Testosterone and Adipokines are Determinants of Physical Performance, Strength, and Aerobic Fitness in Frail, Obese, Older Adults by Lina E. Aguirre, Irum Zeb Jan, Kenneth Fowler, Debra L. Waters, Dennis T. Villareal, Reina Armamento-Villareal

“…Our results showed significant positive correlations between circulating testosterone and insulin growth factor-1 (IGF-1) with knee flexion, knee extension, one-repetition maximum (1-RM), and peak oxygen consumption (VO2 peak), while no correlation was observed with estradiol. …”
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Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents by Jie Mi, Mercedes Nancy Munkonda, Ming Li, Mei-Xian Zhang, Xiao-Yuan Zhao, Ponce Cedric Wamba Fouejeu, Katherine Cianflone

“…Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, and insulin concentrations as well as body size parameters and pubertal development were evaluated in a large population of Chinese children/adolescents (n=3505, 6–18 years, 1722 girls and 1783 boys). …”
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Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats by Vandana Zaman, Denise Matzelle, Naren L. Banik, Azizul Haque

“…Interestingly, levels of several hormonal peptides related to hyperinsulinemia, such as insulin, leptin, pancreatic peptide (PP), peptide YY (PYY), and gastric inhibitory polypeptide (GIP), were significantly upregulated. …”
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Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis by Jie Yang, Lin Yang, Yanjiao Wang, Lu Huai, Bohan Shi, Di Zhang, Wei Xu, Di Cui

“…Focused on the interactions of sepsis and IL-6 related pathways, some chronic diseases have been studied for association with sepsis, containing insulin resistance, Alcoholic liver disease (ALD), Alzheimer disease (AD), and atherosclerosis. …”
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Efficacy and Safety of Bicyclol Treatment for Non-Alcoholic Fatty Liver Disease: Results of a Cohort Study by I. Yu. Pirogova, S. V. Yakovleva, T. V. Neuymina, S. P. Sinitsyn, V. S. Chulkov, T. N. Shamaeva

“…Bicyclol therapy in NAFLD is accompanied by positive dynamics of inflammation activity markers, insulin resistance and lipid spectrum, which suggests a positive dynamics of the stages of liver fibrosis and steatosis.…”
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Perbedaan Rerata Kadar Resistin dan TNF-Α Antara Wanita Hamil Yang Obesitas dengan yang Memiliki Berat Badan Normal Pada Preeklamsi Berat Awitan Lambat by Ira Suryanis, Eva Decroli, Yusrawati Yusrawati, Eryati Darwin

“…Salah satu faktor maternal adalah resistin, TNF-α yang dihubungkan dengan inflamasi dan resistensi insulin.. Tujuan penelitian ini adalah mengetahui perbedaan rerata kadar Resistin dan TNF-α maternal antara wanita hamil obesitas dan berat badan normal pada Preeklamsi Berat Awitan Lambat. …”
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Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism by Giacomo Tirabassi, Nicola delli Muti, Giovanni Corona, Mario Maggi, Giancarlo Balercia

“…Results. Testosterone, insulin-like growth factor 1 (IGF-1), and estradiol were the only hormones, which varied significantly between the two phases. …”
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Resistin Regulates Pituitary Lipid Metabolism and Inflammation In Vivo and In Vitro by F. Rodriguez-Pacheco, M. G. Novelle, M. J. Vazquez, E. Garcia-Escobar, F. Soriguer, G. Rojo-Martinez, E. García-Fuentes, M. M. Malagon, C. Dieguez

“…The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. …”
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Characteristics of different lipid droplet-mitochondrial contacts patterns during lipid droplet metabolism in T2DM-induced MASLD by Ye Xu, Yuan Zhang, Wen Sun, Qiang Tang, Wanyu Feng, Hongjian Xiao, Jingjie Wang, Xinmeng Yuan, Mengqi Xiang, Yaran Gao, Hanyu Zhang, Jiao Lu

“…This work aimed to investigate the alterations of CM and PDM in metabolic dysfunction-associated steatotic liver disease (MASLD) induced by spontaneous type-2 diabetes mellitus (T2DM) in db/db mice. It was found that insulin resistance increased both the number and size of lipid droplets in the liver by enhancing the accumulation of free fatty acids, which is accompanied by an increase in contacts with mitochondria. …”
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Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration by Susanne W. Bruun, Knud Josefsen, Julia T. Tanassi, Aleš Marek, Martin H. F. Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C. Antvorskov, Jesper Larsen, Niels H. Heegaard, Karsten Buschard

“…Further, gliadin fragments stimulate insulin secretion from beta cells directly. We hypothesized that gluten fragments may cross the intestinal barrier to be distributed to organs other than the gut. …”
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Radish Seed Exerts Anti-Diabetic and Obesity-Reducing Effects in Mice by Promoting the Activation of Uncoupling Protein 1 and Peroxisome Proliferator-Activated Receptor-γ Coactivat... by Yao-Chien Wang MD, Yu-An Hsu PhD, Sheng-Chun Lin MD, Li-Shan Chien MS, Jamie Jiin Yi Chen MD, Ming Yen Wu MD, Hui-Ju Lin MD, PhD, Chih-Sheng Chen MD, PhD, Yi-Qi Huang MS, Yu-Chi Tsai PhD, Lei Wan PhD

“…Additionally, RSE and SE improved glucose homeostasis and insulin sensitivity in high-fat diet-fed mice, indicating RSE's potential to prevent obesity and diabetes by enhancing adipocyte thermogenesis.…”
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Association between early ondansetron use and the risk of sepsis in intensive care unit patients: a secondary data of the Medical Information Mart for Intensive Care IV database by Xuan Liu, Qiuye Kou, Enhe Liu

