Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…Dose-dependent expression of PIK3CA H1047R in human cervical cancer and induced pluripotent stem cells corrupted the fidelity of growth factor-induced information transfer, with preferential amplification of epidermal growth factor receptor (EGFR) signaling responses compared to insulin-like growth factor 1 (IGF1) and insulin receptor signaling. PIK3CA H1047R did not only shift these responses to a higher mean but also enhanced signaling heterogeneity. …”
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Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(N,N-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance by Samuel Treviño, Alfonso Díaz, Eduardo Sánchez-Lara, Víctor Enrique Sarmiento-Ortega, José Ángel Flores-Hernández, Eduardo Brambila, Francisco J. Meléndez, Enrique González-Vergara

“…Nevertheless, when the toxicological profile was evaluated at a 10 µmol dose, it did not show complete improvement, tested by the liver and adipose histology, as well as by insulin receptor phosphorylation and GLUT-4 expression. …”
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Dietary Alpha-Lipoic Acid Alleviated Hepatic Glycogen Deposition and Improved Inflammation Response of Largemouth Bass (<i>Micropterus salmoides</i>) Fed on High Dietary Carbohydra... by Zishuo Fang, Xianwei Pan, Ye Gong, Nihe Zhang, Shiwen Chen, Ning Liu, Naisong Chen, Songlin Li

“…The relative expression of insulin receptor a (<i>ira</i>) in the LA500 group was the highest, while the relative expression of glycerol kinase (<i>gk</i>), phosphofructokinase liver type (<i>pfkl</i>) and phosphoenolpyruvate carboxykinase (<i>pepck</i>) was the highest in the LA1000 group (<i>p</i> < 0.05). …”
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Insulin-Sensitizing Properties of Decoctions from Leaves, Stems, and Roots of <i>Cucumis prophetarum</i> L. by Zewdie Mekonnen, Giuseppe Petito, Getasew Shitaye, Gianluca D’Abrosca, Belete Adefris Legesse, Sisay Addisu, Maurizio Ragni, Antonia Lanni, Roberto Fattorusso, Carla Isernia, Lara Comune, Simona Piccolella, Severina Pacifico, Rosalba Senese, Gaetano Malgieri, Solomon Tebeje Gizaw

“…Particularly, key proteins of insulin signaling were investigated, i.e., insulin receptor substrate (IRS-1), protein kinase B (PKB/AKT), and glycogen synthase kinase-3 (GSK-3β), which have gained considerable attention from scientists for the treatment of diabetes. …”
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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model by Wei Xu, Yang Zhou, Ling Lin, Dongyin Yuan, Yingqi Peng, Li Li, Wenjun Xiao, Zhihua Gong

“…These teas can promote blood glucose transport and absorption by upregulating the protein and mRNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and mRNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. …”
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Diabetes Mellitus: A Public Health Challenge by Ydalsys Naranjo Hernández

“…It is a complex process of the carbohydrate, fat, and protein metabolism, which occurs as a result of such relative or complete impairment of insulin secretion from the β-cells of the pancreas or a defect in the insulin receptors.…”
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CORN SILK TEA EXTRACT AS ANTIDIABETIC : A REVIEW by Ila Maratush Shalihah, Vega Yoesepa Pamela, Septariawulan Kusumasari

“…Flavonoids in corn silk reduce blood glucose levels by stimulating insulin secretion by pancreatic β cells, activating insulin receptors, and repairing damaged pancreatic β cells through antioxidant activity; flavonoids also inhibit the breakdown of carbohydrates. …”
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The Physiological Role of GABA in Fine-Tuning Control of Blood Glucose and Diabetes Treatment by Mohsen Davari, Shahla Sohrabipour, Atefeh Golkari

“…In normal individuals, insulin in α-cells, through insulin receptors and the mammalian target of rapamycin/protein kinase B/phosphatidylinositol-3-kinase pathway, causes α-cells to proliferate and ultimately increase blood glucagon. …”
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EFFECT OF BIDARA LEAF EXTRACT (Ziziphus Mauritiana L.) ON THE FUNCTION OF THE PANCREAS OF MALE WISTAR STRAIN RATS IN REDUCING BLOOD SUGAR LEVELS by Musdayani Nasution, Ali Napiah Nasution, Maya Sari Mutia

“…Flavonoids are thought to also improve the sensitivity of insulin receptors, making them useful in DM conditions. …”
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Exploring the prevalence of gout among underrepresented low socioeconomic status type 2 diabetes populations by Jessica Smith, Abey Martin, Jane Mundadan, Michael Roberts, Youssef Roman, Arturo Bravo-Nuevo, Farzaneh Daghigh

“…Type 2 Diabetes is a condition characterized by the denaturation of the insulin receptors, due to chronically high blood glucose levels, leading to impaired regulation of blood sugar. …”
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