Reproductive performance of female largemouth bass (Micropterus salmoides) broodstock was enhanced by dietary small peptides by Jie Wei, Mingwei Tao, Jiaming Huang, Hangxian Zhou, Qiyou Xu

“…The mRNA expression levels of vgr (1.90 ± 0.29), insulin-like growth factor-1 (1.53 ± 0.67), steroidogenic acute regulatory protein (2.59 ± 0.78), fshr (1.97 ± 0.35) and cyp17a (2.78 ± 1.32) in gonad were up-regulated in the HS group (P < 0.05). …”
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CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp by Jie Zhang, Liqiang Zhang, Xiaoman Wu, Minhui Tao, Yang Chen, Mingxian Chang

“…Compared with uninfected WT grass carp, the uninfected PI4KB F0 juvenile grass carp crispants exhibit a higher expression level of many genes involved in growth- and development-related metabolic pathways such as the FoxO signaling pathway and insulin signaling pathway. Compared with WT grass carp without infection, PI4KB F0 juvenile grass carp crispants without infection or WT grass carp infected with GCRV-II, higher expression levels for many genes involved in metabolic diseases and viral infections were observed in the liver from PI4KB F0 juvenile grass carp crispants infected with GCRV-II. …”
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The effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis by Yijia Song, Yijia Song, Yijia Song, Sutong Liu, Lihui Zhang, Lihui Zhang, Wenxia Zhao, Yuanmei Qin, Yuanmei Qin, Minghao Liu

“…Probiotics and Allogenic FMT was associated with a significant reduction of Homeostatic Model Assessment for Insulin Resistance [HOMA-IR, (MD: −0.7, 95%CI: −1.26, −0.15), (MD: −1.8, 95%CI: −3.53, − 0.07)]. …”
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Atherosclerotic Risk Factors in Children with Celiac Disease by Anna Rybak, Aldona Wierzbicka, Piotr Socha, Anna Stolarczyk, Bożena Cukrowska, Łukasz Obrycki, Zbigniew Wawer, Roman Janas, Beata Oralewska, Anna Szaflarska-Popławska, Barbara Iwańczak, Elżbieta Cyrta-Jarocka, Urszula Grzybowska-Chlebowczyk, Wojciech Cichy, Grażyna Czaja-Bulsa, Jerzy Socha

“…Analysis of physical activity showed an increase in the insulin levels with inactivity (r=0.36; p=0.0025). …”
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Significance of Biogenetic Markers in Giant Cell Tumor Differentiation and Prognosis: A Narrative Review by Muhammad Taqi, Haseeb ul Rasool, Mobeen Zaka Haider, Munjed Al Muderis

“…MDM2 (mouse double minute 2 homolog), IGF1 (insulin-like growth factor 1), STAT1 (signal transducer and activator of transcription 1), and RAC1 (Ras-related C3 botulinum toxin substrate 1) are associated with GCTB recurrence, and might serve as biomarkers for it. …”
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Impact of the initiation of isCGM soon after type 1 diabetes mellitus diagnosis in adults on glycemic indices and fear of hypoglycemia: a randomized controlled trial by Jerzy Hohendorff, Jerzy Hohendorff, Agata Grzelka-Wozniak, Marta Wrobel, Michal Kania, Michal Kania, Lidia Lapinska, Dominika Rokicka, Dorota Stoltny, Irina Kowalska, Krzysztof Strojek, Dorota Zozulinska-Ziolkiewicz, Maciej T. Malecki, Maciej T. Malecki

“…All participants were on multiple daily insulin injections. TB70 changed from 2.42% to 2.25% in the intervention, and from 2.81% to 1.82% in the control group, and the between-therapy difference of 0.83% was insignificant. …”
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Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers by Xiufen Zheng, Zikai Chen, Miao Liang, Liting Zhou, Miaoru Wang, Silin Zhang, Shuyun Zhang, Lei Ma, Wei Yi, Xiawen Liu

