Circulating T Cell Subsets in Type 1 Diabetes by Aldo Ferreira-Hermosillo, Paola Santana-Sánchez, Ricardo Vaquero-García, Manuel R. García-Sáenz, Angélica Castro-Ríos, Adriana K. Chávez-Rueda, Rita A. Gómez-Díaz, Luis Chávez-Sánchez, María V. Legorreta-Haquet

“…Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. …”
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Annexin V+ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study by Vibeke Bratseth, Hanna D. Margeirsdottir, Gemma Chiva-Blanch, Martin Heier, Svein Solheim, Harald Arnesen, Knut Dahl-Jørgensen, Ingebjørg Seljeflot

“…This indicates that our young diabetics on intensive insulin treatment have preserved vascular homeostasis and absence of procoagulant cMVs.…”
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Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis by Prabhakar Yellanur Konda, Vijayakumar Poondla, Krishna Kumar Jaiswal, Sreenivasulu Dasari, Reddemma Uyyala, Venkata Prasad Surtineni, Janardhan Yadav Egi, Anthony Johnson Antony Masilamani, Lakshmi Bestha, Sreenath Konanki, Muthukumaran Muthulingam, Lakshman Kumar Lingamgunta, Bindu Prasuna Aloor, Sridevi Tirumalaraju, Ankanna Sade, Venkata Ratnam Kamsala, Sreeharsha Nagaraja, Ranjani Ramakrishnan, Vijayakumar Natesan

“…Reduction (p < 0.05) in insulin resistance (5.20 ± 0.03), lipid profile (TC 120 ± 0.05; TG 160 ± 0.24; HDL 38 ± 0.03), liver lipid peroxidation (0.7 ± 0.01), hepatic enzyme markers (AST 82 ± 0.06; ALT 78 ± 0.34; ALP 42 ± 0.22), and hepatic steatosis by increasing liver antioxidant potential (CAT 1.4 ± 0.30; GSH 1.04 ± 0.04; SOD 0.82 ± 0.22) with normal hepatic triglycerides (15 ± 0.02) and glycogen (0.022 ± 0.15) contents and also showed normal liver size, less accumulation of lipid droplets with only a few congestion. …”
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Intravitreal Bevacizumab (Avastin) for Diabetic Retinopathy: The 2010 GLADAOF Lecture by J. Fernando Arevalo, Juan G. Sanchez, Andres F. Lasave, Lihteh Wu, Mauricio Maia, Sergio Bonafonte, Miguel Brito, Arturo A. Alezzandrini, Natalia Restrepo, Maria H. Berrocal, Mario Saravia, Michel Eid Farah, Jans Fromow-Guerra, Virgilio Morales-Canton

“…Most patients had poorly controlled diabetes mellitus associated with elevated HbA1c, insulin administration, PDR refractory to panretinal photocoagulation, and longer time between IVB and vitrectomy.…”
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Class 3 Obesity in a Multidisciplinary Metabolic Weight Management Program: The Effect of Preexisting Type 2 Diabetes on 6-Month Weight Loss by David M. Medveczky, Raymond Kodsi, Kathryn Skelsey, Kathy Grudzinskas, Flavia Bueno, Vincent Ho, Nic Kormas, Milan K. Piya

“…The multidisciplinary medical management of obesity can be difficult in T2DM due to potential weight gain from medications including sulphonylureas and insulin. However, newer weight-neutral/losing diabetes medications can aid additional weight loss. …”
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Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats by Michael J. Butler, Stephanie M. Muscat, Maria Elisa Caetano-Silva, Akriti Shrestha, Brigitte M. González Olmo, Sabrina E. Mackey-Alfonso, Nashali Massa, Bryan D. Alvarez, Jade A. Blackwell, Menaz N. Bettes, James W. DeMarsh, Robert H. McCusker, Jacob M. Allen, Ruth M. Barrientos

“…However, changes to fasting glucose, insulin, and inflammation in peripheral tissues such as the distal colon and visceral adipose tissue were increased in young and aged rats only after long-term, but not short-term, HFD consumption. …”
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Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study by Zhen Guo, Zhenyu Xiong, Lixiang He, Shaozhao Zhang, Xinghao Xu, Guanzhong Chen, Mengjie Xie, Wenjing Zhang, Ziwen Hui, Jiaying Li, Xinxue Liao, Xiaodong Zhuang

“…Abstract Background Triglyceride-glucose-BMI (TyG-BMI) index is a surrogate marker of insulin resistance and an important predictor of cardiovascular disease. …”
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Dairy Foods in a Moderate Energy Restricted Diet Do Not Enhance Central Fat, Weight, and Intra-Abdominal Adipose Tissue Losses nor Reduce Adipocyte Size or Inflammatory Markers in... by Marta D. Van Loan, Nancy L. Keim, Sean H. Adams, Elaine Souza, Leslie R. Woodhouse, Anthony Thomas, Megan Witbracht, Erik R. Gertz, Brian Piccolo, Andrew A. Bremer, Michael Spurlock

“…No diet differences were observed in weight, fat, or IAAT loss; nor SAT mRNA expression of inflammation, circulating cytokines, fasting lipids, glucose, or insulin. There was a significant increase (P=0.02) in serum 25-hydroxyvitamin D in the AD group. …”
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A comprehensive review of probiotics and human health-current prospective and applications by Bhutada Sarita, Dahikar Samadhan, Md Zakir Hassan, Md Zakir Hassan, Elena G. Kovaleva

“…Recent studies indicate that probiotics may assist in the regulation of weight and blood glucose levels and influence metabolism and insulin sensitivity. Emerging research indicates that the “gut-brain axis” connects mental and gastrointestinal health. …”
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High-starchy carbohydrate diet aggravates NAFLD by increasing fatty acids influx mediated by NOX2 by Yuqi Gao, Rui Hua, Kezheng Peng, Yuemiao Yin, Chenye Zeng, Yannan Guo, Yida Wang, Liyuan Li, Xue Li, Ying Qiu, Zhao Wang

