Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis by Maryam Mukhtar, Andleeb Batool, Abdul Wajid, Iram Qayyum

“…The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D. …”
Get full text

Patient Knowledge About Diabetes: Illness Symptoms, Complications and Preventive Personal Lifestyle Factors by Rakesh Kumar, Ramaiah Itumalla, Bilesha Perera, Mohamed Tharwat Elabbasy, Mahesh Singh

“…Most respondents indicated that insulin injection (92%) and avoiding sugary foods (91.6%) were the best ways to control blood sugar. …”
Get full text

Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C by Hala O. El-Mesallamy, Nadia M. Hamdy, Hanan H. Rizk, Abdel-Rahman El-Zayadi

“…Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. The present study was conducted to evaluate blood apelin level changes among 73 chronic hepatitis C (CHC) Egyptian patients and if associated with body mass index (BMI), IR, and tumor necrosis factor-alpha (TNF-α). …”
Get full text

The Systematic Analysis of Exercise Mechanism in Human Diseases by Lei Pu, Peng Sun

“…Through analysis, it was found that these DEGs-enriched pathways, such as the VEGF signaling pathway, the Wnt signaling pathway, and the insulin signaling pathway, were all involved in the regulation of various diseases. …”
Get full text

Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate with Metabolite Changes of Human Diabetes by Anna Weiser, Pieter Giesbertz, Hannelore Daniel, Britta Spanier

“…Principal component analysis (PCA) including all ACs and AAs confirmed our hypothesis especially in plasma samples by clustering females, males with high BCAA-derived ACs, and males with slight increases in BCAA-derived ACs. Concentrations of insulin, blood glucose, NEFAs, and triacylglycerols (TAGs) further supported the hypothesis of high BCAA-derived ACs being able to mirror the onset of diabetic traits in male individuals. …”
Get full text

Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes by L. Torres-Rovira, S. Astiz, A. Caro, C. Lopez-Bote, C. Ovilo, P. Pallares, M. L. Perez-Solana, R. Sanchez-Sanchez, A. Gonzalez-Bulnes

“…After three months of differential feeding, SFAD animals developed central obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, and elevated blood pressure; the five parameters associated with the metabolic syndrome. …”
Get full text

High triglyceride-glucose index in patients with diabetes mellitus is associated with an increased likelihood of nephropathy development: evidence from a meta-analysis among Asian... by Raphael Enrique Tiongco, Neil David Cayanan, Michael John Dominguez, Kyll Geonzon, Julie Ann Mercado, Maria Ruth Pineda-Cortel

“…Abstract Introduction In recent years, the triglyceride-glucose (TyG) index, which is associated with insulin resistance and kidney dysfunction, has emerged as a promising and accessible biomarker for the diagnosis and prognosis of diabetic nephropathy (DN). …”
Get full text

Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences by Giuseppina T. Russo, Annalisa Giandalia, Elisabetta L. Romeo, Morabito Nunziata, Marco Muscianisi, Maria Concetta Ruffo, Antonino Catalano, Domenico Cucinotta

“…The pathophysiological mechanisms linking diabetes to osteoporosis have not been fully explained, but alterations in bone structure and quality are well described in diabetic subjects, likely due to a combination of different factors. Insulin deficiency and dysfunction, obesity and hyperinsulinemia, altered level of oestrogen, leptin, and adiponectin as well as diabetes-related complications, especially peripheral neuropathy, orthostatic hypotension, or reduced vision due to retinopathy may all be associated with an impairment in bone metabolism and with the increased risk of fractures. …”
Get full text

Noncoding RNAs Associated with PPARs in Etiology of MAFLD as a Novel Approach for Therapeutics Targets by Fatemeh Kazeminasab, Maryam Baharlooie, Kamran Ghaedi

“…MAFLD is directly associated with obesity, insulin resistance, diabetes, and metabolic syndrome. …”
Get full text

Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration by Jialiu Zeng, Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo, Chih Hung Lo

“…Inflammatory states within the brain can lead to insulin resistance, mitochondrial dysfunction, autolysosomal dysfunction, and increased oxidative stress. …”
Get full text

Delving into the therapeutic prospects of desmostachya bipinnata (L.) in the context of polycystic ovary syndrome (PCOS): A comprehensive review by Sarthak Mishra, Payal Mittal