“…It is characterized by hyperandrogenism, ovulatory dysfunction, and the presence of polycystic ovarian morphology (PCOM) on ultrasound, often accompanied by metabolic disturbances such as insulin resistance and obesity. Current treatments, including oral contraceptives and anti-androgen medications, often yield limited efficacy and undesirable side effects. …”
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Predicting Time in Range Without Hypoglycaemia Using a Risk Calculator for Intermittently Scanned CGM in Type 1 Diabetes by Fernando Sebastian‐Valles, Jose Alfonso Arranz Martin, Julia Martínez‐Alfonso, Jessica Jiménez‐Díaz, Iñigo Hernando Alday, Victor Navas‐Moreno, Teresa Armenta Joya, Maria del Mar delFandiño García, Gisela Liz Román Gómez, Jon Garai Hierro, Luis Eduardo Lander Lobariñas, Carmen González‐Ávila, Purificación deMartinez de Icaya, Vicente Martínez‐Vizcaíno, Miguel Antonio Sampedro‐Nuñez, Mónica Marazuela

“…Results Out of 2314 models explored, the most effective predictor model included annual net income per person, sex, age, diabetes duration, pre‐isCGM HbA1c, insulin dose/kg, and the interaction between sex and HbA1c. …”
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Multiomics unravels the complexity of male obesity: a prospective observational study by Georgios E. Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J. Niederländer, Michela Adamo, James S. Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan, Julijana Ivanisevic, Emmanuelle Paccou, Hector Gallart-Ayala, Tim Reyns, Elise Van Caeneghem, Bruno Lapauw, Jérôme Pasquier, Yasser Aleman, Styliani Mantziari, Olivier Salamin, Raul Nicoli, Tiia Kuuranne, Tom Fiers, Patric Hagmann, Federico Santoni, Andrea Messina, Nelly Pitteloud

“…Despite having comparable body mass indices, obese individuals with HH presented with worse metabolic defects than obese individuals without HH, including higher insulin resistance, as well as MRI signs of hypothalamic inflammation and a specific blood transcriptomics signature. …”
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Emirates consensus recommendations on cardiovascular risk management in type 2 diabetes by Hani Sabbour, Hani Sabbour, Hani Sabbour, Wael Almahmeed, Wael Almahmeed, Fatheya Alawadi, Fatheya Alawadi, Abdullah Shehab, Abdulamjeed Al Zubaidi, Alaaeldin Bashier, Abdul Rauf Ghulam, Fauzia Rashid, Hosam Zaky, Hussien Heshmat Kassemn, Hussien Heshmat Kassemn, Jamila Bin Adi, Juwairia Tahir, Khadija Hafidh, Mohammed Farghali, Mohamed Hassanien, Mohamed Hassanien, James Januzzi

“…While SGLT2i must be an important part of the standard of care, insulin, GLP1 receptor agonists and/or metformin can be useful for additional glycemic control.ConclusionThe consensus panel hopes that the recommendations presented herein can offer guidance for optimal screening, treatment and referral of people with a concomitance of diabetes and high cardiovascular risk in the United Arab Emirates.…”
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Urinary biomarkers for diagnosing acute kidney injury in sepsis in the emergency department by Sumin Baek, Inwon Park, Seonghye Kim, Young Woo Um, Hee Eun Kim, Kyunghoon Lee, Jae Hyuk Lee, You Hwan Jo

“…Initial urine samples were collected, and urinary biomarkers (dickkopf-3, soluble triggering receptor expressed on myeloid cells-1, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin (NGAL), and tissue inhibitor of metalloproteinases-2 (TIMP-2), and insulin-like growth factor binding protein-7 (IGFBP-7), and TIMP-2 × IGFBP-7) were analyzed using an enzyme-linked immunosorbent assay kit. …”
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Impaired hemodynamic forces assessed by routine CMR and its determinants in different duration T2DM patients with normal LV function and myocardial strain by Guozhu Shao, Guozhu Shao, Guozhu Shao, Yukun Cao, Yukun Cao, Yukun Cao, Yue Cui, Yue Cui, Yue Cui, Hongyan Li, Heshui Shi, Heshui Shi, Heshui Shi

“…In addition, HDF Strength (RMS) L-S (%) was also independently correlated with insulin treatment(β = 0.291, p = 0.013).ConclusionsHDF analysis can provide valuable insights into subclinical myocardial dysfunction prior to changes in ejection fraction and myocardial strain, suggesting that HDF analysis may be a potential early marker of subclinical myocardial dysfunction. …”
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Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza

