The impact of sodium-glucose cotransporter-2 inhibitors on the incidence, therapy, and outcomes of fournier gangrene: insights from a systematic review of case reports by Yufi Aulia Azmi, Firas F. Alkaff, Kevin Muliawan Soetanto, Soetojo Wirjopranoto, Maarten J. Postma, Abdul Khairul Rizki Purba

“…Therapy options included perianal ring block, insulin, rigid sigmoidoscopy, aggressive debridement, antibiotics, fluid resuscitation, incision, drainage, surgery, hyperbaric oxygen therapy, plastic surgery, and fasciocutaneous flaps. …”
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Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome by Chenxi Yang, Yi Chen, Guangfeng Tang, Tongtong Shen, Li Li

“…The incidences of metabolic syndrome (MetS), denoting insulin resistance-associated various metabolic disorders, are increasing. …”
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Clinical profile of stress hyperglycemia in medical intensive care units by Geethanjali Ganesan, Sudha Vidyasagar, Nandakrishna Bolanthakodi, Cynthia Amrutha Sukumar

“…In the setting of medical intensive care units (ICU), it significantly contributes to patient morbidity and mortality.It initates a cascade of pathophysiological responses that in turn increase blood glucose and insulin resistance. As research in this area of SH in ICU patients is sparse with conflicting results, we conducted this study to evaluate the clinical profile and prognostic outcome of Stress hyperglycemia (SH) in ICU. …”
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Omega-3 Fatty Acids and Vitamin D in Cardiology by Norbert Güttler, Kirila Zheleva, Mariana Parahuleva, Ridvan Chasan, Mehmet Bilgin, Christiane Neuhof, Mehmet Burgazli, Bernd Niemann, Ali Erdogan, Andreas Böning

“…Vitamin D deficiency appears to be related to an increase in parathyroid hormone levels and can predispose to essential hypertension and left ventricular hypertrophy, increased insulin resistance, and eventually to atherosclerosis and adverse cardiovascular events. …”
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Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes by Hirofumi Nagao, Hitoshi Nishizawa, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Norikazu Maeda, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura

“…In patients with type 2 diabetes, plasma glutamate was positively correlated with BMI, eVFA, and fasting insulin but negatively correlated with APN and duration of diabetes. …”
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Effects of White Quinoa Polysaccharide on Regulation of Glucolipid Metabolism in Type 2 Diabetic Mice by Yanqing ZANG, Yingying CHUANG, Changyuan WANG, Yang CAO

“…Results showed that compared with diabetic mice, WQP intake could significantly inhibit the increase of body weight and FBG, improve OGTT, and alleviate insulin resistance in diabetic mice. At the same time, the total cholesterol (TC) content of diabetic mice decreased by 19%, and the low-density lipoprotein cholesterol (LDL-C) content decreased by 33%. …”
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Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings by Rushika Conroy, Gerardo Febres, Donald J. McMahon, Michael O. Thorner, Bruce D. Gaylinn, Irene Conwell, Louis Aronne, Judith Korner

“…At weeks 0 and 16, a liquid meal challenge was performed. Glucose, insulin, C-peptide, GLP-1, PYY, glucagon, and ghrelin (total, acyl, and desacyl) were measured fasting and postprandially. …”
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SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2 by Katarzyna Blaszczyk, Anna P. Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A. Beamish, Jolanta Chmielowiec, Omaima M. Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak

“…Treatment with the MMP2 protein resulted in pronounced short- and long-term SC-β-cell expansion, significantly increasing glucose-stimulated insulin secretion in vitro and in vivo. These findings suggest that SPOCK2 mediates fetal β-cell proliferation and maturation. …”
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Hyperglycemia Inhibits Complement-Mediated Immunological Control of S. aureus in a Rat Model of Peritonitis by Clifford T. Mauriello, Pamela S. Hair, Reuben D. Rohn, Nicholas S. Rister, Neel K. Krishna, Kenji M. Cunnion

“…Hyperglycemia decreased C4-fragment and C3-fragment opsonization of S. aureus recovered in peritoneal fluids, compared with euglycemic or insulin-rescued rats. Hyperglycemic rats showed decreased phagocytosis efficiency compared with euglycemic rats, which correlated inversely with bacterial survival. …”
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Inactivity‐mediated molecular adaptations: Insights from a preclinical model of physical activity reduction by Alice Meyer, Nicole Kim, Melissa Nguyen, Monica Misch, Kevin Marmo, Jacob Dowd, Christian Will, Milica Janosevic, Erin J. Stephenson

