Genetic Variants of SIRT1 Gene Promoter in Type 2 Diabetes by Shuchao Pang, Zhengjun Zhang, Yu Zhou, Jie Zhang, Bo Yan

“…Accumulating evidence indicates that SIRT1 is involved in insulin resistance and impaired pancreatic β-cell function, the two hallmarks of T2D. …”
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Winery By-Products In Vitro and In Vivo Effects on Atherothrombotic Markers: Focus on Platelet-Activating Factor by Maria Choleva, Smaragdi Antonopoulou, Elizabeth Fragopoulou

“…Evidence from long-term studies shows that consumption may lower total and low density lipoprotein (LDL) cholesterol, improve insulin sensitivity, decrease lipid and protein oxidative damage, enhance antioxidant capacity, and have mild anti-inflammatory action toward reducing cytokine expression and levels. …”
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Effect of Ileal Transposition (IT) on Angiopoietin-Like Protein-8 (ANGPTL8) and Pentraxin (PTX3) Plasma Level in Sprague-Dawley Rats Fed High-Fat Diet (HFD) by Tomasz Sawczyn, Dominika Stygar, Katarzyna Nabrdalik, Michał Kukla, Oliwia Masri, Łukasz Magrowski, Wojciech Karcz, Jerzy Jochem

“…Metabolic surgery procedures are designed not only for sustained weight loss but also for achieving positive metabolic changes, including improved glucose tolerance and insulin sensitivity, along with an increase in energy expenditure. …”
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Association between weight-adjusted waist index and cognitive impairment in Chinese older men: a 7-year longitudinal study by Jie Lin, Hongchen Shen, Wenjuan Yang, Guojun Zhang, Jie Sun, Wenqin Shen, Li Huang, Huajian Chen

“…BackgroundObesity, through mechanisms such as insulin resistance and systemic low-grade inflammation, can damage the central nervous system and impair cognitive function. …”
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CONDITION OF HORMONAL STATUS OF THE BODY IN WHITE RATS UNDER THE EXPOSURE TO SODIUM FLUORIDE by I.Yu. Bagmut, I.L. Kolisnyk, S.I. Kryzhna, A.V. Titkova, L.Yu. Svyrydenko

“…The results showed reduced levels of folliculotropin and progesterone, increased levels of thyroxine, adrenocorticotropin, glucagon, triiodothyronine, thyrotropin and calcitonin, while insulin, somatostatin and serum glucose levels decreased. …”
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Experiences of adults with type 2 diabetes mellitus with low socioeconomic status: a qualitative study by Vahide Semerci Çakmak, Ebru Sönmez Sari, Serap Çetinkaya Özdemir

“…According to Theme 3, it was observed that the participants faced difficulties related to diabetes self-management, including blood glucose monitoring, insulin injection administration, and maintaining glycemic control.” …”
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IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…Although ionizing radiation (IR) has provided considerable improvements in nasopharyngeal carcinoma (NPC) treatment, radioresistance is still a major threat for some subsets of patients. The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is tightly regulated and plays critical roles in mediating cell proliferation, growth, and survival. …”
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The protective role of GLP-1 in neuro-ophthalmology by Sohum Sheth, Aashay Patel, Marco Foreman, Mohammed Mumtaz, Akshay Reddy, Ramy Sharaf, Siddharth Sheth, Brandon Lucke-Wold

“…This article describes GLP-1 peptide characteristics and the mechanisms mediating its known role in increasing insulin, decreasing glucagon, delaying gastric emptying, and promoting satiety. …”
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Protein Intake, Especially Vegetable Protein Intake, Is Associated with Higher Skeletal Muscle Mass in Elderly Patients with Type 2 Diabetes by Akane Miki, Yoshitaka Hashimoto, Shinobu Matsumoto, Emi Ushigome, Takuya Fukuda, Takafumi Sennmaru, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui

“…Protein intake was independently correlated with SMI after adjusting for age, hemoglobin A1c, C-peptide index, exercise, smoking, insulin treatment, total energy intake, and C-reactive protein (standardized regression coefficient = 0.664, P<0.001 in men and standardized regression coefficient = 0.516, P=0.005 in women). …”
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Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study by Jie Yang, Wenna Wang, Yizhen Lu, Chunyao Li, Shuwu Wei, Weiwei Sun

“…Compared with the small nodule group, patients in the large nodule group had higher fasting blood glucose (FBG) and lower fasting insulin (FINS); meanwhile, patients with decreased homeostasis model assessment-β (HOMA-β) and high smoking index (SI) were higher in the large nodule group; decreased HOMA-β and high SI were independent risk factors for large nodules. …”
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Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans by Soo Heon Kwak, Yoon Ji Kim, Jeesoo Chae, Cue Hyunkyu Lee, Buhm Han, Jong-Il Kim, Hye Seung Jung, Young Min Cho, Kyong Soo Park

