Digital health technologies for metabolic disorders in older adults: a scoping review protocol by Michael Brändle, Elgar Fleisch, Tobias Kowatsch, Panitda Huynh, Mia Jovanova

“…Introduction Metabolic disorders (type 2 diabetes, insulin resistance, hyperglycaemia, obesity, hyperlipidaemia, hypertension, non-alcoholic fatty liver disease and metabolic syndrome) are leading causes of mortality and disability worldwide. …”
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Associations of Triglyceride-Glucose Index and Its Derivatives with Hyperuricemia Risk: A Cohort Study in Chinese General Population by Qing Gu, Xue Hu, Jian Meng, Jun Ge, Sui Jun Wang, Xing Zhen Liu

“…Identification and intervention of insulin resistance may be beneficial to the prevention of hyperuricemia (HUA) and its related diseases. …”
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High-Yield Generation of Glucose-Responsive Pseudoislets From Murine Insulinoma Cells for Studies and Longitudinal Monitoring of Graft Survival by Grisell C. Gonzalez, Chris M. Li, Ilaria Pasolini, Sophia I. Pete, Connor Verheyen, Sofia M. Vignolo, Teresa De Toni, Aaron A. Stock, Alice A. Tomei

“…These pseudoislets are homogeneous in size and morphology (~150 µm), exhibit functional glucose-stimulated insulin secretion (GSIS) up to 18 days (NIT-1) enabling long-term studies, are produced in high yield [>35,000 Islet Equivalence from 30 ml culture], and are suitable for both in vitro and in vivo studies, including for encapsulation studies. …”
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Effects of coenzyme q10 on lipid profile in streptozotocin induced diabetic rats by Deniz Uluışık, Ercan Keskin, Yasemin Öznurlu, Tuğba Özaydın

“…It was determined plasma triglyceride, total cholesterol, LDL, HDL, insulin and glucose levels in all groups. In liver sections, the staining intensity of hepatocytes containing lipid droplets were evaluated.…”
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Family Support and Its Association with Glycemic Control in Adolescents with Type 1 Diabetes Mellitus in Riyadh, Saudi Arabia by Adwa M. AlHaidar, Norah A. AlShehri, Munira A. AlHussaini

“…This cross-sectional observational study assessed adolescents aged 10–19 years diagnosed with T1DM on insulin and receiving follow-up care at the King Saud University Medical City in Riyadh, Saudi Arabia. …”
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Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle by Gustavo R. D. Rodrigues, Joslaine N. S. G. Cyrillo, Lúcio F. M. Mota, Patrícia I. Schmidt, Júlia P. S. Valente, Eduarda S. Oliveira, Lúcia G. Albuquerque, Luiz F. Brito, Maria E. Z. Mercadante

“…The gene networks were involved in metabolic pathways including ovarian steroidogenesis, oocyte meiosis, and insulin secretion. Matings between carrier dam and carrier sire led to a reduction of up to -203.46% in pregnancy success probability, an increase of 275.15% in probability of pregnancy loss, 295.03% for stillbirth occurrence, and 301.40% for pre-weaning mortality when compared to non-carrier dam and sire matings. …”
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Medroxyprogesterone Acetate Plus Metformin to Prevent Persistent Endometrial Hyperplasia by Vakkas Korkmaz, Enis Özkaya, Tuncay Küçüközkan, Fadıl Kara, Yasemin Çekmez, Hilal Korkmaz

“…Seventy two of these women were administered cylic oral medroxyprogesterone acetate 10 mg/day for 3 months, 62 of these women were also receiving metformin 1000 mg/day due to preexisting insulin resistance and and all subjects underwent control endometrial sampling after treatment. …”
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Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice by Xiao Meng Zhang, Hao Deng, Jin Dong Tong, Yi Zhen Wang, Xu Chao Ning, Xiu Hong Yang, Fang Qiang Zhou, Hui Min Jin

“…Both Pyr-ORS and 1% pyruvate showed comparable therapeutic effectiveness with controls of body weight and blood sugar, increases of blood insulin levels, and improvement of renal function and pathological changes. …”
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Gender Differences in Metabolic Disorders and Related Diseases in Spontaneously Diabetic Torii-Leprfa Rats by Takeshi Ohta, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Shuichi Kimura, Bin Tong, Takahisa Yamada

“…Progression of diabetes, including increases in blood glucose and declines in blood insulin, was observed earlier in male rats than in females, and diabetic grade was more critical in male rats. …”
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The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes by Kira V. Derkach, Vera M. Bondareva, Oxana V. Chistyakova, Lev M. Berstein, Alexander O. Shpakov

