The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway by Nana Wang, Tiegang Li, Ping Han

“…These findings confirm that TMXKP can alleviate insulin resistance in T2DM rats through the PI3K/AKT pathway. …”
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Hepatokine leukocyte cell‐derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction‐associated steatotic liver disease in the general population by Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Reina Yamamoto, Hiroaki Takayama, Atsushi Tajima, Tatsuya Yamashita, Masao Honda, Hiroyuki Nakamura, Toshinari Takamura

Subjects: “…Insulin resistance…”
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Serum galectin-3 and fibroblast growth factor-23 levels in relation with type 2 diabetes and cardiovascular risk by Klisic Aleksandra, Gluscevic Sanja, Karakasis Paschalis, Kotur-Stevuljevic Jelena, Ninic Ana

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Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus by Zhirong Miao, Honghua Wu, Liu Ren, Nan Bu, Lili Jiang, Huixia Yang, Junqing Zhang, Xiaohui Guo

“…HOMA-IR and HOMA-β were used to assess insulin resistance and insulin secretion levels with different glucose statuses. …”
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Integration of transcriptomics and metabolomics data revealed role of insulin resistant SNW1 gene in the pathophysiology of gestational diabetes by Ravi Bhushan, Rimjhim Trivedi, Ritu Raj, Anjali Rani, Sangeeta Rai, Anima Tripathi, Shiv Govind Rawat, Ajay Kumar, Dinesh Kumar, Pawan K. Dubey

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Insulin Resistance: A Proinflammatory State Mediated by Lipid-Induced Signaling Dysfunction and Involved in Atherosclerotic Plaque Instability by Fabrizio Montecucco, Sabine Steffens, François Mach

“…The dysregulation of the insulin-glucose axis represents the crucial event in insulin resistance syndrome. Insulin resistance increases atherogenesis and atherosclerotic plaque instability by inducing proinflammatory activities on vascular and immune cells. …”
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Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus by Subrata Kumar Biswas, Sabreena Mohtarin, Sonchita Rani Mudi, Taznuva Anwar, Laila Anjuman Banu, Sheikh Md. Khorshed Alam, Md. Fariduddin, M. Iqbal Arslan

“…This study examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) alter in prediabetes and correlate with insulin resistance (IR) and beta cell function in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). …”
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The Increased Activity of Liver Lysosomal Lipase in Nonalcoholic Fatty Liver Disease Contributes to the Development of Hepatic Insulin Resistance by Monika Cahova, Helena Dankova, Eliska Palenickova, Zuzana Papackova, Radko Komers, Jana Zdychova, Eva Sticova, Ludmila Kazdova

“…Consequent overproduction of diacylglycerol may represent the causal link between HFD-induced hepatic TAG accumulation and hepatic insulin resistance via PKCε activation.…”
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Visfatin Induces Inflammation and Insulin Resistance via the NF-κB and STAT3 Signaling Pathways in Hepatocytes by Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim

“…It has been suggested that visfatin, which is an adipocytokine, exhibits proinflammatory properties and is associated with insulin resistance. Insulin resistance and inflammation are the principal pathogeneses of nonalcoholic fatty liver disease (NAFLD), but the relationship, if any, between visfatin and NAFLD remains unclear. …”
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The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review by Xue Zhao, Qing Han, Yujia Liu, Chenglin Sun, Xiaokun Gang, Guixia Wang

“…Recent studies have shown the positive association between increased circulating BCAAs (valine, leucine, and isoleucine) and insulin resistance (IR) in obese or diabetic patients. However, results seem to be controversial in different races, diets, and distinct tissues. …”
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Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (orCCL2) in the Regulation of Metabolism by Anna Rull, Jordi Camps, Carlos Alonso-Villaverde, Jorge Joven

“…Main topics cover the relationship between MCP-1/CCL2, insulin resistance, inflammation, obesity, and related metabolic disturbances.…”
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Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes by Peng Duan, Min Yang, Meilin Wei, Jia Liu, Ping Tu

