Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines by Elizabeth Curtiss, Youde Jiang, Li Liu, Claire Hawthorne, Jessica Zhang, Jena J. Steinle

“…We have also published that impaired insulin signaling occurs in the diabetic retina. A reduction in interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) by Epac1 could potentially restore normal insulin signal transduction. …”
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Maternal Fructose Intake Induces Insulin Resistance and Oxidative Stress in Male, but Not Female, Offspring by Lourdes Rodríguez, Paola Otero, María I. Panadero, Silvia Rodrigo, Juan J. Álvarez-Millán, Carlos Bocos

“…Maternal fructose intake induces insulin resistance, hyperleptinemia, and plasma oxidative stress in male, but not female, progeny.…”
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Isoproterenol Induced Insulin Resistance Leading to Diabetic Ketoacidosis in Type 1 Diabetes Mellitus by Ryan Hoff, Chung-Kay Koh

“…Isoproterenol is known to cause insulin resistance and is often used to treat bradyarrhythmias from atrioventricular block. …”
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Correlation between traumatic brain injury, obesity and insulin-resistance – a case report by Laura De Wilde, Charlotte De Ruysscher, Kristine Oostra

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Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs by Jocelyn Mott, Arnon Gal, Antonio Maria Tardo, Alisa Berg, Riley Claude, Alexis Hoelmer, Mei Lun Mui, Avin Arjoonsingh, Chen Gilor

Subjects: “…basal insulin…”
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Improvement of Skin Wound Healing for Diabetic Mice with Thermosensitive Hydrogel Combined with Insulin Injection by Lingling Fang, Haijian Wu, Xiaoyan Li, Jianghua Fang, Yabin Zhu

“…Therefore, we concluded that hydrogel combined with insulin accelerated wound healing. Controlling the glucose level via insulin injection is more beneficial than hydrogel alone for healing chronic wounds, potentially through the increase of α-SMA and TGF-β1 expression in early phase.…”
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Adipocyte DIO2 Expression Increases in Human Obesity but Is Not Related to Systemic Insulin Sensitivity by David Bradley, Joey Liu, Alecia Blaszczak, Valerie Wright, Anahita Jalilvand, Bradley Needleman, Sabrena Noria, David Renton, Willa Hsueh

“…Our results suggest that adipocyte-derived DIO2 may play a role in weight maintenance but is likely not a major contributor to obesity-related insulin resistance.…”
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Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment by Karsten Buschard, Laurits J. Holm, Ulla Feldt-Rasmussen

“…The need for insulin quickly declined, and she took her last dose of insulin 19 days after the first dose of fenofibrate, having regained endogenous control of blood glucose concentrations. …”
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Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China by Yi-Zhong Yan, Ru-Lin Ma, Jing-Yu Zhang, Jia He, Jiao-Long Ma, Hong-Rui Pang, La-Ti Mu, Yu-Song Ding, Heng Guo, Mei Zhang, Jia-Ming Liu, Dong-Sheng Rui, Kui Wang, Shu-Xia Guo

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Relation between Renal Function and Insulin Resistance of Type 2 Diabetic Iraqi Patients by Rami Fadhel Lefta, Ekhlas Abdallah Hassan

“…The objective of this study was to assess the level of insulin in patients with Type 2 diabetes mellitus (T2DM) and to interpret the relationship between insulin resistance (HOMA-IR) and renal function. …”
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A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance by Forough Jahandideh, Jianping Wu

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Effects of Cirsium japonicum var. maackii on avelliation of metabolic disease by improving insulin resistance by Hye-Bin Yoon, Yuseong Jang, Hyeon-Gi Paik, Hwal Choi, Jihye Choi, Jungkee Kwon

“…MetS is characterized by insulin resistance, which leads to abnormal insulin sensitivity. …”
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Insulin Autoimmune Syndrome in a 25-Year-Old, Previously Healthy Kuwaiti Man by Einas Alrashidi, Thamer Alessa

“…Insulin autoimmune syndrome (IAS) is a disease characterized by hyperinsulinaemic hypoglycaemia associated with autoantibodies against endogenous insulin. …”
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Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy by Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov

“…Mitophagy is a critical mitochondrial quality control mechanism that removes dysfunctional mitochondria and contributes to cell survival. Insulin-like growth factor 1 (IGF-1) promotes survival of smooth muscle cells (SMCs), but its potential effect on cellular aging is unknown yet. …”
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Dexamethasone potentiates the insulin-induced Srebp-1c expression in primary rat hepatocytes by Yan Zhang, Xiangming Fang, Fen Shuang, Guoxun Chen

Subjects: “…Insulin…”
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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease by Giuseppe Verdile, Kevin N. Keane, Vinicius F. Cruzat, Sandra Medic, Miheer Sabale, Joanne Rowles, Nadeeja Wijesekara, Ralph N. Martins, Paul E. Fraser, Philip Newsholme

“…Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. …”
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Hypoglycaemia due to insulin therapy for the management of hyperkalaemia in hospitalised adults: A scoping review. by Mogamat-Yazied Chothia, Toby Humphrey, Anel Schoonees, Usuf Mohamed Ebrahim Chikte, Mogamat Razeen Davids

“…The median timing of hypoglycaemia was 124 minutes after insulin administration (IQR 102-168 minutes). There were no differences in the prevalence of hypoglycaemia when comparing insulin dose (<10 units vs. ≥10 units), rate of insulin administration (continuous vs. bolus), type of insulin (regular vs. short-acting) or timing of insulin administration relative to dextrose. …”
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How to improve the quality of euglycemic glucose clamp tests in long-acting insulin studies by Yi Yang, Fu Kuang, XueYing Zhu, Li Li, Yao Huang, Yang Liu, Xian Yu

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Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus by Chan Yew Low, Wei Ling Gan, Su Jeat Lai, Rachel Su-May Tam, Jie Fei Tan, Stefanie Dietl, Lay Hong Chuah, Nicolas Voelcker, Athirah Bakhtiar

Subjects: “…Oral insulin…”
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Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese by Chikako Fujii, Toshihide Kawai, Koichiro Azuma, Yuko Oguma, Fuminori Katsukawa, Hiroshi Hirose, Kumiko Tanaka, Shu Meguro, Hideo Matsumoto, Hiroshi Itoh

“…We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects.…”
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