“…Experimentally reducing physical activity rapidly induces insulin resistance, impairs glucose handling, and drives metabolic inflexibility. …”
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Case report: A case of type 1 diabetes with diabetic ketoacidosis induced by envafolimab treatment in hepatocellular carcinoma by Youjia Li, Kai Qu, Xiuli Li, Xin Yang, Kanghuai Zhang, Jiao Xie

“…Management required intensive insulin therapy and a multidisciplinary approach to stabilize the patient’s health. …”
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Similarity of Fibroglandular Breast Tissue Content Measured from Magnetic Resonance and Mammographic Images and by a Mathematical Algorithm by Fatima Nayeem, Hyunsu Ju, Donald G. Brunder, Manubai Nagamani, Karl E. Anderson, Tuenchit Khamapirad, Lee-Jane W. Lu

“…We also found that the number of completed pregnancies, C-reactive protein, aspartate aminotransferase, and progesterone were more strongly associated with amounts of glandular tissue than adipose tissue, while fat body mass, alanine aminotransferase, and insulin like growth factor-II appear to be more associated with the amount of breast adipose tissue. …”
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Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism by Shan Guo, Reshef Tal, Haoyu Jiang, Tao Yuan, Ying Liu

“…Thirteen randomized controlled trials with 824 patients in total were included. Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo. …”
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Multi-omics reveals the mechanism of Trimethylamine N-oxide derived from gut microbiota inducing liver fatty of dairy cows by Chenlei Li, Feifei Wang, Yongxia Mao, Yanfen Ma, Yansheng Guo

“…KEGG enrichment analysis revealed that the significantly altered molecules were primarily involved in pathways related to the pathology of fatty liver disease, such as metabolic pathways, insulin resistance, hepatitis B, and the AMPK signaling pathway. …”
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How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health by Ayazhan Akhatova, Celine Jones, Kevin Coward, Marc Yeste

“…Smoking may induce DNA hypermethylation in genes related to anti-oxidation and insulin resistance. Paternal diet and obesity are associated with greater risks of metabolic dysfunction in offspring via epigenetic alterations in the sperm. …”
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Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients by Zhengwen Xu, Xisheng Yan, Dongsheng Li, Xiaodong Huang

“…The Triglyceride-Glucose (TyG) index, a surrogate for insulin resistance, may predict HF in this group, though its specific role requires clarification. …”
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Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population by Qianxing Zhou, Yamei Wu, Mingkang Li

“…Although previous studies have demonstrated an association between the atherogenic index of plasma (AIP) and insulin resistance, there remains a scarcity of large cohort studies investigating the association between AIP and the long-term risk of T2D in the general population. …”
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ЖОРСТКІСТЬ ПАРЕНХІМИ ПЕЧІНКИ ЩУРІВ ПРИ МОДЕЛЮВАННІ СТЕАТОЗУ АЛІМЕНТАРНОГО ГЕНЕЗУ ТА ЙОГО КОРЕКЦІЇ... by В.І. Діденко, Ю.А. Гайдар, І.А. Кленіна, О.О. Галінський, І.С. Коненко, А.І. Руденко, О.І. Грабовська

“…Diseases with characteristic changes in the liver, which are combined with metabolic syndrome and insulin resistance, are found in 80% of cases. Therefore, the timely manifestation and appropriate treatment of this pathology is very important today. …”
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Type II Diabetes Patients under Sildenafil Citrate: Case Series Showing Benefits and a Side Effect by Livia M. Zimmermann, Mauricio S. Baptista, João Paulo Tardivo, Maria A. Pinhal

“…Several literature reports showed that the chronic use of phosphodiesterase-5 inhibitors enhances the insulin sensitivity, improves the markers of endothelial function, and helps in the treatment of severe extremity ischemia and pulmonary hypertension. …”
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Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review by David Olufemi Adebo, Mathew Folaranmi Olaniyan, Christian Onosetale Ugege, Odekunle Bola Odegbemi

“…Abstract Background Type 2 Diabetes Mellitus (T2DM) is a significant global health concern characterised by insulin resistance and chronic hyperglycemia. Genetic factors, particularly variations in the CAPN-10 gene, have been implicated in T2DM susceptibility across diverse populations. …”
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