Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus by Lusha Cen, Fengling Xing, Liying Xu, Yi Cao

“…NFAT5 promotes the formation of aldose reductase, pathogenesis of diabetic vascular complications, and insulin resistance. Additionally, NFAT5 activates inflammation at a very early stage of diabetes and induces persistent inflammation. …”
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COVID-19 and Pulmonary Tuberculosis Coinfection in a Moroccan Patient with Pulmonary Embolism: A Case Report and Literature Review by Imane Zouaki, Zakaria Chahbi, Mohamed Raiteb, Mohamed Zyani

“…Treatment was administered as per local protocols: broad spectrum antibiotics, corticosteroids, fixed dose-combination of antituberculosis treatment along with hydration and insulin therapy for ketosis treatment and anticoagulation. …”
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Spontaneous Type 2 Diabetic Rodent Models by Yang-wei Wang, Guang-dong Sun, Jing Sun, Shu-jun Liu, Ji Wang, Xiao-hong Xu, Li-ning Miao

“…Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. In this paper, we aim to investigate the current available spontaneous rodent models for T2DM with regard to their characteristic features, advantages, and disadvantages, and especially to describe appropriate selection and usefulness of different spontaneous rodent models in testing of various new antidiabetic drugs for the treatment of type 2 diabetes.…”
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Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes by Naohiro Nomura, Yuko Tanabe, Miki Minami, Junji Takaya, Kazunari Kaneko

“…Growth Hormone therapy has been shown to induce transient insulin resistance in children, and there is concern regarding the diabetogenic potential of GH therapy in children born small for gestational age (SGA). …”
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Health-Promoting Behaviors in Bulgaria: A Cross-Sectional Study on Non-Communicable Diseases and Lifestyle by Sophia Lazarova, Dessislava Petrova-Antonova

“…We analyzed sociodemographic characteristics, health status (weight, height, existing diagnoses—diabetes, cardiovascular disease, insulin resistance, hypertension, and depression), and lifestyle data. (3) Results: Only 18.8% of the participants maintained a healthy lifestyle and 65% had a moderately healthy lifestyle. …”
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HOSPITALIZATIONS FOR DIABETES IN THE NORTH REGION OF MINAS GERAIS by Eva Vitória Freitas Almeida, Alexis Godinho Junior, Giovana Carneiro Malheiro, Laís Montenegro Oliveira, Lorhane Aguiar Araújo, Karina Prince

“… Diabetes Mellitus is a group of diseases of the endocrine system in which the body does not produce the hormone insulin, or its use is inefficient. This study aims to analyze the number of hospitalizations for diabetes in the northern region of Minas Gerais from 2011 to 2020. …”
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On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides by Marianna Flora Tomasello, Alessandro Sinopoli, Giuseppe Pappalardo

“…Amyloid deposition involves the islet amyloid polypeptide (IAPP), a neuropancreatic hormone cosecreted with insulin by β-cells. IAPP is physiologically involved in glucose homeostasis, but it may turn toxic to β-cells owing to its tendency to misfold giving rise to oligomers and fibrils. …”
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Role of Myokines in Myositis Pathogenesis and Their Potential to be New Therapeutic Targets in Idiopathic Inflammatory Myopathies by Vlad Mageriu, Emilia Manole, Alexandra E. Bastian, Florica Staniceanu

“…Here, we consider the main myokines involved in the pathogenesis of myositis, expressing our view on the possibility of using them as potential therapeutic targets: interleukins IL-6, IL-15, and IL-18; chemokines CXCL10, CCL2, CCL3, CCL4, CCL5, and CCL20; myostatin; follistatin; decorin; osteonectin; and insulin-like 6. An interesting topic regarding the complex connection between myokines and noninflammatory pathways implied in IIM has also been briefly described, because it is an important scientific approach to the pathogenesis of IIM and can be a therapeutic alternative to be considered, especially for the patients who do not respond to immunosuppressive treatment.…”
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Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases by Francisco A. Monsalve, Radha D. Pyarasani, Fernando Delgado-Lopez, Rodrigo Moore-Carrasco

“…PPAR-α and PPAR-γ are mainly involved in regulating lipid metabolism, insulin sensitivity, and glucose homeostasis, and their agonists are used in the treatment of hyperlipidemia and T2DM. …”
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Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography by Andrew W. Francis, Justin Wanek, Mahnaz Shahidi

