Junctional Bradikardia pada Pasien Hiperkalemia by Cokorda Istri Padmi Suwari, Bayu Puradipa, Ni Luh Eka Sriayu Wulandari

“…Unexpectedly the cardiac rhythm was returned into the sinus after correction of hyperkalemia using calcium gluconate, insulin, dextrose, and salbutamol. As serum potassium level rises, sinoatrial and atrioventricular conduction was blocked, causing escape rhythm (junctional escape rhythm). …”
Get full text

Understanding the Role of Exercise in Nonalcoholic Fatty Liver Disease: ERS-Linked Molecular Pathways by Yong Zou, Zhengtang Qi

“…Nonalcoholic fatty liver disease (NAFLD) is globally prevalent and characterized by abnormal lipid accumulation in the liver, frequently accompanied by insulin resistance (IR), enhanced hepatic inflammation, and apoptosis. …”
Get full text

Effect Of Vitamin D Supplements In Improving Glycemic Control In Type 2 Diabetes Mellitus by Yusra Javaid, Roma Sikandar, Amreen Wasif

“…Conclusion: The inclusion of Vitamin D supplements in conjunction with conventional anti-diabetic medications and exogenous insulin demonstrates an improvement the glycemic status of diabetic patients, as indicated by a reduction in HbA1c levels. …”
Get full text

In Vivo Monitoring of Pancreatic β-Cells in a Transgenic Mouse Model by Steven J. Smith, Hongbing Zhang, Anne O. Clermont, Alvin C. Powers, Dixon B. Kaufman, Anthony F. Purchio, David B. West

“…We generated a transgenic mouse model ( RIP-luc ) for the in vivo monitoring of pancreatic islet mass and function in response to metabolic disease. Using the rat insulin promoter fused to firefly luciferase, and noninvasive technology to detect luciferase activity, we tracked changes in reporter signal during metabolic disease states and correlated the changes in luciferase signal with metabolic status of the mouse. …”
Get full text

The Association of Metabolic Syndrome and Urolithiasis by Yee V. Wong, Paul Cook, Bhaskar K. Somani

“…Several hypotheses have been proposed to explain the pathophysiology of urolithiasis resulting from metabolic syndrome, amongst which are the insulin resistance and Randall’s plaque hypothesis. …”
Get full text

From Placenta to Polycystic Ovarian Syndrome: The Role of Adipokines by Chiara Sartori, Pietro Lazzeroni, Silvia Merli, Viviana Dora Patianna, Francesca Viaroli, Francesca Cirillo, Sergio Amarri, Maria Elisabeth Street

“…Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulating insulin sensitivity and inflammation, and have significant effects on growth and reproductive function. …”
Get full text

Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model by Nina Stadelmann, Raymund E. Horch, Rafael Schmid, David Ostendorf, Ajay Peddi, Theresa Promny, Anja M. Boos, Annika Kengelbach-Weigand

“…For optimum translation into the clinical setting, primary human keratinocytes and patient-matched ADSCs were isolated and used in an in vitro wound model.ResultsThe keratinocyte migration and viability increased after treatment with the growth factors insulin-like growth factor 1 (IGF-1) and keratinocyte growth factor (KGF). …”
Get full text

Case Report and Literature Review of Insulinoma in the Geriatric Population: An 86-Year-Old Female with Syncope of Unknown Origin by Gerry Samantha Eichelberger, Jordan Carbono, Zachary Field, KanwarAnoop Kainaur, Federico Montalvo

“…The tumor is characterized by endogenous hypersecretion of insulin and ensuing development of symptoms of neuroglycopenia and the catecholaminergic response. …”
Get full text

Use and Trends of Diabetes Self-Management Technologies: A Correlation-Based Study by Jesús Fontecha, Iván González, Alfonso Barragán, Theodore Lim

“…In this study, more than 70% of participants use Continuous Glucose Systems and additional devices (41.85% also use insulin pumps) which impacts positively on the knowledge of incoming technologies. …”
Get full text

The Effectiveness of Digitalization in Family Caregiver Empowerment Model (FCEM) for Reducing Diabetes Incidence in Rural Areas: An App-Based Literature Review Study by Fahmi Wildana, Lutfian Lutfian, Aufa Azizah, Izdihar Javier Wardika, Fariza Barika Ramadhani, Wahyu Dwi Utomo

