Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon by Ying Zheng, Benjamin Moorlach, Desiree Jakobs-Schönwandt, Anant Patel, Chiara Pastacaldi, Stefan Jacob, Ana R. Sede, Manfred Heinlein, Minna M. Poranen, Karl-Heinz Kogel, Maria Ladera Carmona

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The Utility of Synovial Fluid Interleukin-10 in Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Cohort Study by Zou Y, Yang Y, Yang J, Zhang Y, Zhao C, Qin L, Hu N

“…Adding SF IL-10 to traditional models improved risk prediction for chronic PJI (net reclassification improvement [NRI]: 0.167 [0.023 ~ 0.312]; integrated discrimination improvement [IDI]: 0.160 [0.096 ~ 0.224]).Conclusion: Higher SF IL-10 levels were significantly associated with chronic PJI in revision surgery patients, and incorporating SF IL-10 into the traditional risk model enhanced its predictive value for chronic PJI in these patients.Keywords: periprosthetic infection, synovial fluid, interleukin-10, C-reactive protein, erythrocyte sedimentation rate…”
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Examining the complementarity in belowground water use between different varieties and ages of Arabica coffee plants and dominant shade tree species in an organic agroecosystem by Lyssette Elena Muñoz-Villers, Friso Holwerda, M. Susana Alvarado-Barrientos, Josie Geris, Todd E. Dawson

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Comparison of Anterior Ocular Biometric Measurements Using Swept-Source and Time-Domain Optical Coherence Tomography by Sisi Chen, Rongrong Gao, Colm McAlinden, Junming Ye, Yiran Wang, Min Chen, Jinhai Huang, Yong Sun, A-Yong Yu

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Development of Personas and Journey Maps for Artificial Intelligence Agents Supporting the Use of Health Big Data: Human-Centered Design Approach by Yoon Heui Lee, Hanna Choi, Soo-Kyoung Lee

“…ObjectiveThis study was conducted to integrate and analyze users’ experiences along the HBD analysis journey using the human-centered design methodology and reflect them in the development of AI agents that support future HBD analysis. …”
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The impact of successive Montessori programmes on cognitive achievement by Maria Angelica Paez-Barrameda

“…These findings align with Dr Montessori’s philosophy that education should be an integrated continuum, where each developmental stage prepares the child for the next. …”
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Beclin-1 as a potential prognostic marker in correlation with E-cadherin in oral lichen planus and oral squamous cell carcinoma: an immunohistochemical analysis by Heba N. Shalash, Radwa R. Hussein, Fatma Seragel-Deen

“…The function of Beclin-1, as per a marker for autophagy, still needs to be verified in oral premalignant lesions and their progression to OSCC. E-cadherin is an integral intercellular epithelial component responsible for intercellular adhesion, in which its down-expression denotes diminished cellular adhesion and propensity for invasion. …”
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EXPLORING THE INFLUENCES ON DISPLACED CITIZENS' DECISION TO REPATRIATE: A CLASSIFICATION OF POSITIVE AND NEGATIVE FACTORS by Volodymyr Filippov, Iryna Bashynska, Elvin Yangulov

“…Furthermore, the data can be utilised to develop programmes that encourage displaced persons to return and further integrate into the economy. The research's originality lies in its synthesis of analyses of the impact of military conflicts and natural disasters on migration processes and decisions to return. …”
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DigiLoCS: A leap forward in predictive organ-on-chip simulations. by Manoja Rajalakshmi Aravindakshan, Chittaranjan Mandal, Alex Pothen, Stephan Schaller, Christian Maass

“…The objectives of this study were twofold: first, to predict human clearance values, and second, to propose a framework for bridging the gap between in vitro findings and their clinical relevance. The methodology integrated quantitative Organ-on-Chip (OoC) and cell-based assay analyses of drug depletion kinetics and is further enhanced by incorporating an OoC-digital twin model to simulate drug depletion kinetics in humans. …”
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Polyploidization-driven transcriptomic dynamics in Medicago sativa neotetraploids: mRNA, smRNA and allele-specific gene expression by D. F. Santoro, G. Marconi, S. Capomaccio, M. Bocchini, A. W. Anderson, A. Finotti, M. Confalonieri, E. Albertini, D. Rosellini