“…Increased serum OPG levels (OR = 1.009, p=0.006) may be a risk factor for insulin resistance. The present study suggests that OPG might be implicated in the pathogenesis of diabetes and is a potential biomarker of insulin resistance in subjects with diabetes and prediabetes.…”
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Association of Estimated Insulin Resistance with N-Terminal B-Type Natriuretic Peptide Concentration in Men with Metabolic Syndrome by Paweł Krzesiński, Wiesław Piechota, Katarzyna Piotrowicz, Grzegorz Gielerak, Agnieszka Woźniak-Kosek

“…The difference was even higher in the younger subgroup of patients reaching nearly 50%. Conclusions. Insulin resistance and, to a lesser degree, age were associated with NT-proBNP levels in men with MS. …”
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Association between the Time of Length since Smoking Cessation and Insulin Resistance in Asymptomatic Korean Male Ex-Smokers by Ko-Woon Kim, Sung-Goo Kang, Sang-Wook Song, Na-Rae Kim, Jun-Seung Rho, Yun-Ah Lee

“…Smoking is a major risk factor for diabetes mellitus, mainly due to decreased insulin secretion and increased insulin resistance. However, there has been little research on the effects of smoking cessation period on changes in insulin resistance. …”
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Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance by Hongyun Lu, Fang Hu, Yingjuan Zeng, Lingling Zou, Shunkui Luo, Ying Sun, Hong Liu, Liao Sun

“…From these data, we concluded that ketosis onset T2DM had better islet β-cell function and more serious insulin resistance than nonketotic onset T2DM.…”
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Higher Concentrations of BCAAs and 3-HIB Are Associated with Insulin Resistance in the Transition from Gestational Diabetes to Type 2 Diabetes by Ulrika Andersson-Hall, Carolina Gustavsson, Anders Pedersen, Daniel Malmodin, Louise Joelsson, Agneta Holmäng

“…NMR measurements revealed that levels of branched-chain amino acids (BCAAs) and the valine metabolite 3-hydroxyisobyturate were higher in T2DM and IGT groups and correlated with measures of insulin resistance and lipid metabolism. Conclusion. In addition to well-known clinical risk factors, BCAAs and 3-hydroxyisobyturate are potential markers to be evaluated as predictors of metabolic risk after pregnancy complicated by GDM.…”
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Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice by Wenbin Zheng, Jing Zhou, Shasha Song, Wen Kong, Wenfang Xia, Lulu Chen, Tianshu Zeng

“…This study was aimed at investigating the effect of sitagliptin on hepatic steatosis, insulin resistance, inflammation, and autophagy and exploring the underlying molecular mechanism. …”
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Reduced Systemic Levels of IL-10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans by Sonia Leon-Cabrera, Yoaly Arana-Lechuga, Enrique Esqueda-León, Guadalupe Terán-Pérez, Antonio Gonzalez-Chavez, Galileo Escobedo, Javier Velázquez Moctezuma

“…Obstructive sleep apnea (OSA) has been related to elevation of inflammatory cytokines and development of insulin resistance in morbidly obese (MO) subjects. However, it is still unclear whether the systemic concentration of anti-inflammatory mediators is also affected in MO subjects directly related to the severity of OSA and level of insulin resistance. …”
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Association between Sarcopenia and Insulin-Like Growth Factor-1, Myostatin, and Insulin Resistance in Elderly Patients Undergoing Hemodialysis by Novira Widajanti, SoebagijoAdi Soelistijo, Usman Hadi, Mochammad Thaha, null Aditiawardana, null Widodo, Hadiq Firdausi, YafanitaIzzati Nurina, MiraDelima Asikin, Hersih Srinowati, NoerHalimatus Syakdiyah

“…IGF-1, myostatin, and insulin resistance levels were measured once before hemodialysis. …”
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A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle by R. W. A. Mackenzie, P. Watt

“…Indeed, hypoxia has been widely implicated in the development of insulin resistance either via the direct action on insulin receptor substrate (IRS) and protein kinase B (PKB/Akt) or indirectly through adipose tissue expansion and systemic inflammation. …”
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