Cambios epidemiológicos de pacientes hospitalizados en un servicio de medicina interna del Hospital Edgardo Rebagliati Martins 2008 vs. 2018 by Jorge Luis Solari Yokota, Jesús Alberto Fernández Apolaya, Martín Alonso Gamboa Orozco, John Bryan Chinchayán Méndez, José Luis Qwistgaard Espinal, Fabián André Vargas Giuria, Claudia Consuelo Gamero Montoya, Cristopher César Ortiz Patiño, Lilianna Ofelia Lavado De La Vega, Martín Diego Alonso Uribe Chamochumbi

“…Conclusiones: Existen diferencias estadísticamente significativas que evidencian la transición epidemiológica al comparar la información de ambos periodos, por tanto, resulta necesario establecer un enfoque integral, multidisciplinario e innovador para la atención de los pacientes con enfermedades crónicas.…”
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

“…Of note, mutations that confer tolerance to antibiotics in Escherichia coli also map to the DNA-binding domain of VapBC encoded by the chromosomally integrated F plasmid. We demonstrate that the tolerance mutations also enhance plasmid stabilization by the same mechanism as VapBL12. …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…The regulatory mechanisms of aberrant NAT10-mediated N4-acetylcytidine (ac4C) modifications in cancer progression remains poorly understood. Consequently, an integrated transcriptomic analysis is necessary to fully elucidate the role of NAT10-mediated ac4C modifications in CRC progression. …”
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Estimating and forecasting daily reference crop evapotranspiration in China with temperature-driven deep learning modelsMendeley Data by Jia Zhang, Yimin Ding, Lei Zhu, Yukuai Wan, Mingtang Chai, Pengpeng Ding

“…The results revealed that the differences in the performance of estimating ETo among the DL models were less pronounced compared to the variations that existed between diverse training strategies. By integrating location and seasonality information into the training set, we found a notable improvement in the accuracy of ETo estimating, with the average Root Mean Square Error (RMSE) of the five DL models decreasing from 0.55 mm d−1 to 0.48 mm d−1. …”
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Application of online and offline blended teaching model combined with curriculum ideological and political education: Taking the course of clinical anesthesiology for example (线上线... by LI Jing (李静), FAN Xiaoying (范晓英), ZHANG Wanping (张万平), SU Yuqiang (苏玉强)

“…Contemporary medical education organically integrates theoretical education with ideological and political education, which is an effective way to realize the fundamental task of cultivating morality and human beings. …”
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Influence of spine biomechanics and sagittal balance on the outcome of lumbar discectomy by José Poblete Carrizo, José Poblete Carrizo, Jesús Martínez, Julio González, Alejandra Mosteiro, Ramon Torné, Ramon Torné, Alberto Di Somma, Alberto Di Somma, José Ríos, Joaquim Enseñat, Joaquim Enseñat, Salvador Fuster, Salvador Fuster

“…These concepts translated into objective measurements are progressively being integrated into clinical practice. The present study explores them as prognostic factors in patients undergoing lumbar microdiscectomy, which could help identify those at higher risk of surgical failure.MethodsProspective analysis of patients treated with lumbar microdiscectomy (n = 52) and healthy control subjects (n = 45) in a single tertiary centre. …”
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Process evaluation of Project Daire: a food environment intervention that impacted food knowledge, wellbeing and dietary habits of primary school children by Naomi Anderson, Sarah F. Brennan, Fiona Lavelle, Sarah E. Moore, Dilara Olgacher, Amy Junkin, Moira Dean, Michelle C. McKinley, Patrick McCole, Ruth F. Hunter, Laura Dunne, Niamh E. O’Connell, Chris T. Elliott, Danielle McCarthy, Jayne V. Woodside

“…Findings also identified suggestions for improvement including provision of increased teacher training, support and planning time, content reduction to facilitate easy integration, and implementation across the full academic year. …”
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A socio-ecological model of the management of leprosy reactions in Indonesia and India using the experiences of affected individuals, family members and healthcare providers by Annisa Ika Putri, Ruth M. H. Peters, Kevin De Sabbata, Brittney S. Mengistu, Regitta I. Agusni, Medhi Denisa Alinda, Joydeepa Darlong, M. Yulianto Listiawan, Cita R. S. Prakoeswa, Stephen L. Walker, Marjolein B. M. Zweekhorst

“…Despite its accessibility and wider coverage of public health insurance, the integrated service model in Indonesia faces challenges associated with complex regulations and the availability of medication. …”
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Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway by Li Mei Pang, Guisheng Zeng, Eve Wai Ling Chow, Xiaoli Xu, Ning Li, Yee Jiun Kok, Shu Chen Chong, Xuezhi Bi, Jiaxin Gao, Chaminda Jayampath Seneviratne, Yue Wang

“…Overexpression of the constitutively active version of the Rho1 GTPase Rho1G18V, an upstream activator of the protein kinase C (PKC)-mitogen-activated protein kinase (MAPK) cell-wall integrity pathway, rescued these defects. Affinity purification, mass spectrometry, and co-immunoprecipitation revealed Sdd3’s physical interaction with Bem2, the GTPase-activating protein of Rho1. …”
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Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study by Perrine Burdeyron, Sébastien Giraud, Maryne Lepoittevin, Nina Jordan, Sonia Brishoual, Maïté Jacquard, Virginie Ameteau, Nadège Boildieu, Estelle Lemarie, Jonathan Daniel, Frédéric Martins, Nicolas Mélis, Marine Coué, Raphaël Thuillier, Henri Leuvenink, Luc Pellerin, Thierry Hauet, Clara Steichen

