The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth by Erin Graves, David J. Hill, Susan Evers, Kristine Van Aarsen, Brie Yama, Su Yuan, M. Karen Campbell

“…Objective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. …”
Get full text

A perspective on intermittent fasting and cardiovascular risk in the era of obesity pharmacotherapy by Aristides G. Eliopoulos, Aristides G. Eliopoulos, Aristides G. Eliopoulos, Kalliopi K. Gkouskou, Kalliopi K. Gkouskou, Konstantinos Tsioufis, Despina Sanoudou, Despina Sanoudou, Despina Sanoudou

“…Intermittent fasting has been linked to metabolic health by improving lipid profiles, reducing body weight, and increasing insulin sensitivity. However, several randomized clinical trials have shown that intermittent fasting is not more effective than standard daily caloric restriction for short-term weight loss or cardiometabolic improvements in patients with obesity. …”
Get full text

We Are on the Verge of Breakthrough Cures for Type 1 Diabetes, but Who Are the 2 Million Americans Who Have It? by Rebecca Smith, Samara Eisenberg, Aaron Turner-Phifer, Jacqueline LeGrand, Sarah Pincus, Yousra Omer, Fei Wang, Bruce Pyenson

“…Innovative treatments have standardized insulin delivery and improved outcomes for patients, but patients’ access to such technologies depends on social determinants of health, including insurance coverage, proper diagnosis, and appropriate patient supports. …”
Get full text

Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study by Chunyan Zhou, Yanyu Zhang, Xiaoyi Liu, Chenyu He, Shiyang Li, Shiyang Li

“…This study aimed to explore the association between the metabolic score for insulin resistance (METS-IR) and the incidence of CMM.MethodsThis study included 6,977 individuals in the CHARLS database. …”
Get full text

The Effect of Prior Gestational Diabetes on the Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test 3 Years after Delivery by Timea Tänczer, Márk M. Svébis, Beatrix Domján, Viktor J. Horváth, Adam G. Tabák

“…No differences were found in fasting and 2-hour glucose and insulin levels, or BMI. According to multiple logistic regression, MGR was associated with prior early GDM (OR 2.14, 95% CI 0.92-4.99) and elevated triglyceride levels (OR 2.28, 95% CI 1.03-5.03/log (mmol/l)). …”
Get full text

Elevated levels of serum alpha-2-macroglobulin associate with diabetes status and incident CVD in type 1 diabetes by Baohai Shao, Janet K. Snell-Bergeon, Ian H. de Boer, W. Sean Davidson, Karin E. Bornfeldt, Jay W. Heinecke

“…Of the 28 serum proteins studied, five of them—alpha-2-macroglobulin (A2M), apolipoprotein A-IV, apolipoprotein L1, insulin-like growth factor 2, and phospholipid transfer protein—were significantly associated with T1DM status, with A2M being 1.6-fold higher in T1DM. …”
Get full text

The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure by Luke D. Boyle, Allende Miguelez-Crespo, Mhairi Paul, Elisa Villalobos, Julia N. C. Toews, Lisa Ivatt, Boglarka Nagy, Marisa Magennis, Natalie Z. M. Homer, Ruth Andrew, Victor Viau, Geoffrey L. Hammond, Roland H. Stimson, Brian R. Walker, Mark Nixon

“…Notably, HFD-fed male mice lacking NE have reduced glucocorticoid levels and action specifically in visceral adipose tissue, with improved glucose tolerance and insulin sensitivity, independent of systemic changes in free glucocorticoids. …”
Get full text

The Gut Microbiota in Women Suffering from Gestational Diabetes Mellitus with the Failure of Glycemic Control by Lifestyle Modification by Guangyong Ye, Long Zhang, Min Wang, Yunbo Chen, Silan Gu, Keyi Wang, Jianhang Leng, Yujia Gu, Xinyou Xie

“…However, a number of patients whose blood glucose is not controlled by lifestyle modification still require exogenous insulin to control blood glucose. No observational study is available about the relationship between the gut microbiota in GDM patients and lifestyle modifications. …”
Get full text

Assessing the impact of magnesium-based nutritional education on lipid profiles in individuals with type 2 diabetes mellitus: a quasi-experimental study by Eram Albajri, Arwa S. Almasaudi, Hala H. Mosli, Noor A. Hakim, Reem O. Basaqr, Manal Naseeb

“…Abstract Background The potential therapeutic role of magnesium (Mg) in type 2 diabetes mellitus (T2DM) remains insufficiently studied despite its known involvement in critical processes like lipid metabolism and insulin sensitivity. This study examines the impact of Mg-focused nutritional education on lipid profile parameters, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients. …”
Get full text

