Using Sequence Mining to Predict Complex Systems: A Case Study in Influenza Epidemics by Theyazn H. H. Aldhyani, Manish R. Joshi, Shahab A. AlMaaytah, Ahmed Abdullah Alqarni, Nizar Alsharif

“…The INTS model combines clustering with a time series model to enhance the prediction of influenza outbreaks. The innovation of our proposed model integrates the results obtained from the existing weighted exponential smoothing model with centroids obtained from clustering. …”
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Accurate phenotype-to-genotype mapping of high-diversity yeast libraries by heat-shock-electroporation (HEEL) by Marcus Wäneskog, Emma Elise Hoch-Schneider, Shilpa Garg, Christian Kronborg Cantalapiedra, Elena Schäfer, Michael Krogh Jensen, Emil Damgaard Jensen

“…Here, we describe an innovative yeast library transformation method that is both simple and highly efficient. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Moreover, the combination of biology and computational data will lead to the development of innovative target therapies dampening CSC-TME interaction. …”
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Evaluation of health care providers’ ability to identify patient-ventilator triggering asynchrony in intensive care unit: a translational observational study in China by Shengjun Liu, Zhangyi Zhao, Xiangyu Chen, Yi Chi, Siyi Yuan, Fuhong Cai, Zhangwei Song, Yue Ma, Huaiwu He, Longxiang Su, Yun Long

“…Further analysis based on professional title, role in critical care team, years of experience in managing invasive mechanical ventilation, number of published articles in the field of clinical critical respiratory medicine and training in respiratory waveform/respiratory mechanics was carried out among qualified professionals. A self-innovate Remote-VentlateView platform was used to discriminate the patient-ventilator triggering asynchrony. …”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…Our studies offer valuable insights, opening avenues for the development of innovative therapeutic strategies in the prevention and treatment of HFpEF.…”
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CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection by Shinichiro Hama, Miho Watanabe-Takahashi, Hiroki Nishimura, Jumpei Omi, Masakazu Tamada, Takashi Saitoh, Katsumi Maenaka, Yuta Okuda, Aoi Ikegami, Asami Kitagawa, Koudai Furuta, Kana Izumi, Eiko Shimizu, Takashi Nishizono, Makoto Fujiwara, Tomohiro Miyasaka, Shigeo Takamori, Hiroshi Takayanagi, Keizo Nishikawa, Toshihiko Kobayashi, Noriko Toyama-Sorimachi, Makoto Yamashita, Toshiya Senda, Takatsugu Hirokawa, Haruhiko Bito, Kiyotaka Nishikawa

“…Thus, regulation of the CaMKII-dependent non-canonical RIG-I pathway may provide a novel host-factor-directed antiviral therapy.IMPORTANCEThe recent emergence of IAV strains resistant to commonly used therapeutic agents that target viral proteins has exacerbated the need for innovative strategies. Here, we originally identified CaMKII-inhibitory peptide M3, which efficiently inhibits IAV-lethality in vitro and in vivo. …”
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Totally endoscopic mitral valve repair with novel technique of left atrial exposure: five years experience from a single center by Thanh Dat Pham, Thanh Huyen Tran, Ngoc Thanh Le, Cong Huu Nguyen

“…Abstract Background .Endoscopic mitral valve repair has progressively been adopted as the standard approach for treating isolated mitral regurgitation across numerous renowned cardiac surgery centers worldwide. Our innovative method for mitral valve exposure has been previously described. …”
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A quantitative PCR to detect non-toxigenic Clostridioides difficile by Khurshida Begum, Hubert C. Chua, M. Jahangir Alam, Kevin W. Garey, Jinhee Jo

“…In this study, we developed and validated a qPCR assay capable of uniquely identifying NTCD strains. This innovative assay holds significant potential for applications in public health, infection control, diagnostic, and therapeutic strategies related to CDI.…”
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Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response by Aquib Ehtram, Mohd Shariq, Neha Quadir, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain

“…Further studies focusing on their structure-function relationships and interactions with host proteins could accelerate the development of innovative therapeutic strategies.…”
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Current regenerative approaches to the treatment of generalized periodontitis in young people (literature review) by O.V Kopchak, I.V. Kovach, Y.V. Litvinova, K.A. Yanishevsky, N.S. Marchenko

