Gene Expression of Adhesion Molecules in Endothelial Cells from Patients with Peripheral Arterial Disease Is Reduced after Surgical Revascularization and Pharmacological Treatment by Franca Marino, Luigina Guasti, Matteo Tozzi, Laura Schembri, Luana Castiglioni, Elisabetta Molteni, Gabriele Piffaretti, Patrizio Castelli, Marco Cosentino

“…We investigated gene expression of the adhesion molecules (AMs) ICAM-1, VCAM-1, and β1-integrin in endothelial cells (ECs) isolated from venous blood (circulating EC, cEC) and purified from femoral plaques (pEC) obtained from 9 patients with peripheral artery disease (PAD) submitted to femoral artery thrombendarterectomy (FEA). …”
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Comparison of Rapidly Proliferating, Multipotent Aortic Valve-Derived Stromal Cells and Valve Interstitial Cells in the Human Aortic Valve by Yuming Huang, Kang Xu, Tingwen Zhou, Peng Zhu, Nianguo Dong, Jiawei Shi

“…In addition, runt-related transcription factor 2 and Ki-67 proteins were also markedly upregulated in VDSCs, whereas there was less expression of the focal adhesion genes integrin alpha and laminin alpha in VDSCs compared to VICs. …”
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Comprehensive Screening of Cell Surface Markers Expressed by Adult-Derived Human Liver Stem/Progenitor Cells Harvested at Passage 5: Potential Implications for Engraftment by Pierre-Edouard Dollet, Joachim Ravau, Floriane André, Mustapha Najimi, Etienne Sokal, Catherine Lombard

“…However, ADHLSCs express all the integrin couples and matrix metalloproteinases needed to bind and integrate the extracellular matrix once the endothelial barrier is crossed. …”
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Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis by Fatemeh Khodadust, Eva M. L. Philippon, Maarten M. Steinz, Jan Piet van Hamburg, Johan van Meerloo, Judy R. van Beijnum, Gerrit Jansen, Sander W. Tas, Conny J. van der Laken

“…This study evaluated potential anti-angiogenic effects of several compounds including small-molecule kinase inhibitors, such as sunitinib (pan-kinase inhibitor), tofacitinib (JAK-inhibitor), NIKi (NF-κB-inducing kinase inhibitor), and the integrin-targeting peptide fluciclatide, using a scratch assay and 3D spheroid-based models of angiogenesis. …”
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Stepwise Adipogenesis of Decellularized Cellular Extracellular Matrix Regulates Adipose Tissue-Derived Stem Cell Migration and Differentiation by Ziang Zhang, Rongmei Qu, Tingyu Fan, Jun Ouyang, Feng Lu, Jingxing Dai

“…In contrast, ASCs seeded on adipogenic d-ECM underwent adipogenic differentiation. In addition, integrin subunit αv and integrins α6 and α7 were detected at significantly greater levels in ASCs cultured on growth and adipogenic d-ECM, respectively, suggesting that integrins play an important role in ASC migration and adipogenesis. …”
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Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors by Gang Li, Jing Zhang, Bentuo Zhang, Dan Wang, Zequn Wang, Yan Pan, Lijie Ma

“…Our analysis of differentially expressed RNA and circRNA genes revealed that tumor cell adhesion and integrin activation, regulated by genes like PIEZO1, IFT74, SKAP1, GPX1, F7, VTN, and OMG, are strongly linked to pNET metastasis. …”
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Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation by Daisuke Katoh, Yoshiyuki Senga, Kento Mizutani, Kazuaki Maruyama, Daishi Yamakawa, Tadashi Yamamuro, Michiaki Hiroe, Keiichi Yamanaka, Akihiro Sudo, Naoyuki Katayama, Toshimichi Yoshida, Kyoko Imanaka-Yoshida

“…Mechanistically, TNC facilitates integrin αvβ1 heterodimer formation, leading to the activation of non-canonical (TAK1/p38MAPK/ATF-2) TGFβ signaling to suppress lymphangiogenesis. …”
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A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease by Vladimira Durmanova, Zuzana Parnicka, Juraj Javor, Gabriel Minarik, Lubomir Vrazda, Barbora Vaseckova, Karin Gmitterova, Maria Kralova, Jan Pecenak, Peter Filipcik, Ivana Shawkatova

“…Many studies support the hypothesis that the inflammation of the CNS contributes to the neurodegeneration and disease progression. The integrin molecule α4β1, also known as very late antigen 4 (VLA-4), belongs to adhesion molecules that activate the inflammatory process through the migration of immune cells into the CNS. …”
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Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells by Ashok Singh, Anupama Singh, Jordan M. Sand, Erika Heninger, Bilal Bin Hafeez, Ajit K. Verma

“…The percent of double HSCs (CD34+ and α6-integrin or CD34+/CD49f+) in the isolated keratinocytes were determined by flow cytometric analysis. …”
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Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice by Hiroki Goto, Aiko Inoue, Limei Piao, Lina Hu, Zhe Huang, Xiangkun Meng, Yusuke Suzuki, Hiroyuki Umegaki, Masafumi Kuzuya, Xian Wu Cheng

“…On day 3 postinjury, rPLF-1 increased the levels of proteins or genes for p-Akt, p-mTOR, p-GSK3α/β, p-Erk1/2, p-p38MAPK, interleukin-10, Pax7, MyoD, and Cyclin B1, and it increased the numbers of CD34+/integrin-α7+ muscle stem cells and proliferating cells in the muscles and/or bone marrow of CTX mice. …”
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Proteomic profiling of Labeo rohita intestine infected with Edwardsiella tarda: Unveiling the mucosal defense mechanisms, cell adhesion, and cytoskeletal pathways by Nevil Pinto, Mehar Un Nissa, Gowhar Iqbal, Yashwanth BS, Darshan P, Sanjeeva S, Mukunda Goswami

