Loss of Mfn1 but not Mfn2 enhances adipogenesis. by Jake P Mann, Luis Carlos Tábara, Satish Patel, Pushpa Pushpa, Anna Alvarez-Guaita, Liang Dong, Afreen Haider, Koini Lim, Panna Tandon, Fabio Scurria, James E N Minchin, Stephen O'Rahilly S, Daniel J Fazakerley, Julien Prudent, Robert K Semple, David B Savage

“…<h4>Results</h4>Mfn1-/- MEFs displayed striking fragmentation of the mitochondrial network, with surprisingly enhanced propensity to differentiate into adipocytes, as assessed by lipid accumulation, expression of adipocyte markers (Plin1, Fabp4, Glut4, Adipoq), and insulin-stimulated glucose uptake. RNA sequencing revealed a corresponding pro-adipogenic transcriptional profile including Pparg upregulation. …”
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Position statement of the Polish Society of Allergology and Polish Dermatological Society regarding the limited accessibility of materials necessary for patch testing. Part I: Tech... by Roman Nowicki, Magdalena Czarnecka-Operacz, Elżbieta Grubska-Suchanek, Marta Kieć-Świerczyńska, Cezary Kowalewski, Beata Kręcisz, Jerzy Kruszewski, Maciej Kupczyk, Cezary Pałczyński, Jacek Szepietowski, Magdalena Trzeciak, Jolanta Walusiak-Skorupa, Radosław Śpiewak

“…Cases of allergic reactions to implanted medical devices are also on the rise, causing failures of endoprostheses, implants, insulin pumps, pacemakers and vascular stents. At present, the only validated method and a gold standard of detecting type IV allergy are patch tests. …”
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The Effect of Long-Term Exercise on the Production of Osteoclastogenic and Antiosteoclastogenic Cytokines by Peripheral Blood Mononuclear Cells and on Serum Markers of Bone Metabol... by J. Kelly Smith, Rhesa Dykes, David S. Chi

“…We also measured lymphocyte phenotypes and serum markers of bone formation (osteocalcin), bone resorption (C-terminal telopeptides of Type I collagen), and bone homeostasis (25 (OH) vitamin D, estradiol, testosterone, parathyroid hormone, and insulin-like growth factor 1). A combination of aerobic, resistance, and flexibility exercises done on average of 2.5 hours a week attenuated the production of osteoclastogenic cytokines and enhanced the production of antiosteoclastogenic cytokines. …”
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Effect of Dietary Administration of Green Macroalgae (Ulva intestinalis) on Mucosal and Systemic Immune Parameters, Antioxidant Defence, and Related Gene Expression in Zebrafish (D... by Elaheh Rouhani, Roghieh Safari, Mohammad Reza Imanpour, Seyed Hossein Hoseinifar, Metin Yazici, Ehab El-Haroun

“…Antioxidant-related genes (SOD and CAT) and growth-related genes, including growth hormone (GH) and insulin-like growth factor-I (IGF-1), were remarkably upregulated with gutweed treatment (P<0.05). …”
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Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab by Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe

“…Glutamic acid decarboxylase autoantibodies, zinc transporter 8 autoantibodies, insulin autoantibodies, islet antigen 2 autoantibodies, and islet cell antibodies were all negative. …”
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A Study of Serum Adiponectin Levels in Patients with Polycystic Ovarian Syndrome and its Correlation with Various Cardiometabolic Risk Markers by G. Surendra Prasad, Uma Kaimal Saikia, Ashok Krishna Bhuyan, Abhamoni Baro

“…Materials and Methods: All the included subjects underwent detailed clinical, biochemical and hormonal evaluation, including lipid profile, 75 g oral glucose tolerance test, fasting serum insulin, fasting serum adiponectin, oxLDL, total testosterone and anti-Mullerian hormone. …”
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Effect of Vitamin D on Fasting Blood Sugar and HbA1c in Type 2 Diabetes Mellitus Patients by Rabab Zehra, Zareen Naz, Samina Mohyuddin, Saima Zainab, Aarfa Amjad, Ittafaq Hussain

“…Conclusion: According to the study's findings, vitamin D addition has improved plasma vitamin D3 levels and improved insulin sensitivity in patients with T2DM. The current analysis did not find a significant contribution to reducing HbA1c or enhancing glycemic control in individuals with T2DM. …”
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Innovation of kwetiau with red rice and red bean flour: evaluation of nutritional value and potential fiber source for patients with diabetes mellitus by Mulus Gumilar, Gurid Pramintarto Eko Mulyo, Dila Evianda, Roro Nur Fauziyah

“… Diabetes mellitus is characterized by hyperglycemia and metabolic dysfunctions in carbohydrates, fats, and proteins, primarily due to impaired insulin action and/or secretion. Dietary fiber can help delay carbohydrates conversion to glucose, slow the rise in blood sugar, and aid in blood sugar regulation. …”
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Association between TyG related parameters and metabolic dysfunction associated fatty liver disease among nondiabetic individuals by Qian Zhang, Zhilong Liu, Jiaqi Zhang, Shangjie Yang, Liping Liu