“…Diabetes mellitus (DM) is a condition characterised by anomalies in insulin production, action, or both, which result in hyperglycemia and insufficient management of blood glucose levels. …”
Get full text

Usability Pitfalls of Diabetes mHealth Apps for the Elderly by Maša Isaković, Urban Sedlar, Mojca Volk, Janez Bešter

“…The latter have proven benefits for monitoring blood glucose levels and insulin tracking in the general population. In this paper, we analyse a diabetes monitoring app DeStress Assistant (DeSA), which was developed as a part of an EU project and tested in a hospital setting. …”
Get full text

Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL by Bodvael Pennarun, Jan H. Kleibeuker, Tjitske Oenema, Janet H. Stegehuis, Elisabeth G.E. de Vries, Steven de Jong

“…Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1) survival pathway is often increased in cancer, influencing both cell proliferation and apoptosis. …”
Get full text

Surgical Treatment for Chronic Pancreatitis: Past, Present, and Future by Stephanie Plagemann, Maria Welte, Jakob R. Izbicki, Kai Bachmann

“…Surgical procedures remained less successful until the discovery of insulin, blood groups, and finally the possibility of blood donation. …”
Get full text

Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome by Alicia A. Thorp, Markus P. Schlaich

“…Furthermore there is mounting evidence to suggest that chronic sympathetic overactivity can potentiate two of the key metabolic alterations of the MetS, central obesity and insulin resistance. This review will discuss the regulatory role of the sympathetic nervous system in metabolic control and the proposed pathophysiology linking sympathetic overactivity to metabolic abnormalities. …”
Get full text

Sympathoexcitation Associated with Renin-Angiotensin System in Metabolic Syndrome by Takuya Kishi, Yoshitaka Hirooka

“…In fact, previous studies have suggested that SNS activation has the interaction with RAS activation and/or insulin resistance. As a novel aspect connecting the importance of SNS and RAS activation, we and other investigators have recently demonstrated that angiotensin II type 1 receptor (AT1R) blockers (ARBs) improve SNS activation in patients with MetS. …”
Get full text

Increased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1 by Simone Maria Kluth, Teja Falk Radke, Gesine Kögler

“…Compared to CB MSC, USSC lead to a higher expansion of haematopoietic cells and in addition express significantly higher levels of insulin-like growth factor binding protein 1 (IGFBP1), but lower levels of IGF2. …”
Get full text

Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials by Jixin Zhong, Quan Gong, Aditya Goud, Srividya Srinivasamaharaj, Sanjay Rajagopalan

“…DPP4 inhibitors (DPP4i) are a class of newly developed antidiabetic drugs which preserve incretin hormones and promote postprandial insulin secretion. Although the cardiovascular effect of DPP4 inhibition has been substantially studied, the exact role of DPP4 in cardiovascular disease especially in humans remains elusive. …”
Get full text

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism by Tsuyoshi Goto, Nobuyuki Takahashi, Shizuka Hirai, Teruo Kawada

“…Because PPARs are dietary lipid sensors that control energy homeostasis, daily eating of these terpenoids might be useful for the management for obesity-induced metabolic disorders, such as type 2 diabetes, hyperlipidemia, insulin resistance, and cardiovascular diseases.…”
Get full text

Thiazolidinedione-Induced Fluid Retention: Recent Insights into the Molecular Mechanisms by Jerzy Bełtowski, Jolanta Rachańczyk, Mirosław Włodarczyk

“…Peroxisome proliferator-activated receptor-γ (PPARγ) agonists such as rosiglitazone and pioglitazone are used to improve insulin sensitivity in patients with diabetes mellitus. …”
Get full text

Lipid Chaperones and Metabolic Inflammation by Masato Furuhashi, Shutaro Ishimura, Hideki Ota, Tetsuji Miura

“…It is now clear that obesity and associated disorders such as insulin resistance and type 2 diabetes are associated with a metabolically driven, low-grade, chronic inflammatory state, referred to as “metaflammation.” …”
Get full text