Metabolic Syndrome, Obesity, and Gastrointestinal Cancer by Shintaro Fujihara, Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Mitsuyoshi Kobayashi, Makoto Oryu, Tsutomu Masaki

“…Adipose tissue, particularly visceral fat, is an important metabolic tissue as it secretes systemic factors that alter the immunologic, metabolic, and endocrine milieu and also promotes insulin resistance. Within the growth-promoting, proinflammatory environment of the obese state, cross-talk between macrophages, adipocytes, and epithelial cells occurs via obesity-associated hormones, adipocytokines, and other mediators that may enhance cancer risk and progression. …”
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Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease by Kelly N. Z. Fuller, Edwin R. Miranda, John P. Thyfault, Jill K. Morris, Jacob M. Haus

“…Stratification by BMI classification, median fat mass, median HOMA-IR, median insulin, and median amylin were all metabolic or anthropometric factors which significantly interacted with sRAGE profiles within AD subjects. …”
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Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan by Cécile Canlet, Marie Tremblay-Franco, Roselyne Gautier, Jérôme Molina, Benjamin Métais, Florence Blas-Y Estrada, Laurence Gamet-Payrastre

“…In conclusion, our results show that metabolic changes in liver could be linked to the onset of pathologies like diabetes and insulin resistance. Moreover from our results it appears that the NMR-based metabonomic approach could be useful for the characterization in plasma of a dietary exposure to low dose of pesticide in human.…”
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Elevations of N-Terminal Mid-Fragment of Osteocalcin and Cystatin C Levels are Associated with Disorders of Glycolipid Metabolism and Abnormal Bone Metabolism in Patients with Type... by Xiaofang Guo, Yun Shen, Teng Du, Yan He, Jie Lu, Qianhong Yang

“…Elderly T2DM-OP patients showed elevated disease duration, age, body mass index, glycated hemoglobin (HbA1c), Homer’s insulin resistance (HOMA-IR), total cholesterol (TC), beta-carboxy-terminal crosslinked telopeptide of type 1 collagen (β-CTX), tartrate-resistant acid phosphatase 5b (TRACP-5b), N-MID and Cys C levels, and reduced high-density lipoprotein cholesterol (HDL-C), bone alkaline phosphatase (B-ALP), aminoterminal propeptide of type I procollagen (PINP), carboxyterminal propeptide of type I procollagen (PICP), BMD, and calcium supplementation. …”
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Nonlinear modeling of oral glucose tolerance test response to evaluate associations with aging outcomes. by Grant Schumock, Karen Bandeen-Roche, Chee W Chia, Rita R Kalyani, Luigi Ferrucci, Ravi Varadhan

“…First, we fit OGTT curves with the Ackerman model-a nonlinear, parametric model of the glucose-insulin system-and with functional principal components analysis. …”
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Review of Metabolic Surgery for Type 2 Diabetes in Patients with a BMI < 35 kg/m2 by Hideharu Shimizu, Poochong Timratana, Philip R. Schauer, Tomasz Rogula

“…To evaluate current status of metabolic surgery, we reviewed the available clinical studies which described surgical treatment for T2DM with mean BMI  <  35 kg/m2. 18 studies with 477 patients were identified. 30% of the patients was insulin users. The follow-up period ranged from 6 to 216 months. …”
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Screening of Trace Elements in Hair of the Female Population with Different Types of Cancers in Wielkopolska Region of Poland by Bogusław Czerny, Krzysztof Krupka, Marcin Ożarowski, Agnieszka Seremak-Mrozikiewicz

“…Disturbance in the axis glucose-insulin and changes in concentrations of heavy metals and toxic elements were also noted. …”
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N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells by Benxu Cheng, Pinki Anand, Anxiu Kuang, Feroz Akhtar, Virginia L. Scofield

“…The aim of this study was to determine whether cotreatment of NAC and insulin-like growth factor-1 (IGF-1) efficiently protected against proteasome inhibitor-induced cytotoxicity in SH-SY5Y cells. …”
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions by Miranda Movahed, Ruy A. Louzada, Manuel Blandino-Rosano

“…Prodynorphin levels are regulated in parallel with insulin in response to glucose, palmitate, and amino acids. …”
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Association of age at menopause with type 2 diabetes mellitus in postmenopausal women: a systematic review and meta-analysis by Faezeh Zakerinasab, Taif Haiham Al Saraireh, Amirhesam Amirbeik, Rasoul Hossein Zadeh, Fariba Arbab Mojeni, Qumars Behfar

