Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…A prognostic nomogram integrating POSTN expression and clinicopathological features demonstrated superior predictive accuracy for OS. …”
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Knowledge, behaviour and attitudes towards Chagas disease among the Bolivian migrant population living in Japan: a cross-sectional study by Chris Smith, Kenji Hirayama, Nguyen Tien Huy, Inés María Iglesias Rodríguez, Dao Huy Manh, Tieu Minh Thuan, Hugo Alberto Justiniano, Sachio Miura, George Ito

“…The barriers encountered in care-seeking behaviour were language, the migration process and difficulties to access the healthcare system.Conclusion EA with an integrative approach is useful to increase the knowledge of CD within the Bolivian migrant population living in Japan. …”
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Enhanced vehicle routing for medical waste management via hybrid deep reinforcement learning and optimization algorithms by Norhan Khallaf, Osama Abd-El Rouf, Abeer D. Algarni, Mohy Hadhoud, Ahmed Kafafy

“…In this study, artificial intelligence algorithms were trained using Homogeneous agent systems with a capacity of 3 tons to optimize routes between hospitals within the Closed Capacitated Vehicle Routing Problem framework. Integrating AI with pathfinding techniques, especially the hybrid A*-Deep Q Network approach, led to advanced results despite initial challenges. …”
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Estimating Long-Term Fractional Vegetation Cover Using an Improved Dimidiate Pixel Method With UAV-Assisted Satellite Data: A Case Study in a Mining Region by Shuang Wu, Lei Deng, Qinghua Qiao

“…Results demonstrate that 1) the IDPM, by developing distinct DPM improvement models for different NDVI intervals, considerably improves UAV and satellite data integration, with a 48.51&#x0025; increase in <italic>R</italic>² and a 56.47&#x0025; reduction in root mean square error (RMSE) compared to the DPM and UCS and 2) HM is found to be more suitable for mining areas, increasing <italic>R</italic>² by 25.00&#x0025; and reducing RMSE by 54.05&#x0025; compared to LSR. …”
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A 7,000 years trajectory of socio-ecosystems in the montane belt of the northern French Alps by Andréa Julien, Andréa Julien, Erwan Messager, Elise Doyen, David Etienne, Laurent Marquer, Charline Giguet-Covex

“…To study these interactions as a whole and by integrating their complexity, we used two conceptual frameworks: the agroecosystem and the trajectory.MethodsThe analyses conducted are based on a detailed analysis of pollen, NPP, macro-charcoal, and geochemical data from peat cores.ResultsThe vegetation history of the Plateau des Glières is dominated by forest, due to its location within the montane belt (1,435 m). …”
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Value-based healthcare in Latin America: a survey of 70 healthcare provider organisations from Argentina, Brazil, Chile, Colombia and Mexico by Pedro Ramos, Marcia Makdisse, Daniel Malheiro, Marcelo Katz, Luisa Novoa, Miguel Cendoroglo Neto, Jose Henrique Germann Ferreira, Sidney Klajner

“…Most VBHC initiatives were related to care delivery organisation (56.9%) and outcomes measurement (22.4%) but in most cases, integrated practice unit features had not been fully developed and outcome data was not used to guide improvement. …”
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Protocol for a feasibility study and process evaluation of a psychosocially modelled diabetes education programme for young people with type 1 diabetes: the Youth Empowerment Skill... by Nick Sevdalis, Khalida Ismail, Tayana Soukup, Trevor Murrells, Dulmini Kariyawasam, Stephen Thomas, Judith Parsons, Angus Forbes, Rita Forde, Maria Baldellou Lopez, Marie Jones, Martha Ford-Adams, Nardos Yemane, Siobhan Pender, Alex Silverstien

“…We will conduct a feasibility randomised controlled trial (waiting-list design) with integrated process evaluation. Fifty young people with type 1 diabetes (aged 14–19 years) will be randomly allocated to either the YES intervention or a waiting-list control. …”
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Policy and practice implication of - and tools to address - mental health and psychosocial support needs in Sierra Leone by Alastair Ager, Rebecca Horn, Abdulai Bah, Abdulai Bah, Haja Wurie, Mohamed Samai, Mohamed Samai

“…In terms of policy, findings reinforce key principles regarding community-based provision, integration of mental health care into primary health care, and actions to reduce stigma associated with mental health.…”
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Up-to-Date Imaging for Parathyroid Tumor Localization in MEN1 Patients with Primary Hyperparathyroidism: When and Which Ones (A Narrative Pictorial Review) by Valentina Berti, Francesco Mungai, Paolo Lucibello, Maria Luisa Brandi, Carlo Biagini, Alessio Imperiale

“…Additionally, we will explore integrated imaging approaches that combine multiple modalities to enhance localization accuracy and optimize surgical planning—an essential component of holistic management in MEN1 cases. …”
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Effective Facial Expression Recognition System Using Artificial Intelligence Technique by Imad S. Yousif, Tarik A. Rashid, Ahmed S. Shamsaldin, Sabat A. Abdulhameed, Abdulhady Abas Abdullah

“…Importantly, results on the study show that this integrated model has a large-scale promoting effect in emotion detection upon varied scenes and is therefore generalizable to many domains from security and surveillance over biomedicine up to interactive AI-driven systems. …”
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Post‐operative incidence of lymphedema after RARP with or without extended pelvic lymph node dissection in a cohort study by Andries Clinckaert, Laura Ysenbaardt, Annabel Bijnens, Charlotte Van Calster, Inge Geraerts, Steven Joniau, Nele Devoogdt, Luc Bijnens, Wouter Everaerts

