Single-cell RNA sequencing revealed PPARG promoted osteosarcoma progression: based on osteoclast proliferation by Lei Sun, Jinhao Zhang, Zhikai Xiahou, Zhenzhen Zhao, Yanchen Liang

“…Given the pivotal role of osteoclasts in OS progression, we speculated that these signaling pathways and transcription factors could emerge as novel therapeutic targets, offering innovative strategies for OS treatment.ConclusionThis study enhanced our understanding of OS and osteoclasts through scRNA-seq. …”
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Forensic Support of Pre-Trial Investigative and Inquiry Agencies’ Activities on Combating Crime by O. O. Yukhno

“…The author has studied the issues of current state and tendencies of criminalistics development, existing problematic issues and expediency of changing the scientific paradigm of criminalistics, application of innovations, introduction of modern achievements in the field of telecommunication and digital technologies, communication lines, Internet and the ways of their practical usage and further improvement. …”
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Smart blockchain-powered natural resource asset management and ecological governance countermeasures by Wende Huang, Yuan Han, Qiang Gu, Xiaolong Han, Tiansheng Gao

“…In response to the challenges of significant governance difficulties, low regulatory efficiency, and high enforcement difficulty in the ecological governance system of Qinghai Province, this study proposes an innovative solution aimed at remarkably enhancing the ecological governance system and capabilities nationwide. …”
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How to convert a 3D printer to a personal automated liquid handler for life science workflows by Dulguunnaran Naranbat, Benjamin Phelps, John Murphy, Anubhav Tripathi

“…This study presents an innovative approach to decentralizing a liquid handling system by converting a low-cost 3D printer into a customizable and accurate liquid handler. …”
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High-throughput phenotyping of wheat root angle and coleoptile length at different temperatures using 3D-printed equipment by Nevzat Aydin, Mesut Ersin Sönmez, Tuğba Güleç, Bedrettin Demir, Hadi Alipour, Aras Türkoğlu

“…Abstract Background Innovation in crop establishment is crucial for wheat productivity in drought-prone climates. …”
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Strategic Coupling and Its Impact on the Survival of Taiwan-Invested Enterprises in Chinese Mainland: A Configuration-Based Perspective by Sun Jiping, Wei Suqiong, You Xiaojun, Chen Jindong

“…The key factors influencing TDI shifted from labor costs to regional market size and then to high value-added, innovation-driven fields with more mainland cooperation. …”
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Planetary health education in undergraduate medical education in Germany: results from structured interviews and an online survey within the national PlanetMedEd Project by Fabio Grieco, Sandra Parisi, Anne Simmenroth, Michael Eichinger, Michael Eichinger, Janina Zirkel, Janina Zirkel, Sarah König, Jana Jünger, Jana Jünger, Eva Geck, Eva-Maria Schwienhorst-Stich

“…Key criteria defining high-quality Planetary Health Education, such as innovative educational approaches, practical skills, and transformative learning, were primarily reflected in electives, that reach only a minority of students. …”
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Hydrothermal synthesis of a nickel-oxide-infused orange peel nanobiocomposite for enhanced heavy metal removal from mining wastewater by Jacques Romain Njimou, Velma Fai, Mary Tamwa Sieugaing, Djimongbaye Nguenamadje, John Godwin, Oben Bessem Genola, Guy Bertrand Noumi, Bankim Chandra Tripathy

“…This study presents an innovative nanobiocomposite synthesized via hydrothermal methods, combining nickel oxide (NiO) and orange peel (OP) with alginate to create nickel-orange peel beads (Alg/OP-Ni). …”
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Application of core functions and forms in complex health intervention research: a scoping review protocol by Eunyoung Kang, Maria E Fernández, Jessica D Austin, Monica Perez Jolles, Katelyn Fox, Debbie Passey, Laura Zeigen, Erin Kenzie, Rachel J Meadows

“…Introduction The ability of healthcare, community and public health systems to effectively implement and disseminate research innovations depends on contextual factors at multiple interconnected levels of influence (eg, the innovation, individual, provider/implementor, organisation and health system). …”
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Customer Care and Increased Clientele: A Case Study of Centenary Bank Kabale Branch. by Tusiime, Bridget

“…Personalized interactions and efficient problem resolution create a loyal customer base, the 27% response rate for product and service innovation shows that clients value a bank that continually improves and diversifies its offerings. …”
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Evaluation of the efficiency of Russian universities: Do we need to change the paradigm? by E. V. Romanov