“…The goal of this literature review was to identify innovative approaches to the reparation and regeneration of affected periodontal tissues that could be used as non-invasive treatment modes. …”
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Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial by Katsutoshi Sugimoto, Kento Imajo, Hidekatsu Kuroda, Go Murohisa, Kazue Shiozawa, Kentaro Sakamaki, Takuya Wada, Hirohito Takeuchi, Kei Endo, Tamami Abe, Takashi Matsui, Takahiro Murakami, Masato Yoneda, Atsushi Nakajima, Shigehiro Kokubu, Takao Itoi

“…Microwave ablation (MWA) is an innovative approach believed to have theoretical benefits over RFA; however, these advantages are yet to be empirically verified. …”
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University students’ ambition levels and vocational tendencies associated with common culture by H. A. Danaa, M. M. Al-mzary, W. N. Halasa, L. M. Obeidat, M. A. Rababah, M. Kh. Al-Alawneh

“…Educators can develop students’ ambition level and identify vocational tendencies to excel in their own goals toward innovation and creativity in light of the common culture.Practical significance. …”
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Visual analysis of Traditional Chinese Medicine nursing for lung cancer patients with chemotherapy induced nausea and vomiting based on CiteSpace (基于CiteSpace的肺癌患者化疗相关性恶心呕吐中医护理研究热点... by LIN Haiqing (林海青), CHEN Yang (陈扬), LIU Jie (刘杰), HOU Yanli (侯燕丽), BAI Xue (白雪), CHEN Mengna (陈梦娜), TANG Xinyu (唐新宇)

“…Conclusion Efforts had been made to investigate the effect of TCM nursing on chemotherapy-induced nausea and vomiting in recent two decades over china, and numbers of published studies continues to increase. Given the lack of innovation and in-depth studies, it is required to enhance the training of TCM nursing specialists and improve the quality of TCM nursing for lung cancer patients with nausea and vomiting (目的 采用知识图谱分析近二十年针对肺癌患者恶心呕吐中医护理领域的研究现状、热点和未来发展趋势。…”
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Impact of a new case-based payment scheme on volume distribution across public hospitals in Zhejiang, China: does ‘Same disease, same price’ matter by Meiteng Yu, Jing Liu, Tao Zhang

“…Abstract Background With the implementation of the hierarchical medical system (HMS) in China, Zhejiang Province introduced an innovative payment scheme called “payment method by disease types with point counting”. …”
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Assessment of Learning Styles of First-year Medical Students’ using VARK 8.02 Model Questionnaire: A Cross-sectional Study by Senthil Ganesh P Kannappan, Ravichandran Doraisamy, Vijayakumar Jagadesan

“…Introduction: Students are constantly in search of additional and innovative ways to stimulate their attention in learning various subjects. …”
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A web-based pilot randomized controlled trial to test the efficacy of education and contact-based interventions in reducing public suicide stigma by Nathalie Oexle, Matthias Lühr, Daniele Valacchi, Nicolas Rüsch

“…Future research should explore innovative and safe approaches to reduce public suicide stigma. …”
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Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics... by Chaoyan Yue, Qi Zhang, Fenyong Sun, Qiuhui Pan

“…Funding: This study was supported by National Natural Science Foundation of China (No. 82293662, No 82172357 and No 81930066), Key project of Shanghai ''Science and Technology Innovation Action Plan (22JC1402304) and Research fund of Shanghai Municipal Health Bureau (No. 2019cxjq03).…”
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Microstructural, Morphological, and Magnetic Effects of NiFe₂O₄ Shell Formation Around Nanospherical ZnFe₂O₄ Cores by Marija Šuljagić, Vuk Uskoković, Lukasz Kilanski, Sabina Lewinska, Abdul Khaliq, Anna Ślawska-Waniewska, Aleksandar Kremenović, Vladimir Pavlović, Dejan A. Jeremić, Ljubica Andjelković

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Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion by Carmine Pinto, Sara Lonardi, Evaristo Maiello, Erika Martinelli, Michele Prisciandaro, Lisa Salvatore, Lisa Salvatore, Andrea Sartore-Bianchi, Andrea Sartore-Bianchi, Mario Scartozzi, Giuseppe Aprile, Chiara Cremolini, Alberto Sobrero

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Avoiding ‘second victims’ in healthcare: what support do staff want for coping with patient safety incidents, what do they get and is it effective? A systematic review by Reema Harrison, Rebecca Lawton, Ruth Simms-Ellis, Raabia Sattar, Elizabeth Sweeting, Hannah Hartley, Matthew Morys-Edge

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