Ectopic Fat Deposition on Insulin Sensitivity: Correlation of Hepatocellular Lipid Content and M Value by Beverly S. Hong, Ying Li, Shuiqing Lai, Juan Liu, Hongyu Guan, Weijian Ke, Xiaoying He, Yanbing Li

“…HCL is an independent risk factor for insulin resistance and may be used to evaluate the risk of developing T2DM as a noninvasive marker of insulin sensitivity index.…”
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Relationship of Serum Total Insulin-Like Growth Factor Binding Protein-3 with Insulin-Like Growth Factor-I and Glucose Tolerance in Korean Children and Adolescents by Sun-Young Kim, Minsun Kim, Youngman Oh, Dae-Yeol Lee

“…Serum IGF-I and total IGFBP-3 levels, fasting plasma glucose levels, lipid profiles, insulin levels, C-peptide levels, homeostasis model assessment of insulin resistance (HOMA-IR) index, and glycated hemoglobin (HbA1c) levels were measured. …”
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Association between weight-adjusted waist index and cognitive impairment in Chinese older men: a 7-year longitudinal study by Jie Lin, Hongchen Shen, Wenjuan Yang, Guojun Zhang, Jie Sun, Wenqin Shen, Li Huang, Huajian Chen

“…BackgroundObesity, through mechanisms such as insulin resistance and systemic low-grade inflammation, can damage the central nervous system and impair cognitive function. …”
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The Different Insulin-Sensitising and Anti-Inflammatory Effects of Palmitoleic Acid and Oleic Acid in a Prediabetes Model by Denisa Miklankova, Irena Markova, Martina Hüttl, Barbora Stankova, Hana Malinska

“…HHTg rats exhibiting genetically determined hypertriglyceridemia, insulin resistance, and impaired glucose tolerance were fed a standard diet. …”
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Serum Zinc Levels in Women with Polycystic Ovarian Syndrome are Lower as Compared to Those without Polycystic Ovarian Syndrome: A Cohort Study by Swati Dhar, Reena Yadav, Akash Tomar

“…It is unclear if serum zinc levels are correlated with polycystic ovary syndrome (PCOS) and its pathophysiology, although relation between diabetes and insulin resistance has been established. Aims: This study aimed to investigate circulating serum zinc levels in PCOS subjects compared with non-PCOS subjects. …”
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Caffeic Acid Phenethyl Ester Regulates PPAR’s Levels in Stem Cells-Derived Adipocytes by Luca Vanella, Daniele Tibullo, Justyna Godos, Francesca Romana Pluchinotta, Claudia Di Giacomo, Valeria Sorrenti, Rosaria Acquaviva, Alessandra Russo, Giovanni Li Volti, Ignazio Barbagallo

“…Finally we tested the effects of Cape on insulin-resistant adipocytes. Quantification of Oil Red O-stained cells showed that lipid droplets decreased following Cape treatment as well as radical oxygen species formation. …”
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Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension by Ulla Kampmann, Ole N. Mathiassen, Kent L. Christensen, Niels H. Buus, Mette Bjerre, Henrik Vase, Niels Møller, Anne Kaltoft, Per L. Poulsen

“…Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. Afferent signaling from the kidneys elevates the central sympathetic drive. …”
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Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model by Kaya Hacer Kayhan, Demirtas Berjan, Yokus Beran, Kesim Dilek Aygün, Tasdemir Ezel, Sermet Abdurrahman

“…At the end of the experiment, body masses, the levels of fasting blood glucose, serum insulin, insulin resistance (HOMA-IR), liver glycogen, and liver enzymes related to carbohydrate metabolism were measured. …”
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Nonalcoholic Fatty Liver Disease as a Potential Risk Factor for Cardiovascular Disease in Patients with Type 2 Diabetes: A Prospective Cohort Study by Mohammad Dehghani Firouzabadi, Amirhossein Poopak, Ali Sheikhy, Fatemeh Dehghani Firouzabadi, Fatemeh Moosaie, Soghra Rabizadeh, Sara Momtazmanesh, Manouchehr Nakhjavani, Alireza Esteghamati

“…Although the etiology of NAFLD is unknown, insulin resistance is a key mechanism of lipid deposition in hepatocytes leading to steatosis and potentially steatohepatitis in patients with diabetes. …”
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Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility by Xiaomei Jiang, Yongfeng Wang, Hong Tang, Jin Ma, Heyue Li

“…Differences in general clinical data, anthropometric indicators, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), fasting plasma glucose (FPG), fasting insulin (FINS), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)) were compared between the two groups.Results After treatment, both groups showed significant reductions in FSH, LH, E2, and P levels compared to baseline (p < .05). …”
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Mechanism of TGIF1 on glycolipid metabolism disorders in mice with type 2 diabetes by Yuchen Li, Li Tao, Shikai Wang, Fuyan Bai, Liping Zheng, Lijun Hou

