Selective epithelial expression of KRASG12D in the Oncopig pancreas drives ductal proliferation and desmoplasia that is accompanied by an immune response by Carlos P. Jara, Al-Murtadha Al-Gahmi, Audrey Lazenby, Michael A. Hollingsworth, Mark A. Carlson

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable challenge in oncology, characterized by a high mortality rate, largely attributable to delayed diagnosis and the intricacies of its tumor microenvironment. Innovations in modeling pancreatic epithelial transformation provide valuable insights into the pathogenesis and potential therapeutic strategies for PDAC. …”
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Analyzing the Perspectives of Instructors of General Medical Modules on the Inclusion of Health Humanities Fundamentals in the Curriculum by SeyedAmir Mohseni, Fattaneh Amuei, Siavash Moradi

“…The samples included university faculty members who had innovative educational processes and general course lecturers, or experts in medical education. …”
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Application of synthesized Fe3O4@Gelatin nanoparticles on interfacial properties and enhanced oil recovery by Hossein Ghalenavi, Abdolhossein Hemmati-Sarapardeh, Mahin Schaffie, Saeid Norouzi-Apourvari

“…Abstract Due to the unique properties of nanoparticles (NPs), their application has been proposed as an innovative and promising enhanced oil recovery (EOR) technique. …”
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The Role of 3D Virtual Anatomy and Scanning Environmental Electron Microscopy in Understanding Morphology and Pathology of Ancient Bodies by Sara Salucci, Mirko Traversari, Laura Valentini, Ilaria Versari, Luca Ventura, Emanuela Giampalma, Elena Righi, Enrico Petrella, Pietro Gobbi, Gianandrea Pasquinelli, Irene Faenza

“…Conclusions: These morphological and analytical techniques make it possible to study mummified bodies and describe their anatomical details in real size, in a non-invasive and innovative way, demonstrating that these interdisciplinary approaches could have great potential for improving knowledge in the study of ancient corpses.…”
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Effects of Different Intertillage Practices on Soil Biochemical Properties and Soybean Yield in Soybean Fields by Mingcong Zhang, Yanhong Zhou, Chenglin Li, Cheng Yuan, Mingfen Shan, Yuxin Fan, Zhongxia Yu, Linfeng Ren, Liu Cui, Chen Wang

“…The results provide a theoretical basis for increasing the yield and efficiency of soybean fields under corn–soybean rotation, as well as innovation and development of cultivation systems…”
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Regional-scale precision mapping of cotton suitability using UAV and satellite data in arid environments by Jianqiang He, Yonglin Jia, Yi Li, Asim Biswas, Hao Feng, Qiang Yu, Shufang Wu, Guang Yang, Kadambot.H.M. Siddique

“…This study addresses the critical issues of water scarcity and soil salinization impacting cotton production in South Xinjiang, China. It introduces an innovative framework for assessing regional cotton crop suitability by integrating ground-measured soil water and salt data with UAV multispectral and Sentinel-2A satellite imagery from the 2022 cotton growing season. …”
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Expression of CSTF2 in oral squamous cell carcinoma and its relationship with immune infiltration and poor prognosis by Zumulaiti Aierken, Muertiza Muhetaer, Zhang Lei, Ainiwaerjiang Abudourousuli, Ainiwaerjiang Abudourousuli

“…Notably, elevated CSTF2 expression is significantly associated with reduced patient outcomes.ConclusionElevated CSTF2 expression in OSCC is associated with poor prognostic outcomes, highlighting its capacity to function as an innovative prognostic biomarker and a target for therapeutic interventions.…”
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Inovação em segurança pública: um estudo bibliométrico by Carlos Nunes, Alexandre Augusto Biz, Patrícia de Sá Freire, Clarissa Stefani Teixeira, João André Rigo

“…Foram analisadas 261 publicações, sem filtro de tempo, espaço ou linguagem, encontradas na base de dados da Scopus, a partir da sintaxe: (“Public Security” or “Public Safety”) and Innovation. Os resultados evidenciam que há dois fortes movimentos, não dicotômicos, sendo desenvolvidos, em concomitância, na área de segurança pública: o primeiro, mais disciplinar, tem enfoque no desenvolvimento de tecnologias e na gestão da informação; o segundo, com enfoque mais transdisciplinar, trata, sobretudo, de ocupação territorial inteligente. …”
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Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model by Tatiane M. Preisser, Vanessa P. da Cunha, Mariana P. Santana, Vanessa B. Pereira, Denise C. Cara, Bianca M. Souza, Anderson Miyoshi

“…Therefore, our study demonstrates this innovative strategy provides immunomodulatory potential for further investigations in T1D and other autoimmune diseases.…”
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Screening fungi for use as biocatalysts in self-healing concrete with protocol simulating concrete environment by Ahsanul Kabir Sumon, Krutika Invally, Lu-Kwang Ju

“…The objective of this work was to develop an effective and innovative screening protocol that mimics not only the concrete-relevant pH and temperature but also the essential process/scenario of MESHC, that is, microbial spores remain dormant through the harsh conditions during concrete mixing and curing and germinate later at the less harsh condition (pH 9–11, ambient temperature) in concrete cracks. …”
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Gelatin/PLA-loaded gold nanocomposites synthesis using Syzygium cumini fruit extract and their antioxidant, antibacterial, anti-inflammatory, antidiabetic and anti-Alzheimer’s acti... by Manickam Rajkumar, S. I. Davis Presley, Nathiya Thiyagarajulu, Koyeli Girigoswami, Gopalarethinam Janani, Chinnaperumal Kamaraj, Bharathi Madheswaran, Bhupendra Prajapati, Nemat Ali, Mohammad Rashid Khan

