An unmet need: Pancreatic beta cell replacement by F Mohamed, C Adams, B Mansfield

“…A century has passed since the discovery of insulin, and despite advances in diabetes management, exogenous insulin remains a primary treatment for type 1 DM, posing challenges of hyperglycaemia and hypoglycaemia. …”
Get full text

High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report by Fatimatuz Zahro, Tita Sugesti, Siska Hermawati, M. Hari Pristantiningtyas, Herya Putra Dharma, Muhammad Muchlis, Jainuri Erik Pratama, Fauna Herawati, Adji Prayitno, Marisca Evalina Gondokesumo

“…In this particular case, human insulin was selected to rapidly control the patient's hyperglycemic condition. …”
Get full text

KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus by Polin Haghvirdizadeh, Zahurin Mohamed, Nor Azizan Abdullah, Pantea Haghvirdizadeh, Monir Sadat Haerian, Batoul Sadat Haerian

“…It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. …”
Get full text

Obese Children with Metabolic Syndrome Have 3 Times Higher Risk to Have Nonalcoholic Fatty Liver Disease Compared with Those without Metabolic Syndrome by Dimitrios Papandreou, Mirey Karavetian, Zacharoula Karabouta, Eleni Andreou

“…Insulin resistance was present in 78 (62.4%) children. …”
Get full text

CORN SILK TEA EXTRACT AS ANTIDIABETIC : A REVIEW by Ila Maratush Shalihah, Vega Yoesepa Pamela, Septariawulan Kusumasari

“…Patients with diabetes mellitus are characterized by high blood glucose levels (hyperglycemia) due to a lack of insulin secretion, insulin action, or both. Decreasing blood sugar levels can be done in several ways, namely by diet and consumption of drugs. …”
Get full text

Blood Glukose Response of Giant Gouramy (Osphronemus gaouramy, Lac.) to the Stress of Environmental Temperature Changes by S. Hastuti, Eddy Supriyono, Ing Mokoginta, . Subandiyono

“…To study the role of insulin activation on reducing the stress effects, thirty fish were injected with insulin 2 IU/100 g body weight before subjected them to stressar. …”
Get full text

Decompensation of β-Cells in Diabetes: When Pancreatic β-Cells Are on ICE(R) by Roberto Salvi, Amar Abderrahmani

“…Insulin production and secretion are temporally regulated. …”
Get full text

Diagnostic Challenges in Ovarian Hyperthecosis: Clinical Presentation with Subdiagnostic Testosterone Levels by Sanket Shah, Callie Torres, Naser Gharaibeh

“…In this case series, we discuss two patients who presented with symptoms of hyperandrogenism and metabolic abnormalities including insulin resistance stemming from ovarian hyperthecosis. …”
Get full text

Bone Marrow Stem Cell as a Potential Treatment for Diabetes by Ming Li, Susumu Ikehara

“…Diabetes mellitus (DM) is a group of metabolic diseases in which a person has high blood glucose levels resulting from defects in insulin secretion and insulin action. The chronic hyperglycemia damages the eyes, kidneys, nerves, heart, and blood vessels. …”
Get full text

Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals? by Joseph A. Houmard, Walter J. Pories, G. Lynis Dohm

“…Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. …”
Get full text

Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome by Luciana Tock, Gláucia Carneiro, Andrea Z. Pereira, Sérgio Tufik, Maria Teresa Zanella

“…Objective. Insulin resistance (IR) and ovarian and adrenal hyperandrogenism are a common finding in women with polycystic ovary syndrome (PCOS). …”
Get full text

Pregnant Women with Type 2 Diabetes Mellitus and Hypertension: A Physiological Overview by Muhsin Hmeadi Ubeid

“…Objectives: This study includes hematological variables on type 2 diabetes mellitus (T2DM) in pregnant women that rely on insulin intake. Materials and Methods: In this study, there are 60 pregnant individuals with insulin-dependent T2DM and severe hypertension (HTN). …”
Get full text

Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats by Yogendra Nayak, Venkatachalam Hillemane, Vijay Kumar Daroji, B. S. Jayashree, M. K. Unnikrishnan

“…Plasma lipids and serum insulin were estimated. Homeostatic model assessment (HOMA-IR) was then calculated from serum insulin. …”
Get full text

Serum Adiponectin Level in Diabetic Patients with and without Helicobacter pylori Infection: Is There Any Difference? by Jamshid Vafaeimanesh, Akram Heidari, Marzieh Effatpanah, Mahmoud Parham

“…Background. Increased insulin resistance is an extragastrointestinal manifestation of Helicobacter pylori (HP) infection. …”
Get full text

Assessment of Cardiovascular Risk Factors in Women Having Female Pattern Hair Loss by Damini Verma, Vibhu Mendiratta, Taru Garg, Smita Tripathi, Shaili Tomer

“…The prevalence of Metabolic syndrome (MetS) and Insulin resistance were evaluated. Results: Metabolic syndrome and insulin resistance were found in 12 (24%) and 17 (34%) cases respectively. …”
Get full text

The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus by Yuliang Cui, Hemei Bu, Xianghua Ma, Sha Zhao, Xiaona Li, Shan Lu

“…However, we found no significant relationship between uric acid and HbA1c by regression analysis after adjusting total insulin. The concentration of uric acid was inversely correlated with HbA1c in the high insulin group, regardless of patient sex. …”
Get full text

Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS) by Kristine Hovde Jacobsen, Jori Aalders, Katrine Sølling, Marianne Skovsager Andersen, Lena Sønder Snogdal, Maria Hornstrup Christensen, Christina Anne Vinter, Kurt Højlund, Dorte Møller Jensen

“…Both beta cell dysfunction and reduced insulin sensitivity seem to contribute to this increased risk.…”
Get full text

Cognitive dysfunction in diabetes – the ‘forgotten’ diabetes complication: a narrative review by Åke Sjöholm, Louise Bennet, Peter M. Nilsson

“…Recent years have seen research that has clarified cerebral insulin resistance and defective insulin signaling as examples of pathogenic factors behind this cognitive impairment in diabetes.Method We provide a narrative review of select and contemporary publications with relevance for the interface between diabetes/prediabetes and cognitive function.Results Recently published studies show that physical activity can reverse insulin resistance in the brain as well as cognitive impairment and pathological appetite regulation. …”
Get full text

Differential Relationship between Intermuscular Adipose Depots with Indices of Cardiometabolic Health by Robert E. Bergia, Jung Eun Kim, Wayne W. Campbell

“…IMAT was regressed separately against fasting serum glucose concentrations, insulin, homeostatic model assessment-insulin resistance (HOMA-IR), and lipids and lipoproteins. …”
Get full text

FGF21 Is Associated with Acanthosis Nigricans in Obese Patients by Yueye Huang, Jie Yang, Yan Li, Jiaqi Chen, Kexiu Song, Xingchun Wang, Le Bu, Xiaoyun Cheng, Jiying Wang, Shen Qu

“…Compared with OB group, AN group had higher levels of fasting insulin and homeostasis model of assessment for insulin resistance (HOMA-IR) (P<0.05), but lower serum levels of blood glucose. …”
Get full text