Hyperinsulinemia, cancer and maqui berry: The promise of nutritional supplementation by Brett Deters, Mir Saleem

“…Keywords: Hyperinsulinemia, Cardiovascular disease, Diabetes, Insulin, Maqui berry, Cancer…”
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Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 by Chandrama Shrestha, Honghui He, Yiqun Liu, Shaihong Zhu, Jing Xiong, Zhaohui Mo

“…Significant reductions in anthropometric measurements and indicators of glucose and lipid metabolism and moderate reductions in insulin resistance and fasting insulin were observed at three months after LRYGB. …”
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The Effects Of Simvastatin On Islets Of Langerhans In The Pancreas Of Rats: A Histological And Biochemical Study by Abdullah Qamar, Hammad Gul Khan, Hina Kundi, Ayesha Ali, Sumyyia Bashir, Tooba Khurshid

“… Objective: This study explored the effect of simvastatin on the histomorphology of islets of Langerhans, glucose and insulin levels in rats. Study Design: The study was a one-year laboratory-based experimental control trial. …”
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Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway by Jie Yu, Yuan Zhao, Lingling Xu, Wei Li, Huabing Zhang, Fan Ping, Yuxiu Li

“…Forty female C57BL/6J mice were equally assigned into five groups: diabetic group, insulin+diabetic group, liraglutide+diabetic group, insulin+liraglutide+diabetic group, and control group for eight weeks. …”
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Renewable Human Cell Model for Type 1 Diabetes Research: EndoC-βH5/HUVEC Coculture Spheroids by James M. Porter, Michael Yitayew, Maryam Tabrizian

“…Human insulin-producing immortalized EndoC-βH5 cells are cocultured with human endothelial cells in varying ratios to evaluate 3D cell culture models for type 1 diabetes research. …”
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Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium Ameliorates Diabetes-Induced Testicular Damage and Sperm Abnormalities by Mitigating Oxidative Stress, Apoptosis, and Infla... by Mojtaba Sargazi, Narges Karbalaei, Saied Karbalay-Doust, Sara Keshtgar, Zohre Aghaei

“…Blood glucose and insulin levels, along with sperm parameters, were assessed. …”
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Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic β-Cells by Mackenzie S. Frost, Aqib H. Zehri, Sean W. Limesand, William W. Hay, Paul J. Rozance

“…Baseline insulin concentrations were higher in CHG fetuses (P<0.05) compared to controls and PHG. …”
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Characteristics of metabolic syndrome in the servicemen with erosive esophagitis in wartime conditions by L.M. Mosiychuk, O.M. Shevtsova, O.M. Tatarchuk, O.P. Petishko

“…Body composition was assessed using Tanita MC-780МА (Japan) scales-analyzers whose mechanism is based on the technique of bioimpedance analysis with computer processing. Insulin resistance was evaluated using the HOMA-IR index, for the calculation of which the level of insulin was determined by enzyme-linked immunosorbent assay systems of the Xema company (Ukraine) on the Stat Fax 303 Plus analyzer (USA). …”
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Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation by Chia-Hao Wang, Christopher Orr, Jeannette Hacker-Stratton, Mohamed El-Shahawy, Keiko Omori, Meirigeng Qi, Fouad Kandeel

“…Islets from multiple donors are often needed to achieve insulin independence, and even then, islet function can decline over time when metabolic demand exceeds islet mass/insulin secretory capacity. …”
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Transient Decrease in Circulatory Testosterone and Homocysteine Precedes the Development of Metabolic Syndrome Features in Fructose-Fed Sprague Dawley Rats by Anil Sakamuri, Sujatha Pitla, Uday Kumar Putcha, Sugeedha Jayapal, Sailaja Pothana, Sai Santosh Vadakattu, Nagabhushan Reddy Konapalli, Siva Sankara Vara Prasad Sakamuri, Ahamed Ibrahim

“…Plasma testosterone and homocysteine levels were measured along with insulin, glucose, and lipids. Body composition, insulin resistance, and hepatic lipids were measured. …”
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Metabolic Effects of Testosterone Hormone Therapy in Normal and Orchiectomized Male Rats: From Indirect Calorimetry to Lipolytic Enzymes by Mahmoud Mustafa Ali Abulmeaty, Ali Madi Almajwal, Mohamed Farouk ElSadek, Mohamed Y Berika, Suhail Razak

