Release Profile and Antibacterial Activity of <i>Thymus sibthorpii</i> Essential Oil-Incorporated, Optimally Stabilized Type I Collagen Hydrogels by Caglar Ersanli, Ioannis Skoufos, Konstantina Fotou, Athina Tzora, Yves Bayon, Despoina Mari, Eleftheria Sarafi, Konstantina Nikolaou, Dimitrios I. Zeugolis

“…In conclusion, this work presents an innovative antibacterial biomaterial system for tissue engineering applications, which could serve as a promising alternative to antibiotics, contributing to coping with the issue of antimicrobial resistance.…”
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Conceptual model of sustainable development of pedagogical staff competences in quality assurance of higher education by Andrii Biloshchytskyi, Andrii Biloshchytskyi, Oleksandr Kuchanskyi, Oleksandr Kuchanskyi, Oleksandr Kuchanskyi, Yurii Andrashko, Aidos Mukhatayev, Khanat Kassenov

“…Thus, the authors proposed an innovative approach to improving the level of competence of teachers of higher education institutions, which is focused on the effective assimilation of learning outcomes not only directly by teachers, but also by students of academic groups in which these teachers teach.…”
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Using Attention for Improving Defect Detection in Existing RC Bridges by Sergio Ruggieri, Angelo Cardellicchio, Andrea Nettis, Vito Reno, Giuseppina Uva

“…Hence, traditional methods of on-site inspection can be enhanced by leveraging digital innovations and by developing new instruments that support road management companies in ensuring the safety of the existing infrastructure. …”
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Anterolateral Minithoracotomy Mitral Valve Surgery with Central Cannulation: A Three-year Single-Center Experience by Anil Sharma, Sunil Dixit, Mohit Sharma, Jai Kishan Suthar, Sourabh Mittal

“…A simplified and reproducible technique for performing mitral valve surgery through a right minithoracotomy with central aortocaval cannulation from the same incision, utilizing conventional instruments, has been developed. This innovative approach eliminates the requirement for endoscopic assistance, femoral arterial cannulation, and associated complications. …”
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Specific Features of Interaction between Criminal Police Divisions and Other Subjects within Counteracting Criminal Offenses against Morality by O. M. Yemets

“…During the research the author has used the system of methods of scientific cognition: formal logic (abstraction, analogy, deduction, induction, synthesis) for the detailed clarification of the content of the considered issues; empirical – during the experimental study; method of system analysis – to determine the directions of introduction of innovative approaches to solve the problem; theoretical – during the study of scientific and educational literature; modeling – in the study of certain objects by modeling their individual features. …”
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Comparative analyses of the hemostatic efficacy and surgical device performance of powdered oxidized regenerated cellulose and starch-based powder formulations by Marianne Stark, Allen Y. Wang, Brittny Corrigan, Henok G. Woldu, Samar Azizighannad, Gustavo Cipolla, Richard Kocharian, Hector De Leon

“…The current study highlights the relevance of combining high-efficacy powder hemostats with innovative, high-performance applicators to effectively manage bleeding control in surgical settings.…”
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Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes by Amina Lazrek, Sebastiano Finocchi Ghersi, Adeline Petre, Sarah Houabes, Anne-Agathe Serre, Frederic Gassa, Magali Sandt, Cecile Laude, Camille Roukoz, Salvatore Cozzi

“…IntroductionProstate cancer remains a prevalent malignancy among men, often necessitating innovative therapeutic strategies for effective management of recurrent cases. …”
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Myeloid cell-derived apCAFs promote HNSCC progression by regulating proportion of CD4+ and CD8+ T cells by Feilong Ren, Lin Meng, Shize Zheng, Jiasen Cui, Shaoyi Song, Xing Li, Dandan Wang, Xing Li, Qilin Liu, Wenhuan Bu, Hongchen Sun