“…Subgroup analysis revealed that the association between early ondansetron use and decreased risk of sepsis was significant in participants aged <65 years, men, not complicated with trauma, no surgery, systemic inflammatory response syndrome ≥2, Charlson Comorbidity Index ≥2, with ventilation use, without antibiotics use or without insulin use. In both patients with SOFA <3 or SOFA ≥3, early ondansetron use was correlated with a reduced risk of sepsis.Conclusion Patients with early ondansetron use had lower odds of experiencing sepsis than patients without early ondansetron use, which might provide a reference for the management of sepsis in ICU patients.…”
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Confirmation of the Absence of Somogyi Effect in Patients with Type 2 Diabetes by Retrospective Continuous Glucose Monitoring Systems by Yuxin Huang, Xudan Lou, Weicong Huang, Jieyuzhen Qiu, Cuiping Jiang, Jiao Sun, Xiaoming Tao

“…We collected retrospective CGMs data from 2,600 patients with type 2 diabetes with stable treatment of insulin. Nocturnal hypoglycemia was defined as a CGMs sensor glucose of less than 3.9 mmol/L for at least 15 min between 24:00 and 06:00. …”
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Association between dietary patterns and glycemic control in type II diabetes mellitus patients by Ye Qiang, Xingchen Lu, Yuchao Zhang

“…In patients with the hyperglycemic drug and insulin free, higher PC2 levels were related to lower odds of hyperglycemia (OR: 0.45, 95% CI: 0.21–0.96). …”
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Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized... by Anthony C Keech, Vijaya Sundararajan, Bruce R King, Sara Vogrin, Richard J MacIsaac, Leon A Bach, Jane Speight, Alicia J Jenkins, Christel Hendrieckx, David O’Neal, Sybil A McAuley, Geoff R Ambler, Fergus J Cameron, Jan M Fairchild, Elizabeth A Davis, Timothy W Jones, Morton G Burt, Philip M Clarke, Neale D Cohen, Peter G Colman, Joey Kaye, Kavita Kumareswaran, Melissa H Lee, Roland W Mccallum, Barbora Paldus, Stephen N Stranks, Steven Trawley, Glenn M Ward, David N O’Neal, Sienna Russell-Green, Deborah Jane Holmes-Walker, Benjamin Lam, Jennifer A Halliday, Glenn Ward, Catriona M Sims, D Jane Holmes-Walker, Andrzej Januszewski, Hanafi Mohammed Husin, Martin I de Bock, Mary B Abraham

“…Introduction This analysis aimed to investigate diabetes-specific psychological outcomes among adults with type 1 diabetes (T1D) using hybrid closed-loop (HCL) versus standard therapy.Research design and methods In this multicenter, open-label, randomized, controlled, parallel-group clinical trial, adults with T1D were allocated to 26 weeks of HCL (MiniMed™ 670G) or standard therapy (insulin pump or multiple daily injections without real-time continuous glucose monitoring). …”
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Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus by Xiaoqian Yin, Yan Huo, Li Liu, Yixing Pan, Suxin Liu, Runfang Wang

“…Moreover, serum NGAL levels exhibited a positive correlation with various parameters of insulin resistance. Maternal serum NGAL levels positively correlated with the NGAL levels found in the cord blood of the control (r = 0.399, P=0.012) and the GDM subjects (r = 0.349, P=0.014). …”
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Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome by Fabio Lanfranco, Giovanna Motta, Marco Alessandro Minetto, Matteo Baldi, Marcella Balbo, Ezio Ghigo, Emanuela Arvat, Mauro Maccario

“…Obese patients with OSAS show a reduction of both spontaneous and stimulated growth hormone (GH) secretion coupled to reduced insulin-like growth factor-I (IGF-I) concentrations and impaired peripheral sensitivity to GH. …”
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Integration of Gastric Cancer RNA‐Seq Datasets Along With PPI Network Suggests That Nonhub Nodes Have the Potential to Become Biomarkers by Akram Siavoshi, Mehran Piran, Ali Sharifi‐Zarchi, Fatemeh Ataellahi

“…Considering the overall survival (OS) analysis and the evaluation of expression levels alongside statistical parameters of the PPIN cluster nodes, it is plausible to suggest that THY1, CDH17, TGIF1, and AEBP1, categorized as nonhub nodes, along with ITGA5, COL1A1, FN1, and MMP2, identified as hub nodes, possess characteristics that render them applicable as biomarkers for the GC. Additionally, insulin‐like growth factor (IGF)‐binding protein‐2 (IGFBP2), classified as a nonhub node, demonstrates a significant negative correlation with both groups within the same cluster. …”
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Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells by Min Tang, Rui Chen, Hao Wang, Guowei Sun, Fan Yin, Beibei Liang, Yang Yang, Gaowa Sharen, Huafeng Wei, Xuyu Zhou, Gang Huang, Jian Zhao

“…Consistent with these in vitro results, by intravenous injection of OPN-expressing adenovirus to the mice, we found OPN can delay the development of obesity and improve insulin sensitivity. Therefore, our study demonstrates an important role of OPN in regulating the development of obesity, indicating OPN might be a novel target to attenuate obesity and its complications.…”
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Impact of clinical pharmacist integration on diabetes management: a prospective cohort by Nur Burcu Kutluay, Muhammed Yunus Bektay, Betul Sumbul-Sekerci, Abdusselam Sekerci, Fikret Vehbi Izzettin

“…The effects were assessed by comparing fasting plasma glucose, HbA1c, the homeostasis model assessment-estimated insulin resistance (HOMA-IR), lipid profile, BMI, waist circumference, illness perception, and diabetes knowledge. …”
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