Identification of Crotonylation Metabolism Signature Predicting Overall Survival for Clear Cell Renal Cell Carcinoma by Jie Zheng, Yingqing Liu, Kai Wei, Jiewu Shi, Lin Li, Xuefeng Jiang, Lingsong Tao

“…KAT2A shows strong associations with clinical factors and the immunosuppressive environment, suggesting potential for innovative immunotherapies in ccRCC treatment.…”
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Citrullinated Autoantigen–Specific T and B Lymphocytes in Rheumatoid Arthritis: Focus on Follicular T Helper Cells and Expansion by Coculture by Tim Ammon, Julia Zeiträg, Vanessa Mayr, Manuela Benedicic, Hans‐Peter Holthoff, Martin Ungerer

“…Novel combinations of major histocompatibility complex class II citrulline epitope tetramers were developed, which enabled robust detection of CAS T cells and showed increases of CAS‐naive T helper cells, Th1.17 cells, CAS total circulating T follicular helper (cTfh) cells, and cTfh1 cells in ACPA+ patients with RA. In addition, an innovative assay using dual labeling with CCP–biotin probes allowed for reproducible identification of primary CAS B cells after enrichment with advantages over existing detection methods. …”
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Development of an algorithm impacting COPD care through personalized nutrition and IoT-based monitoring by Prachi Sharma, Mihir Gharia, Devina Aswal, Vishva Trivedi, Bhavnita Soni, Prerna Soni, Devesh Joshi, Dhvni Lalan, Vrushali Athavale, Irfan Shaikh, Koshy Jacob

“…These findings highlight the promise of this innovative digital therapeutic approach in addressing chronic respiratory conditions.…”
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The value-for-money assessment and funding arrangements for high-priced drugs in an era of uncertainty: a comparative analysis of national health technology assessment agencies in... by Jihyung Hong, Eun-Young Bae, Sohee Cha, Joohyun Lee

“…Abstract Background Innovative health technologies have increasingly emerged as a promising solution for patients with untreatable or challenging conditions. …”
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Piano Works by Dora Pejačević – A Personal Perspective of an Interpreter by Kyra Steckeweh

“…Dora Pejačević (1885–1923), a Croatian noblewoman and composer, emerges as a figure of profound musical depth and innovation. The article begins with an evocative description of Pejačević improvising at the piano, a scene recounted by Countess Sidonie Nádherný von Borutin in a letter to the poet Rainer Maria Rilke dated 5 October 1914. …”
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Patients’ and physiotherapists’ perspectives on implementing a tailored stratified treatment approach for low back pain in Nigeria: a qualitative study by Kay Stevenson, Mishael Adje, Jost Steinhäuser, Chidozie Emmanuel Mbada, Sven Karstens

“…Seven key categories emerged: recognising the need for change, acceptance of innovation, resistance to change, adapting practice, patient’s learning journey, trusting the therapist and needing conviction. …”
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Development and Optimization of Nano-Hydroxyapatite Encapsulating Tocotrienol-Rich Fraction Formulation Using Response Surface Methodology by Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias

“…However, its application is limited due to its poor oral bioavailability profile, warranting an innovative approach to overcome its pharmacokinetic limitations. …”
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Exploring patient preferences for intraocular lenses selection in age-related cataract: a discrete choice experiment study by Qiaolin Zhu, Qiaolin Zhu, Qiaolin Zhu, Qianqian Sun, Qianqian Sun, Qianqian Sun, Yujia Huo, Yujia Huo, Yujia Huo, Xiaoling Yang, Xiaoling Yang, Xiaoling Yang, Hehe Huang, Hehe Huang, Hehe Huang, Shanshan Qian, Shanshan Qian, Shanshan Qian, Wenjing Lin, Wentao Yan, Wentao Yan, Wentao Yan

“…These findings underscore the need for personalized IOLs recommendations and signal opportunities for innovation and customization in the IOLs industry.…”
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Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice by Peng Yu, Weiyin Xu, Yanqi Li, Zhaoyang Xie, Simeng Shao, Jianing Liu, Ying Wang, Long Wang, Hongmei Yang

“…This study aims to evaluate the effectiveness of ginsenosides 20R-Rg3 and Rg5 enriched BG (Rg3/Rg5-BG), innovatively prepared by low temperature steam-heating process, against colorectal cancer (CRC), and elucidate its potential molecular mechanism. …”
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Intelligent Turning Tool Monitoring with Neural Network Adaptive Learning by Maohua Du, Peixin Wang, Junhua Wang, Zheng Cheng, Shensong Wang

