Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection by Ali Vural, John H. Kehrl

“…This review focuses on the intimately linked molecular mechanisms that help govern the autophagic pathway and macrophage innate immune responses.…”
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Host Cell Autophagy in Immune Response to Zoonotic Infections by Panagiotis Skendros, Ioannis Mitroulis

“…Accumulating evidence supports the pivotal role of autophagy in host defense against intracellular pathogens implicating both innate and adaptive immunity. Many of these pathogens cause common zoonotic infections worldwide. …”
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Interleukin-1 signaling and CD4+ T cells control B cell recruitment to the lungs in chronic beryllium disease by Joseph M. Gaballa, Caley Valdez, Douglas G. Mack, Faiz Minhajuddin, Masoom Raza, Tabrez A. Mohammad, Allison K. Martin, Andrew Getahun, Charles A. Dinarello, Andrew P. Fontenot, Shaikh M. Atif

“…However, the mechanisms by which innate molecules influence the recruitment of B cells and B cell-mediated protection in CBD are poorly understood. …”
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Effects of Microbes on Insect Host Physiology and Behavior Mediated by the Host Immune System by Shan Zhang, Zhengyan Wang, Qiong Luo, Lizhen Zhou, Xin Du, Yonglin Ren

“…Innate immunity is critical for insects to adjust to complicated environments. …”
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Investigation of genes expression of the JAK/STAT signalling pathway and AMPs in the presence of Borrelia spirochetes in Ixodes ricinus by Magdalena Szczotko, Sandra Antunes, Ana Domingos, Małgorzata Dmitryjuk

“…This is a particular challenge for blood-feeding vectors such as ticks, which ingest large amounts of blood potentially laden with harmful microorganisms. Ticks have a basic innate immune system and protect themselves from infection through innate immune responses involving pathways such as Janus kinase (JAK) or the signalling transducer activator of transcription (STAT). …”
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Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…Our immune defense depends on two specialized armed forces. The innate force acts as an alarm mechanism that senses changes in the microenvironment through the recognition of common microbial patterns by Toll-like receptors (TLR) and NOD proteins. …”
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Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives by Giuseppe Lopalco, Luca Cantarini, Antonio Vitale, Florenzo Iannone, Maria Grazia Anelli, Laura Andreozzi, Giovanni Lapadula, Mauro Galeazzi, Donato Rigante

“…A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance, and systemic inflammation. …”
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Mucosal Herpes Immunity and Immunopathology to Ocular and Genital Herpes Simplex Virus Infections by Aziz Alami Chentoufi, Lbachir BenMohamed

“…The understanding of innate and adaptive immune mechanisms operating at muco-cutaneous surfaces is fundamental to the design of next-generation herpes vaccines. …”
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Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract by Kaei Nasu, Hisashi Narahara

“…Rapid innate immune defenses against microbial infection usually involve the recognition of invading pathogens by specific pattern-recognition receptors recently attributed to the family of Toll-like receptors (TLRs). …”
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Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing. by Tiana M Scott, Lydia M Arnold, Jordan A Powers, Delaney A McCann, Ana B Rowe, Devin E Christensen, Miguel J Pereira, Wen Zhou, Rachel M Torrez, Janet H Iwasa, Philip J Kranzusch, Wesley I Sundquist, Jarrod S Johnson

“…Retroviruses can be detected by the innate immune sensor cyclic GMP-AMP synthase (cGAS), which recognizes reverse-transcribed DNA and activates an antiviral response. …”
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Inflammation and Immune Response in COPD: Where Do We Stand? by Nikoletta Rovina, Antonia Koutsoukou, Nikolaos G. Koulouris

“…Cigarette smoke activates innate immune cells by triggering pattern recognition receptors (PRRs) to release “danger signal”. …”
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Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Catalytic antibacterial nanoparticles that generate reactive oxygen species (ROS) are emerging, as a promising therapeutic approach in treating bacterial infection by boosting the innate immune defenses. However, the interaction between innate immune cells and these catalytic nanoparticles remains poorly understood. …”
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Untangling the Web of Systemic Autoinflammatory Diseases by Donato Rigante, Giuseppe Lopalco, Antonio Vitale, Orso Maria Lucherini, Francesco Caso, Caterina De Clemente, Francesco Molinaro, Mario Messina, Luisa Costa, Mariangela Atteno, Franco Laghi-Pasini, Giovanni Lapadula, Mauro Galeazzi, Florenzo Iannone, Luca Cantarini

“…The innate immune system is involved in the pathophysiology of systemic autoinflammatory diseases (SAIDs), an enlarging group of disorders caused by dysregulated production of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α, in which autoreactive T-lymphocytes and autoantibodies are indeed absent. …”
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Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice by Ryan Brown, Donna M. Small, Declan F. Doherty, Leslie Holsinger, Robert Booth, Richard Williams, Rebecca J. Ingram, J. Stuart Elborn, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon

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NK-DC Crosstalk in Immunity to Microbial Infection by Rony Thomas, Xi Yang

“…The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. …”
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Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells by Rapeepat Sangsuwan, Bhasirie Thuamsang, Noah Pacifici, Phum Tachachartvanich, Devan Murphy, Abhineet Ram, John Albeck, Jamal S. Lewis

“…This study identifies key biochemical pathways in innate immune cells that are impacted by lactate, which advances our understanding of the interplay between the tumor microenvironment and innate immunity.…”
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ILC2 Proliferated by IL-33 Stimulation Alleviates Acute Colitis in Rag1-/- Mouse through Promoting M2 Macrophage Polarization by Yong You, Xiaoqing Zhang, Xiao Wang, Dan Yue, Fanxiang Meng, Junfeng Zhu, Yuanyuan Wang, Xun Sun

“…This study was to identify functions of ILC2, a newly found innate lymphoid cell which mainly locates in mucosa organs like lungs and intestines, in IBD. …”
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Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population densit... by Stephen C. Gironda, Samuel W. Centanni, Jeffrey L. Weiner

“…Further, ELS can induce innate immune memory formation in microglia and brain macrophages resulting in altered responsivity to future environmental stimuli. …”
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Elevated Proportions of Circulating CXCR5+ Follicular Helper T Cells Reflect the Presence of Airway Obstruction in Asthma by Tsukie Kin Tsukuda, Kimiko Tsuji, Akari Nishimori, Takehiko Ito, Yuka Kobayashi, Taro Suzuki, Akihito Yokoyama

“…Using flow cytometry, we identified and quantified Group 2 innate lymphocytes, T helper 2 cells, follicular helper T cells, and T helper 17 cells in peripheral blood samples from 49 individuals with asthma. …”
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Inflammasome in Intestinal Inflammation and Cancer by Tiago Nunes, Heitor S. de Souza

“…Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens.…”
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