Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…The safety profile was consistent with previous reports.DiscussionDeep longitudinal immunophenotyping, analysis of transcriptional changes, reduction in cells expressing pro-inflammatory cytokines, along with the marker of neuroaxonal damage provide novel and innovative evidence of CladT rebalancing the immune system towards a more homeostatic and less pathogenic state.Clinical Trial Registrationhttps://clinicaltrials.gov/study/, identifier NCT03364036.…”
Get full text

MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…Conclusion This study highlighted the innovative use of Danshensu in enhancing MSC-derived exosome therapy for PF. …”
Get full text

Dynamic Digital Radiography (DDR) in the Diagnosis of a Diaphragm Dysfunction by Elisa Calabrò, Tiana Lisnic, Maurizio Cè, Laura Macrì, Francesca Lucrezia Rabaiotti, Michaela Cellina

“…Dynamic Digital Radiography (DDR) has emerged as a valuable and innovative imaging technique due to its unique ability to evaluate diaphragm movement in real time, integrating dynamic functional information with static anatomical data. …”
Get full text

FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis by Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila

“…The complex etiology and pathophysiology of AP emphasize the need for innovative treatments. This study explores mRNA-based therapies delivering fibroblast growth factor 21 (FGF21) and apolipoprotein A1 (APOA1), alone and in combination, for treating experimental AP. …”
Get full text

Risk prediction models for feeding intolerance in patients with enteral nutrition: a systematic review and meta-analysis by Huijiao Chen, Jin Han, Jing Li, Jianhua Xiong, Dong Wang, Mingming Han, Yuehao Shen, Wenli Lu

“…Future research should emphasize the development of innovative predictive models. These endeavors should incorporate more extensive and diverse sample sizes, adhere to stringent methodological designs, and undergo rigorous multicenter external validation to ensure robustness and generalizability.Systematic review registrationIdentifier CRD42024585099, https://www.crd.york.ac.uk/prospero/display_record.php?…”
Get full text

Novel Procedures for Evaluating Autism Online in a Culturally Diverse Population of Children: Protocol for a Mixed Methods Pathway Development Study by Venus Mirzaei, Jeanne Wolstencroft, Georgia Lockwood Estrin, Eleanor Buckley, Shermina Sayani, Panos Katakis, Reena Anand, Tessa Squire, Eleanor Short, Paige Frankson, David Skuse, Michelle Heys

“…The COVID-19 pandemic accelerated the adoption of telemedicine, highlighting the benefits of innovative diagnostic tools. Telemedicine-based pathways could enhance accessibility and equity in autism diagnostics. …”
Get full text

Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment by Tangyi Wang, Yadian Lei, Jingwei Sun, Li Wang, Yuxin Lin, Zhijing Wu, Shoude Zhang, Chengzhu Cao, Chengzhu Cao, Chengzhu Cao, Haiyan Wang, Haiyan Wang, Haiyan Wang

“…Researchers may explore FDA-approved drugs targeting the potential target NANOS1 for TOE (Taraxacum officinale extract) treatment to develop innovative therapeutic strategies. In this context, Dig (Digoxin) and AA (Algestone acetophenide) have been identified as potential drug candidates for further exploration of their therapeutic effects and application potential in targeting NANOS1.MethodsRNA sequencing (RNA-seq) was employed to identify potential targets for triple-negative breast cancer (TNBC) from TOE. …”
Get full text

Study on the aquaculture capacity of whiteleg shrimp (Litopenaeus vannamei)-razor clam (Sinonovacula constricta) tandem mariculture pond by Chunpu Zhao, Gege Bao, Bocheng Mei, Yunhui Luo, Jilin Xu, Shanliang Xu, Danli Wang

“…Tandem aquaculture mode is an innovative and burgeoning approach in aquaculture, designed to enhance aquatic biological production while achieving zero discharge of aquaculture effluent. …”
Get full text

Critical technologies and geology-engineering integration practices for deep CBM production in the Yanchuannan CBM field by Zhenlong CHEN, Yunhai WANG, Xiao LIU, Bin CUI, Song YANG, Xin LI, Qilong FANG

“…Results and ConclusionsThe results indicate that the production capacity construction process of the Yanchuannan CBM field has undergone three stages: large-scale production capacity construction, addressing technological challenges, and technological innovations and their popularization. [Results and Conclusions] The following achievements were obtained: (1) The geological understanding of four critical indicators for the selection of optimal geological-engineering “sweet spots” and efficient CBM production. (2) The concept of fracturing through effective propping and key supporting technologies for reservoir stimulation. (3) The optimal and fast production technologies characterized by four stages, three pressures, and three aspects of control. …”
Get full text

Impact of cardiac factors on central airway anatomical parameters in patients undergoing lung mass surgery by Yingding Ruan, Hongsheng Xue, Wenjun Cao, Jianwei Han, Aiming Yang, Jincheng Xu, Ting Zhang

“…Conclusion This study innovatively examined the impact of cardiac factors on central airway anatomical parameters in adult patients with lung masses. …”
Get full text

