Acromegaloid Facial Appearance: Case Report and Literature Review by Adline Ghazi, Shikha Khosla, Kenneth Becker

“…It encompasses a spectrum of acromegaloid physical findings, normal growth hormone (GH) and insulin-like growth factor one (IGF-1) levels, and variable mode of inheritance. …”
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Virtual Screening as a Technique for PPAR Modulator Discovery by Stephanie N. Lewis, Josep Bassaganya-Riera, David R. Bevan

“…It is well recognized that PPARγ agonists have therapeutic applications as insulin sensitizers in type 2 diabetes or as anti-inflammatories. …”
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Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study by Marcia L. Brackbill, Ateequr Rahman, Jeffrey S. Sandy, M. Denton Stam, Arthur F. Harralson

“…We aimed to determine if sitagliptin added to standard postoperative standardized sliding-scale insulin regimens improved blood glucose. Methods. …”
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RELAÇÃO ENTRE O FATOR DE CRESCIMENTO SEMELHANTE À INSULINA (IGF-1) E ATIVIDADE FÍSICA by Maria de Rezende Gomes, Julio Tirapegui

“…Os IGFs (insulin-like growth factors 1 e 2) ou somastomedinas (A e C) são pepitídeos de estrutura e função semelhante à insulina. …”
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Therapeutic Implications of PPARγ in Cardiovascular Diseases by Hiroshi Hasegawa, Hiroyuki Takano, Issei Komuro

“…Many studies suggest that PPARγ ligands not only ameliorate insulin sensitivity, but also have pleiotropic effects on the pathophysiology of atherosclerosis, cardiac hypertrophy, ischemic heart, and myocarditis.…”
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Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic β-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1 by Satoshi Okano

“…The duct-like structures contained insulin-positive cells, suggesting neogenesis of β-cells in the Tg mice. …”
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Functional Expression Study of Igf2 Antisense Transcript in Mouse by Carolina Duart-Garcia, Martin H. Braunschweig

“…Insulin-like growth factor antisense gene (Igf2as) expression was investigated in different mouse tissues during development, in differentiating C2C12 cells and in a ΔDMR1-U2 knockout mouse model. …”
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JAK inhibitors: a new choice for diabetes mellitus? by Mengjun Zhou, Qi Shen, Bo Li

“…In vivo and in vitro experimental studies have elucidated some of the mechanisms behind this effect, which seem to be based mainly on the reduction in β-cell disruption and the improvement of insulin resistance. In this review, we briefly describe the beneficial effects of JAK inhibitors among nonreceptor tyrosine kinase inhibitors for the treatment of DM and attempt to analyze the mechanisms involved.…”
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Low-Dose Gallic Acid Administration Does Not Improve Diet-Induced Metabolic Disorders and Atherosclerosis in Apoe Knockout Mice by Jie Bai, Qiu-Yue Lin, Xiangbo An, Shuang Liu, Yao Wang, Yunpeng Xie, Jiawei Liao

“…Our data showed that GA administration by oral gavage at a daily dosage of 20 mg/kg body weight did not significantly ameliorate WTD-induced hyperlipidemia, hepatosteatosis, adipogenesis, or insulin resistance; furthermore, GA administration did not significantly ameliorate WTD-induced atherosclerosis. …”
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Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis by Xiaofang Yu, Saifei Zhang, Long Zhang

“…That the hormonal interactions in DKA may differ from the severity of insulin deficiency also may have served in the scenario of EDKA. …”
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Maturity-Onset Diabetes of Young Type 5: Diabetes with Extrapancreatic Features by Adnan Haider, Oksana Symczyk, Ayesha Hassan, Muhammad Atif Khan, Inderpreet Madahar, Dylan Holland