“…Small RNA-seq revealed that very few miRNAs were significantly associated with WGD, but they target several hundred genes, and their role in the WGD response may be relevant. Integrated network analysis led to the identification of putative miRNA: mRNA interactions potentially involved in transcriptome reprogramming. …”
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Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…In vivo experiments demonstrated that QAFF effectively ameliorated colitis symptoms, reduced IL-6, IL-1β, and TNF-α levels, enhanced intestinal barrier integrity, and downregulated PI3K/AKT pathway activation. …”
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Intravenous Immunoglobulin Therapy Administered Early after Narcolepsy Type 1 Onset in Three Patients Evaluated by Clinical and Polysomnographic Follow-Up by Elisabeth Ruppert, Hélène Zagala, Juliette Chambe, Henri Comtet, Ulker Kilic-Huck, François Lefebvre, Marc Bataillard, Carmen Schroder, Laurent Calvel, Patrice Bourgin

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Risk Estimation of Severe Primary Graft Dysfunction in Heart Transplant Recipients Using a Smartphone by Souhila Ait-Tigrine, Roger Hullin, Elsa Hoti, Matthias Kirsch, Piergiorgio Tozzi

“…This study sought to develop a user-friendly score integrating variables from these systems to enhance the efficacy of the organ allocation process. …”
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Exploring the comorbidity mechanisms between atherosclerosis and hashimoto’s thyroiditis based on microarray and single-cell sequencing analysis by Yirong Ma, Shuguang Wu, Junyu Lai, Qiang Wan, Jingxuan Hu, Yanhong Liu, Ziyi Zhou, Jianguang Wu

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The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response by Bush NJ, Cushnie AK, Boissoneault J, Aghabeigi S, Alexander C, Staud R, Robinson ME

“…Expected pain was significantly associated with pain in the placebo session for the responders (b=0.37, R2=0.29, p< 0.001), but not for the non-responders (b=0.11, R2=0.04, p=0.42). gPPI analysis revealed three clusters exhibiting greater increases in FC in areas related to attention and sensory integration in placebo responders compared to non-responders. …”
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Inverse relationship of oxidative balance score with hyperuricemia among Chinese adults: a population-based cross-sectional study by Hewei Peng, Ying Han, Jingru Huang, Wenxin Qiu, Huajing Chang, Jiangwang Fang, Xian-E Peng

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Information technologies in the implementation of Language education in a non-linguistic University by Anna L. Morozova, Tat’yana A. Kostyukova, Dzhamilya Kh. Godina

“…You should also create a new model of competencies of the teachers to work in the paradigm of online student -oriented pedagogy, which requires an understanding of the role of learning environment as Navigator training, ownership integration technologies full-time and e-media, external resources and systems of learning (MOOCS, adaptive systems, external platforms) and build on these foundations training route.…”
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The e-STROKE Study: The Design of a Prospective Observational Multicentral Study by Kateřina Dvorníková, Veronika Kunešová, Svatopluk Ostrý, Robert Mikulík, Michal Bar

“…This study also aims to investigate whether the use of multimodal CT imaging increases the number of patients eligible for recanalization therapy. The analysis will integrate data from the RES-Q registry and radiological data from the e-STROKE system provided by Brainomix Ltd. …”
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Expert Consensus on Clinical Application of Lower Limb Rehabilitation Robots by ZHANG Lixin, BAI Dingqun, BAI Yulong, CHEN Wenhua, CHEN Yan, DU Qing, FAN Maohua, HE Hongchen, HUANG Liping, JIA Jie, LI Jianhua, LI Lei, PAN Yu, SU Min, WANG Hongtu, YIN Yong, ZHANG Bi

“…With the gradual increase in the application of lower limb robots in motor function rehabilitation, there is a need to standardize the clinical application of lower limb rehabilitation robots in China. This consensus integrates the characteristics of lower limb rehabilitation robots applications in the treatment for patients with hemiplegia, paraplegia, cerebral palsy, and other common lower limb dysfunctions in China. …”
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Application of deep learning model based on unenhanced chest CT for opportunistic screening of osteoporosis: a multicenter retrospective cohort study by Chengbin Huang, Dengying Wu, Bingzhang Wang, Chenxuan Hong, Jiasen Hu, Zijian Yan, Jianpeng Chen, Yaping Jin, Yingze Zhang

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