Aberrant B cell receptor signaling responses in circulating double-negative 2 B cells from radiographic axial spondyloarthritis patients by Rick Wilbrink, Stefan F.H. Neys, Rudi W. Hendriks, Anneke Spoorenberg, Frans G.M. Kroese, Odilia B.J. Corneth, Gwenny M.P.J. Verstappen

“…Objective: Radiographic axial spondyloarthritis (r-axSpA) is a chronic rheumatic disease in which innate immune cells and T cells are thought to play a major role. …”
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Interactive effects of triploidy induction and culture densities on growth performance and stress, immune, and metabolic responses in juvenile rainbow trout (Oncorhynchus mykiss) by Roghayeh Mahmoudi, Mahdi Naderi, Hakimeh Dopeikar, Seyed Ali Khorasaninasab, Seyed Hadi Seyedalhosseini

“…Overall, high density (50 kg/m3) negatively influenced fish performance, but moderate culture densities (20, 30, and 40 kg/m3) do not influence growth and stress, innate immune, and metabolic responses of fish. Thus, triploid rainbow trout juveniles can act well and be recommended to the aquaculture industry at a culture density of 40 kg/m3.…”
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Dietary rosemary oil with/without zymogen forte improves water quality, growth hormones, immune-physiological response, stress resilience, and health status of Chelon ramada grown... by Ashraf I. G. Elhetawy, Mohammed F. El Basuini, Ahmed I. A. Mansour, Shimaa A. Shahin, Amira A. Omar, Mohamed M. Zayed, Mohamed M. Abdel-Rahim

“…In addition, there were significant enhancements observed in the levels of innate immune markers, such as white blood cells, total protein, albumin, and immunoglobulin. …”
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New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A by Marina Vladimirovna Silkina, Alena Sergeevna Kartseva, Alena Konstantinovna Riabko, Mariia Aleksandrovna Makarova, Metkhun Madibronovich Rogozin, Yana Olegovna Romanenko, Igor Georgievich Shemyakin, Ivan Alekseevich Dyatlov, Victoria Valerievna Firstova

“…Hybridoma technology remains the preferred method for producing MAbs with naturally paired immunoglobulin genes and with preserved innate functions of immune cells. The affinity-matured human antibody repertoire may be ideal as a source for antibody therapeutics against BoNTs. …”
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Nutritional Innovation Using Green Seaweed (Ulva sp.) and Garlic Powder Extracts for White‐Leg Shrimp (Litopenaeus vannamei) Challenged by Vibrio harveyi by Nashwa Abdel‐Razek, Riad H. Khalil, Abeer A. M. Afifi, Afrah F. Alkhuriji, Dina M. Metwally

“…The stimulatory effects of Ulva sp. extract (UE) and garlic powder extract (GPE) on the growth performance and innate immune responses of white‐leg shrimp, Litopenaeus vannamei, and their challenge against V. harveyi infection were also investigated. …”
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SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…When compared in an in vitro human innate immunity construct to AS01B, the QS21/MPL® liposomal adjuvant system of GSK, and with QS21-Liposomes used as benchmarks, SPA14 displayed the strongest immunostimulatory potential based on antigen-presenting cell (APC) activation and cytokine secretion, which was essentially driven by the highly active E6020 agonist in this assay. …”
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Association between the attentional network efficiency and change of direction speed ability in young male Indian footballers by Debabrata Chatterjee, Santi Ranjan Dasgupta, Santi Ranjan Dasgupta, Arkadeb Dutta, Arkadeb Dutta

“…Hence, it may be concluded that better CODS ability is possibly an outcome of innate competence in executive control of the attentional network in young male footballers. …”
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Surgical Injury and Ischemia Prime the Adipose Stromal Vascular Fraction and Increase Angiogenic Capacity in a Mouse Limb Ischemia Model by Satoko Kishimoto, Ken-ichi Inoue, Ryoichi Sohma, Shigeru Toyoda, Masashi Sakuma, Teruo Inoue, Ken-ichiro Yoshida

“…Among the differentially expressed genes were innate immunity-related signals on both days 1 and 3 after priming. …”
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Involvement of Cholesterol Metabolic Pathways in Recovery from Noise-Induced Hearing Loss by Na Sai, Xi Shi, Yan Zhang, Qing-qing Jiang, Fei Ji, Shuo-long Yuan, Wei Sun, Wei-Wei Guo, Shi-Ming Yang, Wei-Ju Han

“…Our results showed that activation of metabolic, inflammatory, and innate immunity pathways may be involved in acute noise-induced hearing loss, while cholesterol metabolic pathways may play an important role in recovery of hearing ability following noise-induced hearing loss.…”
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Preparedness, prevention and control related to zoonotic avian influenza by EFSA Panel on Animal Health and Animal Welfare (AHAW), ECDC, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Claire Brugerolles, Thorsten Wolff, Anna Parys, Erika Lindh, Neus Latorre‐Margalef, Marie‐Anne Rameix Welti, Ralf Dürrwald, Ramona Trebbien, Sylvie Van der Werf, Magnus Gisslén, Isabella Monne, Alice Fusaro, Claire Guinat, Alessio Bortolami, Leonidas Alexakis, Theresa Enkirch, Olov Svartstrom, Katriina Willgert, Francesca Baldinelli, Ludovica Preite, Malin Grant, Alessandro Broglia, Angeliki Melidou

