Exploring the comorbidity mechanisms between atherosclerosis and hashimoto’s thyroiditis based on microarray and single-cell sequencing analysis by Yirong Ma, Shuguang Wu, Junyu Lai, Qiang Wan, Jingxuan Hu, Yanhong Liu, Ziyi Zhou, Jianguang Wu

“…Lastly, Single-cell analysis was instrumental in uncovering common diagnostic markers. …”
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The efficacy and safety of peroperative statin treatment during coronary artery bypass grafting by I.V. Shklianka, O.J. Zharinov, К.O. Mikhaliev, O.A. Yepanchintseva, B.M. Todurov

“…The data from clinical and instrumental examination of 155 patients with stable coronary heart disease (CHD) consecutively selected for CABG surgery were analyzed in a single-center study. …”
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Large language models generating synthetic clinical datasets: a feasibility and comparative analysis with real-world perioperative data by Austin A. Barr, Joshua Quan, Eddie Guo, Emre Sezgin, Emre Sezgin

“…BackgroundClinical data is instrumental to medical research, machine learning (ML) model development, and advancing surgical care, but access is often constrained by privacy regulations and missing data. …”
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Global longitudinal strain and its dynamics after replacement of aortal valve in patients with severe aortic stenosis by N.V. Ponych, O.O. Nemchyna, O.J. Zharinov, O.A. Yepanchintseva, B.M. Todurov

“…All patients underwent clinical and instrumental study, including transthoracic echocardiography (TTE) and coronary angiography. …”
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Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension by Jia-Yong Qiu, Shen-Shen Huang, Chao Liu, Dong Ding, Yan-Hong Xu, Yi-Min Mao, Ya-Dong Yuan

“…Methods We utilized genetic variants associated with CH as instrumental variables, identified from two large genome-wide association studies (GWAS) involving 359,088 participants in the discovery cohort and 184,121 participants in the validation cohort, all of European descent. …”
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Natural population cohort study on long-lived adults: West China longevity and ageing procedure (WCLAP) by Li Wang, Yan Zhang, Qiukui Hao, Xiaoyan Chen, Birong Dong, Yan He, Meijuan Chen, Jirong Yue, Xiaochu Wu, Tianyao Zhang, Yan She, Yanling Gao, Yiping Deng

“…Data collection included a comprehensive assessment of the participant’s health (including physical, psychological, social and common chronic disease assessments), instrumental tests (body composition and muscle percentage) and the collection of biomedical-biobank samples (include blood, urine, faeces, hair and urine).Future plans Through the annual cohort follow-up, survival-related information is collected at a group level. …”
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Self-assessment of didactic performance of psychology and education professors in Mexico and Peru by Aldo Bazán-Ramírez, Walter Capa-Luque, Roberto Chávez-Nava, Mónica C. Dávila-Navarro, Homero Ango-Aguilar, Edmundo Hervias-Guerra, Catalina Bello-Vidal

“…Method: Methodological, instrumental, descriptive, comparative and predictive cross-sectional study. …”
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Patients’ Perspectives on the Preference for the Gender of Medical Professionals in Perioperative Care and Attitudes Toward Anaesthesiologists: A Cross-sectional Study by Usha Devi, Minnu Panditrao, Shilpa Bansal

“…As women’s roles in healing became more complex and lucrative, they faced social opposition to taking on instrumental healing tasks. Currently, women make up about 50% of the medical workforce; however, they still face discrimination in healthcare due to their gender, both from patients and professional colleagues. …”
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Knowledge, Attitudes, and Practices of ICU Medical Staff toward Nutrition Care and its Impact on Patient Recovery in Taiz, Yemen by Haitham T. S. Mohammed, Lamia A. S. Ali, Malak Anwar Saif, Nada Khalid Al-Adeemy, Noha Kamel Al-Nadhary, Raghad Sameer Saif, Shaima Kamel Al-Nadhary, Yomna Mukarram Al-Dobai, Nur Mufida Wulan Sari

“…ICU medical staff are instrumental in providing appropriate nutritional care, which significantly affects patients' health outcomes. …”
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Malnutrition among the Elderly in Malaysia and Its Associated Factors: Findings from the National Health and Morbidity Survey 2018 by Mohamad Hasnan Ahmad, Ruhaya Salleh, Cheong Siew Man, Munawara Pardi, Norsyamlina Che Abdul Rahim, Norhafizah Shahril, Mohd Hatta Abdul Mutalib, Suzana Shahar, Noor Ani Ahmad