“…Orchiectomy decreased ghrelin, GH, and insulin levels, increased TEE and RQ, and lowered FI and wt. …”
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Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction by Xiaoting Luo, Rongrong Li, Liang-Jun Yan

“…Pancreatic β cells not only use glucose as an energy source, but also sense blood glucose levels for insulin secretion. While pyruvate and NADH metabolic pathways are known to be involved in regulating insulin secretion in response to glucose stimulation, the roles of many other components along the metabolic pathways remain poorly understood. …”
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Importance of Android/Gynoid Fat Ratio in Predicting Metabolic and Cardiovascular Disease Risk in Normal Weight as well as Overweight and Obese Children by Lennie Samsell, Michael Regier, Cheryl Walton, Lesley Cottrell

“…The purpose of our study was to determine if the android/gynoid fat ratio is positively correlated with insulin resistance, HOMA2-IR, and dislipidemia in a child sample of varying body sizes. …”
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The Influence of Treated and Untreated Subclinical Hypothyroidism on Metabolic Profile in Women with Polycystic Ovary Syndrome by Karolina Kowalczyk, Patrycja Radosz, Kamil Barański, Dagmara Pluta, Dariusz Kowalczyk, Grzegorz Franik, Paweł Madej

“…Serum lipids, fasting glucose, and insulin, as well as oral glucose tolerance tests were performed. …”
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A Novel Approach to Numerical Modeling of Metabolic System: Investigation of Chaotic Behavior in Diabetes Mellitus by Payam Sadeghi Shabestari, Karthikeyan Rajagopal, Bahareh Safarbali, Sajad Jafari, Prakash Duraisamy

“…Although many mathematical models have been presented for glucose and insulin interaction, none of these models can describe diabetes disease completely. …”
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Acute Exposure to a Precursor of Advanced Glycation End Products Induces a Dual Effect on the Rat Pancreatic Islet Function by Ghada Elmhiri, Luiz Felipe Barella, Didier Vieau, Sylvaine Camous, Paulo C. F. Mathias, Latifa Abdennebi-Najar

“…Different effects of MG on insulin secretion were evidenced. In basal glucose stimulation (5.6 mM), MG induced a significant (P<0.05) increase of insulin secretion. …”
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The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects by Sijie Zhang, Wenxuan Bian, Yan Wang, Min Shen, Yu Qian, Hao Dai, Shuai Zheng, Qi Fu, Kuanfeng Xu, Tao Yang, Hemin Jiang

“…ObjectiveThis study aims to investigate the associations between MTNR1B rs724030 A&gt;G variant and prediabetes risk, along with their correlations with clinical features, including plasma glucose and serum insulin levels during oral glucose tolerance test (OGTT), islet function, insulin resistance, and plasma lipid levels. …”
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Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice by Yu Fu, Jing Luo, Zhenquan Jia, Wei Zhen, Kequan Zhou, Elizabeth Gilbert, Dongmin Liu

“…In both type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cell, leading to the impaired insulin secretion. Here, we show that dietary supplementation of baicalein, a flavone isolated from the roots of Chinese herb Scutellaria baicalensis, improved glucose tolerance and enhanced glucose-stimulated insulin secretion (GSIS) in high-fat diet (HFD-) induced middle-aged obese mice. …”
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Long-term effects of duodenal mucosal resurfacing and liraglutide on glycaemic control in patients with type 2 diabetes by Max Nieuwdorp, Annieke C G van Baar, Jacques J G H M Bergman, Celine B E Busch, Julia Rubingh

“…The INSPIRE study (n=16) aimed to eliminate insulin by combining DMR with a glucagon-like peptide-1 receptor agonist (GLP-1RA). …”
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Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio by Gloria Lena Vega, Scott M. Grundy

“…Adipokine levels may reflect adipose tissue triglyceride storage capacity and insulin sensitivity. Leptin is an index of fat mass, and adiponectin is a biomarker of triglyceride metabolism and insulin sensitivity. …”
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