Molecular mechanisms and comparative transcriptomics of diapause in two corn rootworm species (Diabrotica spp.) by Melise C. Lecheta, Chad Nielson, B. Wade French, Emily A.W. Nadeau, Nicholas M. Teets

“…During post-diapause development, there is a dramatic activation cellular respiration, which may be controlled by insulin signaling. Comparative transcriptomic analyses between WCR and NCR indicated that while many gene expression changes were conserved across species, overall gene expression profiles were distinct, indicating that many transcriptional changes are species-specific, despite the close phylogenetic relationship and phenotypic similarity between these species. …”
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The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth by Erin Graves, David J. Hill, Susan Evers, Kristine Van Aarsen, Brie Yama, Su Yuan, M. Karen Campbell

“…Objective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. …”
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We Are on the Verge of Breakthrough Cures for Type 1 Diabetes, but Who Are the 2 Million Americans Who Have It? by Rebecca Smith, Samara Eisenberg, Aaron Turner-Phifer, Jacqueline LeGrand, Sarah Pincus, Yousra Omer, Fei Wang, Bruce Pyenson

“…Innovative treatments have standardized insulin delivery and improved outcomes for patients, but patients’ access to such technologies depends on social determinants of health, including insurance coverage, proper diagnosis, and appropriate patient supports. …”
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Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study by Chunyan Zhou, Yanyu Zhang, Xiaoyi Liu, Chenyu He, Shiyang Li, Shiyang Li

“…This study aimed to explore the association between the metabolic score for insulin resistance (METS-IR) and the incidence of CMM.MethodsThis study included 6,977 individuals in the CHARLS database. …”
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The Effect of Prior Gestational Diabetes on the Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test 3 Years after Delivery by Timea Tänczer, Márk M. Svébis, Beatrix Domján, Viktor J. Horváth, Adam G. Tabák

“…No differences were found in fasting and 2-hour glucose and insulin levels, or BMI. According to multiple logistic regression, MGR was associated with prior early GDM (OR 2.14, 95% CI 0.92-4.99) and elevated triglyceride levels (OR 2.28, 95% CI 1.03-5.03/log (mmol/l)). …”
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Elevated levels of serum alpha-2-macroglobulin associate with diabetes status and incident CVD in type 1 diabetes by Baohai Shao, Janet K. Snell-Bergeon, Ian H. de Boer, W. Sean Davidson, Karin E. Bornfeldt, Jay W. Heinecke

“…Of the 28 serum proteins studied, five of them—alpha-2-macroglobulin (A2M), apolipoprotein A-IV, apolipoprotein L1, insulin-like growth factor 2, and phospholipid transfer protein—were significantly associated with T1DM status, with A2M being 1.6-fold higher in T1DM. …”
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The Gut Microbiota in Women Suffering from Gestational Diabetes Mellitus with the Failure of Glycemic Control by Lifestyle Modification by Guangyong Ye, Long Zhang, Min Wang, Yunbo Chen, Silan Gu, Keyi Wang, Jianhang Leng, Yujia Gu, Xinyou Xie

“…However, a number of patients whose blood glucose is not controlled by lifestyle modification still require exogenous insulin to control blood glucose. No observational study is available about the relationship between the gut microbiota in GDM patients and lifestyle modifications. …”
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A Systematic Review and Meta-Analysis of Outcomes for Type 1 Diabetes after Bariatric Surgery by Alexandra Chow, Noah J. Switzer, Jerry Dang, Xinzhe Shi, Christopher de Gara, Daniel W. Birch, Richdeep S. Gill, Shahzeer Karmali

“…Preoperative weighted mean total daily insulin requirement was 98±26 IU/d, which decreased significantly to 36±15 IU/d (P<0.00001) and 42±11 IU/d (P<0.00001) at 12 months and at study endpoint, respectively. …”
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Incidence and Contributing Factors of Persistent Hyperglycemia at 6–12 Weeks Postpartum in Iranian Women with Gestational Diabetes: Results from LAGA Cohort Study by Sedigheh Nouhjah, Hajieh Shahbazian, Nahid Shahbazian, Alireza Jahanshahi, Shayesteh Jahanfar, Bahman Cheraghian