“…Complex sample multiple logistic regression found that the elderly who lived in a rural area, with no formal or primary level of education, had depression, Instrumental Activity of Daily Living (IADL) dependency, and low quality of life (QoL), were underweight, and had food insecurity and inadequate plain water intake were at a significant risk of malnutrition (malnutrition and at-risk), while Chinese, Bumiputra Sarawak, and BMI more than 25 kgm−2 were found to be protective. …”
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Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…In summary, we generated a number of genetic and biochemical tools that were exploited for an initial characterization of Non3, and will be instrumental for future functional studies on this gene and its protein product.…”
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Digital transformation of relocated higher education institutions in Ukraine under martial law by Hanna Alieksieieva, Nataliia Kravchenko, Larysa Horbatiuk, Tetyana Nestorenko, Viktoriia Zhyhir, Antonina Kalinichenko, Yana Glazova

“…Over 85% of surveyed participants identified learning management systems’ platforms as pivotal in maintaining educational quality, while AI chatbots were instrumental during crises, offering real-time communication and support even during power outages. …”
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GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells by Sonia Bergante, Pasquale Creo, Marco Piccoli, Andrea Ghiroldi, Alessandra Menon, Federica Cirillo, Paola Rota, Michelle M. Monasky, Giuseppe Ciconte, Carlo Pappone, Pietro Randelli, Luigi Anastasia

“…In particular, we found an increase of GM1 levels during osteogenesis that is instrumental for driving the process. In fact, supplementation of the ganglioside in the medium significantly increased the osteogenic differentiation capability of hTSCs. …”
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) by Mengmeng Shi, Yike Wang, Peng Lv, Yujie Gong, Qi Sha, Xinyan Zhao, Wen Zhou, Lingtao Meng, Zegang Han, Lingxiao Zhang, Lingxiao Zhang, Yongwang Sun, Yongwang Sun

“…Additionally, they are instrumental in modulating stress responses in plants. …”
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Effects of biophilic virtual reality on cognitive function of patients undergoing laparoscopic surgery: study protocol for a sham randomised controlled trial by Bin Gao, Yanling Zhou, Jianhua Wang, Binbin Zhu, Qiuyan Weng, Wenjun Luo, Xiuchao He, Lufei Jin, Qinwen Wang, Ahmad Khaled Ahmad Harb

“…Secondary outcomes include perioperative anxiety and instrumental activities of daily living. Changes in the performance of the neurocognitive batteries are measured by a local resident doctor. …”
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Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases by Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu

“…Bidirectional Mendelian randomization (MR), employing instrumental variables (IVs), was used to assess causal relationships. …”
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Association of workforce participation with depression among US older adults: results from NHANES 2005–2018 by Zhenyu Sun, Yi Wang, Xi Chen, Dongfu Qian

“…Analyses of subgroup and sensitivity were conducted: using data from non-multiple imputation, participants aged over 65, and all non-excluded participants aged 60 or above to execute repeated analysis; recruiting propensity score matching (PSM) method that focused on selected SDoH, lifestyle, and health status-related factors to strengthen essential comaparability between workers and non-workers; employing two-stage least squares (2SLS) model and setting retirement age (over 65 years or not) as an instrumental variable (IV) to solve the potential reverse causation between work status and depression. …”
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Impact of gas composition, pressure, and temperature on interfacial Tension dynamics in CO₂-Enhanced oil recovery by Rahul Gajbhiye

“…This knowledge is instrumental in designing processes such as CO2-EOR and condensate banking, incorporating the effects of pressure, temperature, and gas composition at the reservoir scale.…”
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Classification of Slovenian Dry-Cured Ham – Kraški pršut – According to Texture Profile by Mateja Lušnic Polak, Tomaž Polak, Mojca Kuhar, Iva Zahija Jazbec, Tadej Kaltnekar, Lea Demšar

“…Slices cut transversally from the thigh at approximately 8 cm from the femur head were used for physicochemical parameter (pH, contents of moisture, total fat, protein, NaCl, and NPN) analysis, instrumental texture analysis profile analysis (TPA), and sensory analysis. …”
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Characterizing a complex buildup in the Pearl River Mouth Basin of the northern South China Sea: an interplay of carbonates and igneous rocks by Beichen Chen, Leyi Xu, Baojun Liu, Lili Zhang, Dong Xiao, Ya Gao, Ya Gao, Feng Wu, Xueqi Yang, Yaming Zou, Yongkun Ma, Yinglin Zhang

“…Furthermore, the analysis of high-quality reservoir development within the complex buildups is instrumental for advancing oil and gas exploration in volcanic seamounts and carbonate buildups.…”
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