“…Visceral obesity and diminished estrogen level during the menopausal phase are associated with unfavorable metabolic changes, resulting in insulin resistance and increased risk of type 2 diabetes mellitus (T2DM). …”
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Induction of Expression of CD271 and CD34 in Mesenchymal Stromal Cells Cultured as Spheroids by Bruno Corrêa Bellagamba, Patrícia Bencke Grudzinski, Pedro Bins Ely, Paulo de Jesus Hartmann Nader, Nance Beyer Nardi, Lindolfo da Silva Meirelles

“…Consequently, surface expression of CD271 and CD34 was detected in roughly half of the MSCs cocultured with ECs as spheroids in the presence of insulin-like growth factor 1 (IGF-1). Conversely, expression of CD271 and CD34 was detected in a similar proportion of MSCs cultured under these conditions without ECs, and expression of these markers was low or absent when no IGF-1 was added. …”
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Congenital malformations in children of diabetic mothers in the province of Cienfuegos. 2016-2019 by Fanny Arbolay Sanabria, Lázaro Roberto Herrera Fragoso, Maylé Santos Solí, Gladys Bárbara Barberis Pérez, Walkiria Díaz Senra, María Soledad Vilches León

“…The treatments most used by pregnant women were diet and insulin. Major congenital malformations constituted the largest percentage and the most affected system was the cardiovascular system. …”
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Concentration of Asprosin Associated with Poor Control of Type 2 Diabetes Mellitus in Diyala Province by Alaa Abed Mahmoud, Walaa Ismael Jassim, Ahmed Abdul Hussein Mohsin, Ahmed M. Senan

“…Its loss of function through immunologic or genetic methods has a significant effect on lowering glucose and insulin as a result of decreased hepatic glucose release. …”
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High-fat diet triggers transcriptomic changes in the olfactory bulb by Young-Kook Kim, Danbi Jo, Seoyoon Choi, Juhyun Song

“…We found differences in the expression of protein-coding and non-coding RNAs involved in insulin, lipid metabolism, neurogenesis, serotonin, dopamine, and gamma-aminobutyric acid–related signaling in the olfactory bulb of HFD-fed mice compared to control mice. …”
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White adipose tissues and skeletal muscles as a target of chrysin during the treatment of obesity in rats by Omar S. Hassan, Magda A. Megahed, Nesma A. Ghazal

“…In obese rats, therapy with chrysin reduced weight gain, hyperglycaemia, and insulin resistance. Also, the effects of chrysin may be mediated through acting as an anti-inflammatory and antioxidative stress agent. …”
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Adjuvant Treatment with Empagliflozin or Semaglutide Increases Endothelial Progenitor Cells in Subjects with Well-Controlled Type 1 Diabetes Mellitus by Maja Preložnik Navodnik, Katarina Reberšek, Katarina Klinar, Andrej Janež, Helena Podgornik

“…Both groups receiving adjuvant therapy were compared with the insulin-only group (N = 26) at two time points: before the start of therapy and after 12 weeks of adjuvant therapy. …”
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Effect of high-intensity interval training and moderate-intensity continuous training with quercetin supplementation on the mitochondrial gene expression in the diabetic heart by Mojdeh Khajehlandi, Lotfali Bolboli

“…Background: Mitochondrial function is an integral part of glucose-stimulated insulin secretion in pancreatic β-cells and is a hallmark feature of cardiovascular disease. …”
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Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats by Louiza Belkacemi, Ghalem Selselet-Attou, Emeline Hupkens, Evrard Nguidjoe, Karim Louchami, Abdullah Sener, Willy J. Malaisse

“…Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. …”
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Bioinformatics Analysis of Exercise-Related Biomarkers in Diabetes by Xiaoju Bao, Jingyue Qiu, Qin Xuan, Xinming Ye

“…It is shown that regular exercise can improve the insulin sensitivity of diabetic patients and have an important function in adjuvant therapy. …”
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OSAS-Related Inflammatory Mechanisms of Liver Injury in Nonalcoholic Fatty Liver Disease by Elena Paschetta, Paola Belci, Anna Alisi, Daniela Liccardo, Renato Cutrera, Giovanni Musso, Valerio Nobili

“…In NAFLD patients, liver disease may be caused by hypoxia both indirectly by promoting inflammation and insulin resistance and directly by enhancing proinflammatory cytokine production and metabolic dysregulation in liver cells. …”
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