“…Moreover, the large amounts of ROS produced by NOX2 further exacerbated insulin resistance and increased lipolysis in perirenal white adipose tissue (periWAT), thereby providing fatty acids for hepatic lipid synthesis. …”
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Angiographic Restenosis in Coronary Bifurcations Treatment with Regular Drug Eluting Stents and Dedicated Bifurcation Drug-Eluting BiOSS Stents: Analysis Based on Randomized POLBOS... by Robert J. Gil, Jacek Bil, Adam Kern, Luis A. Iñigo-Garcia, Radoslaw Formuszewicz, Slawomir Dobrzycki, Dobrin Vassilev, Roxana Mehran

“…In multivariate regression analysis proximal optimization technique was associated with the lowest chance for restenosis (OR 0.15, 95% CI 0.06–0.33), whereas diabetes on insulin was associated with the highest risk of restenosis (OR 4.21, 95% CI 1.48–11.44). …”
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Prescription pattern, glycemic control status, and predictors of poor glycemic control among diabetic patients with comorbid chronic kidney disease in Ethiopia: a facility-based cr... by Oumer Sada Muhammed, Minimize Hassen, Samuel Mamusha

“…Only 4.4% achieved good glycemic control (glycated hemoglobin [HbA1c] < 7%), while 95.6% had poor glycemic control (HbA1c ≥ 7%). Insulin, metformin, and sodium glucose cotransporter-2 (SGLT-2) inhibitors were the most frequently prescribed anti-diabetic drug classes which accounted for 80.2%, 59.1%, and 41.4%, respectively. …”
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Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency by Yunting Zhou, Junming Zhou, Yumin Zhang, Jun Tang, Bo Sun, Wei Xu, Xiaohang Wang, Yang Chen, Zilin Sun

“…VAD diet-fed mice displayed reduction of tissue VA levels, increased area under the curve (AUC) of glucose challenge, reduced glucose-stimulated insulin secretion, and loss of β cell mass. Redundancy analysis showed intestinal microbiota diversity was significantly associated with AUC of glucose challenge and β cell mass. …”
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Triglyceride glucose index–body mass index as a predictor of coronary artery disease severity in patients with H-type hypertension across different glucose metabolic states by Lian Wang, Zijin Li, Rui Qiu, Li Luo, Xisheng Yan

“…Abstract Background The triglyceride glucose-body mass index (TyG-BMI) is considered to be a reliable surrogate marker of insulin resistance (IR). However, limited evidence exists regarding its association with the severity of coronary artery disease (CAD), particularly in hypertensive patients with different glucose metabolic states, including those with H-type hypertension. …”
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Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…Confounders included for adjustment were age, sex, and comorbidities (hypertension, hyperlipidemia, coronary artery disease, obesity, diabetic retinopathy, chronic kidney disease, and insulin treatment). Furthermore, propensity score (PS) matching method was used to choose the matched sample, and PS-adjusted Cox regression was performed. …”
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The Role of Physical Activity in Pregnancy: Impact on Preeclampsia, Gestational Diabetes Mellitus, and Labor Outcomes by Paulina Woźniak, Ewa Wietrzykowska, Wiktoria Gajek-Flanczewska, Sebastian Flanczewski, Małgorzata Wirkijowska, Jakub Wirkijowski, Katarzyna Wójtowicz, Agata Walczak, Dominika Sobolewska, Katarzyna Michalczyk-Fraszka, Martyna Śliwińska, Anna Podraza

“…Additionally, women with GDM treated with insulin who regularly participate in PA require a lower dosage compared to those leading sedentary lifestyles. …”
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Single-cell RNA sequencing reveals the dysfunctional characteristics of PBMCs in patients with type 2 diabetes mellitus by Jindong Zhao, Jindong Zhao, Jindong Zhao, Zhaohui Fang, Zhaohui Fang, Zhaohui Fang

“…The observed clinical indicators included weight and fasting blood glucose (FBG), glycosylated haemoglobin A1c (HbA1c) and fasting insulin levels. Direct separation and purification of peripheral blood mononuclear cells (PBMCs) were performed via the Ficoll density gradient centrifugation method. …”
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Effect of 2,4-Thiazolidinedione on Limousin Cattle Growth and on Muscle and Adipose Tissue Metabolism by M. Arévalo-Turrubiarte, L. González-Dávalos, A. Yabuta, J. D. Garza, J. L. Dávalos, O. Mora, A. Shimada

“…The main adipogenic transcription factor PPARγ possesses high affinity to 2,4-TZD, a member of the Thiazolidinedione family of insulin-sensitizing compounds used as adipogenic agents. …”
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Sex-specific alterations in creatine metabolism in cellular compartments of peripheral blood leukocytes in type 1 diabetes by Nina Alchujyan, Elena Aghajanova, Nina Movsesyan, Arthur Melkonyan, Artashes Guevorkian, Armen Andreasyan, Margarita Hovhannisyan

“…This study aimed to investigate this system in the peripheral blood leukocytes (PBL) of Armenians with type 1 diabetes (T1D) who received insulin therapy. A total of 270 Armenian participants were enrolled in the study and were divided into two age groups: Group I - included children and preadolescents; and Group II - included adolescents and young adults. …”
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Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide by Martin Javorský, Eva Babjaková, Lucia Klimčáková, Zbynek Schroner, Jozef Židzik, Mária Štolfová, Ján Šalagovič, Ivan Tkáč

“…All sulfonylureas stimulate insulin secretion by the closure of ATP-sensitive potassium (KATP) channel. …”
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