Effectiveness and Safety of Preoperative Halo Gravity Traction-Assisted Posterior Spinal Fusion Surgery for Severe and Rigid Scoliosis: A Comparative Matched-Cohort Study by Yangpu Zhang, Bo Han, Jianqiang Wang, Yuzeng Liu, Yiqi Zhang, Yong Hai, Lijin Zhou

“…Severe and rigid scoliosis poses significant challenges in surgical correction, and innovative approaches are continually sought to enhance effectiveness and ensure patient safety. …”
Get full text

PSTR: A Test Case Reuse Method Based on Path Similarity by Xinyue Xu, Sinong Chen, Zhonghao Guo, Xiangxian Chen

“…Specifically, PSTR achieved comparable coverage with fewer reused test cases while significantly reducing the misuse rate. In summary, as an innovative test case reuse method, PSTR has demonstrated remarkable effectiveness and practicality. …”
Get full text

Community-based models of care for management of type 2 diabetes mellitus among non-pregnant adults in sub-Saharan Africa: A scoping review. by Emmanuel Firima, Lucia Gonzalez, Fabiola Ursprung, Elena Robinson, Jacqueline Huber, Jennifer M Belus, Fabian Raeber, Ravi Gupta, Gibrilla F Deen, Alain Amstutz, Bailah Leigh, Maja Weisser, Niklaus Daniel Labhardt

“…To facilitate access to quality care and improve treatment outcomes, there is a need for innovative community care models and optimized use of non-physician healthcare workers bringing diagnosis and care closer to patients' homes.…”
Get full text

A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in He... by Lee HW, Kang WY, Park JS, Lee JH, Park JJ, Gwon MR, Yoon YR, Seong SJ

“…Hae Won Lee,1 Woo Youl Kang,2 Ji Seo Park,1 Jae Hwa Lee,1 Jin Ju Park,1 Mi-Ri Gwon,1 Young-Ran Yoon,1 Sook Jin Seong1 1School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea; 2Clinical Trial Dossier Evaluation Team, Innovative Products Support Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of KoreaCorrespondence: Young-Ran Yoon, Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongdeok-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-420-4950, +82-53-420-5218, Email yry@knu.ac.kr Sook Jin Seong, Clinical Associate Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongduk-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-200-6351, +82-53-420-5218, Email wintersj@knu.ac.krBackground: YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma exposure and prolong the duration of acid suppression.Purpose: This study aimed to evaluate the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of YYD601 20 mg following single and multiple oral administrations in healthy, fasting adult Koreans, and to compare these outcomes to those of the conventional esomeprazole 20 mg capsule.Methods: A randomized, open-label, two-period crossover study was conducted in 28 participants, who were divided into two treatment groups: one group received YYD601 20 mg, and the other received conventional esomeprazole 20 mg, once daily for five consecutive days. …”
Get full text

Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“… BackgroundAdvancements in mobile technology have paved the way for innovative interventions aimed at promoting physical activity (PA). …”
Get full text

Network Design and Route Analysis Using Outside Plant by Isaac Adjaye Aboagye, Nii Longdon Sowah, Wiafe Owusu-Banahene, Aryee Shaelijah, Margaret Ansah Richardson, Emmanuel Baah-Boadi

“…The integration of novel technologies and innovative methodologies makes them relevant in today’s fast-evolving technologies.…”
Get full text

Does awake prone positioning prevent the use of mechanical respiratory support or death in COVID-19 patients on standard oxygen therapy hospitalised in general wards? A multicentre... by Benjamin Planquette, Christophe Perrin, Thierry Boulain, Mai-Anh Nay, Louis Bernard, Laurent Plantier, Léa Colombain, Jérémy Clément, Aymeric Sève, Sylvie Druelle, Marine Morrier, Jean-Baptiste Lainé, Grégory Corvaisier, Nicolas Bizien, Xavier Pouget-Abadie, Adrien Bigot, Elsa Nyamankolly, Guillaume Fossat

Get full text

Changes in the Advertisement of Goods and Services in the Lithuanian Periodic Press during 1918-1940 by Giedrė Polkaitė

“…An analysis of the advertising during 1918-1940 allows one to state that vehicles from the most well-known manufacturers, as well as contemporary technical innovations, reached Lithuania. Sewing machines, electric light bulbs, bicycles, typewriters, and radios were especially heavily advertised in this group. …”
Get full text

Design and Validation of Policy Making Model with Open Government Approach by Zahra Mohammadi, Abdolmajid Imani, Farahnaz Ahang

“…The beneficial consequences of implementing open government in higher education were evident in improved organizational accountability across organizational, legal, and professional domains, enhanced organizational performance including better social, economic, and innovative outcomes, and a reduction in academic corruption, which includes a decrease in data falsification, fraud, and other violations. …”
Get full text

Characterization and simulation of AlGaN barrier structure effects in normally-off recessed gate AlGaN/GaN MISHEMTs by An-Chen Liu, Hsin-Chu Chen, Po-Tsung Tu, Yan-Lin Chen, Yan-Chieh Chen, Po-Chun Yeh, Chih-I Wu, Shu-Tong Chang, Tsung-Sheng Kao, Hao-Chung Kuo

Get full text