“…TyG index and its related parameters TyG-WHtR, TyG-WC and TyG-BMI have been proven to label insulin resistance reliably, which makes it an important parameter to reflect the composition and health status of human body. …”
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Sweets and other sugary foods – a scoping review for Nordic Nutrition Recommendations 2023 by Henna Vepsäläinen, Emily Sonestedt

“…We found some evidence linking chocolate consumption with lower blood pressure, lower risk of type 2 diabetes, and improved insulin markers, but the evidence was ranked low or very low. …”
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Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy by Tao Tang, Xu-Sheng Zhao, Zhong-Jun Chen, Tie-Ping Fan, Aline M. Thomas, Man-Hong Zhao, Di Li, Shen Li

“…BACKGROUND: Insulin resistance is more prevalent in the overweight population, which can affect their glucose metabolism. …”
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Anthropometric Indicators to Determine the Obesity and its Relations with the Cardiometabolic Risk by Raúl Cedeño Morales, Maricel Castellanos González, Mikhail Benet Rodríguez, Luis Mass Sosa, Carlos Mora Hernández, Jorge Carlos Parada Arias

“…<strong>Background:</strong> it has become a controversy if obesity per se is an independent cardiometabolic risk factor it self or it influences like a contributing element of other factors, specially hypertension, insulin resistance and dislipidemias. <strong><br />Objective:</strong> determining which of the anthropometric parameters used to quantify obesity is more associated to the cardiometabolic risk factors. …”
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Fifty-Two-Week Results of Clinical and Imaging Assessments of a Patient with Rheumatoid Arthritis Complicated by Systemic Sclerosis with Interstitial Pneumonia and Type 1 Diabetes... by Yuya Fujita, Masao Nawata, Atsushi Nagayasu, Kazuki Someya, Kazuyoshi Saito, Yoshiya Tanaka

“…Regarding the influence on type 1 diabetes, the required daily dose of insulin and hemoglobin A1c (HbA1c) levels decreased. …”
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Evaluation of Antidiabetic Properties of the Leaves Extract of Ficus vallis-choudae Delile in a Model of Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin by Kilenma Kolefer, David Miaffo, Roger Ponka

“…The AEFV also lowered blood glucose levels, insulinemia, homeostatic model assessment of insulin resistance (HOMA-IR) index, and total cholesterol (TC), triglycerides (TG), low-density lipoproteins cholesterol (LDL-c), and very-low-density lipoproteins cholesterol (VLDL-c) levels. …”
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Association of Epicardial Adipose Tissue Thickness with Cardiovascular Risk in Acromegaly by Bulent CAN, Fatma OLCAY COSKUN, Sercin OZKOK, Mumtaz TAKIR

“…Patients with acromegaly were divided into controlled and uncontrolled acromegaly groups based on insulin-like growth factor-1 levels. Epicardial adipose tissue thickness measurements were obtained from chest computed tomography, and laboratory data were extracted from patient files. …”
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Changes in Cross-Sectional Area of the Median Nerve and Body Composition Parameters after Treatment of Acromegaly: 1 year Follow-Up by Ivana Ságová, Daniela Kantárová, Marián Mokáň, Peter Vaňuga

“…Changes in levels of growth hormone (GH) and insulin-like growth factor I (IGF-I) and body composition are potential parameters in pathology of median neuropathy in acromegaly. …”
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Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents by Mar Quiñones, Cintia Folgueira, Estrella Sánchez-Rebordelo, Omar Al-Massadi

“…In spite of these negative results we find a negative correlation between irisin and insulin in DIO animals and a positive correlation between irisin and glucose under short-term changes in nutritional status. …”
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The Impact of Abdominal Obesity Status on Cardiovascular Response to the Mediterranean Diet by Alexandra Bédard, Sylvie Dodin, Louise Corneau, Simone Lemieux

“…For all variables related to glucose/insulin homeostasis, no change was observed except for a decrease in 2 h glucose concentrations (time effect: P=0.03). …”
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Identification of Flavonoid C-Glycosides as Promising Antidiabetics Targeting Protein Tyrosine Phosphatase 1B by Athika Rampadarath, Fatai Oladunni Balogun, Charlene Pillay, Saheed Sabiu

“…Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of the insulin signaling pathway, has gained attention as a validated druggable target in the management of type 2 diabetes mellitus (T2DM). …”
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IGFBP2 and IGFBP4 interact to activate complement pathway in diabetic kidney disease by Jieling Liang, Yangxiao Huang, Daping Peng, Yali Xie, Yifei Liu, Xiuxia Lu, Junfa Xu

“…Recent research has identified insulin-like growth factor-binding proteins 2 (IGFBP2) and 4 (IGFBP4) as potential biomarkers for DKD. …”
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