“…., (a) through distinctively designed experimental technique with comprehensive consideration of cutting parameters and tool wear values as variables, (b) through bisensor fusion for simultaneous measurements of low and high frequency signals, (c) through multitheory fusion of wavelet decomposition and the Relief-F algorithm for performing dual feature extraction and feature dimension reduction to achieve more accurate state identification using neural network, and (d) through an innovative programming technique of MATLAB-nested labVIEW. …”
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Effect of Web-Based Education on Self-efficacy and Self-care Ability in Heart Failure Patients by Ratih Arum Vatmasari, Kuswantoro Rusca Putra, Heni Windarwati

“…A web-based educational platform might be one of the innovations included in the development of health education for people with heart failure. …”
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UAV Hyperspectral Remote Sensing Image Classification: A Systematic Review by Zhen Zhang, Lehao Huang, Qingwang Wang, Linhuan Jiang, Yemao Qi, Shunyuan Wang, Tao Shen, Bo-Hui Tang, Yanfeng Gu

“…In recent years, significant advances in unmanned aerial vehicle (UAV) technology and hyperspectral remote sensing have spurred rapid and innovative developments in UAV-based hyperspectral image (HSI) classification across a range of fields, including environmental monitoring, precision agriculture, forest health assessment, and disaster management. …”
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Computational design of potent dimeric phenylthiazole NS5A inhibitors for hepatitis C virus by Wissal Liman, Mehdi Oubahmane, Nouhaila Ait Lahcen, Ismail Hdoufane, Driss Cherqaoui, Rachid Daoud, Achraf El Allali

“…While significant progress has been achieved in therapeutic interventions since the disease was first identified, its resurgence underscores the need for innovative strategies to combat it. The nonstructural protein NS5A is crucial in the life cycle of the HCV, serving as a significant factor in both viral replication and assembly processes. …”
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Metaphorical Toponyms of Present-Day Vilnius County: Extending Toponymy Research through Cognitive Metaphor Theory by Pavel Skorupa

“… Taking present-day Vilnius County, which marks the cultural and linguistic periphery, as a case study, the attempt is made in this paper to expand the horizons of traditional onomastic research by introducing Cognitive Metaphor Theory (CMT) as an innovative approach to understanding the motivation of toponyms. …”
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Design of an Improved Method for Visual Rendering in the Metaverse Using CIEM and MSRANet by Janapati Venkata Krishna, Priyanka Singh, Regonda Nagaraju, Setti Vidya Sagar Appaji, Attuluri Uday Kiran, K. Spandana

“…This paper alleviates these challenges by proposing a set of innovative models tailored to optimize visual rendering in deployments of the metaverse. …”
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Archibald Henry Sayce (1845–1933) and the Transition from 19th-Century Comparative Philology to 20th-Century General Linguistics by Subbiondo Joseph L., Kilarski Marcin

“…As an example of Sayce’s innovative contribution, we examine his theoretical and methodological principles, including the need for inductive generalizations based on large samples of data, the value of lesser-known languages as a window onto fundamental principles of language, and the status of linguistics vis-à-vis emerging fields of related study. …”
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Impact of pharmacist-prescriber partnerships to track antibiotic prescribing in publicly funded primary care in the Cape Town metropole, South Africa: An implementation study by O Van Hecke, Y Adegoke, M Allwood, K von Pressentin, M Namane, C Butler, M Mendelson, R Coetzee

“…Our findings have filled a fundamental gap in the evidence base that will inform antibiotic stewardship innovations, guideline development and future interventions. …”
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First note of QTL mapping of low vigor traits using the updated F2 ‘Koroneiki’ linkage map of olive by Irene Granata, Aparna S. Balan, Aparna S. Balan, Claudio Di Vaio, Antonino Ioppolo, Tiziano Caruso, Silvia Fretto, Jubina Benny, Antonio Giovino, Daniel James Sargent, Francesco Paolo Marra, Annalisa Marchese

“…By targeting the identified candidate genes, this research represents a pivotal step toward selecting new low-vigor genotypes and rootstocks, contributing to innovations in olive cultivation.…”
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Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica by Idrissi Amine Mounadi, Mahraz Mohamed Adil, Drioua Soufiane, Assouguem Amine, Ali Essam A., Ibrahim Mohamed A., Mehta Chandra Mohan, Lahlali Rachid, Tlemcani Sara, Moussaoui Fatima, En-nabety Ghizlan, Eloutassi Noureddine, Lahkimi Amal

“…Diabetes mellitus is a global health problem requiring innovative approaches for effective management. Natural compounds derived from medicinal plants offer promising avenues due to their diverse biological activities. …”
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A novel approach for agricultural carbon emission reduction by integrating fermatean neutrosophic set with WINGS and AHP-EWM by Kecheng Zhang, Zhicheng Chen, Yawen Wang

“…This study presents an innovative integrated model that employs Fermatean Neutrosophic Set in conjunction with the Weighted Influence Nonlinear Gauge System and the Analytic Hierarchy Process combined with the Entropy Weight Method to assess key factors influencing agricultural carbon reduction. …”
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