“…Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor gamma (PPARγ) ligand, has been reported to act as insulin sensitizer and exert cardiovascular actions. …”
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Case Report: Efficacy and safety of recombinant growth hormone therapy in a girl with Loeys–Dietz syndrome by Kamil Dyrka, Aleksander Jamsheer, Michal Bartecki, Waldemar Bobkowski, Malgorzata Pawelec-Wojtalik, Justyna Rajewska-Tabor, Andzelika Tomaszewska, Justyna Balcerzak, Zuzanna Aniol, Marek Niedziela, Monika Obara-Moszynska

“…At age 6, GHD was recognized [the maximum GH after stimulation 7.2 ng/ml; insulin-like growth factor-1 (IGF-1), 35 ng/ml; N: 84–447]. …”
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Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with Clonorchis sinensis by Zeli Tang, Zeli Tang, Zeli Tang, Caibiao Wei, Xueling Deng, Qiumei Lin, Qiping Hu, Qiping Hu, Qiping Hu, Shitao Li, Jilong Wang, Yuhong Wu, Dengyu Liu, Dengyu Liu, Dengyu Liu, Min Fang, Min Fang, Tingzheng Zhan, Tingzheng Zhan, Tingzheng Zhan

“…Furthermore, C. sinensis triggered inflammation, insulin resistance, and pro-tumor immune escape, and exacerbated the complication of degenerative diseases.ConclusionThis study not only provides compelling evidence for elucidating the mechanisms underlying C. sinensis-mediated HCC development but also identifies potential therapeutic targets for HCC patients co-infected with C. sinensis.…”
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Relationship between mucin gene polymorphisms and different types of gallbladder stones by Gongqing Ren, Yongmao Fan, Ruizi Zhong, Gang Zou, Xiaojun Huang, Yue Zhang

“…The development of gallstones is linked to abnormal cholesterol and bilirubin metabolism, reduced gallbladder function, insulin resistance, biliary infections, and genetic factors. …”
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IGF2BP3 curbed by miR-15c-3p restores disrupted lipid storage and progesterone secretion in chicken granulosa cells under oxidative stress through AKT-Raf1-ERK1/2 signaling pathway by Zhongzhen Lin, Yanrong Gong, Chunlin Yu, Chaowu Yang, Lingqian Yin, Donghao Zhang, Yuan Tang, Feng Xu, Ye Wang, Yiping Liu

“…Functional validation with miR-15c-3p mimic and inhibitor confirmed the role of miR-15c-3p in exacerbating oxidative stress and resultant suppression of lipid droplet storage and progesterone secretion in chicken granulosa cells by targeting insulin-like growth factor 2 binding protein 3 (IGF2BP3). …”
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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model by Wei Xu, Yang Zhou, Ling Lin, Dongyin Yuan, Yingqi Peng, Li Li, Wenjun Xiao, Zhihua Gong

“…These teas can promote blood glucose transport and absorption by upregulating the protein and mRNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and mRNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. …”
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The Efficacy and Safety of the Chinese Herbal Formula, JTTZ, for the Treatment of Type 2 Diabetes with Obesity and Hyperlipidemia: A Multicenter Randomized, Positive-Controlled, Op... by Xiaotong Yu, Lipeng Xu, Qiang Zhou, Shengping Wu, Jiaxing Tian, Chunli Piao, Hailong Guo, Jun Zhang, Liping Li, Shentao Wu, Meizhen Guo, Yuzhi Hong, Weirong Pu, Xiyan Zhao, Yang Liu, Bing Pang, Zhiping Peng, Song Wang, Fengmei Lian, Xiaolin Tong

“…JTTZ also appeared to alleviate insulin resistance and increase HOMA-β. In addition, symptoms were significantly relieved in participants in the JTTZ group compared to those in the MET group. …”
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Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts by Yanqiu Huang, Yi Zhou, Yadan Xu, Xiaoyu Wang, Ziyi Zhou, Kang Wu, Qiqi Meng, Liao Wang, Yang Yang, Hong Gao, Juan Ji, Xu Jiang, Yang Yang, Lipeng Hao, Hui Wang

“…Results Five measures of insulin resistance were linked to CVD and related death in a U-shaped pattern, with the highest group having different risk increases. …”
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