A Systematic Review and Meta-Analysis of Outcomes for Type 1 Diabetes after Bariatric Surgery by Alexandra Chow, Noah J. Switzer, Jerry Dang, Xinzhe Shi, Christopher de Gara, Daniel W. Birch, Richdeep S. Gill, Shahzeer Karmali

“…Preoperative weighted mean total daily insulin requirement was 98±26 IU/d, which decreased significantly to 36±15 IU/d (P<0.00001) and 42±11 IU/d (P<0.00001) at 12 months and at study endpoint, respectively. …”
Get full text

Incidence and Contributing Factors of Persistent Hyperglycemia at 6–12 Weeks Postpartum in Iranian Women with Gestational Diabetes: Results from LAGA Cohort Study by Sedigheh Nouhjah, Hajieh Shahbazian, Nahid Shahbazian, Alireza Jahanshahi, Shayesteh Jahanfar, Bahman Cheraghian

“…Independent risk factors for glucose intolerance were FPG ≥ 100 at the time of OGTT (OR 3.86; 95% CI; 1.60–9.32), earlier diagnosis of GDM (OR 0.92; 95% CI; 0.88–0.97), systolic blood pressure (OR 1.02; 95% CI; 1.002–1.04), and insulin or metformin therapy (OR 3.14; 95% CI; 1.20–8.21). …”
Get full text

Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice by Dianzhi Hou, Jian Tang, Meili Huan, Fang Liu, Sumei Zhou, Qun Shen

“…Results showed that MBC could effectively alleviative the obese phenotype, reduce the lipid accumulation and insulin resistance, and improve the hepatic oxidative stress and inflammatory response. …”
Get full text

Exploring a Chemotactic Role for EVs from Progenitor Cell Populations of Human Exfoliated Deciduous Teeth for Promoting Migration of Naïve BMSCs in Bone Repair Process by Lin Luo, Steven J. Avery, Rachel J. Waddington

“…Moreover, different EV groups were found to be abundant with multiple growth factors including transforming growth factor-β1 (TGF-β1), platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-1), and fibroblast growth factor-2 (FGF-2) given the detections through ELISA. …”
Get full text

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model by Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi

“…Bredemolic acid, a pentacyclic triterpene, has been found to improve insulin sensitivity in diet-induced prediabetic rats. …”
Get full text

miR-375 Promotes Pancreatic Differentiation In Vitro by Affecting Different Target Genes at Different Stages by Zhenyu Lu, Jing Wang, Xu Wang, Zhiying Li, Dan Niu, Min Wang, Jinzhu Xiang, Yongli Yue, Yajuan Xia, Xueling Li

“…Human embryonic stem cells (hESCs) possess the ability to differentiate into insulin-producing cells (IPCs), which can be used to treat type I diabetes. miR-375 is an essential transcriptional regulator in the development and maturation of the pancreas. …”
Get full text

Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients by Rahul Saxena, Baskar Chakrapani, M. P. Sarath Krishnan, Amit Gupta, Sweety Gupta, Jayanta Das, Subash C. Gupta, Anissa A. Mirza, Shalinee Rao, Bela Goyal

“…Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. …”
Get full text

From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…Its prevalence is intricately linked to obesity, insulin resistance, and other components of the metabolic syndrome. …”
Get full text

EFFECT OF BIDARA LEAF EXTRACT (Ziziphus Mauritiana L.) ON THE FUNCTION OF THE PANCREAS OF MALE WISTAR STRAIN RATS IN REDUCING BLOOD SUGAR LEVELS by Musdayani Nasution, Ali Napiah Nasution, Maya Sari Mutia

“…Flavonoids are thought to also improve the sensitivity of insulin receptors, making them useful in DM conditions. …”
Get full text

IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A‐Mediated NLRP3 Inflammasome by Wu Jingrui, Yang Haihui, Yan Jinjin, Fang Le

“…Aims The present study aimed to explore the effect of human insulin‐like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2), one of the m6A‐binding proteins on the progression of AD. …”
Get full text

Growth, Feed Utilization, Lipid Metabolism, and Metamorphosis of Bullfrog (Aquarana catesbeianus) Tadpoles Fed Diets With Different Lipid Levels by Juan Gao, Ling Wang, Jian Zhang, Kangle Lu, Kai Song, Xueshan Li, Chunxiao Zhang

“…Weight gain (WG), specific growth rate (SGR), crude protein content of the whole body, apparent digestibility of dry matter and gross energy, intestinal lipase (LPS) capacity, lipoprotein lipase (LPL), and carnitine palmitoyltransferase-I (CPT-I) and contents of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in the liver, high-density lipoprotein cholesterol (HDL-C) content in the serum, and metamorphosis rate at stages 40 and 41 increased as the dietary lipid level increased from 4.46% to 12.34% and then decreased. …”
Get full text