The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment by Yi-Cheng Chang, Siow-Wey Hee, Meng-Lun Hsieh, Yung-Ming Jeng, Lee-Ming Chuang

“…ROS scavengers, chemical chaperones, and autophagy activators have demonstrated promising effects for the treatment of insulin resistance and diabetes in preclinical models. …”
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Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature by Noormuhammad Oosman Abbasakoor, Marie Louise Healy, Donal O'Shea, Donal Maguire, Cian Muldoon, Kieran Sheahan, Dermot O'Toole

“…Most patients with insulinomas present with neuroglycopenic symptoms and weight gain attributable to insulin excess. Here, we report a case where a 67-year-old lady with a background history of type 2 diabetes mellitus and breakthrough hyperinsulinism who presented with coma. …”
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Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus by Md. Sakib Hossen, Siew Hua Gan, Md. Ibrahim Khalil

“…The main antidiabetic activity of melittin is increasing insulin secretion via depolarization of pancreatic β-cells. …”
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A Case of Chronic Calcific Nonalcoholic Pancreatitis by Aaron Kangas-Dick, Umair Khan, Oluwafunbi Awoniyi, Shanza Waqar, Nu Nwe Tun, Karthikeyan Viswanathan, Cynthia Wong

“…It is associated with the formation of pancreatic calculi and a high probability of developing insulin-dependent diabetes mellitus. Epidemiologic studies have shown that these patients have an increased risk of developing pancreatic carcinoma. …”
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Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications by Almudena Gómez-Hernández, Nuria Beneit, Sabela Díaz-Castroverde, Óscar Escribano

“…Therefore, low systemic inflammation responsible for insulin resistance contributes to atherosclerotic process. …”
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Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis by Bushra Rehman, Fozia Memon, Khadija Nuzhat Humayun, Muzna Arif

“…The management challenges encountered while managing this case were the need for high glucose infusion rate fluids with insulin for hypertriglyceridemia, electrolyte imbalances secondary to forced diuresis, difficulties in providing fat-free formula, gradual introduction of maternal breastfeeding due to pancreatitis and rebound hypercalcemia requiring steroid treatment. …”
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Development and Evaluation of an Edutainment Tool for Imparting Education and Awareness among Type 1 Diabetes Children in Qatar by Abdulla Al Hamaq, Ahmed A Elasyouti, Rasha T Abou-Amona, Nedaa G ElKhatib

“…The games were designed to provide essential information about food, exercise, and insulin. A total of 46 children with T1DM evaluated the degree of entertainment, usability, and clinical usefulness of the games with the structured questionnaire. …”
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Successful Pregnancy after Simultaneous Pancreas-Kidney Transplantation by A. Smyth, G. Gaffney, D. Hickey, D. Lappin, D. Reddan, F. Dunne

“…Blood glucose levels and HbA1c remained within normal limits, and she did not require insulin treatment at any point. She experienced deterioration in renal indices and underwent an uncomplicated, elective Caesarean section at thirty-week gestation. …”
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Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes by Feng-Cheng Chou, Heng-Yi Chen, Shyi-Jou Chen, Mei-Cho Fang, Huey-Kang Sytwu

“…Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells that selectively destroy the insulin-producing β cells. Previous reports based on epidemiological and animal studies have demonstrated that both genetic factors and environmental parameters can either promote or attenuate the progression of autoimmunity. …”
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PPAR Agonists and Cardiovascular Disease in Diabetes by Anna C. Calkin, Merlin C. Thomas

“…To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance, these agents have been considered to reduce cardiovascular risk. …”
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Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro by Claudia J. Labrador-Rached, Rebecca T. Browning, Laura K. Braydich-Stolle, Kristen K. Comfort

“…However, lower, subtoxic PtNP concentrations were able to elicit multiple stress responses, secretion of proinflammatory cytokines, and modulation of insulin-like growth factor-1 dependent signal transduction. …”
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Information avoidance by younger adults with Type 1 diabetes: a preliminary empirical study by Bruce Ryan, Gemma Webster

“…People with Type 1 diabetes need to collect data to calculate their own insulin doses, and collect information about potential complications. …”
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Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation by Annette Plesner, C. Bruce Verchere

“…Given the limited number of donor pancreata selected for islet isolation and that islets from multiple donors are typically required to obtain insulin independence, it is critical to improve pancreas procurement rates and yield of islets for transplantation. …”
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Arv1; a “Mover and Shaker” of Subcellular Lipids by J. Jose Corbalan, Karla K. Frietze, Joseph Nickels, Stephen L. Sturley

“…Murine in vivo studies point to a role for ARV1 in regulating obesity, glucose tolerance, insulin sensitivity and brain function. Multiple human ARV1 variants have been associated with epileptic encephalopathy, cerebellar ataxia, and severe intellectual deficits. …”
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IL-6 Promotes Islet β-Cell Dysfunction in Rat Collagen-Induced Arthritis by Huan Jin, Yaogui Ning, Haotong Zhou, Youlian Wang

“…Fasting plasma glucose (FBG) was measured by the glucose oxidase method. Fasting insulin (FIns) and the expressions of IL-6 were detected by ELISA. …”
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Linum usitatissimum Delivery over Chitosan Nanobiopolymer: Enhanced Effects on Polycystic Ovary Syndrome Condition by Abolfazl Bayrami, Maryam Sojoudi, Shima Rahim Pouran, Aziz Habibi-Yangjeh, Sanaz Sojoudi

“…After 16 days of treatment, CHIT-FSE represented the best performance for controlling the serum levels of the studied biochemical (lipid profile and blood glucose level) and hormonal (insulin, testosterone, luteinizing, and follicle-stimulating hormone) parameters. …”
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Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes by Tong-Huan Li, Chun-Jian Qiu, Xiao-Juan Yu, Dan-Dan Liu, Peng-Fei Zhou, Liang Wu

“…Univariate correlations showed that serum PEDF levels were positively correlated with fasting glucose and fasting insulin levels, respectively, and negatively correlated with adiponectin. …”
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Euglycemic Ketoacidosis in a Patient with Metastatic Non-Small-Cell Lung Adenocarcinoma and Concomitant Pulmonary Embolism by Robert Sean O’Neill, Lauren Tyack, Mary Freeman, Hussein Soudy Hussein

“…The patient required admission to the intensive care unit for fluid resuscitation and regular intravenous insulin to ensure resolution of acidosis and maintenance of normoglycaemia. …”
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Bile acids and incretins as modulators of obesity-associated atherosclerosis by Andrijana Kirsch, Juergen Gindlhuber, Diana Zabini, Elena Osto, Elena Osto

“…Bile acids (BAs) and incretins are gut hormones involved in digestion and absorption of fatty acids, and insulin secretion, respectively. In recent years BAs and incretins are increasingly recognized as key signaling molecules, which target multiple tissues and organs, beyond the gastro-intestinal system. …”
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The Impact of Obesity on the Cardiovascular System by Imre Csige, Dóra Ujvárosy, Zoltán Szabó, István Lőrincz, György Paragh, Mariann Harangi, Sándor Somodi

“…It is associated with an increased cardiovascular risk on the one hand of obesity itself and on the other hand of associated medical conditions (hypertension, diabetes, insulin resistance, and sleep apnoea syndrome). Obesity has an important role in atherosclerosis and coronary artery disease. …”
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