“…Background: PCOS, a prevalent endocrine condition in reproductive years, exhibits irregular ovulation, polycystic ovaries, insulin resistance, and elevated androgen levels. …”
Get full text

Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic Nematodes Strongyloides ratti and Trichuris suis Affects Mucosal Homeostasis by Dana Ditgen, Emmanuela M. Anandarajah, Jan Hansmann, Dominic Winter, Guido Schramm, Klaus D. Erttmann, Eva Liebau, Norbert W. Brattig

“…The primary antioxidative activity was assured by reduction of insulin and IgM. Further analysis applying an in vitro mucosal 3D-cell culture model revealed that the secreted Trx-lps were able to bind to monocytic and intestinal epithelial cells and induce the time-dependent release of cytokines such as TNF-α, IL-22, and TSLP. …”
Get full text

Targeting ferroptosis: opportunities and challenges of mesenchymal stem cell therapy for type 1 diabetes mellitus by Le Dai, Qing Wang

“…Abstract Type 1 diabetes mellitus (T1DM) is characterized by progressive β-cell death, leading to β-cell loss and insufficient insulin secretion. Mesenchymal stem cells (MSCs) transplantation is currently one of the most promising methods for β-cell replacement therapy. …”
Get full text

Metabolic Basis for Thyroid Hormone Liver Preconditioning: Upregulation of AMP-Activated Protein Kinase Signaling by Luis A. Videla, Virginia Fernández, Pamela Cornejo, Romina Vargas

“…This is achieved by mechanisms involving direct allosteric activation and reversible phosphorylation of AMPK, in response to signals such as energy status, serum insulin/glucagon ratio, nutritional stresses, pharmacological and natural compounds, and oxidative stress status. …”
Get full text

Study the effect of urokinase-type plasminogen activator (UPA) and some biochemical parameters in Iraqi hemodialysis patients with type 2 diabetes by Fatima Ali Essa Al-Sudani, Nawal Mohammed Jawad Al-Shammaa

“…Urea, Creatinine, fasting serum glucose (FSG), HbA1c, Insulin, HOMA-IR, and lipid profile levels were determined. …”
Get full text

Type 2 diabetes remission through lifestyle intervention in a geriatric patient with long-standing diabetes and at thirty-three-months follow-up by Pramod Tripathi, Diptika Tiwari, Milanjeet Kaur Raizada, Nidhi Kadam

“…The patient showed an improvement in HbA1c (7.7 to 5.3%) and insulin resistance (HOMA-IR; 6.2 to 1.8) and a shift in BMI (25.3 to 23.7 kg/m2) through weight loss (73 to 67 kg). …”
Get full text

Leptin Deficiency and Its Effects on Tibial and Vertebral Bone Mechanical Properties in Mature Genetically Lean and Obese JCR:LA-Corpulent Rats by Raylene A. Reimer, Jeremy M. LaMothe, Ronald F. Zernicke

“…Leptin signaling deficient rodents have emerged as models of obesity/insulin resistance syndrome. Altered leptin signaling, however, can affect axial and appendicular bone geometrical properties differently, and, thus, we hypothesized that leptin-deficiency would differentially influence mechanical properties of vertebrae and tibiae compared to lean rats. …”
Get full text

Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 by Aziz Alami Chentoufi, Simon Gaudreau, Alex Nguyen, Mahmoud Sabha, Abdelaziz Amrani, Geyhad ElGhazali

“…Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. …”
Get full text

Modern Digital Query Analytics of Patient Education Materials on Acanthosis Nigricans: Systematic Search and Content Analysis by Kevin Johny Varghese, Som Singh, Emily Kamali, Fahad Qureshi, Aleena Jamal, Fawad Qureshi

“…Acanthosis nigricans (AN) is a common condition, often associated with underlying diseases such as insulin resistance. Patients frequently search the internet for information related to this cutaneous finding. …”
Get full text

Sevelamer Carbonate Crystal-Induced Colitis by T. Lai, A. Frugoli, B. Barrows, M. Salehpour

“…This case vignette describes an underrecognized adverse effect of a phosphate binder, sevelamer carbonate, inducing colitis in a 47-year-old male with insulin-dependent diabetes complicated by end-stage renal disease. …”
Get full text