“…Therefore, our findings show potential innovative therapeutic approaches for the HNSCC. Significance: ApCAFs derived from myeloid cells promote the progression of HNSCC by increasing the ratio of CD4+/CD8+ cells, indicating potential novel targets to be used to treat the human HNSCC. …”
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Development of “non-places” by means of designing small architectural forms made of metal by M. G. Kruglova, A. Yu. Tikhonov

“…Art metal, as one of the most ancient occupations of mankind, preserves invaluable heritage and experience of the past, and within the framework of modern art culture initiates the creation of innovations based on new materials and approaches, contributing to the development of creative thinking and creative freedom.…”
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Autonomous security analysis and penetration testing model based on attack graph and deep Q-learning network by Cheng FAN, Guoqing HU, Taojie DING, Zhanhua ZHANG

“…With the continuous development and widespread application of network technology, network security issues have become increasingly prominent.Penetration testing has emerged as an important method for assessing and enhancing network security.However, traditional manual penetration testing methods suffer from inefficiency,human error, and tester skills, leading to high uncertainty and poor evaluation results.To address these challenges, an autonomous security analysis and penetration testing framework called ASAPT was proposed, based on attack graphs and deep Q-learning networks (DQN).The ASAPT framework was consisted of two main components:training data construction and model training.In the training data construction phase, attack graphs were utilized to model the threats in the target network by representing vulnerabilities and possible attacker attack paths as nodes and edges.By integrating the common vulnerability scoring system (CVSS) vulnerability database, a “state-action”transition matrix was constructed, which depicted the attacker’s behavior and transition probabilities in different states.This matrix comprehensively captured the attacker’s capabilities and network security status.To reduce computational complexity, a depth-first search (DFS) algorithm was innovatively applied to simplify the transition matrix, identifying and preserving all attack paths that lead to the final goal for subsequent model training.In the model training phase, a deep reinforcement learning algorithm based on DQN was employed to determine the optimal attack path during penetration testing.The algorithm interacted continuously with the environment, updating the Q-value function to progressively optimize the selection of attack paths.Simulation results demonstrate that ASAPT achieves an accuracy of 84% in identifying the optimal path and exhibits fast convergence speed.Compared to traditional Q-learning, ASAPT demonstrates superior adaptability in dealing with large-scale network environments, which could provide guidance for practical penetration testing.…”
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Advancements in Public First Responder Programs for Out-of-Hospital Cardiac Arrest: An Updated Literature Review by Michael Kern, Gerrit Jansen, Bernd Strickmann, Thoralf Kerner

“…Despite guidelines advocating for the “chain of survival”, bystander CPR and defibrillation rates remain suboptimal. Innovative approaches, such as dispatcher-assisted CPR (DA-CPR) and smartphone-based alerts, have emerged to address these challenges. …”
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Enhancing oral cancer treatment via photodynamic therapy: Gold nanoparticle-based delivery system for 5-aminolevulinic acid (5-ALA) by Romesa Soomro, Mohamed Abdelmonem, Bachren Azra Saputra, Che Azurahanim Che Abdullah

“…The novelty of this research lies in the application of green-synthesized AuNPs to enhance PS delivery in PDT, offering a more effective and less toxic treatment option for oral cancer. This innovative approach addresses the limitations of current PDT and nanoparticle synthesis methods, contributing to the development of more sustainable and biocompatible cancer therapies. …”
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CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Evaluation of pharmacokinetics, pharmacodynamics, safety and efficacy of rituximab biosimilar (Acellbia,  BIOCAD, Russia) used as  monotherapy in patients with indolent B-cell non-Hodgkin’s lymphoma in comparison with the parameters of innovator rituximab – MabThera.Materials and methods. 92 patients (aged 18 years and older with diagnosed CD20-positive follicular non-Hodgkin’s lymphoma, stage II-IV by Ann Arbor, 1-2 histologic grade, or marginal zone lymphoma) were enrolled into the study. …”
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Improved printed circuit board defect detection scheme by Lufeng Bai, Wen Hao Xu