“…However, to a certain extent, such principles contradict the strategic goals for the breakthrough socio-economic, scientific and technological development of the country. Innovative development of the scientific and educational sphere is one of the conditions for this breakthrough. …”
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Differentiating Latent Tuberculosis from Active Tuberculosis Through Activation Phenotypes and Chemokine Markers HLA-DR, CD38, MCP-1, and RANTES: A Systematic Review and Meta-Analy... by Chaimae Kadi, Narjisse Ahmadi, Anass Houdou, Imad El Badisy, Oumnia Bouaddi, Zakaria Mennane, Nouhaila Najimi, Maryam Benlamari, Saber Boutayeb, Mohamed Khalis, Noureddine EL Mtili, Fouad Seghrouchni

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Health and social care use, costs, and satisfaction among key workers accessing Resilience Hub support during the COVID-19 pandemic by Aleix Rowlandson, Filippo Varese, Linda M. Davies, Paul French, Kate Allsopp, Lesley-Anne Carter, Daniel Hind, Katherine McGuirk, Alan Barrett, Gita Bhutani, Fay Huntley, Joanne Jordan, May Sarsam, Hein Ten Cate, Holly Walker, Ruth Watson, Jack Wilkinson, Jenni Willbourn, Gemma E. Shields

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Effects of housing conditions on health and gut microbiome of female cynomolgus monkeys and improvement of welfare by checking menstruation under socially housed condition by Yunpeng Yang, Yong Lu, Changshan Gao, Yanhong Nie, Hongfei Wang, Yufei Huang, Haiyan Dong, Qiang Sun

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Revealing the core suppression effects of various Di (2-ethylhexyl) phthalate exposure on early meiosis progression in postnatal male mice via single-cell RNA sequencing by Baoquan Han, Lei Hua, Shuai Yu, Wei Ge, Cong Huang, Yu Tian, Chunxiao Li, Jiamao Yan, Tian Qiao, Jiachen Guo, Dongliang Lu, Bin Wang, Diya Cai, Yunqi Zhang, Shaolin Liang, Jianjuan Zhao, Qi Hou, Wei Shen, Zhongyi Sun

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Perspectives and experiences regarding pre-exposure prophylaxis (PrEP) in a community sample of Veterans with unhealthy alcohol use: overall and across sexual orientation and gende... by Olivia V. Fletcher, Kristine Beaver, Elizabeth J. Austin, Jenna van Draanen, E. Jennifer Edelman, Emily C. Williams

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Modelling the seasonal dynamics of Aedes albopictus populations using a spatio-temporal stacked machine learning model by Daniele Da Re, Giovanni Marini, Carmelo Bonannella, Fabrizio Laurini, Mattia Manica, Nikoleta Anicic, Alessandro Albieri, Paola Angelini, Daniele Arnoldi, Federica Bertola, Beniamino Caputo, Claudio De Liberato, Alessandra della Torre, Eleonora Flacio, Alessandra Franceschini, Francesco Gradoni, Përparim Kadriaj, Valeria Lencioni, Irene Del Lesto, Francesco La Russa, Riccardo Paolo Lia, Fabrizio Montarsi, Domenico Otranto, Gregory L’Ambert, Annapaola Rizzoli, Pasquale Rombolà, Federico Romiti, Gionata Stancher, Alessandra Torina, Enkelejda Velo, Chiara Virgillito, Fabiana Zandonai, Roberto Rosà

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Metabolite Profiling and Association Analysis of Leaf Tipburn in Heat-Tolerant Bunching Onion Varieties by Tetsuya Nakajima, Reina Yamamoto, Kanako Matsuse, Masato Fuji, Koei Fujii, Sho Hirata, Mostafa Abdelrahman, Muneo Sato, Masami Yokota Hirai, Masayoshi Shigyo

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Serine/threonine protein kinase mediates rifampicin resistance in Brucella melitensis through interacting with ribosomal protein RpsD and affecting antioxidant capacity by Yaqin Yuan, Wenqing Ning, Junjie Chen, Jiquan Li, Tianqi Xue, Cuihong An, Lingling Mao, Guangzhi Zhang, Shizhong Zhou, Jiabo Ding, Xiaowen Yang, Jianqiang Ye

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Proximity-based solutions for optimizing autism spectrum disorder treatment: integrating clinical and process data for personalized care by Annarita Vignapiano, Annarita Vignapiano, Francesco Monaco, Francesco Monaco, Stefania Landi, Luca Steardo, Carlo Mancuso, Claudio Pagano, Gianvito Petrillo, Alessandra Marenna, Martina Piacente, Stefano Leo, Carminia Marina Ingenito, Rossella Bonifacio, Benedetta Di Gruttola, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Maria Pontillo, Giorgio Di Lorenzo, Giorgio Di Lorenzo, Alessio Fasano, Alessio Fasano, Alessio Fasano, Giulio Corrivetti, Giulio Corrivetti

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