“…In E. tarda infected intestine, protein pathways were involved in defense response to the bacterium (muc-2), pyruvate metabolism (ldhb), integrin-mediated cell adhesion (ilk), actin filament bundle (lcp1), and collagen-containing extracellular matrix (nid2a). …”
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Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis by Bonnie Hei Man Liu, Yuezhen Lin, Xi Long, Sze Wan Hung, Anna Gaponova, Feng Ren, Alex Zhavoronkov, Frank W. Pun, Chi Chiu Wang

“…Using an artificial intelligence (AI)‐driven target discovery platform, two unreported therapeutic targets, guanylate‐binding protein 2 (GBP2) and hematopoietic cell kinase (HCK) are identified, along with a drug repurposing target, integrin beta 2 (ITGB2) for the treatment of endometriosis. …”
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Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review by Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Sirajunisa Talath, Pooja Shivappa, Sathvik Belagodu Sridhar, Mohamed El-Tanani, Imran Rashid Rangraze, Omnia Ibrahim Mohamed, Nowar Nizar Al Ani

“…It was reviewed that the exposure to certain doses of catechins, piperlongumine, lycopene, isoflavones and cucurbitacinfor a sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis and disruption of signaling pathways including, but not limited to JAK-STAT3, HER2-integrin, and MAPK. Besides, the study also covers the potential adverse effects of these phytochemicals. …”
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The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…Atoh1 stimulated expression of type I collagen (P < 0.005) and small integrin-binding ligand, N-linked glycoproteins (SIBLINGs) such as bone sialoprotein (P < 0.001), dentin matrix protein 1 (P < 0.05), dentin sialophosphoprotein (P < 0.005), and osteopontin (P < 0.001), resulting in increased dentin matrix mineralization (P < 0.05). …”
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Identification of potential geosmin-binding proteins in grass carp gill based on affinity responsive target stability and tandem mass tag proteomics by Jun-ming Zhang, Huan Han, Bing Fu, Yi-chao Li, Kang Li, Jing-wei Liu, Er-meng Yu, Li-ping Liu

“…ARTS analysis identified 56 proteins, predominantly membrane-associated proteins, such as catenin beta-1, annexin, and integrin beta. Proteomic analysis revealed 256 differentially expressed proteins in geosmin-exposure group, with 18 common proteins screened by in vivo and in vitro methods. …”
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Bone Marrow Stromal Cells Generate a Pro-Healing Inflammasome When Cultured on Titanium–Aluminum–Vanadium Surfaces with Microscale/Nanoscale Structural Features by David J. Cohen, Christine M. Van Duyn, Jingyao Deng, Musaddiq K. Lodi, Michelle B. Gallagher, James T. Sugar, Jeremy J. Rawlinson, Preetam Ghosh, Barbara D. Boyan, Zvi Schwartz

“…The MN surface also induced a pro-healing inflammasome with upregulation of anti-inflammatory mediators (170–200% increase) and downregulation of pro-inflammatory factors (40–82% reduction). Integrin expression shifted towards osteoblast-associated integrins on MN surfaces. …”
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Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo by Elena Boggio, Chiara Dianzani, Casimiro Luca Gigliotti, Maria Felicia Soluri, Nausicaa Clemente, Giuseppe Cappellano, Erika Toth, Davide Raineri, Benedetta Ferrara, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

“…Interestingly, thrombin cleavage of osteopontin unmasks a cryptic domain of interaction with α4β1 integrin that is the main adhesion molecule involved in lymphocyte transmigration to the brain and is the target for natalizumab, the most potent drug preventing relapses. …”
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Investigation of <i>ITGB3</i> Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer by Asiye Busra Boz Er

“…It also evaluates the potential of combining Trastuzumab with the integrin β3 inhibitor cilengitide to overcome resistance associated with <i>ITGB3</i> levels. …”
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Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis by Qiong-Yi Zhang, Hai-Biao Gong, Man-Ya Jiang, Fujun Jin, Guan Wang, Chang-Yu Yan, Xiang Luo, Wan-Yang Sun, Shu-Hua Ouyang, Yan-Ping Wu, Wen-Jun Duan, Lei Liang, Yun-Feng Cao, Xin-Xin Sun, Meijing Liu, Gen-Long Jiao, Hua-Jun Wang, Kurihara Hiroshi, Xiaogang Wang, Rong-Rong He, Yi-Fang Li

“…Mechanistically, 4-hydroxynonenal, an end-product of phospholipid peroxidation, binds to integrin-linked kinase and triggers its protein degradation, disrupting RUNX2 signaling and inhibiting osteoblastogenesis. …”
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Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung by Yuanyuan Jia, Xuehong You, Ningxia Ma, Hui Li, Guopan Liu, Ying Wang, Jing Xue, Juan Shi, Jun Wei, Yong Li, Jiali Yang, Xiaoming Liu

“…In addition, the majority of primary epithelial cells able to proliferate in vitro expressed keratin 5, a subpopulation of these keratin 5-positive cells, also expressed CD117 (c-Kit) or CD49f (integrin alpha 6, ITGA6), implying that they might be potential epithelial stem/progenitor cells in conducting airway of a porcine lung. …”
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