“…This improved scheme mainly relies on the basic framework of YOLOv8n, and effectively enhances the detection performance of PCB small defects through multiple innovative designs. First, we incorporate the Efficient Channel Attention Network (ECANet) attention mechanism into the backbone network of YOLOv8, which improves the performance of small-target detection by adaptively enhancing the expressiveness of key features, so that the network possesses higher sensitivity and focus on tiny details in PCB images. …”
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Virtual reality and speech analysis for the assessment of impulsivity and decision-making: protocol for a comparison with neuropsychological tasks and self-administered questionnai... by Marta Ruiz, Maria Luisa Barrigon, Antonio Artes, Philippe Courtet, Enrique Baca-Garcia, Jorge Lopez-Castroman, Santiago de Leon-Martinez, Elena Parra-Vargas, Irene Chicchi-Giglioli, Alejandro Albán Porras-Segovia

“…We hypothesise that these innovative tools will be reliable and acceptable by patients, potentially improving the simultaneous assessment of impulsivity and decision-making.Methods and analysis This study will be carried out at the University Hospital Fundación Jiménez Díaz (Madrid, Spain). …”
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Efficient Beach Litter Monitoring: Accelerated Surveys of Pollution Hotspots—A North African Case Study by Emna Ben Slimane, Mirco Haseler, Lilia Ben Abdallah, Fadhel Mhiri, Abdallah Nassour, Gerald Schernewski

“…To address this gap and support the development of such a program, particularly at pollution hotspots like urban beaches, we conducted a one-year study on six Tunisian beaches. We employed an innovative, accelerated multiple 10 m transect method tailored to highly polluted beaches, focusing on macro-litter (>2.5 cm). …”
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Multifaceted properties of Ni and Zn codoped MgO nanoparticles by A. Chithra Mohan, A. Athira, Bindu P. Nair, G. Sivasubramanian, K. M. Sreekanth, Gopinathan Anoop, Sreeprasanth Pulinthanathu Sree, K. M. Sreedhar

“…By deciphering the complexities of the versatile nanomaterial, MgO, the study aims to deepen our comprehension of the synergistic effects induced by dual doping in MgO, thus propelling the advancement of innovative technologies and materials with broad applications. …”
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Simulator and on-road testing of truck platooning: a systematic review by Telmo Costa Botelho, Sérgio Pedro Duarte, Marta Campos Ferreira, Sara Ferreira, António Lobo

“…Abstract The evolution of transport technologies, marked by integrating connectivity and automation, has led to innovative approaches such as truck platooning. This concept involves linking multiple trucks through automated driving and vehicle-to-vehicle communication, promising to revolutionize the freight industry by enhancing efficiency and reducing operational costs. …”
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Deploying the Qline System for a QKD Metropolitan Network on the Berlin OpenQKD Testbed by Matheus Sena, Georg Harder, Ronny Doring, Ralf-Peter Braun, Michaela Ritter, Oliver Holschke, Marc Kaplan, Marc Geitz

“…In this study, we present a novel approach to address these issues by introducing a trusted-node-free design on a metropolitan scale for the seamless integration of a QKD system into the Berlin OpenQKD optical fiber testbed. Our innovative design leverages conventional telecom modulators and a standard Wavelength-Division Multiplexing - Arrayed Waveguide Grating (WDM-AWG), offering a practical solution for flexible multi-partner communication and enabling full connectivity between non-adjacent nodes. …”
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A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review by Giustino Varrassi, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Marco Cascella, Gabriele Finco, Salvatore Sardo, Chiara Corno, Domenico Tiso, Vittorio Schweiger, Diego Maria Michele Fornasari, Antonella Paladini

“…Finally, it examines some innovative patent, which aims to address obstacles encountered with conventional PEA formulations, for its pharmacodynamic characteristics. …”
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