, Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yiming Shao, Dongguan Key Laboratory of Sepsis Translational Medicine, the Intensive Care Unit,The First Dongguan Affiliated Hospital, Guangdong Medical University, Jiaoping Road 42, Tangxia Town, Dongguan, Guangdong Province, 523710, People’s Republic of China, Tel +86 18826690188, Email sym@gdmu.edu.cn Zhengyuan Xia, Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China, Tel +852-68798794, Email zyxia@hku.hkAbstract: Reversion inducing cysteine rich protein with kazal motifs (RECK), a Kazal motif-containing protein, regulates pro-inflammatory cytokines production, migration of inflammatory cells, vascular endothelial growth factor (VEGF) and Wnt pathways and plays critical roles in septic inflammatory storms and vascular endothelial dysfunction. …”
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Effectiveness of ultra-rapid (20 min) high-frequency in-situ cardiac arrest simulations in a high-volume operating department – A tool for evaluating and implementing emergency rou... by Anna Sundelin, Anders Stålman, Therese Djärv

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Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial by Gilberto Arias-Hernández, Cruz Vargas-De-León, Claudia C Calzada-Mendoza, María Esther Ocharan-Hernández

“…Significantly, patients who received diltiazem had fewer hypertension and hypotension episodes and stayed fewer days in the intensive care unit than those treated with nifedipine. …”
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Effect of floral therapy in mothers of premature newborns: A randomized controlled trial by Tatiana Carneiro de Resende, Karla Oliveira Marcacine, Erika de Sá Vieira Abuchaim, Marcia Barbieri, Maria Cristina Gabrielloni, Ana Cristina Freitas de Vilhena Abrão

“…Conclusions: The use of the Five-Flower essence as a non-pharmacological therapy is effective in reducing the stress and cortisol levels in mothers of premature newborns admitted to neonatal and semi-intensive care units.…”
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Postmortem Analysis of Ethyl Alcohol Concentration in Blood, Urine, Muscle and Bile by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Gabija Laubner-Sakalauskienė, Robertas Badaras, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

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Cardiopulmonary resuscitation coaching for resuscitation teams: A systematic review by Kasper G. Lauridsen, Emma Bürgstein, Sabine Nabecker, Yiqun Lin, Aaron Donoghue, Jonathan P. Duff, Adam Cheng

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Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications by Giovanna Fusco, Rubina Paradiso, Lorena Cardillo, Maria Antonia Salvia, Saveria Dodaro, Veronica Del Monaco, Gianfranco Scarpelli, Francesca Greco, Antonio Rinaldi, Lorella Barca, Stefania Ambrogio, Antonio Limone, Esterina De Carlo, Giorgia Borriello

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Steroid use for established bronchopulmonary dysplasia: study protocol for a systematic review and meta-analysis by Roy K Philip, Joanna Seliga-Siwecka, Eduardo Villamor, Maria Pierro, Niazy Al Assaf, Sabina Strashun, Roberto Chioma, Kinga Zielińska, Krzysztof Włodarczyk

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Development and validation of a nomogram-based risk prediction model for carbapenem-resistant Klebsiella pneumoniae in hospitalized patients by Tingting Xu, Yuxin Shi, Xiongjing Cao, Lijuan Xiong

“…The factors included in the nomogram were prior carbapenem exposure, prior β-lactams–β-lactamase inhibitor combination (BLBLI) exposure, prior intensive care unit (ICU) stay, and prior mechanical ventilation. …”
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Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model by Qiong Liang, Qiqing Lin, Yueyong Li, Weigui Luo, Xia Huang, Yujie Jiang, Chunyan Qin, Jin Nong, Xiang Chen, Suren Rao Sooranna, Liao Pinhu

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Clinical characteristics and mortality risk factors among trauma patients by age groups at a single center in Korea over 7 years: a retrospective study by Jonghee Han, Su Young Yoon, Junepill Seok, Jin Young Lee, Jin Suk Lee, Jin Bong Ye, Younghoon Sul, Seheon Kim, Hong Rye Kim

“…Although group A had the highest intensive care unit admission rate (38.0%), group C had the highest mortality rate (9.5%). …”
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Machine learning-based prediction of in-hospital mortality for critically ill patients with sepsis-associated acute kidney injury by Tianyun Gao, Zhiqiang Nong, Yuzhen Luo, Manqiu Mo, Zhaoyan Chen, Zhenhua Yang, Ling Pan

“…Objectives This study aims to develop and validate a prediction model in-hospital mortality in critically ill patients with sepsis-associated acute kidney injury (SA-AKI) based on machine learning algorithms.Methods Patients who met the criteria for inclusion were identified in the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and divided according to the validation (n = 2440) and development (n = 9756, 80%) queues. …”
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Anti-Inflammatory Effect of Columbianetin on Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells by Junying Lu, Keyong Fang, Shiji Wang, Lingxin Xiong, Chao Zhang, Zhongmin Liu, Xuewa Guan, Ruipeng Zheng, Guoqiang Wang, Jingtong Zheng, Fang Wang

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