“…Abstract Nanotechnology has experienced significant advancements, attracting considerable attention in various biomedical applications. This innovative study synthesizes and characterizes Ge/PLA/AuNCs (gelatin/PLA/gold nanocomposites) using Syzygium cumini extract to evaluate their various biomedical applications. …”
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Privacy-preserving approach for IoT networks using statistical learning with optimization algorithm on high-dimensional big data environment by Fatma S. Alrayes, Mohammed Maray, Asma Alshuhail, Khaled Mohamad Almustafa, Abdulbasit A. Darem, Ali M. Al-Sharafi, Shoayee Dlaim Alotaibi

“…In the period of big data, statistical learning has seen fast progressions in methodological practical and innovation applications. Privacy-preserving machine learning (ML) training in the development of aggregation permits a demander to firmly train ML techniques with the delicate data of IoT collected from IoT devices. …”
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Sustainable and smart multi-analyte HPTLC determination of tolperisone HCl together with three pain killers using smartphone camera as a detector: Comparative study with benchtop d... by Mohamed Rizk, Emad Ramzy, Safaa Toubar, Amr M. Mahmoud, Marwa I. Helmy

“…In this study, we developed a novel and cost-effective method for the simultaneous determination of four drugs (Tolperisone HCl (TOLP), aceclofenac(ACEC), Paracetamol (PARA), and etodolac (ETOD)). Our innovative approach combines high-performance thin-layer chromatography (HPTLC) with a smartphone's camera. …”
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A scoping review on the impact of women’s global leadership: evidence to inform health leadership by Anna Kalbarczyk, Rosemary Morgan, Kelly E Perry, Katherine Banchoff, Charlotte Pram Nielsen, Anju Malhotra

“…Studies found women leaders’ positive influence on six areas of impact: (1) financial performance, risk, and stability, (2) innovation, (3) engagement with ethical initiatives, (4) health, (5) organisational culture and climate outcomes, and (6) influence on other women’s careers and aspirations. …”
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Applying 3D‐Printed Porous Ti6Al4V Prostheses to Repair Osteomyelitis‐Induced Partial Bone Defects of Lower Limbs: Finite Element Analysis and Clinical Outcomes by Bingchuan Liu, Qizhao Tan, Zhengguang Wang, Guojin Hou, Caimei Wang, Yun Tian

“…Conclusions 3D‐printed porous Ti6Al4V prostheses effectively restore anatomical integrity and optimize stress conduction in lower limbs, resulting in substantial functional recovery. This innovative approach shows promise for wider clinical adoption and warrants further investigation in medical practice.…”
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Bayesian Estimation of the True Bovine Brucellosis Prevalence in Vaccinated and Non-Vaccinated Ecuadorian Cattle Populations, and the Sensitivity and Specificity of a Competitive a... by Ana Dolores Garrido Haro, Margoth Yolanda Barrionuevo Samaniego, Paola Moreno-Caballeros, Alexandra Burbano-Enríquez, Verónica Alexandra Salas Torres, María Cristina Galante Mulki, Constance Wielick, Jorge Ron-Román, Claude Saegerman

“…The results of this study suggest that, with similar Se and higher Sp, the iELISA based on an innovative synthetic antigen (which is more standardizable) should be recommended as a possible screening test for bB in Ecuador. …”
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Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species by Yuping Xiong, Chenchen Yi, Haixia Zheng, Ya Ni, Yamei Xue, Kun Li

“…Methods Protein palmitoylation in situ in mouse sperm was observed using innovative click chemistry. Sperm motility and motion parameters were evaluated using a computer-assisted sperm analyzer (CASA) after treatment with 2-bromopalmitic acid (2BP), a specific inhibitor of protein palmitoylation. …”
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Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…In that context, we have developed innovative bottom-up approaches towards ultrabright dye-based fluorescent organic nanoparticles (dFONs). …”
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Immune responses in rodent whole eye transplantation: elucidation and preliminary investigations into rejection diagnosis and monitoring by Bing Li, Yong Wang, Charles R. Owens, Touka Banaee, Charleen T. Chu, Kayvon Jabbari, Anna D. Lee, Neil J. Khatter, Alan G. Palestine, An-Jey A. Su, Christene A. Huang, Kia M. Washington

“…This study delves into the timeline and nature of immune responses in a rodent model of WET without immunosuppression, aiming to elucidate a detailed picture of the immune landscape post-transplantation and establish innovative diagnostic and monitoring methods.MethodsWe employed a multi-faceted approach to analyze immune responses post-WET, including assessments of gross changes in corneal transparency, thickness, and skin condition. …”
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Computational identification of anti-cancer compounds targeting the RNA-binding domain of human FOX-1 protein (RBFOX1) by Muhammad Tahir ul Qamar, Pablo Sanz-Jimenez, Shaima Rabeea Banoon, Xi-Tong Zhu, Fahad M. Aldakheel, Nahlah Makki Almansour, Leen A. Aldaiji, Wafa Abdullah I. Al-Megrin, Faisal Ahmad

“…The aforementioned processes are pivotal in cancer progression, making RBFOX1 a significant target for innovative cancer therapies. The present study seeks to identify new inhibitor compounds that obstruct the biological processes of the target protein associated with cancer. …”
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