“…Fulminant type 1 diabetes (T1DM) is a distinct subtype of T1DM that is characterized by rapid onset hyperglycemia, ketoacidosis, absolute insulin deficiency, and near normal levels of glycated hemoglobin at initial presentation. …”
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Transcriptomic Profile Analysis of Brain Tissue in the Absence of Functional TRPM8 Calcium Channel by Erick B. Saldes, Alexandra Erdmier, Jai Velpula, Timothy E. Koeltzow, Michael X. Zhu, Swapna Asuthkar

“…<b>Background/Objectives:</b> Transient Receptor Potential Melastatin 8 (TRPM8) is a non-selective, Ca²⁺-permeable cation channel involved in thermoregulation and other physiological processes, such as basal tear secretion, cell differentiation, and insulin homeostasis. The activation and deactivation of TRPM8 occur through genetic modifications, channel interactions, and signaling cascades. …”
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Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies by Nadia Sawicka-Gutaj, Ariadna Zybek-Kocik, Aleksandra Klimowicz, Michał Kloska, Dorota Mańkowska-Wierzbicka, Jerzy Sowiński, Marek Ruchała

“…Fasting blood samples were taken for visfatin, TSH, free thyroxine (FT4), free triiodothyronine (FT3), antithyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), glucose, and insulin levels. The highest visfatin serum concentration was in AIT group, and healthy controls had visfatin level higher than TT (p=0.0001). …”
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Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects by Dalia Dauksiene, Janina Petkeviciene, Jurate Klumbiene, Rasa Verkauskiene, Jelena Vainikonyte-Kristapone, Audrone Seibokaite, Jonas Ceponis, Vygantas Sidlauskas, Laura Daugintyte-Petrusiene, Antanas Norkus, Birute Zilaitiene

“…In the nonnodular thyroid group, thyroid volume was also positively related to serum insulin and HOMA-IR, whereas a negative correlation between thyroid volume and leptin was identified in the nodular thyroid group. …”
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Nonalcoholic Fatty Liver Disease as a Potential Risk Factor for Cardiovascular Disease in Patients with Type 2 Diabetes: A Prospective Cohort Study by Mohammad Dehghani Firouzabadi, Amirhossein Poopak, Ali Sheikhy, Fatemeh Dehghani Firouzabadi, Fatemeh Moosaie, Soghra Rabizadeh, Sara Momtazmanesh, Manouchehr Nakhjavani, Alireza Esteghamati

“…Although the etiology of NAFLD is unknown, insulin resistance is a key mechanism of lipid deposition in hepatocytes leading to steatosis and potentially steatohepatitis in patients with diabetes. …”
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Glucose-Sensing Carbohydrate Response Element-Binding Protein in the Pathogenesis of Diabetic Retinopathy by Christopher R. Starr, Assylbek Zhylkibayev, Oleg Gorbatyuk, Alli M. Nuotio-Antar, James Mobley, Maria B. Grant, Marina Gorbatyuk

“…Glucose-sensing ChREBP and MondoA are transcriptional factors involved in the lipogenic, inflammatory, and insulin signaling pathways implicated in metabolic disorders; however, limited ocular studies have been conducted on these proteins. …”
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Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus by Motahare Shabestari, Forouzan Salari, Reyhaneh Azizi, Akram Ghadiri-Anari, Nasim Namiranian

“…Conclusion T2DM patients with mild to moderate COVID-19 infection exhibited improvements in TC, TG, BMI, and insulin-related indices. Lockdown restrictions were associated with decreased TC and LDL-C levels in T2DM patients without a history of COVID-19 infection.…”
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Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines by Mohammed S. Albadah, Hafedh Dekhil, Shaffi Ahamed Shaik, Mohammed A. Alsaif, Mustafa Shogair, Shahid Nawaz, Assim A. Alfadda

“…Studies have suggested that osteocalcin, a bone formation marker, is related to body metabolism and insulin sensitivity. Whether this relation is mediated through an interaction with adipokines remains unclear. …”
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Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats by Baskaran Krishnan, Abirami Ramu Ganesan, Ravindran Balasubramani, Dinh Duc Nguyen, Soon Woong Chang, Shaoyun Wang, Jianbo Xiao, Balamuralikrishnan Balasubramanian

“…Our results indicated that the inclusion of chrysoeriol (20 mg/kg), showed a significant reduction in plasma glucose, hemoglobin and glycosylated hemoglobin level with a rising of plasma insulin sensitivity. Further, downregulated enzymes including glucose 6-phosphatase, fructose 1,6-bisphosphatase, and glycogen phosphorylase as well upregulated enzymes such as hexokinase, glucose-6-phosphate dehydrogenase, pyruvate kinase, and hepatic glycogen content. …”
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Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet by Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zhai

“…Elevated levels of plasma glucose, serum insulin, and glycated haemoglobin in obese rats were significantly reduced by SG. …”
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