Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry by Masafumi Kurajoh, Shinya Fukumoto, Takayo Murase, Takashi Nakamura, Takuma Ishihara, Hirofumi Go, Kouji Yamamoto, Shinya Nakatani, Akihiro Tsuda, Tomoaki Morioka, Katsuhito Mori, Yasuo Imanishi, Masaaki Inaba, Masanori Emoto

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Management strategies for the efficient energy production of brackish water desalination to ensure reliability, cost reduction, and sustainability by A. Bdour, A. Hejab, L. Almakhadmeh, M. Hawa

“…This involved determining the expected savings by calculating the area between two curves: the new actual consumption of the brackish water reverse osmosis plant after implementing energy conservation measures and the curve generated by the model representing the usual consumption in the absence of energy conservation measures.FINDINGS: This study underscores the challenges faced by desalination, particularly regarding intensive energy consumption. It also presents innovative ways to achieve sustainability by emphasizing energy efficiency, integrating renewable energy, and advocating for a holistic water management approach. …”
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Access to context-specific lexical-semantic information during discourse tasks differentiates speakers with latent aphasia, mild cognitive impairment, and cognitively healthy adult... by Brielle C. Stark, Brielle C. Stark, Sarah Grace Dalton, Alyssa M. Lanzi, Alyssa M. Lanzi

“…This study evaluates the potential for variables derived through core lexicon analysis to differentiate two clinical groups (latent aphasia, MCI) from each other, and from a cognitively healthy adult group, across three different discourse tasks (Aim 1). Innovatively, it also contrasts the sensitivity with which each task differentiates the groups based on this metric (Aim 2).MethodsTranscribed connected speech data from TalkBank were analyzed for three discourse tasks (i.e., Sandwich Procedure, Cat Rescue Picture Description, and Cinderella Story) from three participant groups [Mild Cognitive Impairment (MCI) n = 30, stroke-induced latent aphasia n = 29, and Cognitive Healthy Adults (CHA) n = 56]. …”
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A Community-Based Intervention for Mental Health and Wellbeing in Pregnancy and Postpartum: One Healthy Start Site’s Story by Sampson M, Xu W, York FN, Roberson J

“…McClain Sampson,1 Wen Xu,2 Felicia N York,3 Jerry Roberson4 1Graduate College of Social Work, University of Houston, Houston, TX, USA; 2Department of Innovative Social Work, Faculty of Health and Wellbeing, City University of Macau, Macao, SAR, People’s Republic of China; 3Texas A&M University, College Station, TX, USA; 4United Associates, Dallas, TX, USACorrespondence: McClain Sampson, Graduate College of Social Work, University of Houston, Houston, TX, USA, Email mmsampson@uh.eduPurpose: Perinatal mood and anxiety disorders (PMADs) are the leading cause for maternal morbidity and are associated with underlying causes of pregnancy-related death. …”
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Technologies for Interoperable Internet of Medical Things Platforms to Manage Medical Emergencies in Home and Prehospital Care: Scoping Review by Mattias Seth, Hoor Jalo, Åsa Högstedt, Otto Medin, Bengt Arne Sjöqvist, Stefan Candefjord

“…Transitioning to home-based care (HBC) may offer a sustainable solution, supported by technological innovations such as Internet of Medical Things (IoMT) platforms. …”
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Risk barriers and sustainability in payment for ecosystem service implementation in smallholder forestry by A. Ibrahim, S. Withaningsih, R. Kinseng, Parikesit ., D. Muhamad

“…The importance of reliable data is emphasized by technical hurdles like accurate measurement of ecosystem services and monitoring complexities, necessitating innovative solutions and robust methodologies. Biophysical conditions like rainfall patterns and soil health further influence program success, demanding tailored approaches for effective implementation. …”
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An online emergency medical management information system using mobile computing by Sarandis Mitropoulos, Christos Mitsis, Petros Valacheas, Christos Douligeris

“…It proposes the development of an effective, feasible and innovative EMS information system that will improve the existing emergency health care system in Greece (EKAB). …”
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The model of intermediate assessment of future teachers’ professional competencies by I. V. Golovina, Kh.-Akh. S. Khaladov, T. Yu. Medvedeva, G. A. Paputkova, A. V. Milekhin

“…The ideas of forming a unified educational space in the Russian Federation actualise the development of unified content and assessment components of teacher education programmes; therefore, there is the need to introduce innovative approaches to the process of assessing the learning outcomes of undergraduate pedagogical students. …”
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Adopting Positive Selection Technology and Improving Seed Quality in Smallholder Potato Farmers in South-Western Uganda. by Kajura, Tibanyendera Deo

“…To address this, technologies and innovations such as Positive Selection technology have been developed and promoted among smallholders to enable them generate their own clean seed on-farm for increased productivity. …”
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Designing a defensive silence failure model of creative employees in organizations by Azam Khosravi, karam khalili, Esfandyar Mohammadi

