Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance. by Magdalena Widziolek, Anna Mieszkowska, Magdalena Marcinkowska, Bartlomiej Salamaga, Justyna Folkert, Krzysztof Rakus, Magdalena Chadzinska, Jan Potempa, Graham P Stafford, Tomasz K Prajsnar, Craig Murdoch

“…These data demonstrate the important role of phagocytes, especially macrophages, in combating Pg infection and highlight the crucial protective role of gingipains in subverting the innate immune response. This study also emphasizes the advantages of using zebrafish to study interactions of Pg with phagocytes in vivo in real-time, providing a valuable experimental system for testing new therapeutic strategies aimed at reducing periodontal-associated systemic or neurodegenerative disease.…”
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IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection by Robert B. Ashman, Dipti Vijayan, Christine A. Wells

“…IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. …”
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Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of Phosphatidylserine as a Main Regulator by Joao Luiz Mendes Wanderley, Jaqueline França Costa, Valéria Matos Borges, Marcello Barcinski

“…The poor activation of an effective cellular response is correlated with the ability of these parasites to infect mononuclear phagocytic cells without triggering their activation or actively suppressing innate responses of these cells. Here we discuss the possible role of phosphatidylserine exposure by these parasites as a main regulator of the mechanism underlying subversion of the immune system at different steps during the infection.…”
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The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism by Mark Farrugia, Byron Baron

“…Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. …”
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The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation by Malihe Moradzadeh, Sirous Tayebi, Hossein Poustchi, Kourosh Sayehmiri, Parisa Shahnazari, Elnaz Naderi, Ghodratollah Montazeri, Ashraf Mohamadkhani

“…Recognition mechanisms of innate immune response help to improve immunotherapeutic strategies in HBeAg-negative chronic hepatitis B (CHB). …”
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Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury by Lisa Debler, Annette Palmer, Sonja Braumüller, Bettina Klohs, Tom Eirik Mollnes, Karlheinz Holzmann, Markus Huber-Lang, Rebecca Halbgebauer

“…These results demonstrate that an additional HS plays an important role in the immune dysregulation early after PT by shifting the balance to increased innate and reduced adaptive immune responses.…”
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Interview with Marc Prensky on Digital Natives and AI Natives: Reframing and Empowering 21st Century Kids by Gülden Demir

“…Prensky provided insightful definitions of digital natives and AI natives, emphasizing the innate familiarity and adaptability of younger generations to digital tools and emerging AI technologies.…”
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Powering the Immune System: Mitochondria in Immune Function and Deficiency by Melissa A. Walker, Stefano Volpi, Katherine B. Sims, Jolan E. Walter, Elisabetta Traggiai

“…Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. …”
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The Involvement of Microglial Cells in Japanese Encephalitis Infections by Thananya Thongtan, Chutima Thepparit, Duncan R. Smith

“…Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.…”
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Role of Complement in Multiorgan Failure by Daniel Rittirsch, Heinz Redl, Markus Huber-Lang

“…The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. Uncontrolled activation of the complement system during sepsis and SIRS with in excessive generation of complement activation products contributes to an ensuing dysfunction of various organ systems. …”
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Dossier Imitation - Introduction générale by Odile Petit, Olivier Pascalis

“…Learning occurs via imitation and several questions can be asked: Is imitation innate? Will studying its ontogeny help understanding its cognitive processes? …”
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Beyond modular and non-modular states: theoretical considerations, exemplifications, and practical implications by Francesco Benso, Carlo Chiorri, Eleonora Ardu, Paola Venuti, Angela Pasqualotto, Angela Pasqualotto

“…The concept of modularity in neuropsychology remains a topic of significant debate, especially when considering complex, non-innate, hyper-learned, and adaptable modular systems. …”
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Analysis of Reproductive Strategies and Immunological Interactions in <i>Batrachochytrium dendrobatidis</i>-Resistant Japanese Tree Frogs by Ji-Eun Lee, Jun-Kyu Park, Yuno Do

“…During the peak breeding season, we captured 70 males and quantified the chorus size, calling behaviors, physiological states, innate immunity, and sperm quality of individuals. …”
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Induction of translation-suppressive G3BP1+ stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA by Vladimir Majerciak, Zhi-Ming Zheng

“…Here, we found that plasmid DNA transfection mediated by liposomes activates multiple innate immune responses in several widely used cell lines. …”
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Characterization of Transverse Aortic Constriction in Mice Based on the Specific Recruitment of Leukocytes to the Hypertrophic Myocardium and the Aorta Ascendens by Jan Lukas Kleiner, Odilia Köpke, Anton Faron, Yunyang Zhang, Jan Cornelssen, Mark Coburn, Stilla Frede, Lars Eichhorn, Christina Katharina Weisheit

“…In the present study, we characterized the time course in innate immune cell dynamics in response to TAC in the different tissues of mice. …”
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NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation by Agata Habas, Srinivasa Reddy Natala, Jon K. Bowden-Verhoek, Emily M. Stocking, Diana L. Price, Wolfgang Wrasidlo, Douglas W. Bonhaus, Martin B. Gill

“…Toll-like receptors (TLRs) play a critical role in innate immune system responses to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). …”
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Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis by Joes Nogueira-Neto, Flavio V. Loures, Alessandra S. Schanoski, David A. G. Andrade, Michelangelo B. Gonzatti, Tania A. Costa, Bruno C. Vivanco, Patrícia Xander, Daniela S. Rosa, Vera L. G. Calich, Alexandre C. Keller

“…Using splenocytes from CD1d (CD1d-/-) and iNKT-deficient (Jα18-/-) mice, we found that iNKT cells are the innate source of IFN-γ after P. brasiliensis infection and are required to potentiate macrophage oxidative burst and control fungal growth. …”
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Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells by Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie, Aatif Qureshi, Fernando Botelho

“…IL-33 modulates both innate and adaptive immune responses at tissue sites including lung and may play critical roles in inflammatory lung disease. …”
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The liver’s dilemma: sensing real danger in a sea of PAMPs: the (arterial) sinusoidal segment theory by Andrea Henriques-Pons, Natália Vacani-Martins, Carina de Lima Pereira dos Santos, Marcelo Meuser-Batista

“…Therefore, in arterial sinusoidal segments with no sea of PAMPs, the liver could recognize real danger and support innate and adaptive immunity.…”
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Immunomodulatory Effects of Aerobic Training in Obesity by Thomas Nickel, Henner Hanssen, Ingrid Emslander, Verena Drexel, Gernot Hertel, Arno Schmidt-Trucksäss, Claudia Summo, Zeljka Sisic, Marius Lambert, Eva Hoster, Martin Halle, Michael Weis

“…We hereby describe new immune modulatory effects, which—through regular aerobic exercise—modulate innate immunity and pro-inflammatory cytokines in obesity.…”
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