“…The Ins2 (Akita) mouse is a spontaneous diabetic mouse model with a heterozygous mutation in the insulin 2 gene that results in sustained hyperglycemia. …”
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Drug-induced bone disorders: A systematic review by Anshita Aggarwal, Meha Sharma, Indira Maisnam, Soumitra Ghosh, Sameer Aggarwal, Saptarshi Bhattacharya, Deep Dutta

“…Drug-induced bone disorders are either due to the drug directly effecting the bone microarchitecture (osteoblastic or osteoclastic activity) or indirectly by interfering with Vitamin D metabolism, Vitamin D/calcium absorption, and excess calcium loss or due to altered hormone states which promote bone loss (hypogonadism, hyperthyroidism, somatostatin excess states, insulin deficiency, increased systemic inflammation, and oxidative stress). …”
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Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients by Monika Ryba, Karolina Rybarczyk-Kapturska, Katarzyna Zorena, Małgorzata Myśliwiec, Jolanta Myśliwska

“…Diabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells. …”
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Semaglutide Protects against 6-OHDA Toxicity by Enhancing Autophagy and Inhibiting Oxidative Stress by Dong-xing Liu, Chen-sheng Zhao, Xiao-na Wei, Yi-peng Ma, Jian-kun Wu

“…Studies have demonstrated that improving insulin resistance in type 2 diabetes mellitus (T2DM) can benefit patients with PD. …”
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Manhattan Distance-based K-Medoids Clustering Improvement for Diagnosing Diabetic Disease by Solikhun, Muhammad Rahmansyah Siregar, Lise Pujiastuti, Mochamad Wahyudi

“…Diabetes occurs when the body is unable to produce sufficient insulin to regulate blood sugar levels. As a result, blood sugar management becomes impaired and there is no cure for diabetes. …”
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Hsa_circ_0003220 Drives Chemoresistance of Human NSCLC Cells by Modulating miR-489-3p/IGF1 by Shaofeng Xia, Chenliang Wang

“…The NSCLC cell lines H460 and A549 were employed in present work. hsa_circ_0003220, miR-489-3p, and insulin-like growth factors (IGF1) mRNA levels were assessed with a quantitative real time polymerase chain reaction (qRT-PCR). …”
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Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes by Mohamad Alaa Terkawi, Ryo Takano, Kentaro Kato

“…Gene enrichment analysis suggested that the biological pathways involved in the PMN responses to the iRBCs included insulin receptor, Jak-STAT signaling pathway, mitogen-activated protein kinase (MAPK), and interleukin and interferon-gamma (IFN-γ) signaling pathways. …”
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Gestational diabetes versus pregestational diabetes. Perinatal results. by Cristóbal Torres González, Joselin Moreno Torres, Juan Carlos Pastrana Tapia, Vivian Vázquez Martínez

“…According to Marquez Guillén classification , the bad fetal-maternal prognosis (X=16.37, p < 0.05), the treatment with diet plus insulin(X=53.5, p < 0.05),abortio(X=32.2, p < 0.05),pre term delivery (X=11, p < 0.05),maternal morbidity (X=36.8, p < 0.05) and perinatal morbidity (X=39.6, p < 0.05) were the most frequent in pregestationaldiabetes than in gestational diabetes.…”
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RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease by Kamyar Asadipooya, Kamran B. Lankarani, Rishi Raj, Mohammadreza Kalantarhormozi

“…AGE-RAGE interaction contributes to fat accumulation in the liver leading to inflammation, fibrosis, insulin resistance, and other complications of the fatty liver disease. …”
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Epicardial Fat: Physiological, Pathological, and Therapeutic Implications by Juan Salazar, Eliana Luzardo, José Carlos Mejías, Joselyn Rojas, Antonio Ferreira, José Ramón Rivas-Ríos, Valmore Bermúdez

“…When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased proliferation of vascular smooth muscle cells. …”
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Unilocular adipocyte and lipid tracer for immunofluorescent images by Elizabeth K. Johnston, Tal Dassau, Nickia A. Muraskin, Rosalyn D. Abbott

“…Adipocyte cellular size has been recognized as an indicator of cellular status; hypertrophic adipocytes are more prone to insulin resistance and the secretion of pro-inflammatory cytokines. …”
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