“…Thirty‐four mutations associated with five phenotypic traits (increased receptor specificity, haemagglutinin stability, neuraminidase specificity, enhanced polymerase activity and evasion of innate immunity) were shortlisted. AI viruses (AIVs) carrying multiple adaptive mutations and traits belonged to both low and highly pathogenic subtypes, mainly to A(H9N2), A(H7N9), A(H5N6) and A(H3N8), were sporadic and primarily detected in Asia. …”
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Immunoregulatory Effects of Subcutaneous Immunotherapy on Lymphocyte Subgroups and Cytokines in Children with Asthma by Yu-ting He, Ying Zhou, Qi Shao, Cong Gan, Meng Chen, Yu-ling Bao, Hai-yan Gu, Shu-lan Zhang, Yubao Cui, Man Tian

“…Flow cytometry was used to identify lymphocyte subtypes: type 2 innate lymphocytes (ILC2s), type 1 (Th1) and type 2 (Th2) helper T cells, T helper 17 (Th17) cells, and regulatory T (Treg) cells. …”
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Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

“…The regions in the model parameter space, in particular, for the rate of activation of innate immune cells (macrophages), in which the properties of bi-, multistability and hysteresis are expressed, have been identified, and the features cha rac terizing transition kinetics between stable equilibrium states have been explored. …”
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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…Background and aimsClubroot caused by the soilborne obligate parasite Plasmodiophora brassicae, is a devastating disease of Chinese cabbage and other crucifers. The innate diversity and adaptability of this pathogen pose significant challenges to effective control measures. …”
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Group a Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination by Henry M. Vu, Thomas E. Moran, Zhong Liang, Yun-Juan Bao, Paulina G. Carles, Jessica C. Keane, Madelyn G. Cerney, Caitlyn N. Dahnke, Ana L. Flores-Mireles, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee

“…To protect the host, the innate immune system creates fibrin clots to trap bacteria and prevent deeper spread. …”
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Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus... by Dong-Sup Lee, Mi-Ju Park, Namhee Lee, Yun-Hui Jeon, Jiyoon Yoo, Suk-kyung Shin, Songyi Lee, Byung-Jin Jung, Yun-Kyoung Hong, Keunhee Oh

“…Although systemic delivery of the oncolytic virus would maximize viral immunotherapy’s potential, this remains a hurdle due to the rapid removal of the administered virus by the complement and innate immune system. Infected cells produce some vaccinia viruses as extracellular enveloped virions, which evade complement attack and achieve longer survival by expressing host complement regulatory proteins (CRPs) on the host-derived envelope. …”
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Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosisResearch in context by Yali Luo, Jian Gao, Xinliang Su, Helian Li, Yingcen Li, Wenhao Qi, Xuling Han, Jingxuan Han, Yiran Zhao, Alin Zhang, Yan Zheng, Feng Qian, Hongyu He

“…Interpretation: NK cell subsets within innate immunity exhibit significant diagnostic value for sepsis, particularly when combined with B. salyersiae and CRP. …”
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High-fat diet-induced liver injury in Channa argus through lipid metabolism, anti-oxidative status, apoptosis, and inflammation by Jiaxin Tian, Ying Li, Jiwu Wan, Zhinan Yang, Guiqin Wang

“…At 90 days, the L22 group exhibited upregulation of pro-inflammatory genes NF-κB, p65, and MyD88, alongside increased expression of apoptosis-related genes Bax, caspase-3 (Cas3), Cas8, and Cas9. Innate immune-related biochemical parameters were measured by ELISA, the results showed that decreased complement 3 (C3), C4 and lysozyme levels were determined in serum of the L22 group. …”
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Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations by Ezequias Castillo-Lopez, Patrick Biber, Arife Sener-Aydemir, Karin Hummel, Ebrahim Razzazi-Fazeli, Nicole Reisinger, Qendrim Zebeli, Susanne Kreuzer-Redmer, Thomas Hartinger

“…Conclusions This study provides new insights into the bovine colostrum proteome, demonstrating associations between IgG levels and the abundance of other proteins, as well as the enrichment of metabolic processes related to innate immune response. Thus, results suggest that the colostrum proteomic profile is associated with the content of IgG. …”
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Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study by Jing Wang, Chen Chen, Xiaoying Hu, Yi Fan, Yaping Wang, Yu Qiu, Qiujiao Yang, Mingming Xu, Yanfeng Weng, Yanni Li, Lisong Lin, Fa Chen, Baochang He, Fengqiong Liu

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The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

“…RNA-seq analysis indicates that tPA in the SN is required for the upregulation of genes involved in the innate and adaptive immune responses induced by α-synuclein overexpression. …”
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