“…Independent risk factors for glucose intolerance were FPG ≥ 100 at the time of OGTT (OR 3.86; 95% CI; 1.60–9.32), earlier diagnosis of GDM (OR 0.92; 95% CI; 0.88–0.97), systolic blood pressure (OR 1.02; 95% CI; 1.002–1.04), and insulin or metformin therapy (OR 3.14; 95% CI; 1.20–8.21). …”
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Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice by Dianzhi Hou, Jian Tang, Meili Huan, Fang Liu, Sumei Zhou, Qun Shen

“…Results showed that MBC could effectively alleviative the obese phenotype, reduce the lipid accumulation and insulin resistance, and improve the hepatic oxidative stress and inflammatory response. …”
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Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model by Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi

“…Bredemolic acid, a pentacyclic triterpene, has been found to improve insulin sensitivity in diet-induced prediabetic rats. …”
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miR-375 Promotes Pancreatic Differentiation In Vitro by Affecting Different Target Genes at Different Stages by Zhenyu Lu, Jing Wang, Xu Wang, Zhiying Li, Dan Niu, Min Wang, Jinzhu Xiang, Yongli Yue, Yajuan Xia, Xueling Li

“…Human embryonic stem cells (hESCs) possess the ability to differentiate into insulin-producing cells (IPCs), which can be used to treat type I diabetes. miR-375 is an essential transcriptional regulator in the development and maturation of the pancreas. …”
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Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients by Rahul Saxena, Baskar Chakrapani, M. P. Sarath Krishnan, Amit Gupta, Sweety Gupta, Jayanta Das, Subash C. Gupta, Anissa A. Mirza, Shalinee Rao, Bela Goyal

“…Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. …”
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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…Its prevalence is intricately linked to obesity, insulin resistance, and other components of the metabolic syndrome. …”
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IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A‐Mediated NLRP3 Inflammasome by Wu Jingrui, Yang Haihui, Yan Jinjin, Fang Le

“…Aims The present study aimed to explore the effect of human insulin‐like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2), one of the m6A‐binding proteins on the progression of AD. …”
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Growth, Feed Utilization, Lipid Metabolism, and Metamorphosis of Bullfrog (Aquarana catesbeianus) Tadpoles Fed Diets With Different Lipid Levels by Juan Gao, Ling Wang, Jian Zhang, Kangle Lu, Kai Song, Xueshan Li, Chunxiao Zhang

“…Weight gain (WG), specific growth rate (SGR), crude protein content of the whole body, apparent digestibility of dry matter and gross energy, intestinal lipase (LPS) capacity, lipoprotein lipase (LPL), and carnitine palmitoyltransferase-I (CPT-I) and contents of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in the liver, high-density lipoprotein cholesterol (HDL-C) content in the serum, and metamorphosis rate at stages 40 and 41 increased as the dietary lipid level increased from 4.46% to 12.34% and then decreased. …”
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Brown rice: a missing nutrient-rich health food by Xiuxiu Wu, Tianyi Guo, Feijun Luo, Qinlu Lin

“…Underlying mechanisms have also been analyzed, which include regulating lipid synthesis and metabolism, improving insulin levels and increasing glucose metabolism, anti-oxidation, promoting the immune system, transcription and non-transcriptional regulation, blocking cell cycle, thereby improving disease symptoms and reducing its recurrence rate. …”
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miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway by Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu

“…The miR-149-induced protection against HUVECs injury could be reversed by cotreatment with 3-methyladenine (3-MA, an autophagy inhibitor) or insulin (an activator of Akt/mTOR pathway). Conclusions. miR-149 prevents ox-LDL-induced endothelial cell injury by enhancing autophagy via increasing Akt and mTOR expressions.…”
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Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats by Erin E. Gordon, Benjamin E. Reinking, Shanming Hu, Jianrong Yao, Kok L. Kua, Areej K. Younes, Chunlin Wang, Jeffrey L. Segar, Andrew W. Norris

“…However, left-sided fetuses exhibited higher serum insulin and greater JNK phosphorylation compared to controls. …”
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Formononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome by Zhuo Liu, Rui-Han Wang, Ke-Hua Wang

“…Fasting blood glucose, insulin, luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol were detected in DHEA-induced PCOS rats. …”
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