应用CSC-GE-80基因芯片筛查人子宫内膜早期异位种植的血管生长相关基因 by 王宁宁, 张玉凤, 张红霞, 谭金凤, 谢洪哲, 姚书忠, 庄广伦, 牛刚, 黄建昭, 何勉

“…【结果】在基因表达谱中最有显著性上调基因50个,最有显著性下调基因47个,包括生长因子和细胞因子及其受体的变化,其中生长因子受体结合蛋白10（growth factor receptor-bound protein10,Grb10）与丁酸盐反应因子1（butyrate response factor 1）中表皮生长因子（EGF-response factor 1）上调明显,下调明显胰岛素样生长因子结合蛋白7（insulin-like growth factor binding protein 7）。【结论】通过基因筛查我们初步考虑生长因子结合蛋白10（growth factor receptor-bound protein 10）有可能参与早期异位内膜的血管生长。…”
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The role of non-alcoholic fatty liver disease in the formation of atherosclerotic vascular lesions in patients with abdominal obesity by N. L. Denisov, V. B. Grinevich, Ye. V. Chernetsova, Yu. A. Kravchuk, K. V. Ivashkin

“…The relationship between the presence of NAFLD, initial manifestations of atherosclerosis and insulin resistance was established. This resulted in the rank of prognostic factors based on severity of carotid artery changes, making it possible to conclude individual atherosclerotic risk score for AD and different forms of NAFLD. …”
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Red Blood Cell Distribution Width Is Associated with Carotid Atherosclerosis in People with Type 2 Diabetes by J. S. Nam, C. W. Ahn, S. Kang, K. R. Kim, J. S. Park

“…Multiple regression analysis and multivariate logistic regression analysis revealed that RDW was associated with C-IMT in people with type 2 diabetes, and it remained significant after control for various cardiovascular risk factors including body mass index, blood pressure, insulin resistance, and smoking status in multivariate logistic regression analysis. …”
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Dietary Intake of Chromista Oil Alters Hepatic Metabolomic Profile of Mice With Excess Fat Mass by Bret M Rust, Forrest H Nielsen, Lin Yan

“…Intake of chromista oil significantly increased plasma concentration of insulin, the calculated value of HOMA-IR, and plasma concentration of adiponectin in the mice fed the HFD. …”
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Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia by I. K. Hals, A. M. Rokstad, B. L. Strand, J. Oberholzer, V. Grill

“…Nonencapsulated islets released 37.7% (median) more HMGB1 compared to encapsulated islets after hypoxic culture conditions (P<0.001). Glucose-induced insulin release was marginally affected by hypoxia. …”
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Activation of PPAR𝛾 by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats by Mahmoud Mansour, Elaine Coleman, John Dennis, Benson Akingbemi, Dean Schwartz, Tim Braden, Robert Judd, Eric Plaisance, Laura Ken Stewart, Edward Morrison

“…Because PPAR𝛾 activation by thiazolidinedione increased insulin sensitivity in type 2 diabetes, understanding the long term impact of PPAR𝛾 activation on steroid sex hormones in males is critical. …”
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Whole Exome Sequencing Reveals Rare Variants in Genes Associated with Metabolic Disorders in Women with PCOS by Priyal Sharma, Ashutosh Halder, Manish Jain, Manish Tripathi

“…PCOS patients with identified variants exhibited significantly higher average body mass index and fasting insulin levels of PCOS subjects with identified variants compared to those without variants (P < 0.05). …”
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High Fasting Plasma Glucose during Early Pregnancy: A Review about Early Gestational Diabetes Mellitus by E. Cosson, L. Carbillon, P. Valensi

“…Although eGDM is characterized by insulin resistance and associated with classical risk factors for type 2 diabetes and incident diabetes after delivery, it is not necessarily associated with preexisting prediabetes. …”
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Combination of GLP-1 Receptor Activation and Glucagon Blockage Promotes Pancreatic β-Cell Regeneration In Situ in Type 1 Diabetic Mice by Liangbiao Gu, Dandan Wang, Xiaona Cui, Tianjiao Wei, Kun Yang, Jin Yang, Rui Wei, Tianpei Hong

“…Although liraglutide neither lowered the blood glucose level nor increased the plasma insulin level, the immunostaining showed that liraglutide expanded β-cell mass through self-replication, differentiation from precursor cells, and transdifferentiation from pancreatic α cells to β-cells. …”
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Adolescents with Type I Diabetes Mellitus and their Knowledge about the Disease by Marisleidy Denis Rodríguez, Antonio Masot Rangel, Nicolás Ramón Cruz Pérez, Juan Carlos Yanes Macías, Mayumi Hernández Díaz