“…In order for organizations to survive in such conditions, they need employees who can respond to such a challenging environment; that is, those who are not afraid to share their knowledge and information with others and provide their opinions in the form of suggestions and criticisms or innovative ideas to organizations (Alipuor Baei et al, 2022). …”
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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…The safety profile was consistent with previous reports.DiscussionDeep longitudinal immunophenotyping, analysis of transcriptional changes, reduction in cells expressing pro-inflammatory cytokines, along with the marker of neuroaxonal damage provide novel and innovative evidence of CladT rebalancing the immune system towards a more homeostatic and less pathogenic state.Clinical Trial Registrationhttps://clinicaltrials.gov/study/, identifier NCT03364036.…”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…Conclusion This study highlighted the innovative use of Danshensu in enhancing MSC-derived exosome therapy for PF. …”
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FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis by Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila

“…The complex etiology and pathophysiology of AP emphasize the need for innovative treatments. This study explores mRNA-based therapies delivering fibroblast growth factor 21 (FGF21) and apolipoprotein A1 (APOA1), alone and in combination, for treating experimental AP. …”
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Novel Procedures for Evaluating Autism Online in a Culturally Diverse Population of Children: Protocol for a Mixed Methods Pathway Development Study by Venus Mirzaei, Jeanne Wolstencroft, Georgia Lockwood Estrin, Eleanor Buckley, Shermina Sayani, Panos Katakis, Reena Anand, Tessa Squire, Eleanor Short, Paige Frankson, David Skuse, Michelle Heys

“…The COVID-19 pandemic accelerated the adoption of telemedicine, highlighting the benefits of innovative diagnostic tools. Telemedicine-based pathways could enhance accessibility and equity in autism diagnostics. …”
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Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment by Tangyi Wang, Yadian Lei, Jingwei Sun, Li Wang, Yuxin Lin, Zhijing Wu, Shoude Zhang, Chengzhu Cao, Chengzhu Cao, Chengzhu Cao, Haiyan Wang, Haiyan Wang, Haiyan Wang

“…Researchers may explore FDA-approved drugs targeting the potential target NANOS1 for TOE (Taraxacum officinale extract) treatment to develop innovative therapeutic strategies. In this context, Dig (Digoxin) and AA (Algestone acetophenide) have been identified as potential drug candidates for further exploration of their therapeutic effects and application potential in targeting NANOS1.MethodsRNA sequencing (RNA-seq) was employed to identify potential targets for triple-negative breast cancer (TNBC) from TOE. …”
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Study on the aquaculture capacity of whiteleg shrimp (Litopenaeus vannamei)-razor clam (Sinonovacula constricta) tandem mariculture pond by Chunpu Zhao, Gege Bao, Bocheng Mei, Yunhui Luo, Jilin Xu, Shanliang Xu, Danli Wang

“…Tandem aquaculture mode is an innovative and burgeoning approach in aquaculture, designed to enhance aquatic biological production while achieving zero discharge of aquaculture effluent. …”
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Critical technologies and geology-engineering integration practices for deep CBM production in the Yanchuannan CBM field by Zhenlong CHEN, Yunhai WANG, Xiao LIU, Bin CUI, Song YANG, Xin LI, Qilong FANG

“…Results and ConclusionsThe results indicate that the production capacity construction process of the Yanchuannan CBM field has undergone three stages: large-scale production capacity construction, addressing technological challenges, and technological innovations and their popularization. [Results and Conclusions] The following achievements were obtained: (1) The geological understanding of four critical indicators for the selection of optimal geological-engineering “sweet spots” and efficient CBM production. (2) The concept of fracturing through effective propping and key supporting technologies for reservoir stimulation. (3) The optimal and fast production technologies characterized by four stages, three pressures, and three aspects of control. …”
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Effectiveness and Safety of Preoperative Halo Gravity Traction-Assisted Posterior Spinal Fusion Surgery for Severe and Rigid Scoliosis: A Comparative Matched-Cohort Study by Yangpu Zhang, Bo Han, Jianqiang Wang, Yuzeng Liu, Yiqi Zhang, Yong Hai, Lijin Zhou

“…Severe and rigid scoliosis poses significant challenges in surgical correction, and innovative approaches are continually sought to enhance effectiveness and ensure patient safety. …”
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Community-based models of care for management of type 2 diabetes mellitus among non-pregnant adults in sub-Saharan Africa: A scoping review. by Emmanuel Firima, Lucia Gonzalez, Fabiola Ursprung, Elena Robinson, Jacqueline Huber, Jennifer M Belus, Fabian Raeber, Ravi Gupta, Gibrilla F Deen, Alain Amstutz, Bailah Leigh, Maja Weisser, Niklaus Daniel Labhardt

“…To facilitate access to quality care and improve treatment outcomes, there is a need for innovative community care models and optimized use of non-physician healthcare workers bringing diagnosis and care closer to patients' homes.…”
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Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“… BackgroundAdvancements in mobile technology have paved the way for innovative interventions aimed at promoting physical activity (PA). …”
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