“…However, cell damage markers (LDH, ASAT) were decreased in G3 compared with G1, and G3 kidneys displayed a preserved tissue integrity with reduced tubular dilatation and inflammation notably. …”
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Reservoir water level decline accelerates ground subsidence: InSAR monitoring and machine learning prediction of surface deformation in the Three Gorges Reservoir area by Jiaer Yang, Jiaer Yang, Pinglang Kou, Pinglang Kou, Xu Dong, Xu Dong, Ying Xia, Qinchuan Gu, Yuxiang Tao, Jiangfan Feng, Qin Ji, Weizao Wang, Ram Avtar

“…Future research should emphasize developing integrated frameworks for long-term risk assessment and mitigation strategies in reservoir environments.ConclusionsThis study provides new insights into the complex surface dynamics in the Three Gorges Reservoir area, emphasizing the interplay of hydrological, geological, and anthropogenic factors. …”
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Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota by Reng Qiu, Chuangye Pan, Yuxi Qin, Qianfei Wei, Yue Yu, Ying Zhang, Xuehan Xie, Jianqin Li, Shouhai Chen, Kun Li, Dalia Fouad, Yi Wu, Qiu Zhong

“…Pathological analysis found that the majority of the villi in mice induced by LPS were broken and short, while PK-treated animals had longer and considerably integrated villi. The villi length in groups CH (P < 0.0001) and H (P < 0.0001) was longer than that in group M, and the value of villi length/crypt depth in group MH was smaller than that in groups CH (P < 0.0001) and H (P < 0.0001), while the crypt depth in group MH was higher than in groups CH (P < 0.0001) and H (P < 0.0001). …”
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Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…Cross-technique annotation may enhance DL models by integrating benefits from specialized, time-intensive MRI sequences while not relying on them. …”
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Hepatitis B and C Viruses’ Infection and Associated Factors among Pregnant Women Attending Antenatal Care in Hospitals in the Amhara National Regional State, Ethiopia by Mulat Dagnew, Yihenew Million, Mucheye Gizachew, Setegn Eshetie, Gashaw Yitayew, Lakachew Asrade, Mulat Adefris, Feleke Moges, Moges Tiruneh

“…This calls for screening and integration of HBV prevention of mother-to-child transmission (PMTCT) into HIV. …”
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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

“…The six components include: Hello campaign posters, email reminders, integrating greetings in morning huddles, hello jars, lead-by-example initiatives, and a daily updated hello board in each ICU. …”
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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…Significant features were identified using the Mann–Whitney U test and further refined with a least absolute shrinkage and selection operator (LASSO) regression model to construct radiomic features. By integrating clinical characteristics, a radiomics nomogram was developed. …”
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Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels by Cheng Luo, Cheng Luo, Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang, Fan Yang

“…Differentially expressed genes (DEGs) for the specific cell cluster with the highest fibrotic transcription dynamics were identified and integrated with bulk RNA sequencing data for analysis. …”
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Prevalence and Related Risk Factors of Intestinal Parasitosis among Private School-Going Pupils of Dharan Submetropolitan City, Nepal by Bijay Kumar Shrestha, Manita Tumbahangphe, Jenish Shakya, Anu Rai, Kabita Dhakal, Bidhya Dhungana, Romika Shrestha, Jyoti Limbu, Kabiraj Khadka, Santoshi Ghimire, Sujata Chauhan, Lata Chalise, Ashu Ghimire

“…The poor sanitation and sanitary habits like biting nails, consumption of untreated drinking water, and failure to practice proper hand washing were studied as contributors to the acquisition of intestinal parasitic infections. Therefore, integration of control measures such as provision of clean and safe drinking water, improved sanitation and hygiene, with biannual administration of drugs are necessary for effective eradication of parasitic infections.…”
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Development of a core outcome set and core measurement set for kangaroo mother care: a study protocol by Yuan Li, Xia Li, Qiong Chen, Ying Xin Li, Han Mei Peng, Xue Mei Guo, Xiao Wen Li, Yan Ling Hu, Xing Li Wan

“…This study aims to develop both a COS and a CMS for KMC to standardise outcome reporting, improve the quality assessments in clinical trials and facilitate data integration. This protocol outlines the methodology for developing a COS and CMS for KMC.Methods and analysis The development of the COS and CMS for KMC will follow six phases: (1) a systematic review, (2) semistructured interviews, (3) merging outcomes, (4) two/three rounds of international Delphi survey, (5) a consensus meeting and (6) development of the CMS. …”
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Characterization of RAP Signal Patterns, Temporal Relationships, and Artifact Profiles Derived from Intracranial Pressure Sensors in Acute Traumatic Neural Injury by Abrar Islam, Amanjyot Singh Sainbhi, Kevin Y. Stein, Nuray Vakitbilir, Alwyn Gomez, Noah Silvaggio, Tobias Bergmann, Mansoor Hayat, Logan Froese, Frederick A. Zeiler

“…The autoregressive integrated moving average (ARIMA) model was employed to outline the time-series structure of RAP across different temporal resolutions using the autoregressive (<i>p</i>-order) and moving average orders (<i>q</i>-order). …”
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