“…Structured electronic case report forms (eCRFs) integrated into the electronic health record system were used to document intraoperative, perioperative and postoperative data. …”
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Transcriptome and Metabolome Analysis Unveil Anthocyanin Metabolism in Pink and Red Testa of Peanut (Arachis hypogaea L.) by Qiqin Xue, Xiurong Zhang, Hui Yang, Huadong Li, Yuying Lv, Kun Zhang, Yongguang Liu, Fengzhen Liu, Yongshan Wan

“…These differentially expressed genes were significantly enriched in the flavonoid biosynthesis, biosynthesis of secondary metabolites, and metabolic pathways. Integrated analysis of transcriptome and metabolome indicated CHS gene (arahy.CM90T6), F3′H genes (arahy. 8F7PE4 and arahy. …”
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Long-term observations of black carbon and carbon monoxide in the Poker Flat Research Range, central Alaska, with a focus on forest wildfire emissions by T. Kinase, F. Taketani, F. Taketani, M. Takigawa, C. Zhu, Y. Kim, P. Mordovskoi, Y. Kanaya, Y. Kanaya

“…We recommend that FRP be integrated into future bottom-up emission inventories to achieve a better understanding of the dynamics of pollutants from frequently occurring forest wildfires under the rapidly changing climate in the Arctic.…”
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Spartina alterniflora invasion significantly alters the assembly and structure of soil bacterial communities in the Yellow River Delta by Pengyuan Sun, Yuxin Wu, Pengcheng Zhu, Jingfeng Wang, Jingfeng Wang, Xiaona Yu, Weihua Guo

“…Soil microbial communities are integral to almost all terrestrial biogeochemical cycles, which are essential to coastal wetland functioning. …”
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Evaluating Copper-Doped Biochar Composites for Improving Wheat Nutrition and Growth in Oxisols by Loren Chisté, Carlos Alberto Silva, Flávio Henrique Silveira Rabêlo, Keiji Jindo, Leônidas Carrijo Azevedo Melo

“…Fourier Transform Infrared Spectroscopy (FTIR) confirmed successful Cu integration. Results revealed that CSS/CS-5 (FSS + CuSO₄5H₂O at 550 °C) improved Cu uptake and shoot biomass in DRL soil, while CSC/CS-3 (FSC + CuSO₄5H₂O at 300 °C) enhanced wheat CuSO₄5H₂O growth in RYL soil. …”
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Understanding the educational inequalities in suicide attempts and their mediators: a Mendelian randomisation study by Jing Wang, Ye Yang, Rui Gao, Lilu Ding, Jiahao Zhu, Dan Zhou, Yingjun Li, Houpu Liu

“…Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation (MR) analysis to estimate the causal effect of educational attainment on suicide attempts, utilising genome-wide association study summary statistics from the Integrative Psychiatric Research (iPSYCH; 6024 cases and 44 240 controls) and FinnGen (8978 cases and 368 299 controls). …”
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Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis by Ana Maria Vega-Letter, Cynthia García-Guerrero, Liliana Yantén-Fuentes, Carolina Pradenas, Yeimi Herrera-Luna, Eliana Lara-Barba, Felipe A. Bustamante-Barrientos, Masyelly Rojas, María Jesús Araya, Nicole Jeraldo, Constanza Aros, Francisca Troncoso, Daniela Poblete, Angela Court, Alexander Ortloff, Jose Barraza, Francesca Velarde, Carlos Farkas, Claudio Carril, Noymar Luque-Campos, Gonzalo Almarza, Maximiliano Barahona, Jose Matas, Lucas Cereceda, Rocío Lorca, Jorge Toledo, Karina Oyarce, Rolando Vernal, Andrés Caicedo, Andrea del Campo, Yessia Hidalgo, Roberto Elizondo-Vega, Farida Djouad, Maroun Khoury, Fernando E. Figueroa, Patricia Luz-Crawford

“…Results Our findings demonstrate the functional integrity of Mito-MSC and their ability to be efficiently transferred into chondrocytes, synovial macrophages, and synovial fibroblasts. …”
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Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease by Zhongquan Xin, Zhenya Zhai, Hongrong Long, Fan Zhang, Xiaojun Ni, Jinping Deng, Lunzhao Yi, Baichuan Deng

“…Notably, 133 metabolites were identified by an integrated database. Metabolism network and pathway analyses demonstrated that the metabolic disturbance of the liver in IBD mice was mainly enriched in bile acid metabolism, arachidonic acid metabolism, amino acid metabolism, and steroid hormone biosynthesis, while those disturbances were regulated or reversed through cecropin A and antibiotic treatment. …”
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Spatiotemporal Variations of PM2.5 and O3 Relationship during 2014–2021 in Eastern China by Yasong Li, Tijian Wang, Qin’geng Wang, Yawei Qu, Hao Wu, Min Xie, Mengmeng Li, Shu Li, Bingliang Zhuang

“…We quantified the spatiotemporal variations of them in the Yangtze River Delta (YRD) utilizing long-term integrated data during 2014–2021 and examined the evolution of their relationship at different time scales through statistical analysis. …”
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Quantifying Spatiotemporal Changes in Supraglacial Debris Cover in Eastern Pamir from 1994 to 2024 Based on the Google Earth Engine by Hehe Liu, Zhen Zhang, Shiyin Liu, Fuming Xie, Jing Ding, Guolong Li, Haoran Su

“…The classification algorithm integrates spectral features from Landsat images and derived indices (NDVI, NDSI, NDWI, and BAND RATIO), supplemented by auxiliary factors such as slope and aspect. …”
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