Expression Profile of Brain Aging and Metabolic Function are Altered by Resveratrol or α-Ketoglutarate Supplementation in Rats Fed a High-Fat Diet by Paulina Szczurek-Janicka, Katarzyna Ropka-Molik, Maria Oczkowicz, Sylwia Orczewska-Dudek, Mariusz Pietras, Marek Pieszka

“…A 6-week HFD feeding led to significant changes in concentrations of plasma glucose, insulin, lipids, and thyroid hormones. Moreover, 32% of the 84 analyzed genes correlated with aging were differentially expressed compared to the control group, with the largest functional class being related to inflammatory response. …”
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Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology by Yin-Feng Zhang, Hai-Ming Xu, Fei Yu, Man Wang, Meng-Yang Li, Tao Xu, Yan-Yan Gao, Jian-Xun Wang, Pei-Feng Li

“…In addition, obesity, an important cardiovascular risk, is modulated by the regulatory axis of PPARs/miRNAs, including adipogenesis, adipocyte dysfunction, insulin resistance, and macrophage polarization in adipose tissue. …”
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Effects of a Diet Enriched with Polyunsaturated, Saturated, or Trans Fatty Acids on Cytokine Content in the Liver, White Adipose Tissue, and Skeletal Muscle of Adult Mice by Bruno dos Santos, Debora Estadella, Ana Cláudia Losinskas Hachul, Marcos Hiromu Okuda, Mayara Franzoi Moreno, Lila Missae Oyama, Eliane Beraldi Ribeiro, Claudia Maria da Penha Oller do Nascimento

“…The serum levels of free fatty acids were lower in the L group, and insulin, adiponectin, lipid profile, and glucose levels were similar among the groups. …”
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Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia by Hamid Tanzadehpanah, Sima Nobari, Ava Jalalian Hoseini, Farzaneh Ghotbani, Mohsen Mehrabzadeh, Jamal Jalili shahri, Amirreza Alipour, Mohsen Sheykhhasan, Hamed Manoochehri, Susan Darroudi, Hanie Mahaki

“…It utilizes various angiogenic growth factors in platelets, including platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF), which are integral to the tissue repair.Critical limb ischemia (CLI) is a major symptom of peripheral arterial disease (PAD), and PRP therapy aims to improve blood circulation to the distal limb through the development of blood vessels. …”
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Association between physical activity, cardiometabolic risk factors and vitamin D in children and adolescents: a systematic review by Patricia Ribeiro Paes Corazza, Maiara Cristina Tadiotto, Derick Andrade Michel, Jorge Mota, Neiva Leite

“…Cardiometabolic risk factors included obesity, insulin resistance, systemic arterial hypertension and unfavorable changes in the lipid profile (low levels of high-density lipoprotein, elevated low-density lipoprotein and triglycerides). …”
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First Report of Diabetes Phenotype due to a Loss-of-Function ABCC8 Mutation Previously Known to Cause Congenital Hyperinsulinism by Theocharis Koufakis, Amalia Sertedaki, Elizabeth-Barbara Tatsi, Christina-Maria Trakatelli, Spyridon N. Karras, Eleni Manthou, Christina Kanaka-Gantenbein, Kalliopi Kotsa

“…Monogenic Diabetes is relatively rare, representing only 1-2% of total diabetes cases; nevertheless, it is often misdiagnosed primarily as type 1 diabetes, leading to unnecessary insulin therapy and delayed recognition of affected family members. …”
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Factors associated with early-onset androgenetic alopecia: A scoping review. by Li-Ping Liu, Mary Adumo Wariboko, Xiao Hu, Zi-Han Wang, Qian Wu, Yu-Mei Li

“…Comorbidities investigated included MetS, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson's disease. …”
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Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats by Şule Demir, Mustafa Ünübol, Serap Ünübol Aypak, Emrah İpek, Serdar Aktaş, Gamze Sevri Ekren, Murat Yılmaz, Recai Tunca, Engin Güney

“…At the end of week 12, serum glucose, ALT, AST, triglyceride, HDL, LDL, TSH, fT4, fT3, visfatin, and insulin assays were performed. Sections were stained with hematoxylin-eosin and “Oil Red-O” for histopathologic examination of the livers. …”
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Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts by Unjin Shim, Han-Na Kim, Yeon-Ah Sung, Hyung-Lae Kim

“…Metabolic syndrome (MetS) is a complex disorder related to insulin resistance, obesity, and inflammation. Genetic and environmental factors also contribute to the development of MetS, and through genome-wide association studies (GWASs), important susceptibility loci have been identified. …”
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Genetic Variants of SIRT1 Gene Promoter in Type 2 Diabetes by Shuchao Pang, Zhengjun Zhang, Yu Zhou, Jie Zhang, Bo Yan