“…<strong>Background:</strong> diabetes mellitus is an endocrine-metabolic disease characterized by high levels of glucose in blood that occurs due to a deficient secretion or action of insulin. It is a growing health problem.<br /> <strong>Objective:</strong> to identify what knowledge adolescents with type I diabetes mellitus have at the Paquito González Cueto Cienfuegos University Pediatric Hospital. …”
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Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets by Myungji Kim, Seungyeon Cho, Dong Gyu Hwang, In Kyong Shim, Song Cheol Kim, Jiwon Jang, Jinah Jang

“…However, stem cell (SC)-derived islets generated in vitro often lack the three-dimensional extracellular microenvironment and peri-vasculature, which leads to the immaturity of SC-derived islets, reducing their ability to detect glucose fluctuations and insulin release. Here, we bioengineer the in vivo-like pancreatic niches by optimizing the combination of pancreatic tissue-specific extracellular matrix and basement membrane proteins and utilizing bioprinting-based geometrical guidance to recreate the spatial pattern of islet peripheries. …”
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Circulatory Support with Venoarterial ECMO Unsuccessful in Aiding Endogenous Diltiazem Clearance after Overdose by Erin N. Frazee, Sarah J. Lee, Ejaaz A. Kalimullah, Heather A. Personett, Darlene R. Nelson

“…She was given fluids, calcium, vasopressors, glucagon, high-dose insulin, and lipid emulsion. Due to circulatory collapse and multiorgan failure including ischemic hepatopathy, she underwent transvenous pacing and emergent initiation of venoarterial ECMO. …”
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Adipose Tissue Remodeling as Homeostatic Inflammation by Michiko Itoh, Takayoshi Suganami, Rumi Hachiya, Yoshihiro Ogawa

“…Among stromal cells in the adipose tissue, infiltrated macrophages play an important role in adipose tissue inflammation and systemic insulin resistance. We have demonstrated that a paracrine loop involving saturated fatty acids and tumor necrosis factor-α derived from adipocytes and macrophages, respectively, aggravates obesity-induced adipose tissue inflammation. …”
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A Correlation of Alarin with Some Anthropometric Measurements in Iraqi Type II Diabetic Patients by Russell S. A. Al-Shaabani, Shakir F. T. Alaaraj

“…Background: Diabetes mellitus (DM) is a group of chronic metabolic diseases that affect the body’s ability to produce insulin. It is one of the most common endocrine disorders. …”
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A Data Mining Approach Identified Salivary Biomarkers That Discriminate between Two Obesity Measures by Ping Shi, J. Max Goodson

“…We identified C-reactive protein (CRP), insulin, leptin, adiponectin, as salivary biomarkers associated with OBW, plus a clinical feature fitness level. …”
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Insights into the systemic risk factors associated with diabetic retinopathy in the Indian population: A comprehensive systematic review and meta-analysis by KT Muhammed Favas, Mamidi Niveditha, Beema T Yoosuf, Manideep Bhukya, Parul Chawla Gupta, Pinaki Dutta, Dipika Bansal

“…Being male (OR: 1.38, 95% CI: 1.11–1.72), intake of insulin (OR: 2.05, 95% CI: 1.02–4.14), higher HbA1c levels (MD: 0.50, 95% CI: 0.06–0.94), higher random (MD: 0.32, 95% CI: 0.10–0.55), and fasting blood glucose levels (MD: 0.51, 95% CI: 0.10–0.93) were found to be significantly associated with increased risks of DR among diabetic patients, while age, body mass index, hypertension, lipid profile, and smoking status did not indicate any association with DR. …”
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Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity by H. Roger Lijnen, Kathleen Freson, Marc F. Hoylaerts

“…In addition, MAb 23A11 had no significant effect on glucose tolerance or insulin resistance in lean or obese C57Bl/6 mice. …”
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Pathophysiologic Mechanisms of Cardiovascular Disease in Obstructive Sleep Apnea Syndrome by Carlos Zamarrón, Luis Valdés Cuadrado, Rodolfo Álvarez-Sala

“…It has been found that CPAP therapy for OSAS provides an objective improvement in symptoms and cardiac function, decreases cardiovascular risk, improves insulin sensitivity, and normalises biomarkers. OSAS contributes to the pathogenesis of cardiovascular disease independently and by interaction with comorbidities. …”
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Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetes by Priambodo Ahmad Faris, Martati Erryana, Firdaus Muhamad

“…The study’s conclusion shows that S. plagiophyllum kombucha has bioactive compounds as hypoglycemic agents and contributes to improving body weight, fasting blood glucose (FBG), lipid profiles, insulin, and MDA in type-2 diabetes rats model.…”
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Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish by Anqi Dong, Wenqian Lei, Weiqi Zhou, Wenwen Li, Jianghua Wang

“…Additionally, a notable reduction in protein level in eggs and the gene expression of both the hormone/insulin-like growth factor (GH/IGF) and hypothalamic-pituitary-thyroid (HPT) pathways were observed. …”
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