“…TGIF1 overexpression reduced hyperglycemia and hyperlipidemia, improved insulin resistance, increased liver glycogen content, and attenuated lipid accumulation and glycolipid metabolism disorders in mice with T2D. …”
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Liver Injury Indicating Fatty Liver but Not Serologic NASH Marker Improves under Metformin Treatment in Polycystic Ovary Syndrome by Susanne Tan, Nils Vollmar, Sven Benson, Jan-Peter Sowa, Lars P. Bechmann, Guido Gerken, Dagmar Fuhrer, Ali Canbay

“…Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance (IR), key features of nonalcoholic steatohepatitis (NASH). …”
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Supplementation with Korean Red Ginseng Improves Current Perception Threshold in Korean Type 2 Diabetes Patients: A Randomized, Double-Blind, Placebo-Controlled Trial by Kahui Park, YuSik Kim, Junghye Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn, Ji Sun Nam

“…In the subgroup analysis, CPT levels were improved in those with a longer diabetes duration or who already had neuropathy at the beginning of the study, and insulin resistance was improved in patients with a shorter diabetes duration. …”
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A Multivariate prediction model for amlodipine therapeutic efficacy in pediatric primary hypertension by Yao Lin, Hui Wang, Yaqi Li, Yang Liu, Yanyan Liu, Hongwei Zhang, Yanjun Deng, Lin Shi

“…After statistical adjustment, 4 variables were found to be independently associated with therapeutic efficacy, including hyperinsulinemia (OR = 3.000, 95% CI: 1.409-6.386, p  = 0.004), insulin resistance (OR = 2.354, 95% CI: 1.032-5.370, p = 0.042), the baseline plasma Endothelin-1 level (OR = 0.627, 95% CI: 0.532-0.740, p &lt; 0.001) and amlodipine dosages (OR = 1.743, 95% CI: 1.400-2.169, p &lt;0.001). …”
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Relevance of Plasma Obestatin and Early Arteriosclerosis in Patients with Type 2 Diabetes Mellitus by Peng-ying Gu, Dong-mei Kang, Wei-dong Wang, Yan Chen, Zhi-hong Zhao, Hui Zheng, Shan-dong Ye

“…We found that higher levels of fasting insulin (Fins), fasting blood glucose, 2 h OGTT glucose, homeostasis model assessment of insulin resistance (HOMA-IR), low density lipoprotein cholesterol, glycated haemoglobin, and C-reactive protein (CRP), as well as lower obestatin level and higher intima-media thickness level (IMT), existed in T2DM group compared with NGT group and IGT group (P<0.01). …”
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SLC6A4 5HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome by Barbara Šenk, Katja Goričar, Nika Aleksandra Kravos, Mojca Jensterle Sever, Andrej Janež, Vita Dolžan

“…Serotonin system may play a role in glucose-stimulated insulin secretion in patients with insulin resistance (IR) and decreased insulin sensitivity. …”
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Quetiapine-related weight loss: Report of a rare adverse effect by Nicodemus Okwudili K Obayi, David HN Nweke, Edidiong Idio, Darlington Okey, Cletus Ozibo

“…Some proposed mechanisms include paradoxical suppression of appetite, induction of deterioration in insulin resistance, induction of hypoglycaemia, as well as mere switching from a high-risk to a low-risk antipsychotic. …”
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Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition by Yu Fu, Xin Hao, Jingru Nie, Peng Shang, Xinxing Dong, Bo Zhang, Dawei Yan, Hao Zhang

“…In vivo, transgenic mice expressing porcine TRPC1 exhibited aggravated high-fat diet–induced obesity, hepatic steatosis, and insulin resistance. Moreover, TRPC1 may facilitate adipogenesis via activating phosphatidylinositol 3 kinase/AKT and β-catenin signaling pathways. …”
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Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians by Polin Haghvirdizadeh, Vasudevan Ramachandran, Ali Etemad, Farzad Heidari, Nooshin Ghodsian, Norzian Bin Ismail, Patimah Ismail

“…Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors. …”
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The value of growth differentiation factor 15 as a biomarker for peripheral artery disease in diabetes patients by Wan-Chi Chuang, Chih-Hsun Chu, Cai-Sin Yao, Mei-Chih Wei, I-Lun Hsieh, Chia-Mei Liao

“…Increased GDF15 levels are associated with obesity, insulin resistance, and diabetes as well as a poorer diabetes progression and prognosis. …”
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