“…We present a case of a 22-year-old female with the congenital dysplastic right kidney diagnosed with gestational diabetes mellitus after failing a 1-hour oral glucose tolerance test, requiring insulin during pregnancy. Because of the family history of diabetes and morphologic renal abnormalities at young ages on the maternal side of the family, our patient was evaluated for maturity-onset diabetes of adult and was found to have HNF-1β mutation. …”
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Hyperinsulinemic Hypoglycaemia in a Turner Syndrome with Ring (X) by Michela Cappella, Vanna Graziani, Antonella Pragliola, Alberto Sensi, Khalid Hussain, Claudia Muratori, Federico Marchetti

“…Hyperinsulinemic hypoglycaemia (HH) is a group of clinically, genetically, and morphologically heterogeneous disorders characterized by dysregulation of insulin secretion by pancreatic beta cells. HH can either be congenital genetic hyperinsulinism or associated with metabolic disorder and syndromic condition. …”
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Ozone therapy as support in the treatment of diabetic foot ulcer. A case report by Isidro Matos Lamote, Jorge Enrique Rodríguez León, Carlos García Arencibia, Maydelin Pérez Reina

“…Drainage of the abscess, modification of insulin treatment, and debridement of the lesion were performed. …”
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Biofilm Forming Intestinal Escherichia coli as a Risk Factor for Increasing BMI in Type 2 Diabetic Patients by Sahar Salih Hussein, Asal Aziz Tawfeeq

“…Background: The term diabetes mellitus (DM) describes a group of chronic diseases and metabolic disorders that accompany hyperglycemia (high blood glucose) which may be the result of an abnormality in secretion or insulin action. Diabetes type 2 is the most common type of diabetes, it usually occurs in adults but is increasingly with overweight. …”
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Gastric Pneumatosis in the Setting of Diabetic Ketoacidosis by Mohammed Rifat Shaik, Chet Ranabhat, Nishat Anjum Shaik, Akshay Duddu, Zaid Bilgrami, Guofeng Xie

“…The patient was managed with aggressive fluid resuscitation and intravenous insulin therapy per diabetic ketoacidosis protocol. …”
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Diabetes mellitus: The pathophysiology as a canvas for management elucidation and strategies by Franklyn Nonso Iheagwam, Olawumi Toyin Iheagwam

“…Diabetes mellitus (DM) is a progressive metabolic disease characterised by high blood glucose due to autoimmune destruction of the β-islet of Langerhans or gradual development of insulin resistance and β-cell degeneration. Numerous risk factors, from genetic to environmental, are associated with this disease. …”
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Osteopetrosis and Its Relevance for the Discovery of New Functions Associated with the Skeleton by Amélie E. Coudert, Marie-Christine de Vernejoul, Maurizio Muraca, Andrea Del Fattore

“…In particular, the interplay of bone with the stomach, insulin metabolism, male fertility, the immune system, bone marrow, and fat is described.…”
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Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease by Kouichi Miura, Ekihiro Seki, Hirohide Ohnishi, David A. Brenner

“…On the other hand, these mediators alter lipid metabolism, insulin signaling, and cell survival. Indeed, some TLR-deficient mice demonstrate lesser degrees of NAFLD even though TLR ligands are increased. …”
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BMI, HOMA-IR, and Fasting Blood Glucose Are Significant Predictors of Peripheral Nerve Dysfunction in Adult Overweight and Obese Nondiabetic Nepalese Individuals: A Study from Cent... by Lekhjung Thapa, P. V. S. Rana

“…Homeostatic model assessment of insulin resistance (HOMA-IR) was the significant predictor (P=0.019, 96% CI = 1.420–49.322) of sensory nerve dysfunction. …”
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Physiopathological Mechanisms of Association between Metabolic Syndrome and Arterial Hypertension: an Update by Luis Enrique Jiménez Franco, Dianelys María Gutiérrez Pérez, Milagros Lisset León Regal, Claudia González Martínez, Lucía Baños Leyva, Arionnis Matos Olivero

“…Hypertension and dyslipidemia often occur together and also accompany resistance to insulin-stimulated glucose uptake; factors that often accompany obesity. …”
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