TLR4/AP-1-Targeted Anti-Inflammatory Intervention Attenuates Insulin Sensitivity and Liver Steatosis by Xiang Hu, Jing Zhou, Sha-sha Song, Wen Kong, Yan-Chuan Shi, Lu-Lu Chen, Tian-Shu Zeng

“…Insulin resistance has been shown to be the common pathogenesis of many metabolic diseases. …”
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Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice by Yu Yang, Yu Chen, Changju Liu, Su Wang, Yijing Zhao, Wen Cao, Kun Wang

“…Conclusion: The perimenopausal period acts as a potential factor in introducing insulin resistance as evidenced by impaired insulin action and altered expression profiles of exosomal miRNAs and hepatic genes. …”
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Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls by Niraj S. Patel, Michael R. Peterson, Grace Y. Lin, Ariel Feldstein, Bernd Schnabl, Ricki Bettencourt, Ekihiro Seki, Claude B. Sirlin, Rohit Loomba

“…Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls. …”
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Acute effect of endurance exercise on human milk insulin concentrations: a randomised cross-over study by Rebecca Lyng Holm, Mads Holmen, Md Abu Jafar Sujan, Md Abu Jafar Sujan, Guro F. Giskeødegård, Trine Moholdt, Trine Moholdt

“…IntroductionInsulin is present in human milk and its concentration correlates with maternal circulating levels. …”
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A Validated RP-HPLC Method for the Determination of Recombinant Human Insulin in Bulk and Pharmaceutical Dosage Form by B. A. Moussa, F. Farouk, H. M. E. Azzazy

“…A modified RP-HPLC method was developed for the quantitative determination of recombinant human insulin in bulk and pharmaceutical dosage form with reduced retention time. …”
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Decreased Levels of Insulin-Regulated Aminopeptidase (IRAP) in Gestational Diabetes Mellitus: A Prospective Cohort Study by Osman Köse, Koray Gök, Elif Köse, Sezen Irmak Gözükara, Abdullah Tüten, Mehmet Sühha Bostancı

Subjects: “…insulin-regulated aminopeptidase…”
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Combination Therapy with GABA and MgSO4 Improves Insulin Sensitivity in Type 2 Diabetic Rat by Shahla Sohrabipour, Mohammad Reza Sharifi, Mohammadreza Sharifi, Ardeshir Talebi, Nepton Soltani

“…Forty randomly selected rats were assigned to four groups: nondiabetic control group was fed the normal diet, insulin-resistant diabetic rat model was induced by streptozotocin and high-fat diet, GABA + MgSO4 group received GABA and MgSO4, and insulin group was treated with insulin. …”
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Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson’s disease pathology by Alise Zagare, Janis Kurlovics, Catarina Almeida, Daniele Ferrante, Daniela Frangenberg, Armelle Vitali, Gemma Gomez-Giro, Christian Jäger, Paul Antony, Rashi Halder, Rejko Krüger, Enrico Glaab, Egils Stalidzans, Giuseppe Arena, Jens C Schwamborn

“…To investigate insulin resistance caused pathological changes in the human midbrain, which could predispose a healthy midbrain to PD development, we exposed iPSC-derived human midbrain organoids from healthy individuals to either high insulin concentration, promoting insulin resistance, or to more physiological insulin concentration restoring insulin signalling function. …”
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Establishment of subcutaneous transplantation platform for delivering induced pluripotent stem cell-derived insulin-producing cells. by Hong Thuan Tran, Watchareewan Rodprasert, Irma Padeta, Saranyou Oontawee, Steven Dwi Purbantoro, Anatcha Thongsit, Parkpoom Siriarchavatana, Sayamon Srisuwatanasagul, Hiroshi Egusa, Thanaphum Osathanon, Chenphop Sawangmake

“…However, the technologies regarding insulin-producing cell (IPC) production and transplantation are still being developed. …”
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Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions by Sandro Gentile, Felice Strollo, Francesca Viazzi, Giuseppina Russo, Pamela Piscitelli, Antonio Ceriello, Carlo Giorda, Piero Guida, Paola Fioretto, Roberto Pontremoli, Salvatore De Cosmo, the AMD-Annals Study Group

“…Each patient was analyzed step-by-step until either eventually starting insulin treatment or getting to the end of the follow-up period. …”
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Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence by Habib Yaribeygi, Mina Maleki, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…In this mechanistic review, we explore the possible interactions between physical inactivity and insulin resistance to help better understand the pathophysiology of physical inactivity-dependent insulin resistance and finding novel interventions against these deleterious pathways.…”
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Correlation Between Serum Uric Acid, Insulin and Hba1c In Type 2 Diabetes Mellitus by Maryam Imtiaz, Samina Saeed, Muhammad Aqeel, Abrar Akbar, Shafaq Saleem, Lubna Meraj

Subjects: “…HbA1c. Serum uric acid. Insulin…”
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Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet by Guangzeng Zhang, Pengfei Yu, Xiaomeng Liu

“…The insulin sensitivity was enhanced in the HFD + swim group than in the HFD + sedentary group. …”
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Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes by Panayota Mitrou, Eleni Petsiou, Emilia Papakonstantinou, Eirini Maratou, Vaia Lambadiari, Panayiotis Dimitriadis, Filio Spanoudi, Sotirios A. Raptis, George Dimitriadis

“…The aim of this randomised, crossover study was to investigate the effect of vinegar on glucose metabolism in muscle which is the most important tissue for insulin-stimulated glucose disposal. Materials and Methods. …”
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Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms by Ruiqi Chen, Xing Lu, Anqi Xiao, Junpeng Ma, Junpeng Ma

“…Given that structural losses are assumed to be the root cause of cognitive impairment in AD, strengthening neurotrophic pathways may be a useful preventative therapeutic approach. Insulin-like growth factor-2 (IGF2), which is widely expressed in the central nervous system (CNS), has emerged as a crucial mechanism of synaptic plasticity and learning and memory, and many studies have indicated that this neurotrophic peptide is a viable candidate for treating and preventing AD-induced cognitive decline. …”
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Efficiency of Stem Cell (SC) Differentiation into Insulin-Producing Cells for Treating Diabetes: a Systematic Review by Marzieh Nemati, GolamHossein Ranjbar Omrani, Bahareh Ebrahimi, Aliakbar Alizadeh

“…This search was done in PubMed, Web of Science (WOS), and Scopus using keywords “insulin-producing cell (IPC),” “pancreatic B cell,” “insulin-secreting cell,” “stem cell,” “progenitor cells,” “mother cell,” and “colony-forming unit.” …”
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Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level by Monika Pazgan-Simon, Anna Szymanek-Pasternal, Joanna Górka-Dynysiewicz, Anna Nowicka, Krzysztof Simon, Ewa Grzebyk, Michał Kukla

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The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway by Nana Wang, Tiegang Li, Ping Han

“…Thus TMXKP appears to be a promising insulin sensitizer.…”
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İdyopatik Hirşutizm Hastalarında QT Dispersiyonu by Tuncay Delibaşı, Ekrem Yeter, Sadık Açıkel, Uğur Arslantaş, Mustafa Gökhan Vural, Mehmet Doğan, Evrim Çakır, Tolga Çimen

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Insulin autoimmune syndrome in a 3-year-old boy: the youngest to date in China and a narrow review by Ming Cheng, Yuan Ding, Dongmei Wang, Chunxiu Gong

Subjects: “…Anti-insulin antibody…”
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