“…The IS treatment of diabetic rats decreased the body weight, and improved glucose tolerance, insulin-induced glucose utilization, and lipid metabolism. …”
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Options of dyslipidemia treatment at non-alcoholic fatty liver disease by M. V. Mayevskaya, M. A. Morozova

“…Results of several studies published at the moment demonstrate that at NAFLD lipid metabolism markers, and serum transaminase levels normalize, sensitivity to insulin increases, the liver histology pattern improves at phenofibrate treatment. …”
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Evaluating the Mechanisms of Improved Glucose Homeostasis after Bariatric Surgery in Ossabaw Miniature Swine by Jonathan G. Sham, Vlad V. Simianu, Andrew S. Wright, Skye D. Stewart, Mouhamad Alloosh, Michael Sturek, David E. Cummings, David R. Flum

“…Large animal models of naturally occurring insulin resistance (IR), which have been lacking, would provide opportunities to elucidate such mechanisms. …”
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Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults by Shujing Sun, Fangting Hu, Yanru Sang, Sheng Wang, Xuechun Liu, Jiafeng Shi, Hongjuan Cao, Fangbiao Tao, Kaiyong Liu

“…Dysregulation of tryptophan (TRP) metabolism, particularly alterations in the kynurenine (KYN) and serotonin pathways, has been linked to the onset of chronic inflammation, oxidative stress, and insulin resistance, key contributors to the development of MetS. …”
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Rhabdomyolysis-Induced Acute Kidney Injury in Diabetic Emergency: Underdiagnosed and an Important Association to Be Aware of by Ami Amin, Bhavika Gandhi, Steven Torre, Alireza Amirpour, Jennifer Cheng, Mayurkumar Patel, Mohammad A. Hossain

“…The patient was discharged on insulin and needed intermittent dialysis for two months. …”
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Interfacility Transfer for VA-ECMO in Beta Blocker and Calcium Channel Blocker Overdoses: A Report of Two Cases by Richard Fisher, Santiago Batista Minaya, Heather Brunette, Joshua Nogar, Payal Sud

“…Treatment involves a combination of vasopressors, calcium, glucagon, and/or high-dose insulin euglycemia therapy. The most severe overdoses may require venoarterial extracorporeal membrane oxygenation (VA-ECMO), which often results in interfacility transfers. …”
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Appetite Response among Those Susceptible or Resistant to Obesity by Rachel C. Brown, Rebecca T. McLay-Cooke, Sara L. Richardson, Sheila M. Williams, David R. Grattan, Alexandra W.-A. H. Chisholm

“…Fingerprick blood samples to measure ghrelin, total peptide YY (PYY), leptin, glucose, and insulin along with appetite ratings were collected at baseline and 15, 30, 60, 120, and 180 min following consumption of a standardized meal. …”
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Effect of session order in combined aerobic and resistance training on glycemic control in older adults with type 2 diabetes: a crossover study by Renato Ferreira Corrêa, João Guilherme Vieira, Marcelo Ricardo Dias

“…Eighteen older adults with type 2 diabetes, 13 men and 5 women, non-insulin and beta-blocker dependents, were recruited. …”
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Autoimmune Polyendocrine Syndrome 3 Onset with Severe Ketoacidosis in a 74-Year-Old Woman by Stefano Benedini, Antonietta Tufano, Elena Passeri, Marco Mendola, Livio Luzi, Sabrina Corbetta

“…The diagnosis of type 1 diabetes mellitus was confirmed by the detection of autoantibodies against glutamic acid decarboxylase 65, islet cell antibodies, and anti-insulin autoantibodies. Anti-thyroperoxidase, anti-thyroglobulin, and anti-gastric parietal cell antibodies were also clearly positive. …”
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Patient Preference for Once-Weekly Dosing in Type 2 Diabetes Mellitus in Japan by Rohini Sen, Alan L. Shields, Koichiro Atsuda

“…Patients with T2DM were categorized into one of the three groups: (1) patients on treatment with oral hypoglycemic agent(s) only, (2) patients on combination treatment with oral hypoglycemic agent(s) and insulin, and (3) patients diagnosed with or suspected to have T2DM with no current or past experience with T2DM drug treatment (treatment naïve). …”
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Solution Structures of PPARγ2/RXRα Complexes by Judit Osz, Maxim V. Pethoukhov, Serena Sirigu, Dmitri I. Svergun, Dino Moras, Natacha Rochel

“…PPARγ is a key regulator of glucose homeostasis and insulin sensitization. PPARγ must heterodimerize with its dimeric partner, the retinoid X receptor (RXR), to bind DNA and associated coactivators such as p160 family members or PGC-1α to regulate gene networks. …”
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