“…Accumulating evidence indicates that SIRT1 is involved in insulin resistance and impaired pancreatic β-cell function, the two hallmarks of T2D. …”
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Winery By-Products In Vitro and In Vivo Effects on Atherothrombotic Markers: Focus on Platelet-Activating Factor by Maria Choleva, Smaragdi Antonopoulou, Elizabeth Fragopoulou

“…Evidence from long-term studies shows that consumption may lower total and low density lipoprotein (LDL) cholesterol, improve insulin sensitivity, decrease lipid and protein oxidative damage, enhance antioxidant capacity, and have mild anti-inflammatory action toward reducing cytokine expression and levels. …”
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Serum resistin increases in gestational diabetes but does not differ among various trimesters by Tahmina Ferdousi, Tania Tofail, Sharmin Jahan, Kishore K. Shil, Hafsa Mahrukh, Muhammad A. Hasanat

“…It is thought that it is related to insulin resistance and pathogenesis of gestational diabetes mellitus (GDM). …”
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Effect of Ileal Transposition (IT) on Angiopoietin-Like Protein-8 (ANGPTL8) and Pentraxin (PTX3) Plasma Level in Sprague-Dawley Rats Fed High-Fat Diet (HFD) by Tomasz Sawczyn, Dominika Stygar, Katarzyna Nabrdalik, Michał Kukla, Oliwia Masri, Łukasz Magrowski, Wojciech Karcz, Jerzy Jochem

“…Metabolic surgery procedures are designed not only for sustained weight loss but also for achieving positive metabolic changes, including improved glucose tolerance and insulin sensitivity, along with an increase in energy expenditure. …”
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Association between weight-adjusted waist index and cognitive impairment in Chinese older men: a 7-year longitudinal study by Jie Lin, Hongchen Shen, Wenjuan Yang, Guojun Zhang, Jie Sun, Wenqin Shen, Li Huang, Huajian Chen

“…BackgroundObesity, through mechanisms such as insulin resistance and systemic low-grade inflammation, can damage the central nervous system and impair cognitive function. …”
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CONDITION OF HORMONAL STATUS OF THE BODY IN WHITE RATS UNDER THE EXPOSURE TO SODIUM FLUORIDE by I.Yu. Bagmut, I.L. Kolisnyk, S.I. Kryzhna, A.V. Titkova, L.Yu. Svyrydenko

“…The results showed reduced levels of folliculotropin and progesterone, increased levels of thyroxine, adrenocorticotropin, glucagon, triiodothyronine, thyrotropin and calcitonin, while insulin, somatostatin and serum glucose levels decreased. …”
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Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a pro‐inflammatory environment in mice by Vanya Nikolova, Alice L. Mitchell, Elena Bellafante, Eugene Jansen, Georgia Papacleovoulou, Per‐Olof Bergh, Hanns‐Ulrich Marshall, Catherine Williamson

“…CA supplementation during pregnancy increased plasma ROM by 1.24‐fold and suppressed inflammatory‐modulating pentraxin‐2/3 and insulin‐like growth factor 1 (IGF‐1) levels by >50% and >80%, respectively. …”
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Experiences of adults with type 2 diabetes mellitus with low socioeconomic status: a qualitative study by Vahide Semerci Çakmak, Ebru Sönmez Sari, Serap Çetinkaya Özdemir

“…According to Theme 3, it was observed that the participants faced difficulties related to diabetes self-management, including blood glucose monitoring, insulin injection administration, and maintaining glycemic control.” …”
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IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…Although ionizing radiation (IR) has provided considerable improvements in nasopharyngeal carcinoma (NPC) treatment, radioresistance is still a major threat for some subsets of patients. The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is tightly regulated and plays critical roles in mediating cell proliferation, growth, and survival. …”
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The protective role of GLP-1 in neuro-ophthalmology by Sohum Sheth, Aashay Patel, Marco Foreman, Mohammed Mumtaz, Akshay Reddy, Ramy Sharaf, Siddharth Sheth, Brandon Lucke-Wold

“…This article describes GLP-1 peptide characteristics and the mechanisms mediating its known role in increasing insulin, decreasing glucagon, delaying gastric emptying, and promoting satiety. …”
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Pituitary Stalk Interruption Syndrome: A Case and Literature Review by Anuja Choure, MD, Leena Shahla, MD

“…Laboratory tests were consistent with hypopituitarism with follicle stimulating hormone 0.5 mIU/mL (16.7-113); luteinizing hormone 1.2 mIU/mL (10.8-58.6); prolactin 10.4 ng/mL (2.7-19.6); estradiol 20 pg/mL; cortisol 2 mcg/dL (6.7-22.6); adrenocorticotropic hormone 18 pg/mL (6-50); thyroid stimulating hormone 10.33 uIU/mL (0.28-3.8); free T4 0.41 ng/dL (0.58-1.64); insulin like growth factor-1 −3.7 SD (17 ng/mL) (52-328); and adrenocorticotropic hormone stimulation confirmed secondary adrenal insufficiency. …”
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